Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H535_LEIDO

TriTrypDb:

LdBPK_030310.1 , LdCL_030008100 , LDHU3_03.0320

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H535

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H535

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.553
CLV_C14_Caspase3-7	388	392	PF00656	0.663
CLV_MEL_PAP_1	486	492	PF00089	0.423
CLV_NRD_NRD_1	135	137	PF00675	0.515
CLV_NRD_NRD_1	220	222	PF00675	0.724
CLV_NRD_NRD_1	247	249	PF00675	0.717
CLV_NRD_NRD_1	424	426	PF00675	0.474
CLV_NRD_NRD_1	465	467	PF00675	0.505
CLV_NRD_NRD_1	599	601	PF00675	0.661
CLV_PCSK_FUR_1	597	601	PF00082	0.461
CLV_PCSK_KEX2_1	135	137	PF00082	0.514
CLV_PCSK_KEX2_1	247	249	PF00082	0.714
CLV_PCSK_KEX2_1	3	5	PF00082	0.764
CLV_PCSK_KEX2_1	354	356	PF00082	0.670
CLV_PCSK_KEX2_1	424	426	PF00082	0.476
CLV_PCSK_KEX2_1	465	467	PF00082	0.557
CLV_PCSK_KEX2_1	599	601	PF00082	0.473
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.793
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.691
CLV_PCSK_SKI1_1	136	140	PF00082	0.582
CLV_PCSK_SKI1_1	168	172	PF00082	0.442
CLV_PCSK_SKI1_1	229	233	PF00082	0.708
CLV_PCSK_SKI1_1	248	252	PF00082	0.631
CLV_PCSK_SKI1_1	354	358	PF00082	0.784
CLV_PCSK_SKI1_1	449	453	PF00082	0.404
DEG_APCC_DBOX_1	267	275	PF00400	0.539
DEG_APCC_DBOX_1	327	335	PF00400	0.620
DEG_APCC_DBOX_1	448	456	PF00400	0.460
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DEG_SPOP_SBC_1	105	109	PF00917	0.706
DEG_SPOP_SBC_1	237	241	PF00917	0.726
DEG_SPOP_SBC_1	252	256	PF00917	0.701
DOC_CYCLIN_RxL_1	287	297	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.508
DOC_MAPK_DCC_7	401	411	PF00069	0.455
DOC_MAPK_DCC_7	545	554	PF00069	0.390
DOC_MAPK_gen_1	165	174	PF00069	0.448
DOC_MAPK_gen_1	2	9	PF00069	0.739
DOC_MAPK_MEF2A_6	168	176	PF00069	0.416
DOC_MAPK_MEF2A_6	2	9	PF00069	0.581
DOC_MAPK_MEF2A_6	545	554	PF00069	0.390
DOC_PP2B_LxvP_1	526	529	PF13499	0.487
DOC_PP4_FxxP_1	380	383	PF00568	0.676
DOC_PP4_FxxP_1	521	524	PF00568	0.534
DOC_PP4_FxxP_1	595	598	PF00568	0.644
DOC_SPAK_OSR1_1	191	195	PF12202	0.528
DOC_USP7_MATH_1	105	109	PF00917	0.665
DOC_USP7_MATH_1	204	208	PF00917	0.826
DOC_USP7_MATH_1	238	242	PF00917	0.698
DOC_USP7_MATH_1	253	257	PF00917	0.735
DOC_USP7_MATH_1	280	284	PF00917	0.420
DOC_USP7_MATH_1	338	342	PF00917	0.729
DOC_USP7_MATH_1	395	399	PF00917	0.745
DOC_USP7_MATH_1	426	430	PF00917	0.666
DOC_USP7_MATH_1	488	492	PF00917	0.432
DOC_USP7_MATH_1	550	554	PF00917	0.456
DOC_USP7_MATH_1	620	624	PF00917	0.603
DOC_USP7_UBL2_3	245	249	PF12436	0.675
DOC_WW_Pin1_4	101	106	PF00397	0.755
DOC_WW_Pin1_4	321	326	PF00397	0.552
DOC_WW_Pin1_4	346	351	PF00397	0.699
DOC_WW_Pin1_4	368	373	PF00397	0.677
DOC_WW_Pin1_4	433	438	PF00397	0.545
DOC_WW_Pin1_4	540	545	PF00397	0.487
LIG_14-3-3_CanoR_1	208	212	PF00244	0.749
LIG_14-3-3_CanoR_1	365	371	PF00244	0.768
LIG_14-3-3_CanoR_1	416	426	PF00244	0.515
LIG_14-3-3_CanoR_1	489	496	PF00244	0.420
LIG_14-3-3_CanoR_1	545	549	PF00244	0.548
LIG_AP2alpha_2	580	582	PF02296	0.674
LIG_APCC_ABBA_1	292	297	PF00400	0.565
LIG_APCC_ABBA_1	88	93	PF00400	0.526
LIG_BIR_III_2	391	395	PF00653	0.662
LIG_BRCT_BRCA1_1	109	113	PF00533	0.613
LIG_BRCT_BRCA1_1	370	374	PF00533	0.561
LIG_deltaCOP1_diTrp_1	182	192	PF00928	0.528
LIG_deltaCOP1_diTrp_1	609	618	PF00928	0.663
LIG_FHA_1	122	128	PF00498	0.544
LIG_FHA_1	188	194	PF00498	0.489
LIG_FHA_1	238	244	PF00498	0.699
LIG_FHA_1	511	517	PF00498	0.448
LIG_FHA_1	532	538	PF00498	0.415
LIG_FHA_1	59	65	PF00498	0.457
LIG_FHA_2	112	118	PF00498	0.485
LIG_FHA_2	201	207	PF00498	0.738
LIG_FHA_2	267	273	PF00498	0.589
LIG_FHA_2	321	327	PF00498	0.567
LIG_FHA_2	386	392	PF00498	0.740
LIG_LIR_Apic_2	519	524	PF02991	0.476
LIG_LIR_Gen_1	371	380	PF02991	0.704
LIG_LIR_Gen_1	443	452	PF02991	0.441
LIG_LIR_Nem_3	443	448	PF02991	0.406
LIG_LIR_Nem_3	615	621	PF02991	0.583
LIG_NRBOX	227	233	PF00104	0.710
LIG_NRBOX	447	453	PF00104	0.433
LIG_Pex14_2	181	185	PF04695	0.525
LIG_SH2_SRC	32	35	PF00017	0.714
LIG_SH2_SRC	332	335	PF00017	0.617
LIG_SH2_STAT3	84	87	PF00017	0.455
LIG_SH2_STAT5	379	382	PF00017	0.457
LIG_SH2_STAT5	417	420	PF00017	0.500
LIG_SH2_STAT5	430	433	PF00017	0.628
LIG_SH2_STAT5	548	551	PF00017	0.416
LIG_SH3_3	180	186	PF00018	0.460
LIG_SH3_3	400	406	PF00018	0.561
LIG_SH3_3	455	461	PF00018	0.514
LIG_SH3_3	99	105	PF00018	0.689
LIG_SUMO_SIM_par_1	290	297	PF11976	0.406
LIG_SUMO_SIM_par_1	407	413	PF11976	0.524
LIG_SUMO_SIM_par_1	524	530	PF11976	0.481
LIG_TRAF2_1	324	327	PF00917	0.626
MOD_CDK_SPK_2	540	545	PF00069	0.478
MOD_CDK_SPxxK_3	321	328	PF00069	0.550
MOD_CK1_1	100	106	PF00069	0.650
MOD_CK1_1	107	113	PF00069	0.576
MOD_CK1_1	116	122	PF00069	0.423
MOD_CK1_1	207	213	PF00069	0.749
MOD_CK1_1	255	261	PF00069	0.802
MOD_CK1_1	491	497	PF00069	0.465
MOD_CK1_1	540	546	PF00069	0.551
MOD_CK1_1	585	591	PF00069	0.548
MOD_CK1_1	623	629	PF00069	0.565
MOD_CK2_1	111	117	PF00069	0.584
MOD_CK2_1	18	24	PF00069	0.718
MOD_CK2_1	196	202	PF00069	0.749
MOD_CK2_1	320	326	PF00069	0.542
MOD_CK2_1	338	344	PF00069	0.661
MOD_CK2_1	619	625	PF00069	0.715
MOD_Cter_Amidation	219	222	PF01082	0.706
MOD_Cter_Amidation	352	355	PF01082	0.682
MOD_GlcNHglycan	240	243	PF01048	0.745
MOD_GlcNHglycan	255	258	PF01048	0.796
MOD_GlcNHglycan	309	312	PF01048	0.591
MOD_GlcNHglycan	351	354	PF01048	0.779
MOD_GlcNHglycan	412	415	PF01048	0.506
MOD_GlcNHglycan	529	532	PF01048	0.341
MOD_GlcNHglycan	587	590	PF01048	0.573
MOD_GSK3_1	105	112	PF00069	0.607
MOD_GSK3_1	196	203	PF00069	0.731
MOD_GSK3_1	251	258	PF00069	0.765
MOD_GSK3_1	366	373	PF00069	0.727
MOD_GSK3_1	527	534	PF00069	0.411
MOD_GSK3_1	540	547	PF00069	0.486
MOD_GSK3_1	619	626	PF00069	0.698
MOD_GSK3_1	97	104	PF00069	0.663
MOD_N-GLC_1	623	628	PF02516	0.636
MOD_NEK2_1	106	111	PF00069	0.671
MOD_NEK2_1	307	312	PF00069	0.541
MOD_NEK2_1	432	437	PF00069	0.651
MOD_NEK2_1	474	479	PF00069	0.505
MOD_NEK2_1	517	522	PF00069	0.553
MOD_NEK2_1	582	587	PF00069	0.591
MOD_NEK2_1	83	88	PF00069	0.404
MOD_NEK2_2	224	229	PF00069	0.628
MOD_PIKK_1	266	272	PF00454	0.606
MOD_PIKK_1	280	286	PF00454	0.475
MOD_PIKK_1	417	423	PF00454	0.547
MOD_PIKK_1	42	48	PF00454	0.657
MOD_PIKK_1	488	494	PF00454	0.460
MOD_PIKK_1	83	89	PF00454	0.462
MOD_PKA_2	10	16	PF00069	0.740
MOD_PKA_2	164	170	PF00069	0.588
MOD_PKA_2	207	213	PF00069	0.724
MOD_PKA_2	215	221	PF00069	0.711
MOD_PKA_2	488	494	PF00069	0.434
MOD_PKA_2	544	550	PF00069	0.512
MOD_Plk_1	116	122	PF00069	0.505
MOD_Plk_1	224	230	PF00069	0.633
MOD_Plk_1	550	556	PF00069	0.450
MOD_Plk_1	608	614	PF00069	0.667
MOD_Plk_1	623	629	PF00069	0.668
MOD_Plk_1	72	78	PF00069	0.503
MOD_Plk_2-3	196	202	PF00069	0.607
MOD_Plk_4	227	233	PF00069	0.710
MOD_Plk_4	338	344	PF00069	0.601
MOD_Plk_4	395	401	PF00069	0.690
MOD_Plk_4	560	566	PF00069	0.406
MOD_Plk_4	608	614	PF00069	0.739
MOD_ProDKin_1	101	107	PF00069	0.755
MOD_ProDKin_1	321	327	PF00069	0.552
MOD_ProDKin_1	346	352	PF00069	0.698
MOD_ProDKin_1	368	374	PF00069	0.678
MOD_ProDKin_1	433	439	PF00069	0.530
MOD_ProDKin_1	540	546	PF00069	0.479
MOD_SUMO_rev_2	164	172	PF00179	0.430
TRG_DiLeu_BaEn_4	326	332	PF01217	0.626
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.483
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.506
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.605
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.515
TRG_ER_diArg_1	134	136	PF00400	0.472
TRG_ER_diArg_1	328	331	PF00400	0.607
TRG_ER_diArg_1	4	7	PF00400	0.770
TRG_ER_diArg_1	424	426	PF00400	0.594
TRG_ER_diArg_1	464	466	PF00400	0.510
TRG_ER_diArg_1	573	576	PF00400	0.546
TRG_ER_diArg_1	597	600	PF00400	0.554
TRG_NES_CRM1_1	161	173	PF08389	0.545
TRG_NLS_MonoCore_2	2	7	PF00514	0.780
TRG_NLS_MonoExtC_3	1	6	PF00514	0.787
TRG_NLS_MonoExtN_4	2	7	PF00514	0.777
TRG_NLS_MonoExtN_4	245	252	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I3	Leptomonas seymouri	56%	88%
A0A0S4KI67	Bodo saltans	33%	100%
A0A1X0P8P7	Trypanosomatidae	44%	100%
A4H3K3	Leishmania braziliensis	76%	100%
A4HRU3	Leishmania infantum	99%	100%
D0A241	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACH8	Leishmania major	92%	100%
E9AJR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BSU9	Trypanosoma cruzi	42%	100%