LeishMANIAdb
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FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative
Gene product:
FYVE zinc finger/Apolipoprotein A1/A4/E domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H530_LEIDO
TriTrypDb:
LdBPK_030260.1 * , LdCL_030007600 , LDHU3_03.0270
Length:
1594

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0000795 synaptonemal complex 3 1
GO:0099086 synaptonemal structure 2 1

Expansion

Sequence features

A0A3S5H530
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 7
GO:0006810 transport 3 7
GO:0006869 lipid transport 5 7
GO:0008152 metabolic process 1 7
GO:0019538 protein metabolic process 3 7
GO:0042157 lipoprotein metabolic process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0044238 primary metabolic process 2 7
GO:0051179 localization 1 7
GO:0051234 establishment of localization 2 7
GO:0071702 organic substance transport 4 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0006996 organelle organization 4 1
GO:0007130 synaptonemal complex assembly 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0022607 cellular component assembly 4 1
GO:0051276 chromosome organization 5 1
GO:0070192 chromosome organization involved in meiotic cell cycle 3 1
GO:0070193 synaptonemal complex organization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903046 meiotic cell cycle process 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0008289 lipid binding 2 7
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1042 1046 PF00656 0.458
CLV_C14_Caspase3-7 1187 1191 PF00656 0.527
CLV_C14_Caspase3-7 1261 1265 PF00656 0.359
CLV_C14_Caspase3-7 149 153 PF00656 0.455
CLV_C14_Caspase3-7 1590 1594 PF00656 0.340
CLV_C14_Caspase3-7 960 964 PF00656 0.222
CLV_NRD_NRD_1 1049 1051 PF00675 0.635
CLV_NRD_NRD_1 1204 1206 PF00675 0.469
CLV_NRD_NRD_1 1332 1334 PF00675 0.533
CLV_NRD_NRD_1 1355 1357 PF00675 0.597
CLV_NRD_NRD_1 1434 1436 PF00675 0.544
CLV_NRD_NRD_1 1579 1581 PF00675 0.419
CLV_NRD_NRD_1 923 925 PF00675 0.411
CLV_PCSK_KEX2_1 1049 1051 PF00082 0.628
CLV_PCSK_KEX2_1 1204 1206 PF00082 0.469
CLV_PCSK_KEX2_1 1332 1334 PF00082 0.533
CLV_PCSK_KEX2_1 1355 1357 PF00082 0.611
CLV_PCSK_KEX2_1 1434 1436 PF00082 0.544
CLV_PCSK_KEX2_1 1579 1581 PF00082 0.419
CLV_PCSK_KEX2_1 923 925 PF00082 0.411
CLV_PCSK_SKI1_1 1174 1178 PF00082 0.476
CLV_PCSK_SKI1_1 1376 1380 PF00082 0.599
CLV_PCSK_SKI1_1 1499 1503 PF00082 0.480
CLV_PCSK_SKI1_1 1546 1550 PF00082 0.612
CLV_PCSK_SKI1_1 178 182 PF00082 0.445
CLV_PCSK_SKI1_1 207 211 PF00082 0.435
CLV_PCSK_SKI1_1 246 250 PF00082 0.434
CLV_PCSK_SKI1_1 285 289 PF00082 0.434
CLV_PCSK_SKI1_1 324 328 PF00082 0.434
CLV_PCSK_SKI1_1 363 367 PF00082 0.434
CLV_PCSK_SKI1_1 402 406 PF00082 0.434
CLV_PCSK_SKI1_1 441 445 PF00082 0.434
CLV_PCSK_SKI1_1 480 484 PF00082 0.434
CLV_PCSK_SKI1_1 519 523 PF00082 0.434
CLV_PCSK_SKI1_1 558 562 PF00082 0.434
CLV_PCSK_SKI1_1 597 601 PF00082 0.434
CLV_PCSK_SKI1_1 636 640 PF00082 0.434
CLV_PCSK_SKI1_1 675 679 PF00082 0.434
CLV_PCSK_SKI1_1 714 718 PF00082 0.434
CLV_PCSK_SKI1_1 753 757 PF00082 0.434
CLV_PCSK_SKI1_1 792 796 PF00082 0.434
CLV_PCSK_SKI1_1 831 835 PF00082 0.434
CLV_PCSK_SKI1_1 870 874 PF00082 0.521
CLV_PCSK_SKI1_1 924 928 PF00082 0.425
CLV_PCSK_SKI1_1 940 944 PF00082 0.404
CLV_Separin_Metazoa 1467 1471 PF03568 0.585
DEG_APCC_DBOX_1 1093 1101 PF00400 0.427
DEG_APCC_DBOX_1 1545 1553 PF00400 0.615
DEG_SCF_FBW7_1 98 105 PF00400 0.544
DEG_SIAH_1 125 133 PF03145 0.451
DEG_SPOP_SBC_1 93 97 PF00917 0.501
DOC_ANK_TNKS_1 1304 1311 PF00023 0.470
DOC_CKS1_1 1 6 PF01111 0.441
DOC_CKS1_1 1420 1425 PF01111 0.652
DOC_MAPK_gen_1 1298 1306 PF00069 0.464
DOC_MAPK_gen_1 1372 1381 PF00069 0.530
DOC_MAPK_gen_1 1579 1585 PF00069 0.354
DOC_MIT_MIM_1 1092 1100 PF04212 0.458
DOC_USP7_MATH_1 102 106 PF00917 0.552
DOC_USP7_MATH_1 111 115 PF00917 0.595
DOC_USP7_MATH_1 1258 1262 PF00917 0.477
DOC_USP7_MATH_1 1268 1272 PF00917 0.466
DOC_USP7_MATH_1 1341 1345 PF00917 0.647
DOC_USP7_MATH_1 1351 1355 PF00917 0.519
DOC_USP7_MATH_1 1440 1444 PF00917 0.601
DOC_USP7_MATH_1 1454 1458 PF00917 0.546
DOC_USP7_MATH_1 179 183 PF00917 0.279
DOC_USP7_MATH_1 196 200 PF00917 0.211
DOC_USP7_MATH_1 83 87 PF00917 0.400
DOC_USP7_MATH_1 926 930 PF00917 0.211
DOC_USP7_MATH_1 949 953 PF00917 0.222
DOC_WW_Pin1_4 120 125 PF00397 0.594
DOC_WW_Pin1_4 128 133 PF00397 0.444
DOC_WW_Pin1_4 1419 1424 PF00397 0.708
DOC_WW_Pin1_4 1429 1434 PF00397 0.581
DOC_WW_Pin1_4 1459 1464 PF00397 0.625
DOC_WW_Pin1_4 85 90 PF00397 0.463
DOC_WW_Pin1_4 98 103 PF00397 0.533
LIG_14-3-3_CanoR_1 1149 1159 PF00244 0.454
LIG_14-3-3_CanoR_1 1174 1179 PF00244 0.444
LIG_14-3-3_CanoR_1 1243 1252 PF00244 0.506
LIG_14-3-3_CanoR_1 1255 1262 PF00244 0.454
LIG_14-3-3_CanoR_1 1332 1340 PF00244 0.508
LIG_14-3-3_CanoR_1 1402 1410 PF00244 0.468
LIG_14-3-3_CanoR_1 1490 1498 PF00244 0.533
LIG_14-3-3_CanoR_1 1524 1531 PF00244 0.551
LIG_14-3-3_CanoR_1 1535 1542 PF00244 0.394
LIG_Actin_WH2_2 1228 1245 PF00022 0.522
LIG_APCC_ABBA_1 1157 1162 PF00400 0.466
LIG_APCC_ABBA_1 991 996 PF00400 0.447
LIG_BIR_II_1 1 5 PF00653 0.471
LIG_Clathr_ClatBox_1 1269 1273 PF01394 0.424
LIG_CtBP_PxDLS_1 1310 1316 PF00389 0.457
LIG_FHA_1 1152 1158 PF00498 0.478
LIG_FHA_1 1404 1410 PF00498 0.517
LIG_FHA_1 1531 1537 PF00498 0.502
LIG_FHA_1 198 204 PF00498 0.302
LIG_FHA_1 53 59 PF00498 0.343
LIG_FHA_2 1444 1450 PF00498 0.468
LIG_FHA_2 1479 1485 PF00498 0.624
LIG_FHA_2 149 155 PF00498 0.484
LIG_FHA_2 187 193 PF00498 0.279
LIG_LIR_Gen_1 1500 1507 PF02991 0.624
LIG_LIR_Nem_3 1495 1501 PF02991 0.596
LIG_LIR_Nem_3 1576 1581 PF02991 0.428
LIG_REV1ctd_RIR_1 32 42 PF16727 0.311
LIG_SH2_GRB2like 63 66 PF00017 0.341
LIG_SH2_SRC 1503 1506 PF00017 0.483
LIG_SH2_STAP1 1396 1400 PF00017 0.411
LIG_SH2_STAP1 1503 1507 PF00017 0.481
LIG_SH2_STAP1 63 67 PF00017 0.279
LIG_SH2_STAT5 1521 1524 PF00017 0.678
LIG_SH2_STAT5 91 94 PF00017 0.505
LIG_SH3_1 104 110 PF00018 0.603
LIG_SH3_1 1434 1440 PF00018 0.529
LIG_SH3_2 1465 1470 PF14604 0.582
LIG_SH3_3 104 110 PF00018 0.651
LIG_SH3_3 1345 1351 PF00018 0.611
LIG_SH3_3 1417 1423 PF00018 0.785
LIG_SH3_3 1434 1440 PF00018 0.594
LIG_SH3_3 1462 1468 PF00018 0.602
LIG_SUMO_SIM_par_1 1267 1273 PF11976 0.419
LIG_SxIP_EBH_1 51 65 PF03271 0.341
LIG_TRAF2_1 1124 1127 PF00917 0.446
LIG_TRAF2_1 1164 1167 PF00917 0.495
LIG_TRAF2_1 1551 1554 PF00917 0.447
LIG_TRAF2_1 1569 1572 PF00917 0.342
LIG_TRAF2_1 189 192 PF00917 0.277
LIG_TYR_ITIM 1501 1506 PF00017 0.482
LIG_WW_3 1467 1471 PF00397 0.585
MOD_CDK_SPK_2 1429 1434 PF00069 0.571
MOD_CDK_SPxK_1 1429 1435 PF00069 0.631
MOD_CDK_SPxK_1 98 104 PF00069 0.610
MOD_CDK_SPxxK_3 1459 1466 PF00069 0.622
MOD_CK1_1 1257 1263 PF00069 0.545
MOD_CK1_1 1443 1449 PF00069 0.533
MOD_CK1_1 54 60 PF00069 0.263
MOD_CK2_1 1001 1007 PF00069 0.460
MOD_CK2_1 1150 1156 PF00069 0.559
MOD_CK2_1 1332 1338 PF00069 0.519
MOD_CK2_1 1443 1449 PF00069 0.472
MOD_CK2_1 1478 1484 PF00069 0.608
MOD_CK2_1 186 192 PF00069 0.300
MOD_CK2_1 926 932 PF00069 0.215
MOD_GlcNHglycan 1112 1115 PF01048 0.421
MOD_GlcNHglycan 1196 1199 PF01048 0.554
MOD_GlcNHglycan 1256 1259 PF01048 0.529
MOD_GlcNHglycan 1266 1269 PF01048 0.521
MOD_GlcNHglycan 1275 1278 PF01048 0.626
MOD_GlcNHglycan 1442 1445 PF01048 0.642
MOD_GlcNHglycan 1451 1454 PF01048 0.535
MOD_GlcNHglycan 1457 1460 PF01048 0.531
MOD_GlcNHglycan 1526 1529 PF01048 0.534
MOD_GlcNHglycan 1536 1539 PF01048 0.408
MOD_GlcNHglycan 1585 1588 PF01048 0.382
MOD_GlcNHglycan 181 184 PF01048 0.355
MOD_GlcNHglycan 98 101 PF01048 0.551
MOD_GSK3_1 1007 1014 PF00069 0.398
MOD_GSK3_1 116 123 PF00069 0.630
MOD_GSK3_1 1194 1201 PF00069 0.611
MOD_GSK3_1 1243 1250 PF00069 0.542
MOD_GSK3_1 1254 1261 PF00069 0.432
MOD_GSK3_1 1264 1271 PF00069 0.540
MOD_GSK3_1 1404 1411 PF00069 0.525
MOD_GSK3_1 1415 1422 PF00069 0.610
MOD_GSK3_1 142 149 PF00069 0.475
MOD_GSK3_1 1455 1462 PF00069 0.593
MOD_GSK3_1 1480 1487 PF00069 0.548
MOD_GSK3_1 1530 1537 PF00069 0.565
MOD_GSK3_1 92 99 PF00069 0.556
MOD_N-GLC_2 1173 1175 PF02516 0.443
MOD_NEK2_1 1256 1261 PF00069 0.594
MOD_NEK2_1 1536 1541 PF00069 0.514
