Zinc-finger of acetyl-transferase ESCO, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of acetyl-transferase ESCO, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H526_LEIDO

TriTrypDb:

LdBPK_030170.1 , LdCL_030006700 , LDHU3_03.0170

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H526

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H526

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.744
CLV_C14_Caspase3-7	703	707	PF00656	0.649
CLV_NRD_NRD_1	127	129	PF00675	0.766
CLV_NRD_NRD_1	219	221	PF00675	0.817
CLV_NRD_NRD_1	260	262	PF00675	0.812
CLV_NRD_NRD_1	305	307	PF00675	0.318
CLV_NRD_NRD_1	315	317	PF00675	0.593
CLV_NRD_NRD_1	383	385	PF00675	0.788
CLV_NRD_NRD_1	389	391	PF00675	0.818
CLV_NRD_NRD_1	48	50	PF00675	0.488
CLV_NRD_NRD_1	533	535	PF00675	0.601
CLV_NRD_NRD_1	544	546	PF00675	0.553
CLV_NRD_NRD_1	555	557	PF00675	0.462
CLV_NRD_NRD_1	8	10	PF00675	0.461
CLV_PCSK_FUR_1	258	262	PF00082	0.675
CLV_PCSK_KEX2_1	219	221	PF00082	0.817
CLV_PCSK_KEX2_1	260	262	PF00082	0.810
CLV_PCSK_KEX2_1	305	307	PF00082	0.304
CLV_PCSK_KEX2_1	314	316	PF00082	0.620
CLV_PCSK_KEX2_1	383	385	PF00082	0.789
CLV_PCSK_KEX2_1	388	390	PF00082	0.812
CLV_PCSK_KEX2_1	532	534	PF00082	0.583
CLV_PCSK_KEX2_1	544	546	PF00082	0.541
CLV_PCSK_KEX2_1	555	557	PF00082	0.462
CLV_PCSK_KEX2_1	8	10	PF00082	0.461
CLV_PCSK_PC7_1	384	390	PF00082	0.815
CLV_PCSK_SKI1_1	521	525	PF00082	0.516
CLV_PCSK_SKI1_1	556	560	PF00082	0.513
CLV_PCSK_SKI1_1	593	597	PF00082	0.572
CLV_Separin_Metazoa	255	259	PF03568	0.720
DEG_APCC_DBOX_1	284	292	PF00400	0.591
DEG_APCC_DBOX_1	520	528	PF00400	0.466
DEG_SPOP_SBC_1	134	138	PF00917	0.575
DEG_SPOP_SBC_1	155	159	PF00917	0.609
DEG_SPOP_SBC_1	185	189	PF00917	0.563
DOC_ANK_TNKS_1	474	481	PF00023	0.498
DOC_CKS1_1	29	34	PF01111	0.487
DOC_CYCLIN_RxL_1	459	470	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.561
DOC_MAPK_FxFP_2	39	42	PF00069	0.469
DOC_MAPK_gen_1	8	14	PF00069	0.465
DOC_MAPK_MEF2A_6	350	358	PF00069	0.457
DOC_MAPK_MEF2A_6	533	542	PF00069	0.564
DOC_PP2B_LxvP_1	12	15	PF13499	0.472
DOC_PP4_FxxP_1	39	42	PF00568	0.469
DOC_USP7_MATH_1	155	159	PF00917	0.594
DOC_USP7_MATH_1	19	23	PF00917	0.500
DOC_USP7_MATH_1	249	253	PF00917	0.772
DOC_USP7_MATH_1	330	334	PF00917	0.718
DOC_USP7_MATH_1	344	348	PF00917	0.699
DOC_USP7_MATH_1	414	418	PF00917	0.692
DOC_USP7_MATH_1	425	429	PF00917	0.749
DOC_USP7_MATH_1	487	491	PF00917	0.787
DOC_USP7_MATH_1	52	56	PF00917	0.505
DOC_USP7_MATH_1	588	592	PF00917	0.558
DOC_USP7_MATH_1	612	616	PF00917	0.572
DOC_USP7_MATH_1	677	681	PF00917	0.583
DOC_USP7_MATH_1	684	688	PF00917	0.756
DOC_USP7_UBL2_3	579	583	PF12436	0.485
DOC_WW_Pin1_4	122	127	PF00397	0.591
DOC_WW_Pin1_4	148	153	PF00397	0.618
DOC_WW_Pin1_4	223	228	PF00397	0.685
DOC_WW_Pin1_4	232	237	PF00397	0.727
DOC_WW_Pin1_4	28	33	PF00397	0.489
DOC_WW_Pin1_4	340	345	PF00397	0.722
DOC_WW_Pin1_4	367	372	PF00397	0.658
DOC_WW_Pin1_4	428	433	PF00397	0.700
DOC_WW_Pin1_4	434	439	PF00397	0.538
DOC_WW_Pin1_4	467	472	PF00397	0.524
DOC_WW_Pin1_4	567	572	PF00397	0.586
DOC_WW_Pin1_4	685	690	PF00397	0.778
DOC_WW_Pin1_4	98	103	PF00397	0.543
LIG_14-3-3_CanoR_1	148	152	PF00244	0.588
LIG_14-3-3_CanoR_1	335	344	PF00244	0.760
LIG_14-3-3_CanoR_1	408	416	PF00244	0.623
LIG_14-3-3_CanoR_1	426	432	PF00244	0.532
LIG_14-3-3_CanoR_1	443	447	PF00244	0.401
LIG_14-3-3_CanoR_1	555	563	PF00244	0.504
LIG_14-3-3_CanoR_1	652	657	PF00244	0.462
LIG_Actin_WH2_2	459	477	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.471
LIG_BIR_III_4	720	724	PF00653	0.705
LIG_FHA_1	135	141	PF00498	0.595
LIG_FHA_1	203	209	PF00498	0.738
LIG_FHA_1	270	276	PF00498	0.546
LIG_FHA_1	377	383	PF00498	0.674
LIG_FHA_1	413	419	PF00498	0.598
LIG_FHA_1	46	52	PF00498	0.483
LIG_FHA_1	468	474	PF00498	0.473
LIG_FHA_1	507	513	PF00498	0.404
LIG_FHA_2	269	275	PF00498	0.411
LIG_FHA_2	401	407	PF00498	0.786
LIG_FHA_2	408	414	PF00498	0.649
LIG_FHA_2	557	563	PF00498	0.449
LIG_FHA_2	688	694	PF00498	0.706
LIG_FHA_2	701	707	PF00498	0.639
LIG_LIR_Gen_1	88	97	PF02991	0.519
LIG_LIR_Nem_3	4	10	PF02991	0.458
LIG_LIR_Nem_3	468	472	PF02991	0.569
LIG_LIR_Nem_3	88	93	PF02991	0.516
LIG_LYPXL_S_1	24	28	PF13949	0.496
LIG_LYPXL_yS_3	25	28	PF13949	0.496
LIG_MYND_1	105	109	PF01753	0.586
LIG_NRBOX	208	214	PF00104	0.705
LIG_NRBOX	462	468	PF00104	0.508
LIG_NRBOX	519	525	PF00104	0.560
LIG_PCNA_TLS_4	593	600	PF02747	0.639
LIG_Pex14_1	16	20	PF04695	0.489
LIG_REV1ctd_RIR_1	597	607	PF16727	0.606
LIG_SH2_CRK	321	325	PF00017	0.733
LIG_SH2_CRK	7	11	PF00017	0.464
LIG_SH2_NCK_1	321	325	PF00017	0.733
LIG_SH2_NCK_1	656	660	PF00017	0.602
LIG_SH2_STAP1	20	24	PF00017	0.501
LIG_SH2_STAP1	656	660	PF00017	0.500
LIG_SH2_STAT5	293	296	PF00017	0.570
LIG_SH2_STAT5	402	405	PF00017	0.728
LIG_SH2_STAT5	511	514	PF00017	0.337
LIG_SH2_STAT5	641	644	PF00017	0.541
LIG_SH2_STAT5	702	705	PF00017	0.532
LIG_SH3_2	256	261	PF14604	0.629
LIG_SH3_3	149	155	PF00018	0.609
LIG_SH3_3	224	230	PF00018	0.751
LIG_SH3_3	253	259	PF00018	0.626
LIG_SH3_3	419	425	PF00018	0.665
LIG_SH3_3	478	484	PF00018	0.551
LIG_SH3_3	494	500	PF00018	0.657
LIG_SH3_3	525	531	PF00018	0.532
LIG_SH3_3	565	571	PF00018	0.498
LIG_SH3_3	99	105	PF00018	0.532
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.687
LIG_SUMO_SIM_par_1	413	420	PF11976	0.601
LIG_SUMO_SIM_par_1	462	468	PF11976	0.559
LIG_WRC_WIRS_1	596	601	PF05994	0.526
LIG_WW_3	255	259	PF00397	0.622
MOD_CDK_SPK_2	223	228	PF00069	0.628
MOD_CDK_SPK_2	687	692	PF00069	0.713
MOD_CDK_SPxK_1	122	128	PF00069	0.592
MOD_CDK_SPxxK_3	122	129	PF00069	0.610
MOD_CDK_SPxxK_3	685	692	PF00069	0.712
MOD_CK1_1	136	142	PF00069	0.610
MOD_CK1_1	156	162	PF00069	0.501
MOD_CK1_1	166	172	PF00069	0.506
MOD_CK1_1	226	232	PF00069	0.684
MOD_CK1_1	235	241	PF00069	0.659
MOD_CK1_1	325	331	PF00069	0.703
MOD_CK1_1	363	369	PF00069	0.586
MOD_CK1_1	417	423	PF00069	0.591
MOD_CK1_1	427	433	PF00069	0.752
MOD_CK1_1	505	511	PF00069	0.562
MOD_CK1_1	55	61	PF00069	0.530
MOD_CK1_1	611	617	PF00069	0.735
MOD_CK1_1	687	693	PF00069	0.584
MOD_CK1_1	85	91	PF00069	0.518
MOD_CK2_1	162	168	PF00069	0.592
MOD_CK2_1	249	255	PF00069	0.723
MOD_CK2_1	400	406	PF00069	0.744
MOD_CK2_1	567	573	PF00069	0.452
MOD_CK2_1	687	693	PF00069	0.721
MOD_Cter_Amidation	217	220	PF01082	0.724
MOD_GlcNHglycan	122	125	PF01048	0.615
MOD_GlcNHglycan	245	248	PF01048	0.685
MOD_GlcNHglycan	251	254	PF01048	0.705
MOD_GlcNHglycan	360	365	PF01048	0.662
MOD_GlcNHglycan	504	507	PF01048	0.619
MOD_GlcNHglycan	54	57	PF01048	0.516
MOD_GlcNHglycan	573	577	PF01048	0.516
MOD_GlcNHglycan	610	613	PF01048	0.741
MOD_GlcNHglycan	614	617	PF01048	0.644
MOD_GlcNHglycan	719	724	PF01048	0.687
MOD_GlcNHglycan	87	90	PF01048	0.514
MOD_GSK3_1	120	127	PF00069	0.608
MOD_GSK3_1	134	141	PF00069	0.514
MOD_GSK3_1	143	150	PF00069	0.546
MOD_GSK3_1	155	162	PF00069	0.539
MOD_GSK3_1	180	187	PF00069	0.601
MOD_GSK3_1	222	229	PF00069	0.711
MOD_GSK3_1	243	250	PF00069	0.788
MOD_GSK3_1	340	347	PF00069	0.714
MOD_GSK3_1	363	370	PF00069	0.567
MOD_GSK3_1	374	381	PF00069	0.593
MOD_GSK3_1	398	405	PF00069	0.732
MOD_GSK3_1	41	48	PF00069	0.475
MOD_GSK3_1	424	431	PF00069	0.687
MOD_GSK3_1	483	490	PF00069	0.666
MOD_GSK3_1	498	505	PF00069	0.583
MOD_GSK3_1	51	58	PF00069	0.472
MOD_GSK3_1	547	554	PF00069	0.656
MOD_GSK3_1	595	602	PF00069	0.608
MOD_GSK3_1	607	614	PF00069	0.720
MOD_GSK3_1	644	651	PF00069	0.564
MOD_GSK3_1	96	103	PF00069	0.529
MOD_N-GLC_1	134	139	PF02516	0.593
MOD_N-GLC_1	68	73	PF02516	0.542
MOD_N-GLC_2	447	449	PF02516	0.639
MOD_NEK2_1	1	6	PF00069	0.466
MOD_NEK2_1	140	145	PF00069	0.586
MOD_NEK2_1	179	184	PF00069	0.609
MOD_NEK2_1	268	273	PF00069	0.383
MOD_NEK2_1	374	379	PF00069	0.753
MOD_NEK2_1	442	447	PF00069	0.515
MOD_NEK2_1	492	497	PF00069	0.796
MOD_NEK2_1	51	56	PF00069	0.505
MOD_NEK2_1	589	594	PF00069	0.644
MOD_NEK2_1	595	600	PF00069	0.583
MOD_NEK2_1	654	659	PF00069	0.516
MOD_NEK2_2	506	511	PF00069	0.547
MOD_OFUCOSY	675	682	PF10250	0.503
MOD_PIKK_1	180	186	PF00454	0.670
MOD_PIKK_1	266	272	PF00454	0.737
MOD_PIKK_1	330	336	PF00454	0.626
MOD_PIKK_1	41	47	PF00454	0.476
MOD_PIKK_1	654	660	PF00454	0.514
MOD_PIKK_1	82	88	PF00454	0.524
MOD_PKA_2	147	153	PF00069	0.590
MOD_PKA_2	407	413	PF00069	0.579
MOD_PKA_2	425	431	PF00069	0.539
MOD_PKA_2	442	448	PF00069	0.328
MOD_PKA_2	492	498	PF00069	0.648
MOD_PKA_2	502	508	PF00069	0.585
MOD_PKA_2	67	73	PF00069	0.541
MOD_PKB_1	335	343	PF00069	0.720
MOD_Plk_1	412	418	PF00069	0.663
MOD_Plk_2-3	709	715	PF00069	0.738
MOD_Plk_4	1	7	PF00069	0.466
MOD_Plk_4	113	119	PF00069	0.642
MOD_Plk_4	168	174	PF00069	0.687
MOD_Plk_4	487	493	PF00069	0.742
MOD_Plk_4	506	512	PF00069	0.309
MOD_Plk_4	515	521	PF00069	0.407
MOD_Plk_4	595	601	PF00069	0.686
MOD_ProDKin_1	122	128	PF00069	0.592
MOD_ProDKin_1	148	154	PF00069	0.618
MOD_ProDKin_1	223	229	PF00069	0.684
MOD_ProDKin_1	232	238	PF00069	0.727
MOD_ProDKin_1	28	34	PF00069	0.488
MOD_ProDKin_1	340	346	PF00069	0.718
MOD_ProDKin_1	367	373	PF00069	0.661
MOD_ProDKin_1	428	434	PF00069	0.699
MOD_ProDKin_1	467	473	PF00069	0.523
MOD_ProDKin_1	567	573	PF00069	0.587
MOD_ProDKin_1	685	691	PF00069	0.784
MOD_ProDKin_1	98	104	PF00069	0.547
MOD_SUMO_rev_2	198	205	PF00179	0.549
TRG_DiLeu_BaEn_1	168	173	PF01217	0.587
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.706
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.598
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.495
TRG_ENDOCYTIC_2	25	28	PF00928	0.426
TRG_ENDOCYTIC_2	7	10	PF00928	0.461
TRG_ER_diArg_1	257	260	PF00400	0.836
TRG_ER_diArg_1	261	264	PF00400	0.787
TRG_ER_diArg_1	305	307	PF00400	0.518
TRG_ER_diArg_1	313	316	PF00400	0.588
TRG_ER_diArg_1	382	384	PF00400	0.790
TRG_ER_diArg_1	387	390	PF00400	0.810
TRG_ER_diArg_1	531	534	PF00400	0.582
TRG_ER_diArg_1	7	9	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD4	Leptomonas seymouri	33%	100%
A4H3J0	Leishmania braziliensis	65%	99%
A4HRS9	Leishmania infantum	100%	100%
E9ACG5	Leishmania major	86%	100%
E9AJQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%