LeishMANIAdb
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GPR1/FUN34/yaaH family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family, putative
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H540_LEIDO
TriTrypDb:
LdBPK_030380.1 , LdCL_030008800 , LDHU3_03.0390
Length:
303

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005886 plasma membrane 3 2

Expansion

Sequence features

A0A3S5H540
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H540

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0006835 dicarboxylic acid transport 7 2
GO:0006846 acetate transport 6 2
GO:0009987 cellular process 1 2
GO:0015711 organic anion transport 5 2
GO:0015718 monocarboxylic acid transport 7 2
GO:0015740 C4-dicarboxylate transport 8 2
GO:0015744 succinate transport 6 2
GO:0015849 organic acid transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0035433 acetate transmembrane transport 5 2
GO:0046942 carboxylic acid transport 6 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071422 succinate transmembrane transport 5 2
GO:0071702 organic substance transport 4 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0008509 monoatomic anion transmembrane transporter activity 4 2
GO:0008514 organic anion transmembrane transporter activity 5 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015078 proton transmembrane transporter activity 5 2
GO:0015123 acetate transmembrane transporter activity 6 2
GO:0015291 secondary active transmembrane transporter activity 4 2
GO:0015293 symporter activity 5 2
GO:0015294 solute:monoatomic cation symporter activity 5 2
GO:0015295 solute:proton symporter activity 6 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 2
GO:0015360 acetate:proton symporter activity 7 2
GO:0022804 active transmembrane transporter activity 3 2
GO:0022853 active monoatomic ion transmembrane transporter activity 4 2
GO:0022857 transmembrane transporter activity 2 2
GO:0022890 inorganic cation transmembrane transporter activity 4 2
GO:0043893 acetate:monoatomic cation symporter activity 6 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 62 64 PF00675 0.406
CLV_NRD_NRD_1 66 68 PF00675 0.397
CLV_NRD_NRD_1 85 87 PF00675 0.332
CLV_PCSK_KEX2_1 66 68 PF00082 0.452
CLV_PCSK_KEX2_1 85 87 PF00082 0.301
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.443
CLV_PCSK_SKI1_1 265 269 PF00082 0.346
CLV_PCSK_SKI1_1 63 67 PF00082 0.419
DEG_APCC_DBOX_1 264 272 PF00400 0.556
DEG_APCC_DBOX_1 66 74 PF00400 0.587
DOC_CYCLIN_yClb5_NLxxxL_5 205 212 PF00134 0.522
DOC_MAPK_DCC_7 265 273 PF00069 0.556
DOC_MAPK_DCC_7 85 95 PF00069 0.488
DOC_MAPK_MEF2A_6 205 214 PF00069 0.489
DOC_MAPK_MEF2A_6 265 273 PF00069 0.556
DOC_USP7_MATH_1 149 153 PF00917 0.311
DOC_USP7_MATH_1 15 19 PF00917 0.716
DOC_USP7_MATH_1 171 175 PF00917 0.281
DOC_USP7_MATH_1 287 291 PF00917 0.648
DOC_USP7_UBL2_3 64 68 PF12436 0.611
DOC_WW_Pin1_4 280 285 PF00397 0.648
LIG_14-3-3_CanoR_1 141 146 PF00244 0.471
LIG_Actin_RPEL_3 258 277 PF02755 0.499
LIG_APCC_ABBA_1 26 31 PF00400 0.523
LIG_BIR_II_1 1 5 PF00653 0.689
LIG_BRCT_BRCA1_1 180 184 PF00533 0.345
LIG_deltaCOP1_diTrp_1 138 145 PF00928 0.545
LIG_FHA_1 100 106 PF00498 0.315
LIG_FHA_1 115 121 PF00498 0.274
LIG_FHA_1 171 177 PF00498 0.322
LIG_FHA_1 214 220 PF00498 0.343
LIG_FHA_1 272 278 PF00498 0.581
LIG_FHA_2 20 26 PF00498 0.542
LIG_LIR_Gen_1 144 155 PF02991 0.324
LIG_LIR_Gen_1 196 204 PF02991 0.357
LIG_LIR_Gen_1 218 229 PF02991 0.443
LIG_LIR_Nem_3 144 150 PF02991 0.311
LIG_LIR_Nem_3 151 156 PF02991 0.296
LIG_LIR_Nem_3 181 187 PF02991 0.261
LIG_LIR_Nem_3 196 200 PF02991 0.285
LIG_LIR_Nem_3 218 224 PF02991 0.358
LIG_MLH1_MIPbox_1 180 184 PF16413 0.345
LIG_SH2_STAT5 147 150 PF00017 0.316
LIG_SH2_STAT5 183 186 PF00017 0.318
LIG_SH2_STAT5 188 191 PF00017 0.321
LIG_SH2_STAT5 252 255 PF00017 0.314
LIG_SH2_STAT5 27 30 PF00017 0.665
LIG_SH3_3 266 272 PF00018 0.482
LIG_SUMO_SIM_anti_2 196 203 PF11976 0.394
LIG_SUMO_SIM_anti_2 216 221 PF11976 0.303
LIG_WRC_WIRS_1 194 199 PF05994 0.382
MOD_CDC14_SPxK_1 283 286 PF00782 0.556
MOD_CDK_SPxK_1 280 286 PF00069 0.557
MOD_CK1_1 2 8 PF00069 0.741
MOD_CK1_1 228 234 PF00069 0.256
MOD_CK2_1 54 60 PF00069 0.568
MOD_GlcNHglycan 17 20 PF01048 0.465
MOD_GlcNHglycan 231 234 PF01048 0.495
MOD_GlcNHglycan 289 292 PF01048 0.453
MOD_GlcNHglycan 4 7 PF01048 0.606
MOD_GSK3_1 109 116 PF00069 0.369
MOD_GSK3_1 15 22 PF00069 0.714
MOD_GSK3_1 166 173 PF00069 0.304
MOD_GSK3_1 224 231 PF00069 0.441
MOD_GSK3_1 54 61 PF00069 0.651
MOD_N-GLC_1 36 41 PF02516 0.432
MOD_NEK2_1 107 112 PF00069 0.290
MOD_NEK2_1 156 161 PF00069 0.348
MOD_NEK2_1 200 205 PF00069 0.314
MOD_NEK2_1 215 220 PF00069 0.342
MOD_NEK2_1 224 229 PF00069 0.321
MOD_NEK2_1 58 63 PF00069 0.523
MOD_NEK2_1 98 103 PF00069 0.331
MOD_PIKK_1 271 277 PF00454 0.537
MOD_PIKK_1 36 42 PF00454 0.606
MOD_PKA_2 58 64 PF00069 0.630
MOD_Plk_1 263 269 PF00069 0.543
MOD_Plk_4 114 120 PF00069 0.266
MOD_Plk_4 156 162 PF00069 0.317
MOD_Plk_4 215 221 PF00069 0.382
MOD_Plk_4 99 105 PF00069 0.322
MOD_ProDKin_1 280 286 PF00069 0.653
TRG_ENDOCYTIC_2 147 150 PF00928 0.318
TRG_ENDOCYTIC_2 153 156 PF00928 0.328
TRG_ENDOCYTIC_2 188 191 PF00928 0.355
TRG_ENDOCYTIC_2 241 244 PF00928 0.351
TRG_ENDOCYTIC_2 252 255 PF00928 0.282
TRG_ER_diArg_1 67 70 PF00400 0.595
TRG_ER_diArg_1 84 86 PF00400 0.571
TRG_NLS_MonoCore_2 65 70 PF00514 0.505
TRG_NLS_MonoExtC_3 62 67 PF00514 0.511
TRG_NLS_MonoExtN_4 63 70 PF00514 0.513
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 68 72 PF00026 0.394

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I5 Leptomonas seymouri 49% 77%
A0A0N1PAF6 Leptomonas seymouri 66% 83%
A0A1X0P9Q6 Trypanosomatidae 52% 100%
A0A3R7M294 Trypanosoma rangeli 37% 100%
A0A3R7MT82 Trypanosoma rangeli 46% 100%
A0A3S5H538 Leishmania donovani 91% 82%
A0A451EJN9 Leishmania donovani 25% 98%
A4H3K6 Leishmania braziliensis 69% 98%
A4H3K7 Leishmania braziliensis 72% 85%
A4HRU7 Leishmania infantum 26% 100%
A4HRU8 Leishmania infantum 97% 82%
A4HRV0 Leishmania infantum 100% 100%
B0YBR5 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 27% 100%
E9ACI2 Leishmania major 27% 100%
E9ACI3 Leishmania major 92% 82%
E9ACI5 Leishmania major 91% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 81%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 97%
P32907 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P41943 Yarrowia lipolytica (strain CLIB 122 / E 150) 31% 100%
Q24JP1 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 27% 100%
Q460G9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 24% 100%
Q5B2K4 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS