Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H531_LEIDO

TriTrypDb:

LdBPK_030270.1 , LdCL_030007700 , LDHU3_03.0280

Length:

1001

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H531

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H531

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1
GO:0035091	phosphatidylinositol binding	4	1
GO:1901981	phosphatidylinositol phosphate binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.584
CLV_C14_Caspase3-7	424	428	PF00656	0.653
CLV_NRD_NRD_1	10	12	PF00675	0.599
CLV_NRD_NRD_1	109	111	PF00675	0.562
CLV_NRD_NRD_1	172	174	PF00675	0.630
CLV_NRD_NRD_1	215	217	PF00675	0.692
CLV_NRD_NRD_1	354	356	PF00675	0.666
CLV_NRD_NRD_1	38	40	PF00675	0.534
CLV_NRD_NRD_1	546	548	PF00675	0.651
CLV_NRD_NRD_1	647	649	PF00675	0.675
CLV_NRD_NRD_1	922	924	PF00675	0.603
CLV_PCSK_KEX2_1	10	12	PF00082	0.599
CLV_PCSK_KEX2_1	108	110	PF00082	0.577
CLV_PCSK_KEX2_1	172	174	PF00082	0.630
CLV_PCSK_KEX2_1	215	217	PF00082	0.692
CLV_PCSK_KEX2_1	354	356	PF00082	0.667
CLV_PCSK_KEX2_1	38	40	PF00082	0.534
CLV_PCSK_KEX2_1	545	547	PF00082	0.666
CLV_PCSK_KEX2_1	646	648	PF00082	0.672
CLV_PCSK_KEX2_1	921	923	PF00082	0.618
CLV_PCSK_PC7_1	917	923	PF00082	0.610
CLV_PCSK_SKI1_1	109	113	PF00082	0.609
CLV_PCSK_SKI1_1	38	42	PF00082	0.557
CLV_PCSK_SKI1_1	561	565	PF00082	0.657
CLV_PCSK_SKI1_1	939	943	PF00082	0.482
DEG_APCC_DBOX_1	107	115	PF00400	0.603
DEG_APCC_DBOX_1	270	278	PF00400	0.674
DEG_APCC_DBOX_1	37	45	PF00400	0.522
DEG_MDM2_SWIB_1	113	121	PF02201	0.588
DEG_SCF_FBW7_1	940	946	PF00400	0.588
DEG_SPOP_SBC_1	193	197	PF00917	0.567
DEG_SPOP_SBC_1	529	533	PF00917	0.569
DEG_SPOP_SBC_1	57	61	PF00917	0.672
DEG_SPOP_SBC_1	94	98	PF00917	0.618
DEG_SPOP_SBC_1	943	947	PF00917	0.623
DOC_ANK_TNKS_1	685	692	PF00023	0.611
DOC_CDC14_PxL_1	718	726	PF14671	0.680
DOC_CDC14_PxL_1	735	743	PF14671	0.532
DOC_CDC14_PxL_1	752	760	PF14671	0.404
DOC_CKS1_1	867	872	PF01111	0.685
DOC_CKS1_1	909	914	PF01111	0.568
DOC_CKS1_1	940	945	PF01111	0.580
DOC_CYCLIN_RxL_1	107	116	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.592
DOC_MAPK_gen_1	108	114	PF00069	0.597
DOC_MAPK_gen_1	763	770	PF00069	0.564
DOC_MAPK_MEF2A_6	991	998	PF00069	0.598
DOC_PP1_RVXF_1	107	114	PF00149	0.607
DOC_PP2B_LxvP_1	243	246	PF13499	0.655
DOC_PP2B_LxvP_1	411	414	PF13499	0.709
DOC_PP2B_LxvP_1	910	913	PF13499	0.681
DOC_PP2B_LxvP_1	994	997	PF13499	0.602
DOC_PP4_FxxP_1	282	285	PF00568	0.622
DOC_PP4_FxxP_1	482	485	PF00568	0.600
DOC_USP7_MATH_1	136	140	PF00917	0.558
DOC_USP7_MATH_1	155	159	PF00917	0.566
DOC_USP7_MATH_1	187	191	PF00917	0.619
DOC_USP7_MATH_1	192	196	PF00917	0.619
DOC_USP7_MATH_1	254	258	PF00917	0.652
DOC_USP7_MATH_1	463	467	PF00917	0.592
DOC_USP7_MATH_1	493	497	PF00917	0.657
DOC_USP7_MATH_1	565	569	PF00917	0.567
DOC_USP7_MATH_1	663	667	PF00917	0.680
DOC_USP7_MATH_1	71	75	PF00917	0.676
DOC_USP7_MATH_1	757	761	PF00917	0.498
DOC_USP7_MATH_1	812	816	PF00917	0.684
DOC_USP7_MATH_1	835	839	PF00917	0.589
DOC_USP7_MATH_1	84	88	PF00917	0.610
DOC_USP7_MATH_1	852	856	PF00917	0.566
DOC_USP7_MATH_1	857	861	PF00917	0.671
DOC_USP7_MATH_1	877	881	PF00917	0.509
DOC_USP7_MATH_1	941	945	PF00917	0.587
DOC_WW_Pin1_4	159	164	PF00397	0.660
DOC_WW_Pin1_4	258	263	PF00397	0.701
DOC_WW_Pin1_4	28	33	PF00397	0.635
DOC_WW_Pin1_4	349	354	PF00397	0.571
DOC_WW_Pin1_4	458	463	PF00397	0.625
DOC_WW_Pin1_4	581	586	PF00397	0.682
DOC_WW_Pin1_4	612	617	PF00397	0.671
DOC_WW_Pin1_4	659	664	PF00397	0.674
DOC_WW_Pin1_4	689	694	PF00397	0.667
DOC_WW_Pin1_4	709	714	PF00397	0.526
DOC_WW_Pin1_4	72	77	PF00397	0.682
DOC_WW_Pin1_4	824	829	PF00397	0.646
DOC_WW_Pin1_4	866	871	PF00397	0.709
DOC_WW_Pin1_4	908	913	PF00397	0.589
DOC_WW_Pin1_4	939	944	PF00397	0.586
DOC_WW_Pin1_4	95	100	PF00397	0.636
DOC_WW_Pin1_4	953	958	PF00397	0.520
LIG_14-3-3_CanoR_1	144	151	PF00244	0.581
LIG_14-3-3_CanoR_1	207	212	PF00244	0.644
LIG_14-3-3_CanoR_1	215	220	PF00244	0.579
LIG_14-3-3_CanoR_1	258	262	PF00244	0.596
LIG_14-3-3_CanoR_1	566	574	PF00244	0.685
LIG_14-3-3_CanoR_1	634	644	PF00244	0.612
LIG_14-3-3_CanoR_1	674	678	PF00244	0.693
LIG_14-3-3_CanoR_1	68	76	PF00244	0.660
LIG_14-3-3_CanoR_1	704	710	PF00244	0.644
LIG_14-3-3_CanoR_1	765	771	PF00244	0.560
LIG_14-3-3_CanoR_1	85	93	PF00244	0.520
LIG_14-3-3_CanoR_1	863	868	PF00244	0.718
LIG_BRCT_BRCA1_1	415	419	PF00533	0.642
LIG_BRCT_BRCA1_1	465	469	PF00533	0.547
LIG_BRCT_BRCA1_1	538	542	PF00533	0.582
LIG_BRCT_BRCA1_1	837	841	PF00533	0.589
LIG_deltaCOP1_diTrp_1	523	530	PF00928	0.548
LIG_EVH1_2	163	167	PF00568	0.577
LIG_FHA_1	322	328	PF00498	0.608
LIG_FHA_1	346	352	PF00498	0.614
LIG_FHA_1	515	521	PF00498	0.663
LIG_FHA_1	530	536	PF00498	0.524
LIG_FHA_1	587	593	PF00498	0.633
LIG_FHA_1	870	876	PF00498	0.643
LIG_FHA_2	197	203	PF00498	0.625
LIG_FHA_2	236	242	PF00498	0.643
LIG_FHA_2	285	291	PF00498	0.520
LIG_FHA_2	452	458	PF00498	0.632
LIG_FHA_2	459	465	PF00498	0.588
LIG_FHA_2	60	66	PF00498	0.706
LIG_FHA_2	95	101	PF00498	0.657
LIG_IRF3_LxIS_1	76	82	PF10401	0.584
LIG_LIR_Apic_2	280	285	PF02991	0.588
LIG_LIR_Apic_2	658	663	PF02991	0.587
LIG_LIR_Gen_1	473	484	PF02991	0.515
LIG_LIR_Gen_1	631	640	PF02991	0.730
LIG_LIR_Gen_1	750	759	PF02991	0.584
LIG_LIR_Gen_1	966	975	PF02991	0.542
LIG_LIR_Nem_3	466	472	PF02991	0.628
LIG_LIR_Nem_3	473	479	PF02991	0.550
LIG_LIR_Nem_3	631	635	PF02991	0.732
LIG_LIR_Nem_3	750	755	PF02991	0.600
LIG_LIR_Nem_3	838	844	PF02991	0.601
LIG_MYND_1	693	697	PF01753	0.640
LIG_Pex14_1	777	781	PF04695	0.565
LIG_Pex14_2	113	117	PF04695	0.591
LIG_Rb_pABgroove_1	736	744	PF01858	0.650
LIG_Rb_pABgroove_1	962	970	PF01858	0.506
LIG_SH2_CRK	125	129	PF00017	0.630
LIG_SH2_PTP2	752	755	PF00017	0.574
LIG_SH2_SRC	125	128	PF00017	0.601
LIG_SH2_STAP1	742	746	PF00017	0.621
LIG_SH2_STAT5	337	340	PF00017	0.613
LIG_SH2_STAT5	476	479	PF00017	0.533
LIG_SH2_STAT5	660	663	PF00017	0.591
LIG_SH2_STAT5	752	755	PF00017	0.574
LIG_SH2_STAT5	842	845	PF00017	0.682
LIG_SH2_STAT5	924	927	PF00017	0.583
LIG_SH3_3	124	130	PF00018	0.651
LIG_SH3_3	160	166	PF00018	0.599
LIG_SH3_3	259	265	PF00018	0.700
LIG_SH3_3	26	32	PF00018	0.647
LIG_SH3_3	275	281	PF00018	0.504
LIG_SH3_3	304	310	PF00018	0.574
LIG_SH3_3	707	713	PF00018	0.731
LIG_SH3_3	733	739	PF00018	0.656
LIG_SH3_3	750	756	PF00018	0.451
LIG_SH3_3	808	814	PF00018	0.663
LIG_SH3_3	822	828	PF00018	0.532
LIG_SH3_3	845	851	PF00018	0.602
LIG_SH3_3	864	870	PF00018	0.560
LIG_SH3_3	906	912	PF00018	0.588
LIG_SH3_3	952	958	PF00018	0.565
LIG_SH3_3	987	993	PF00018	0.621
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.640
LIG_SUMO_SIM_par_1	588	593	PF11976	0.572
LIG_SUMO_SIM_par_1	956	963	PF11976	0.569
LIG_TRAF2_1	132	135	PF00917	0.585
MOD_CDC14_SPxK_1	352	355	PF00782	0.570
MOD_CDK_SPK_2	349	354	PF00069	0.571
MOD_CDK_SPxK_1	349	355	PF00069	0.572
MOD_CK1_1	235	241	PF00069	0.643
MOD_CK1_1	257	263	PF00069	0.699
MOD_CK1_1	28	34	PF00069	0.632
MOD_CK1_1	321	327	PF00069	0.607
MOD_CK1_1	366	372	PF00069	0.617
MOD_CK1_1	451	457	PF00069	0.742
MOD_CK1_1	496	502	PF00069	0.637
MOD_CK1_1	531	537	PF00069	0.731
MOD_CK1_1	59	65	PF00069	0.695
MOD_CK1_1	659	665	PF00069	0.705
MOD_CK1_1	685	691	PF00069	0.611
MOD_CK1_1	74	80	PF00069	0.562
MOD_CK1_1	859	865	PF00069	0.699
MOD_CK1_1	866	872	PF00069	0.663
MOD_CK1_1	876	882	PF00069	0.556
MOD_CK1_1	944	950	PF00069	0.637
MOD_CK1_1	98	104	PF00069	0.600
MOD_CK2_1	284	290	PF00069	0.574
MOD_CK2_1	367	373	PF00069	0.679
MOD_CK2_1	59	65	PF00069	0.695
MOD_CK2_1	6	12	PF00069	0.595
MOD_CK2_1	663	669	PF00069	0.678
MOD_CK2_1	787	793	PF00069	0.588
MOD_CK2_1	813	819	PF00069	0.604
MOD_GlcNHglycan	130	133	PF01048	0.600
MOD_GlcNHglycan	157	160	PF01048	0.656
MOD_GlcNHglycan	196	199	PF01048	0.676
MOD_GlcNHglycan	234	237	PF01048	0.590
MOD_GlcNHglycan	320	323	PF01048	0.653
MOD_GlcNHglycan	370	373	PF01048	0.644
MOD_GlcNHglycan	379	382	PF01048	0.597
MOD_GlcNHglycan	498	501	PF01048	0.729
MOD_GlcNHglycan	538	541	PF01048	0.602
MOD_GlcNHglycan	558	561	PF01048	0.605
MOD_GlcNHglycan	598	601	PF01048	0.709
MOD_GlcNHglycan	637	640	PF01048	0.638
MOD_GlcNHglycan	652	655	PF01048	0.535
MOD_GlcNHglycan	687	690	PF01048	0.703
MOD_GlcNHglycan	69	72	PF01048	0.713
MOD_GlcNHglycan	707	710	PF01048	0.589
MOD_GlcNHglycan	743	747	PF01048	0.476
MOD_GlcNHglycan	759	762	PF01048	0.456
MOD_GlcNHglycan	789	792	PF01048	0.594
MOD_GlcNHglycan	833	836	PF01048	0.673
MOD_GlcNHglycan	837	840	PF01048	0.619
MOD_GlcNHglycan	859	862	PF01048	0.706
MOD_GlcNHglycan	875	878	PF01048	0.592
MOD_GlcNHglycan	886	889	PF01048	0.618
MOD_GlcNHglycan	900	903	PF01048	0.564
MOD_GlcNHglycan	947	950	PF01048	0.649
MOD_GlcNHglycan	978	981	PF01048	0.492
MOD_GSK3_1	155	162	PF00069	0.654
MOD_GSK3_1	192	199	PF00069	0.628
MOD_GSK3_1	254	261	PF00069	0.653
MOD_GSK3_1	314	321	PF00069	0.608
MOD_GSK3_1	345	352	PF00069	0.600
MOD_GSK3_1	363	370	PF00069	0.567
MOD_GSK3_1	377	384	PF00069	0.574
MOD_GSK3_1	386	393	PF00069	0.687
MOD_GSK3_1	529	536	PF00069	0.638
MOD_GSK3_1	586	593	PF00069	0.668
MOD_GSK3_1	659	666	PF00069	0.676
MOD_GSK3_1	67	74	PF00069	0.672
MOD_GSK3_1	685	692	PF00069	0.698
MOD_GSK3_1	705	712	PF00069	0.539
MOD_GSK3_1	831	838	PF00069	0.604
MOD_GSK3_1	84	91	PF00069	0.582
MOD_GSK3_1	852	859	PF00069	0.683
MOD_GSK3_1	869	876	PF00069	0.562
MOD_GSK3_1	939	946	PF00069	0.622
MOD_GSK3_1	94	101	PF00069	0.574
MOD_N-GLC_1	555	560	PF02516	0.558
MOD_N-GLC_1	852	857	PF02516	0.630
MOD_N-GLC_1	884	889	PF02516	0.640
MOD_N-GLC_1	976	981	PF02516	0.514
MOD_N-GLC_2	976	978	PF02516	0.511
MOD_NEK2_1	331	336	PF00069	0.568
MOD_NEK2_1	363	368	PF00069	0.722
MOD_NEK2_1	530	535	PF00069	0.563
MOD_NEK2_1	590	595	PF00069	0.654
MOD_NEK2_1	79	84	PF00069	0.579
MOD_OFUCOSY	328	335	PF10250	0.588
MOD_PIKK_1	386	392	PF00454	0.637
MOD_PIKK_1	431	437	PF00454	0.630
MOD_PIKK_1	877	883	PF00454	0.681
MOD_PK_1	207	213	PF00069	0.691
MOD_PK_1	863	869	PF00069	0.693
MOD_PKA_1	215	221	PF00069	0.583
MOD_PKA_2	215	221	PF00069	0.583
MOD_PKA_2	257	263	PF00069	0.592
MOD_PKA_2	366	372	PF00069	0.665
MOD_PKA_2	565	571	PF00069	0.606
MOD_PKA_2	656	662	PF00069	0.693
MOD_PKA_2	67	73	PF00069	0.683
MOD_PKA_2	673	679	PF00069	0.734
MOD_PKA_2	685	691	PF00069	0.576
MOD_PKA_2	766	772	PF00069	0.509
MOD_PKA_2	84	90	PF00069	0.513
MOD_Plk_1	463	469	PF00069	0.570
MOD_Plk_1	630	636	PF00069	0.647
MOD_Plk_1	742	748	PF00069	0.613
MOD_Plk_1	852	858	PF00069	0.632
MOD_Plk_2-3	930	936	PF00069	0.581
MOD_Plk_2-3	963	969	PF00069	0.500
MOD_Plk_4	136	142	PF00069	0.566
MOD_Plk_4	463	469	PF00069	0.570
MOD_Plk_4	506	512	PF00069	0.625
MOD_Plk_4	656	662	PF00069	0.582
MOD_Plk_4	747	753	PF00069	0.580
MOD_Plk_4	766	772	PF00069	0.443
MOD_Plk_4	963	969	PF00069	0.548
MOD_ProDKin_1	159	165	PF00069	0.661
MOD_ProDKin_1	258	264	PF00069	0.701
MOD_ProDKin_1	28	34	PF00069	0.632
MOD_ProDKin_1	349	355	PF00069	0.572
MOD_ProDKin_1	458	464	PF00069	0.624
MOD_ProDKin_1	581	587	PF00069	0.684
MOD_ProDKin_1	612	618	PF00069	0.665
MOD_ProDKin_1	659	665	PF00069	0.676
MOD_ProDKin_1	689	695	PF00069	0.668
MOD_ProDKin_1	709	715	PF00069	0.524
MOD_ProDKin_1	72	78	PF00069	0.682
MOD_ProDKin_1	824	830	PF00069	0.646
MOD_ProDKin_1	866	872	PF00069	0.710
MOD_ProDKin_1	908	914	PF00069	0.583
MOD_ProDKin_1	939	945	PF00069	0.595
MOD_ProDKin_1	95	101	PF00069	0.630
MOD_ProDKin_1	953	959	PF00069	0.515
TRG_DiLeu_BaEn_1	107	112	PF01217	0.611
TRG_DiLeu_BaEn_1	425	430	PF01217	0.707
TRG_DiLeu_BaLyEn_6	955	960	PF01217	0.558
TRG_DiLeu_LyEn_5	107	112	PF01217	0.611
TRG_ENDOCYTIC_2	125	128	PF00928	0.649
TRG_ENDOCYTIC_2	476	479	PF00928	0.485
TRG_ENDOCYTIC_2	752	755	PF00928	0.599
TRG_ER_diArg_1	108	110	PF00400	0.625
TRG_ER_diArg_1	172	174	PF00400	0.630
TRG_ER_diArg_1	215	217	PF00400	0.692
TRG_ER_diArg_1	268	271	PF00400	0.587
TRG_ER_diArg_1	353	355	PF00400	0.658
TRG_ER_diArg_1	545	547	PF00400	0.663
TRG_ER_diArg_1	645	648	PF00400	0.585
TRG_ER_diArg_1	683	686	PF00400	0.619
TRG_ER_diArg_1	762	765	PF00400	0.510
TRG_ER_diArg_1	921	923	PF00400	0.601
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	923	927	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3K0	Leishmania braziliensis	56%	95%
A4HRT9	Leishmania infantum	99%	100%
E9ACH5	Leishmania major	84%	97%
E9AJR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	97%