Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H529_LEIDO

TriTrypDb:

LdBPK_030250.1 , LdCL_030007500 , LDHU3_03.0260

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S5H529

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H529

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.865
CLV_NRD_NRD_1	123	125	PF00675	0.568
CLV_NRD_NRD_1	64	66	PF00675	0.581
CLV_PCSK_KEX2_1	123	125	PF00082	0.585
CLV_PCSK_KEX2_1	64	66	PF00082	0.581
CLV_PCSK_SKI1_1	124	128	PF00082	0.564
DOC_MAPK_gen_1	295	301	PF00069	0.597
DOC_USP7_MATH_1	76	80	PF00917	0.704
DOC_WW_Pin1_4	143	148	PF00397	0.779
DOC_WW_Pin1_4	74	79	PF00397	0.840
LIG_14-3-3_CanoR_1	136	142	PF00244	0.779
LIG_14-3-3_CanoR_1	153	161	PF00244	0.598
LIG_14-3-3_CanoR_1	182	188	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.808
LIG_BIR_III_2	71	75	PF00653	0.862
LIG_EVH1_2	150	154	PF00568	0.805
LIG_FHA_1	231	237	PF00498	0.524
LIG_FHA_2	28	34	PF00498	0.810
LIG_FHA_2	45	51	PF00498	0.668
LIG_LIR_Gen_1	229	240	PF02991	0.524
LIG_LIR_Nem_3	116	122	PF02991	0.778
LIG_LIR_Nem_3	155	161	PF02991	0.791
LIG_LIR_Nem_3	229	235	PF02991	0.524
LIG_LIR_Nem_3	87	93	PF02991	0.799
LIG_LYPXL_yS_3	158	161	PF13949	0.781
LIG_PCNA_PIPBox_1	219	228	PF02747	0.730
LIG_PCNA_PIPBox_1	45	54	PF02747	0.772
LIG_PCNA_yPIPBox_3	44	52	PF02747	0.765
LIG_Pex14_2	52	56	PF04695	0.812
LIG_Pex14_2	86	90	PF04695	0.802
LIG_SH2_SRC	267	270	PF00017	0.543
LIG_SH2_STAP1	267	271	PF00017	0.543
LIG_SH2_STAT5	18	21	PF00017	0.673
LIG_SH3_1	144	150	PF00018	0.701
LIG_SH3_1	172	178	PF00018	0.669
LIG_SH3_3	144	150	PF00018	0.806
LIG_SH3_3	172	178	PF00018	0.746
LIG_SH3_3	233	239	PF00018	0.524
LIG_SH3_3	31	37	PF00018	0.752
LIG_SH3_3	72	78	PF00018	0.725
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.555
MOD_CK1_1	108	114	PF00069	0.730
MOD_CK1_1	166	172	PF00069	0.802
MOD_CK2_1	27	33	PF00069	0.743
MOD_GlcNHglycan	10	13	PF01048	0.608
MOD_GlcNHglycan	115	118	PF01048	0.591
MOD_GlcNHglycan	133	136	PF01048	0.419
MOD_GlcNHglycan	164	168	PF01048	0.579
MOD_GlcNHglycan	66	70	PF01048	0.655
MOD_GlcNHglycan	78	81	PF01048	0.466
MOD_GSK3_1	105	112	PF00069	0.690
MOD_GSK3_1	226	233	PF00069	0.632
MOD_GSK3_1	36	43	PF00069	0.738
MOD_GSK3_1	51	58	PF00069	0.721
MOD_GSK3_1	8	15	PF00069	0.731
MOD_GSK3_1	91	98	PF00069	0.776
MOD_LATS_1	63	69	PF00433	0.737
MOD_N-GLC_1	137	142	PF02516	0.601
MOD_NEK2_1	168	173	PF00069	0.805
MOD_NEK2_1	189	194	PF00069	0.707
MOD_NEK2_1	226	231	PF00069	0.712
MOD_NEK2_1	40	45	PF00069	0.734
MOD_NEK2_1	51	56	PF00069	0.707
MOD_PIKK_1	111	117	PF00454	0.804
MOD_PIKK_1	12	18	PF00454	0.726
MOD_PIKK_1	153	159	PF00454	0.678
MOD_PKA_1	64	70	PF00069	0.827
MOD_PKA_2	152	158	PF00069	0.774
MOD_PKA_2	24	30	PF00069	0.706
MOD_PKA_2	64	70	PF00069	0.863
MOD_PKB_1	129	137	PF00069	0.821
MOD_Plk_1	137	143	PF00069	0.712
MOD_ProDKin_1	143	149	PF00069	0.779
MOD_ProDKin_1	74	80	PF00069	0.837
TRG_DiLeu_BaEn_2	259	265	PF01217	0.557
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.405
TRG_ENDOCYTIC_2	158	161	PF00928	0.781
TRG_ENDOCYTIC_2	231	234	PF00928	0.515
TRG_ER_diArg_1	122	124	PF00400	0.780
TRG_ER_diArg_1	128	131	PF00400	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRT7	Leishmania infantum	99%	100%
E9ACH3	Leishmania major	88%	100%
E9AJR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%