Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H524_LEIDO

TriTrypDb:

LdBPK_030110.1 , LdCL_030006100 , LDHU3_03.0110

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	5
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S5H524

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H524

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	806	810	PF00656	0.573
CLV_C14_Caspase3-7	921	925	PF00656	0.556
CLV_NRD_NRD_1	194	196	PF00675	0.525
CLV_NRD_NRD_1	339	341	PF00675	0.696
CLV_NRD_NRD_1	503	505	PF00675	0.542
CLV_NRD_NRD_1	517	519	PF00675	0.530
CLV_NRD_NRD_1	588	590	PF00675	0.552
CLV_NRD_NRD_1	610	612	PF00675	0.632
CLV_NRD_NRD_1	723	725	PF00675	0.744
CLV_NRD_NRD_1	764	766	PF00675	0.605
CLV_NRD_NRD_1	788	790	PF00675	0.600
CLV_PCSK_FUR_1	192	196	PF00082	0.523
CLV_PCSK_KEX2_1	194	196	PF00082	0.525
CLV_PCSK_KEX2_1	339	341	PF00082	0.744
CLV_PCSK_KEX2_1	503	505	PF00082	0.632
CLV_PCSK_KEX2_1	507	509	PF00082	0.613
CLV_PCSK_KEX2_1	517	519	PF00082	0.530
CLV_PCSK_KEX2_1	552	554	PF00082	0.584
CLV_PCSK_KEX2_1	588	590	PF00082	0.552
CLV_PCSK_KEX2_1	610	612	PF00082	0.632
CLV_PCSK_KEX2_1	723	725	PF00082	0.744
CLV_PCSK_KEX2_1	764	766	PF00082	0.605
CLV_PCSK_KEX2_1	788	790	PF00082	0.600
CLV_PCSK_KEX2_1	907	909	PF00082	0.612
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.653
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.584
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.612
CLV_PCSK_PC7_1	503	509	PF00082	0.539
CLV_PCSK_PC7_1	606	612	PF00082	0.564
CLV_PCSK_SKI1_1	250	254	PF00082	0.726
CLV_PCSK_SKI1_1	258	262	PF00082	0.668
CLV_PCSK_SKI1_1	339	343	PF00082	0.716
CLV_PCSK_SKI1_1	359	363	PF00082	0.522
CLV_PCSK_SKI1_1	534	538	PF00082	0.594
CLV_PCSK_SKI1_1	67	71	PF00082	0.543
CLV_PCSK_SKI1_1	724	728	PF00082	0.628
CLV_PCSK_SKI1_1	764	768	PF00082	0.598
CLV_PCSK_SKI1_1	913	917	PF00082	0.718
CLV_Separin_Metazoa	134	138	PF03568	0.471
DEG_APCC_DBOX_1	129	137	PF00400	0.496
DEG_APCC_DBOX_1	196	204	PF00400	0.524
DEG_APCC_DBOX_1	268	276	PF00400	0.679
DEG_APCC_DBOX_1	53	61	PF00400	0.488
DEG_APCC_DBOX_1	594	602	PF00400	0.518
DEG_APCC_DBOX_1	723	731	PF00400	0.501
DOC_CKS1_1	246	251	PF01111	0.710
DOC_CKS1_1	35	40	PF01111	0.499
DOC_CKS1_1	425	430	PF01111	0.713
DOC_CYCLIN_RxL_1	594	604	PF00134	0.526
DOC_CYCLIN_RxL_1	721	731	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.606
DOC_MAPK_gen_1	22	31	PF00069	0.472
DOC_PP2B_LxvP_1	894	897	PF13499	0.664
DOC_PP4_FxxP_1	35	38	PF00568	0.500
DOC_PP4_FxxP_1	462	465	PF00568	0.648
DOC_USP7_MATH_1	264	268	PF00917	0.694
DOC_USP7_MATH_1	284	288	PF00917	0.584
DOC_USP7_MATH_1	305	309	PF00917	0.721
DOC_USP7_MATH_1	311	315	PF00917	0.640
DOC_USP7_MATH_1	421	425	PF00917	0.730
DOC_USP7_MATH_1	5	9	PF00917	0.618
DOC_USP7_MATH_1	649	653	PF00917	0.754
DOC_USP7_MATH_1	65	69	PF00917	0.498
DOC_USP7_MATH_1	655	659	PF00917	0.623
DOC_USP7_MATH_1	662	666	PF00917	0.554
DOC_USP7_MATH_1	681	685	PF00917	0.585
DOC_USP7_MATH_1	717	721	PF00917	0.612
DOC_USP7_MATH_1	745	749	PF00917	0.625
DOC_USP7_MATH_1	752	756	PF00917	0.571
DOC_USP7_MATH_1	810	814	PF00917	0.730
DOC_USP7_MATH_1	844	848	PF00917	0.723
DOC_USP7_UBL2_3	913	917	PF12436	0.621
DOC_WW_Pin1_4	174	179	PF00397	0.492
DOC_WW_Pin1_4	239	244	PF00397	0.711
DOC_WW_Pin1_4	245	250	PF00397	0.671
DOC_WW_Pin1_4	292	297	PF00397	0.645
DOC_WW_Pin1_4	322	327	PF00397	0.764
DOC_WW_Pin1_4	34	39	PF00397	0.506
DOC_WW_Pin1_4	379	384	PF00397	0.677
DOC_WW_Pin1_4	386	391	PF00397	0.693
DOC_WW_Pin1_4	424	429	PF00397	0.710
DOC_WW_Pin1_4	440	445	PF00397	0.724
DOC_WW_Pin1_4	461	466	PF00397	0.797
DOC_WW_Pin1_4	624	629	PF00397	0.672
DOC_WW_Pin1_4	657	662	PF00397	0.841
DOC_WW_Pin1_4	666	671	PF00397	0.709
DOC_WW_Pin1_4	840	845	PF00397	0.681
DOC_WW_Pin1_4	872	877	PF00397	0.737
LIG_14-3-3_CanoR_1	120	125	PF00244	0.476
LIG_14-3-3_CanoR_1	156	161	PF00244	0.461
LIG_14-3-3_CanoR_1	195	201	PF00244	0.477
LIG_14-3-3_CanoR_1	229	237	PF00244	0.678
LIG_14-3-3_CanoR_1	470	478	PF00244	0.619
LIG_14-3-3_CanoR_1	517	527	PF00244	0.530
LIG_14-3-3_CanoR_1	556	566	PF00244	0.589
LIG_14-3-3_CanoR_1	575	580	PF00244	0.347
LIG_14-3-3_CanoR_1	611	620	PF00244	0.622
LIG_14-3-3_CanoR_1	664	670	PF00244	0.711
LIG_14-3-3_CanoR_1	71	77	PF00244	0.527
LIG_14-3-3_CanoR_1	723	727	PF00244	0.728
LIG_14-3-3_CanoR_1	759	763	PF00244	0.541
LIG_14-3-3_CanoR_1	845	854	PF00244	0.716
LIG_14-3-3_CanoR_1	908	916	PF00244	0.542
LIG_Actin_WH2_2	523	540	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BIR_III_4	809	813	PF00653	0.651
LIG_Clathr_ClatBox_1	207	211	PF01394	0.491
LIG_CtBP_PxDLS_1	86	90	PF00389	0.396
LIG_DLG_GKlike_1	120	127	PF00625	0.478
LIG_eIF4E_1	76	82	PF01652	0.473
LIG_EVH1_1	894	898	PF00568	0.664
LIG_FHA_1	144	150	PF00498	0.605
LIG_FHA_1	175	181	PF00498	0.523
LIG_FHA_1	225	231	PF00498	0.544
LIG_FHA_1	480	486	PF00498	0.710
LIG_FHA_1	642	648	PF00498	0.673
LIG_FHA_1	691	697	PF00498	0.608
LIG_FHA_1	714	720	PF00498	0.626
LIG_FHA_1	869	875	PF00498	0.726
LIG_FHA_2	197	203	PF00498	0.551
LIG_FHA_2	35	41	PF00498	0.497
LIG_FHA_2	401	407	PF00498	0.734
LIG_FHA_2	46	52	PF00498	0.471
LIG_FHA_2	569	575	PF00498	0.528
LIG_FHA_2	576	582	PF00498	0.494
LIG_FHA_2	585	591	PF00498	0.405
LIG_FHA_2	804	810	PF00498	0.657
LIG_FHA_2	862	868	PF00498	0.716
LIG_GBD_Chelix_1	688	696	PF00786	0.638
LIG_GBD_Chelix_1	718	726	PF00786	0.611
LIG_LIR_Gen_1	115	125	PF02991	0.462
LIG_LIR_Gen_1	571	580	PF02991	0.471
LIG_LIR_Gen_1	694	703	PF02991	0.648
LIG_LIR_Gen_1	75	82	PF02991	0.559
LIG_LIR_Nem_3	115	121	PF02991	0.572
LIG_LIR_Nem_3	694	700	PF02991	0.662
LIG_LIR_Nem_3	75	79	PF02991	0.547
LIG_PCNA_TLS_4	764	771	PF02747	0.596
LIG_RPA_C_Fungi	513	525	PF08784	0.482
LIG_RPA_C_Fungi	584	596	PF08784	0.545
LIG_SH2_CRK	437	441	PF00017	0.706
LIG_SH2_CRK	697	701	PF00017	0.592
LIG_SH2_CRK	76	80	PF00017	0.590
LIG_SH2_GRB2like	221	224	PF00017	0.602
LIG_SH2_NCK_1	76	80	PF00017	0.469
LIG_SH2_SRC	221	224	PF00017	0.602
LIG_SH2_STAP1	221	225	PF00017	0.597
LIG_SH2_STAP1	580	584	PF00017	0.546
LIG_SH2_STAT3	580	583	PF00017	0.546
LIG_SH2_STAT5	164	167	PF00017	0.623
LIG_SH3_1	331	337	PF00018	0.694
LIG_SH3_2	334	339	PF14604	0.756
LIG_SH3_2	465	470	PF14604	0.653
LIG_SH3_3	183	189	PF00018	0.611
LIG_SH3_3	272	278	PF00018	0.708
LIG_SH3_3	331	337	PF00018	0.815
LIG_SH3_3	347	353	PF00018	0.575
LIG_SH3_3	380	386	PF00018	0.839
LIG_SH3_3	422	428	PF00018	0.733
LIG_SH3_3	462	468	PF00018	0.702
LIG_SH3_3	838	844	PF00018	0.677
LIG_SH3_3	873	879	PF00018	0.709
LIG_SH3_3	892	898	PF00018	0.599
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.463
LIG_SUMO_SIM_par_1	206	211	PF11976	0.497
LIG_SUMO_SIM_par_1	42	48	PF11976	0.463
LIG_SUMO_SIM_par_1	85	90	PF11976	0.392
LIG_SUMO_SIM_par_1	865	875	PF11976	0.714
LIG_TRAF2_1	37	40	PF00917	0.498
LIG_TRAF2_2	782	787	PF00917	0.723
LIG_TYR_ITIM	435	440	PF00017	0.728
LIG_UBA3_1	544	552	PF00899	0.580
LIG_WRC_WIRS_1	576	581	PF05994	0.540
LIG_WRC_WIRS_1	767	772	PF05994	0.549
MOD_CDC14_SPxK_1	389	392	PF00782	0.709
MOD_CDC14_SPxK_1	467	470	PF00782	0.701
MOD_CDC14_SPxK_1	669	672	PF00782	0.722
MOD_CDK_SPK_2	245	250	PF00069	0.710
MOD_CDK_SPK_2	379	384	PF00069	0.611
MOD_CDK_SPK_2	840	845	PF00069	0.635
MOD_CDK_SPxK_1	386	392	PF00069	0.710
MOD_CDK_SPxK_1	464	470	PF00069	0.700
MOD_CDK_SPxK_1	666	672	PF00069	0.728
MOD_CDK_SPxxK_3	322	329	PF00069	0.768
MOD_CDK_SPxxK_3	657	664	PF00069	0.725
MOD_CK1_1	206	212	PF00069	0.506
MOD_CK1_1	228	234	PF00069	0.660
MOD_CK1_1	245	251	PF00069	0.609
MOD_CK1_1	287	293	PF00069	0.714
MOD_CK1_1	318	324	PF00069	0.688
MOD_CK1_1	424	430	PF00069	0.719
MOD_CK1_1	45	51	PF00069	0.371
MOD_CK1_1	464	470	PF00069	0.736
MOD_CK1_1	554	560	PF00069	0.592
MOD_CK1_1	660	666	PF00069	0.779
MOD_CK1_1	731	737	PF00069	0.662
MOD_CK1_1	755	761	PF00069	0.579
MOD_CK1_1	8	14	PF00069	0.626
MOD_CK1_1	813	819	PF00069	0.715
MOD_CK2_1	196	202	PF00069	0.540
MOD_CK2_1	264	270	PF00069	0.700
MOD_CK2_1	322	328	PF00069	0.687
MOD_CK2_1	34	40	PF00069	0.512
MOD_CK2_1	374	380	PF00069	0.559
MOD_CK2_1	50	56	PF00069	0.468
MOD_CK2_1	568	574	PF00069	0.528
MOD_CK2_1	575	581	PF00069	0.496
MOD_CK2_1	584	590	PF00069	0.404
MOD_CK2_1	863	869	PF00069	0.739
MOD_GlcNHglycan	10	13	PF01048	0.622
MOD_GlcNHglycan	146	149	PF01048	0.443
MOD_GlcNHglycan	266	269	PF01048	0.734
MOD_GlcNHglycan	281	284	PF01048	0.653
MOD_GlcNHglycan	362	365	PF01048	0.698
MOD_GlcNHglycan	366	369	PF01048	0.698
MOD_GlcNHglycan	454	457	PF01048	0.804
MOD_GlcNHglycan	553	556	PF01048	0.589
MOD_GlcNHglycan	603	606	PF01048	0.609
MOD_GlcNHglycan	664	667	PF01048	0.733
MOD_GlcNHglycan	729	733	PF01048	0.622
MOD_GlcNHglycan	747	750	PF01048	0.564
MOD_GlcNHglycan	847	850	PF01048	0.679
MOD_GlcNHglycan	854	857	PF01048	0.672
MOD_GlcNHglycan	902	905	PF01048	0.661
MOD_GlcNHglycan	909	912	PF01048	0.615
MOD_GSK3_1	1	8	PF00069	0.597
MOD_GSK3_1	172	179	PF00069	0.516
MOD_GSK3_1	224	231	PF00069	0.621
MOD_GSK3_1	241	248	PF00069	0.604
MOD_GSK3_1	284	291	PF00069	0.758
MOD_GSK3_1	311	318	PF00069	0.706
MOD_GSK3_1	339	346	PF00069	0.825
MOD_GSK3_1	360	367	PF00069	0.734
MOD_GSK3_1	436	443	PF00069	0.728
MOD_GSK3_1	575	582	PF00069	0.543
MOD_GSK3_1	660	667	PF00069	0.788
MOD_GSK3_1	709	716	PF00069	0.632
MOD_GSK3_1	835	842	PF00069	0.679
MOD_GSK3_1	861	868	PF00069	0.684
MOD_GSK3_1	885	892	PF00069	0.667
MOD_GSK3_1	918	925	PF00069	0.619
MOD_LATS_1	905	911	PF00433	0.504
MOD_N-GLC_1	292	297	PF02516	0.628
MOD_N-GLC_1	311	316	PF02516	0.589
MOD_N-GLC_1	374	379	PF02516	0.689
MOD_N-GLC_1	72	77	PF02516	0.451
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	114	119	PF00069	0.442
MOD_NEK2_1	172	177	PF00069	0.498
MOD_NEK2_1	355	360	PF00069	0.738
MOD_NEK2_1	411	416	PF00069	0.567
MOD_NEK2_1	478	483	PF00069	0.602
MOD_NEK2_1	485	490	PF00069	0.479
MOD_NEK2_1	50	55	PF00069	0.462
MOD_NEK2_1	579	584	PF00069	0.545
MOD_NEK2_1	599	604	PF00069	0.655
MOD_NEK2_1	696	701	PF00069	0.638
MOD_NEK2_1	72	77	PF00069	0.451
MOD_NEK2_1	722	727	PF00069	0.688
MOD_NEK2_1	730	735	PF00069	0.651
MOD_NEK2_1	87	92	PF00069	0.316
MOD_NEK2_2	421	426	PF00069	0.648
MOD_NEK2_2	436	441	PF00069	0.681
MOD_PIKK_1	103	109	PF00454	0.429
MOD_PIKK_1	253	259	PF00454	0.740
MOD_PIKK_1	471	477	PF00454	0.618
MOD_PIKK_1	518	524	PF00454	0.528
MOD_PIKK_1	525	531	PF00454	0.464
MOD_PIKK_1	568	574	PF00454	0.514
MOD_PIKK_1	579	585	PF00454	0.469
MOD_PIKK_1	740	746	PF00454	0.664
MOD_PIKK_1	803	809	PF00454	0.687
MOD_PIKK_1	813	819	PF00454	0.671
MOD_PIKK_1	87	93	PF00454	0.480
MOD_PK_1	709	715	PF00069	0.537
MOD_PKA_1	339	345	PF00069	0.716
MOD_PKA_1	907	913	PF00069	0.495
MOD_PKA_2	119	125	PF00069	0.471
MOD_PKA_2	144	150	PF00069	0.465
MOD_PKA_2	196	202	PF00069	0.480
MOD_PKA_2	228	234	PF00069	0.750
MOD_PKA_2	339	345	PF00069	0.821
MOD_PKA_2	537	543	PF00069	0.554
MOD_PKA_2	557	563	PF00069	0.593
MOD_PKA_2	599	605	PF00069	0.596
MOD_PKA_2	722	728	PF00069	0.624
MOD_PKA_2	758	764	PF00069	0.540
MOD_PKA_2	8	14	PF00069	0.626
MOD_PKA_2	844	850	PF00069	0.709
MOD_PKA_2	907	913	PF00069	0.628
MOD_Plk_1	114	120	PF00069	0.450
MOD_Plk_1	311	317	PF00069	0.660
MOD_Plk_1	421	427	PF00069	0.710
MOD_Plk_1	525	531	PF00069	0.535
MOD_Plk_1	58	64	PF00069	0.524
MOD_Plk_1	709	715	PF00069	0.600
MOD_Plk_1	72	78	PF00069	0.455
MOD_Plk_1	885	891	PF00069	0.589
MOD_Plk_2-3	861	867	PF00069	0.717
MOD_Plk_4	203	209	PF00069	0.514
MOD_Plk_4	42	48	PF00069	0.409
MOD_Plk_4	485	491	PF00069	0.568
MOD_Plk_4	575	581	PF00069	0.543
MOD_Plk_4	691	697	PF00069	0.589
MOD_Plk_4	709	715	PF00069	0.537
MOD_Plk_4	758	764	PF00069	0.543
MOD_Plk_4	766	772	PF00069	0.516
MOD_Plk_4	868	874	PF00069	0.734
MOD_Plk_4	918	924	PF00069	0.710
MOD_ProDKin_1	174	180	PF00069	0.487
MOD_ProDKin_1	239	245	PF00069	0.712
MOD_ProDKin_1	292	298	PF00069	0.648
MOD_ProDKin_1	322	328	PF00069	0.765
MOD_ProDKin_1	34	40	PF00069	0.503
MOD_ProDKin_1	379	385	PF00069	0.678
MOD_ProDKin_1	386	392	PF00069	0.698
MOD_ProDKin_1	424	430	PF00069	0.712
MOD_ProDKin_1	440	446	PF00069	0.725
MOD_ProDKin_1	461	467	PF00069	0.798
MOD_ProDKin_1	624	630	PF00069	0.671
MOD_ProDKin_1	657	663	PF00069	0.842
MOD_ProDKin_1	666	672	PF00069	0.713
MOD_ProDKin_1	840	846	PF00069	0.683
MOD_ProDKin_1	872	878	PF00069	0.735
TRG_DiLeu_BaEn_1	594	599	PF01217	0.559
TRG_DiLeu_LyEn_5	594	599	PF01217	0.559
TRG_ENDOCYTIC_2	437	440	PF00928	0.731
TRG_ENDOCYTIC_2	573	576	PF00928	0.545
TRG_ENDOCYTIC_2	697	700	PF00928	0.663
TRG_ENDOCYTIC_2	76	79	PF00928	0.582
TRG_ER_diArg_1	192	195	PF00400	0.536
TRG_ER_diArg_1	338	340	PF00400	0.699
TRG_ER_diArg_1	458	461	PF00400	0.747
TRG_ER_diArg_1	502	504	PF00400	0.546
TRG_ER_diArg_1	517	519	PF00400	0.530
TRG_ER_diArg_1	595	598	PF00400	0.559
TRG_ER_diArg_1	722	724	PF00400	0.739
TRG_ER_diArg_1	763	765	PF00400	0.720
TRG_NES_CRM1_1	100	115	PF08389	0.432
TRG_NES_CRM1_1	42	56	PF08389	0.457
TRG_NES_CRM1_1	522	535	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3I4	Leishmania braziliensis	70%	98%
E9ACF9	Leishmania major	90%	100%
E9AG31	Leishmania infantum	100%	100%
E9AJP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%