MOD_NEK2_1 1556 1561 PF00069 0.463
MOD_NEK2_1 34 39 PF00069 0.343
MOD_PIKK_1 1011 1017 PF00454 0.391
MOD_PIKK_1 111 117 PF00454 0.664
MOD_PIKK_1 1342 1348 PF00454 0.562
MOD_PIKK_1 1484 1490 PF00454 0.542
MOD_PIKK_1 1530 1536 PF00454 0.437
MOD_PIKK_1 209 215 PF00454 0.330
MOD_PIKK_1 716 722 PF00454 0.311
MOD_PIKK_1 833 839 PF00454 0.247
MOD_PIKK_1 911 917 PF00454 0.247
MOD_PKA_1 1332 1338 PF00069 0.501
MOD_PKA_2 1254 1260 PF00069 0.533
MOD_PKA_2 1331 1337 PF00069 0.497
MOD_PKA_2 1449 1455 PF00069 0.581
MOD_PKA_2 1489 1495 PF00069 0.562
MOD_PKA_2 1523 1529 PF00069 0.551
MOD_PKA_2 1534 1540 PF00069 0.406
MOD_PKA_2 83 89 PF00069 0.423
MOD_Plk_1 1001 1007 PF00069 0.439
MOD_Plk_1 1104 1110 PF00069 0.448
MOD_Plk_1 1342 1348 PF00069 0.577
MOD_Plk_1 1571 1577 PF00069 0.394
MOD_Plk_2-3 1001 1007 PF00069 0.439
MOD_Plk_4 1248 1254 PF00069 0.549
MOD_Plk_4 1404 1410 PF00069 0.517
MOD_Plk_4 54 60 PF00069 0.343
MOD_ProDKin_1 120 126 PF00069 0.588
MOD_ProDKin_1 128 134 PF00069 0.439
MOD_ProDKin_1 1419 1425 PF00069 0.710
MOD_ProDKin_1 1429 1435 PF00069 0.577
MOD_ProDKin_1 1459 1465 PF00069 0.624
MOD_ProDKin_1 85 91 PF00069 0.467
MOD_ProDKin_1 98 104 PF00069 0.541
MOD_SUMO_for_1 998 1001 PF00179 0.467
MOD_SUMO_rev_2 1077 1081 PF00179 0.487
MOD_SUMO_rev_2 891 901 PF00179 0.215
TRG_DiLeu_BaEn_1 1302 1307 PF01217 0.468
TRG_DiLeu_BaEn_1 904 909 PF01217 0.215
TRG_DiLeu_BaEn_4 1007 1013 PF01217 0.437
TRG_DiLeu_BaEn_4 192 198 PF01217 0.375
TRG_DiLeu_BaEn_4 904 910 PF01217 0.215
TRG_DiLeu_LyEn_5 1302 1307 PF01217 0.468
TRG_ENDOCYTIC_2 1160 1163 PF00928 0.482
TRG_ENDOCYTIC_2 1498 1501 PF00928 0.588
TRG_ENDOCYTIC_2 1503 1506 PF00928 0.590
TRG_ENDOCYTIC_2 75 78 PF00928 0.311
TRG_ER_diArg_1 1093 1096 PF00400 0.428
TRG_ER_diArg_1 1146 1149 PF00400 0.532
TRG_ER_diArg_1 1203 1205 PF00400 0.459
TRG_ER_diArg_1 1316 1319 PF00400 0.583
TRG_ER_diArg_1 1355 1357 PF00400 0.583
TRG_ER_diArg_1 1433 1435 PF00400 0.554
TRG_ER_diArg_1 1469 1472 PF00400 0.580
TRG_ER_diArg_1 1578 1580 PF00400 0.424
TRG_ER_diArg_1 923 925 PF00400 0.351
TRG_NES_CRM1_1 1071 1084 PF08389 0.462
TRG_NES_CRM1_1 1302 1315 PF08389 0.465
TRG_Pf-PMV_PEXEL_1 1161 1166 PF00026 0.533
TRG_Pf-PMV_PEXEL_1 1205 1209 PF00026 0.516
TRG_Pf-PMV_PEXEL_1 1305 1309 PF00026 0.447
TRG_Pf-PMV_PEXEL_1 1318 1322 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 1550 1554 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 923 928 PF00026 0.215

Homologs

Protein Taxonomy Sequence identity Coverage
A4H3J9 Leishmania braziliensis 61% 100%
A4H3R9 Leishmania braziliensis 61% 96%
A4HRT8 Leishmania infantum 98% 74%
E9ACH4 Leishmania major 79% 68%
E9AJR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS