DDRGK domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DDRGK domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H536_LEIDO

TriTrypDb:

LdBPK_030320.1 , LdCL_030008200 , LDHU3_03.0330

Length:

342

Annotations

LeishMANIAdb annotations

Similar to distant Eukaryotic DDRGK proteins. Likely bound to the ER.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S5H536

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H536

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.691
CLV_MEL_PAP_1	322	328	PF00089	0.286
CLV_NRD_NRD_1	137	139	PF00675	0.408
CLV_NRD_NRD_1	150	152	PF00675	0.336
CLV_NRD_NRD_1	177	179	PF00675	0.461
CLV_NRD_NRD_1	194	196	PF00675	0.454
CLV_NRD_NRD_1	58	60	PF00675	0.531
CLV_NRD_NRD_1	84	86	PF00675	0.518
CLV_NRD_NRD_1	94	96	PF00675	0.467
CLV_PCSK_FUR_1	82	86	PF00082	0.560
CLV_PCSK_FUR_1	92	96	PF00082	0.523
CLV_PCSK_KEX2_1	150	152	PF00082	0.388
CLV_PCSK_KEX2_1	177	179	PF00082	0.461
CLV_PCSK_KEX2_1	194	196	PF00082	0.366
CLV_PCSK_KEX2_1	57	59	PF00082	0.506
CLV_PCSK_KEX2_1	82	84	PF00082	0.514
CLV_PCSK_KEX2_1	92	94	PF00082	0.463
CLV_PCSK_SKI1_1	140	144	PF00082	0.462
CLV_PCSK_SKI1_1	273	277	PF00082	0.262
CLV_PCSK_SKI1_1	304	308	PF00082	0.273
DOC_MAPK_gen_1	321	328	PF00069	0.533
DOC_PP4_FxxP_1	307	310	PF00568	0.533
DOC_USP7_MATH_1	246	250	PF00917	0.659
DOC_USP7_MATH_1	29	33	PF00917	0.699
DOC_USP7_MATH_1	51	55	PF00917	0.785
DOC_USP7_UBL2_3	139	143	PF12436	0.594
DOC_WW_Pin1_4	253	258	PF00397	0.673
LIG_14-3-3_CanoR_1	162	170	PF00244	0.535
LIG_14-3-3_CanoR_1	230	235	PF00244	0.632
LIG_14-3-3_CanoR_1	323	329	PF00244	0.450
LIG_Actin_WH2_2	260	278	PF00022	0.524
LIG_Actin_WH2_2	6	24	PF00022	0.404
LIG_BIR_II_1	1	5	PF00653	0.386
LIG_BIR_III_4	127	131	PF00653	0.661
LIG_FHA_1	118	124	PF00498	0.730
LIG_LIR_Nem_3	311	316	PF02991	0.450
LIG_NRBOX	7	13	PF00104	0.360
LIG_PCNA_PIPBox_1	228	237	PF02747	0.579
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.589
LIG_SH2_PTP2	305	308	PF00017	0.533
LIG_SH2_STAP1	205	209	PF00017	0.574
LIG_SH2_STAT5	305	308	PF00017	0.513
LIG_SUMO_SIM_par_1	264	270	PF11976	0.479
LIG_TRAF2_1	184	187	PF00917	0.630
LIG_TRAF2_1	257	260	PF00917	0.717
LIG_TRAF2_1	278	281	PF00917	0.533
LIG_TRAF2_1	327	330	PF00917	0.533
LIG_WRC_WIRS_1	231	236	PF05994	0.551
MOD_CK1_1	2	8	PF00069	0.457
MOD_CK1_1	255	261	PF00069	0.615
MOD_CK2_1	253	259	PF00069	0.694
MOD_CK2_1	275	281	PF00069	0.415
MOD_CK2_1	324	330	PF00069	0.316
MOD_CK2_1	58	64	PF00069	0.644
MOD_Cter_Amidation	80	83	PF01082	0.753
MOD_GlcNHglycan	1	4	PF01048	0.607
MOD_GlcNHglycan	248	251	PF01048	0.612
MOD_GlcNHglycan	30	34	PF01048	0.722
MOD_GlcNHglycan	51	54	PF01048	0.719
MOD_GSK3_1	226	233	PF00069	0.467
MOD_GSK3_1	45	52	PF00069	0.733
MOD_N-GLC_1	49	54	PF02516	0.743
MOD_N-GLC_1	64	69	PF02516	0.707
MOD_NEK2_1	45	50	PF00069	0.678
MOD_PIKK_1	22	28	PF00454	0.554
MOD_PIKK_1	287	293	PF00454	0.457
MOD_PIKK_1	45	51	PF00454	0.685
MOD_PKA_1	58	64	PF00069	0.715
MOD_PKA_2	226	232	PF00069	0.519
MOD_PKA_2	324	330	PF00069	0.302
MOD_PKA_2	45	51	PF00069	0.702
MOD_PKA_2	58	64	PF00069	0.457
MOD_Plk_1	111	117	PF00069	0.693
MOD_Plk_2-3	111	117	PF00069	0.693
MOD_Plk_4	2	8	PF00069	0.454
MOD_Plk_4	230	236	PF00069	0.524
MOD_ProDKin_1	253	259	PF00069	0.610
MOD_SUMO_rev_2	179	185	PF00179	0.504
TRG_DiLeu_BaEn_4	215	221	PF01217	0.659
TRG_DiLeu_LyEn_5	311	316	PF01217	0.457
TRG_ENDOCYTIC_2	305	308	PF00928	0.346
TRG_ER_diArg_1	193	195	PF00400	0.609
TRG_ER_diArg_1	320	323	PF00400	0.415
TRG_ER_diArg_1	44	47	PF00400	0.706
TRG_ER_diArg_1	56	59	PF00400	0.702
TRG_ER_diArg_1	82	85	PF00400	0.662
TRG_ER_diArg_1	91	94	PF00400	0.601
TRG_NLS_MonoExtN_4	135	142	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I6	Leptomonas seymouri	55%	100%
A0A3R7MKY1	Trypanosoma rangeli	44%	100%
A4H3K4	Leishmania braziliensis	77%	100%
A4HRU4	Leishmania infantum	99%	100%
B0WIW5	Culex quinquefasciatus	28%	100%
D0A242	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9ACH9	Leishmania major	92%	100%
E9AJR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5C2C3	Trypanosoma cruzi	44%	100%