LeishMANIAdb
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GPR1/FUN34/yaaH family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/yaaH family, putative
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H538_LEIDO
TriTrypDb:
LdBPK_030360.1 * , LdCL_030008600 , LDHU3_03.0370
Length:
370

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
GO:0005886 plasma membrane 3 3

Expansion

Sequence features

A0A3S5H538
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H538

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0006811 monoatomic ion transport 4 3
GO:0006820 monoatomic anion transport 5 3
GO:0006835 dicarboxylic acid transport 7 3
GO:0006846 acetate transport 6 3
GO:0009987 cellular process 1 3
GO:0015711 organic anion transport 5 3
GO:0015718 monocarboxylic acid transport 7 3
GO:0015740 C4-dicarboxylate transport 8 3
GO:0015744 succinate transport 6 3
GO:0015849 organic acid transport 5 3
GO:0034220 monoatomic ion transmembrane transport 3 3
GO:0035433 acetate transmembrane transport 5 3
GO:0046942 carboxylic acid transport 6 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071422 succinate transmembrane transport 5 3
GO:0071702 organic substance transport 4 3
GO:0098656 monoatomic anion transmembrane transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 3
GO:0008324 monoatomic cation transmembrane transporter activity 4 3
GO:0008509 monoatomic anion transmembrane transporter activity 4 3
GO:0008514 organic anion transmembrane transporter activity 5 3
GO:0015075 monoatomic ion transmembrane transporter activity 3 3
GO:0015078 proton transmembrane transporter activity 5 3
GO:0015123 acetate transmembrane transporter activity 6 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015293 symporter activity 5 3
GO:0015294 solute:monoatomic cation symporter activity 5 3
GO:0015295 solute:proton symporter activity 6 3
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 3
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 3
GO:0015360 acetate:proton symporter activity 7 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022853 active monoatomic ion transmembrane transporter activity 4 3
GO:0022857 transmembrane transporter activity 2 3
GO:0022890 inorganic cation transmembrane transporter activity 4 3
GO:0043893 acetate:monoatomic cation symporter activity 6 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.573
CLV_C14_Caspase3-7 90 94 PF00656 0.646
CLV_NRD_NRD_1 143 145 PF00675 0.305
CLV_NRD_NRD_1 50 52 PF00675 0.466
CLV_NRD_NRD_1 80 82 PF00675 0.463
CLV_PCSK_FUR_1 48 52 PF00082 0.405
CLV_PCSK_KEX2_1 352 354 PF00082 0.344
CLV_PCSK_KEX2_1 50 52 PF00082 0.444
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.327
CLV_PCSK_SKI1_1 31 35 PF00082 0.434
CLV_PCSK_SKI1_1 324 328 PF00082 0.375
DEG_APCC_DBOX_1 323 331 PF00400 0.575
DOC_CYCLIN_yClb5_NLxxxL_5 264 271 PF00134 0.468
DOC_MAPK_DCC_7 144 154 PF00069 0.528
DOC_MAPK_DCC_7 324 332 PF00069 0.524
DOC_MAPK_MEF2A_6 264 273 PF00069 0.517
DOC_MAPK_MEF2A_6 324 332 PF00069 0.575
DOC_USP7_MATH_1 139 143 PF00917 0.428
DOC_USP7_MATH_1 208 212 PF00917 0.375
DOC_USP7_MATH_1 230 234 PF00917 0.348
DOC_USP7_MATH_1 49 53 PF00917 0.623
DOC_USP7_MATH_1 9 13 PF00917 0.833
DOC_WW_Pin1_4 64 69 PF00397 0.619
LIG_14-3-3_CanoR_1 200 205 PF00244 0.535
LIG_14-3-3_CanoR_1 31 39 PF00244 0.620
LIG_14-3-3_CanoR_1 51 57 PF00244 0.636
LIG_Actin_RPEL_3 317 336 PF02755 0.487
LIG_BIR_II_1 1 5 PF00653 0.700
LIG_BRCT_BRCA1_1 239 243 PF00533 0.321
LIG_deltaCOP1_diTrp_1 197 204 PF00928 0.517
LIG_FHA_1 1 7 PF00498 0.694
LIG_FHA_1 159 165 PF00498 0.344
LIG_FHA_1 174 180 PF00498 0.346
LIG_FHA_1 230 236 PF00498 0.312
LIG_FHA_1 273 279 PF00498 0.360
LIG_FHA_1 331 337 PF00498 0.583
LIG_FHA_1 34 40 PF00498 0.642
LIG_FHA_1 97 103 PF00498 0.661
LIG_LIR_Gen_1 203 214 PF02991 0.310
LIG_LIR_Gen_1 255 263 PF02991 0.383
LIG_LIR_Gen_1 277 288 PF02991 0.390
LIG_LIR_Gen_1 55 62 PF02991 0.603
LIG_LIR_Nem_3 203 209 PF02991 0.332
LIG_LIR_Nem_3 210 215 PF02991 0.355
LIG_LIR_Nem_3 240 246 PF02991 0.317
LIG_LIR_Nem_3 255 259 PF02991 0.373
LIG_LIR_Nem_3 277 283 PF02991 0.318
LIG_LIR_Nem_3 55 59 PF02991 0.601
LIG_MLH1_MIPbox_1 239 243 PF16413 0.317
LIG_NRP_CendR_1 369 370 PF00754 0.412
LIG_SH2_CRK 56 60 PF00017 0.642
LIG_SH2_SRC 91 94 PF00017 0.645
LIG_SH2_STAP1 56 60 PF00017 0.625
LIG_SH2_STAT5 115 118 PF00017 0.591
LIG_SH2_STAT5 206 209 PF00017 0.369
LIG_SH2_STAT5 242 245 PF00017 0.384
LIG_SH2_STAT5 247 250 PF00017 0.385
LIG_SH2_STAT5 311 314 PF00017 0.350
LIG_SH2_STAT5 58 61 PF00017 0.674
LIG_SH2_STAT5 91 94 PF00017 0.704
LIG_SH3_3 17 23 PF00018 0.644
LIG_SH3_3 325 331 PF00018 0.484
LIG_SUMO_SIM_anti_2 255 262 PF11976 0.302
LIG_SUMO_SIM_anti_2 275 280 PF11976 0.369
LIG_WRC_WIRS_1 253 258 PF05994 0.369
MOD_CK1_1 100 106 PF00069 0.710
MOD_CK1_1 287 293 PF00069 0.264
MOD_CK1_1 361 367 PF00069 0.712
MOD_CK1_1 52 58 PF00069 0.776
MOD_CK2_1 21 27 PF00069 0.681
MOD_GlcNHglycan 121 124 PF01048 0.353
MOD_GlcNHglycan 290 293 PF01048 0.529
MOD_GlcNHglycan 363 366 PF01048 0.403
MOD_GSK3_1 115 122 PF00069 0.694
MOD_GSK3_1 168 175 PF00069 0.281
MOD_GSK3_1 225 232 PF00069 0.266
MOD_GSK3_1 283 290 PF00069 0.396
MOD_GSK3_1 354 361 PF00069 0.585
MOD_GSK3_1 60 67 PF00069 0.700
MOD_GSK3_1 81 88 PF00069 0.815
MOD_GSK3_1 96 103 PF00069 0.765
MOD_N-GLC_1 353 358 PF02516 0.364
MOD_N-GLC_1 96 101 PF02516 0.480
MOD_N-GLC_2 70 72 PF02516 0.418
MOD_NEK2_1 157 162 PF00069 0.353
MOD_NEK2_1 166 171 PF00069 0.353
MOD_NEK2_1 215 220 PF00069 0.342
MOD_NEK2_1 259 264 PF00069 0.339
MOD_NEK2_1 274 279 PF00069 0.342
MOD_NEK2_1 283 288 PF00069 0.365
MOD_PIKK_1 330 336 PF00454 0.518
MOD_PIKK_1 358 364 PF00454 0.555
MOD_PKA_1 81 87 PF00069 0.683
MOD_PKA_2 354 360 PF00069 0.590
MOD_PKA_2 49 55 PF00069 0.717
MOD_PKA_2 97 103 PF00069 0.703
MOD_Plk_1 322 328 PF00069 0.514
MOD_Plk_1 9 15 PF00069 0.627
MOD_Plk_4 158 164 PF00069 0.353
MOD_Plk_4 173 179 PF00069 0.304
MOD_Plk_4 215 221 PF00069 0.316
MOD_Plk_4 274 280 PF00069 0.373
MOD_ProDKin_1 64 70 PF00069 0.621
TRG_ENDOCYTIC_2 206 209 PF00928 0.351
TRG_ENDOCYTIC_2 212 215 PF00928 0.324
TRG_ENDOCYTIC_2 247 250 PF00928 0.310
TRG_ENDOCYTIC_2 300 303 PF00928 0.396
TRG_ENDOCYTIC_2 311 314 PF00928 0.396
TRG_ENDOCYTIC_2 56 59 PF00928 0.644
TRG_ER_diArg_1 368 370 PF00400 0.656
TRG_ER_diArg_1 47 50 PF00400 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAF6 Leptomonas seymouri 60% 100%
A0A3S5H540 Leishmania donovani 91% 100%
A4H3K6 Leishmania braziliensis 70% 100%
A4H3K7 Leishmania braziliensis 63% 100%
A4HRU8 Leishmania infantum 99% 100%
A4HRV0 Leishmania infantum 90% 100%
E9ACI2 Leishmania major 27% 100%
E9ACI3 Leishmania major 91% 100%
E9ACI5 Leishmania major 82% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
V5BCC6 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS