LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H523_LEIDO
TriTrypDb:
LdBPK_030100.1 * , LdCL_030006000 , LDHU3_03.0100
Length:
891

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H523
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H523

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 274 278 PF00656 0.716
CLV_C14_Caspase3-7 31 35 PF00656 0.490
CLV_C14_Caspase3-7 448 452 PF00656 0.751
CLV_C14_Caspase3-7 636 640 PF00656 0.790
CLV_NRD_NRD_1 10 12 PF00675 0.464
CLV_NRD_NRD_1 193 195 PF00675 0.789
CLV_NRD_NRD_1 24 26 PF00675 0.436
CLV_NRD_NRD_1 296 298 PF00675 0.716
CLV_NRD_NRD_1 319 321 PF00675 0.827
CLV_NRD_NRD_1 555 557 PF00675 0.636
CLV_NRD_NRD_1 689 691 PF00675 0.641
CLV_NRD_NRD_1 74 76 PF00675 0.560
CLV_NRD_NRD_1 838 840 PF00675 0.828
CLV_PCSK_KEX2_1 114 116 PF00082 0.593
CLV_PCSK_KEX2_1 192 194 PF00082 0.786
CLV_PCSK_KEX2_1 24 26 PF00082 0.544
CLV_PCSK_KEX2_1 296 298 PF00082 0.716
CLV_PCSK_KEX2_1 319 321 PF00082 0.827
CLV_PCSK_KEX2_1 482 484 PF00082 0.783
CLV_PCSK_KEX2_1 689 691 PF00082 0.641
CLV_PCSK_KEX2_1 74 76 PF00082 0.560
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.593
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.709
CLV_PCSK_PC7_1 20 26 PF00082 0.545
CLV_PCSK_PC7_1 315 321 PF00082 0.826
CLV_PCSK_SKI1_1 12 16 PF00082 0.593
CLV_PCSK_SKI1_1 187 191 PF00082 0.688
CLV_PCSK_SKI1_1 483 487 PF00082 0.679
CLV_PCSK_SKI1_1 508 512 PF00082 0.706
CLV_PCSK_SKI1_1 787 791 PF00082 0.497
CLV_PCSK_SKI1_1 875 879 PF00082 0.837
CLV_Separin_Metazoa 784 788 PF03568 0.598
DEG_Nend_UBRbox_1 1 4 PF02207 0.624
DEG_SPOP_SBC_1 237 241 PF00917 0.758
DEG_SPOP_SBC_1 375 379 PF00917 0.652
DEG_SPOP_SBC_1 422 426 PF00917 0.589
DEG_SPOP_SBC_1 749 753 PF00917 0.657
DEG_SPOP_SBC_1 850 854 PF00917 0.754
DEG_SPOP_SBC_1 861 865 PF00917 0.605
DOC_CYCLIN_yClb5_NLxxxL_5 537 544 PF00134 0.674
DOC_CYCLIN_yCln2_LP_2 79 85 PF00134 0.578
DOC_MAPK_gen_1 74 85 PF00069 0.456
DOC_MAPK_MEF2A_6 2 9 PF00069 0.590
DOC_MAPK_MEF2A_6 74 83 PF00069 0.569
DOC_MAPK_NFAT4_5 78 86 PF00069 0.578
DOC_MIT_MIM_1 70 79 PF04212 0.565
DOC_PP2B_LxvP_1 79 82 PF13499 0.568
DOC_PP4_FxxP_1 232 235 PF00568 0.582
DOC_PP4_FxxP_1 85 88 PF00568 0.571
DOC_USP7_MATH_1 237 241 PF00917 0.735
DOC_USP7_MATH_1 322 326 PF00917 0.825
DOC_USP7_MATH_1 352 356 PF00917 0.832
DOC_USP7_MATH_1 358 362 PF00917 0.748
DOC_USP7_MATH_1 368 372 PF00917 0.575
DOC_USP7_MATH_1 375 379 PF00917 0.574
DOC_USP7_MATH_1 389 393 PF00917 0.482
DOC_USP7_MATH_1 422 426 PF00917 0.659
DOC_USP7_MATH_1 53 57 PF00917 0.460
DOC_USP7_MATH_1 602 606 PF00917 0.807
DOC_USP7_MATH_1 650 654 PF00917 0.607
DOC_USP7_MATH_1 767 771 PF00917 0.748
DOC_USP7_MATH_1 795 799 PF00917 0.637
DOC_USP7_MATH_1 817 821 PF00917 0.777
DOC_USP7_MATH_1 845 849 PF00917 0.719
DOC_USP7_MATH_1 850 854 PF00917 0.736
DOC_USP7_MATH_1 861 865 PF00917 0.631
DOC_WW_Pin1_4 1 6 PF00397 0.547
DOC_WW_Pin1_4 231 236 PF00397 0.823
DOC_WW_Pin1_4 239 244 PF00397 0.686
DOC_WW_Pin1_4 248 253 PF00397 0.548
DOC_WW_Pin1_4 429 434 PF00397 0.839
DOC_WW_Pin1_4 485 490 PF00397 0.839
DOC_WW_Pin1_4 627 632 PF00397 0.766
DOC_WW_Pin1_4 761 766 PF00397 0.718
DOC_WW_Pin1_4 815 820 PF00397 0.594
DOC_WW_Pin1_4 827 832 PF00397 0.565
DOC_WW_Pin1_4 864 869 PF00397 0.660
LIG_14-3-3_CanoR_1 184 190 PF00244 0.570
LIG_14-3-3_CanoR_1 20 26 PF00244 0.623
LIG_14-3-3_CanoR_1 213 221 PF00244 0.750
LIG_14-3-3_CanoR_1 267 273 PF00244 0.870
LIG_14-3-3_CanoR_1 296 306 PF00244 0.813
LIG_14-3-3_CanoR_1 360 366 PF00244 0.745
LIG_14-3-3_CanoR_1 483 489 PF00244 0.686
LIG_14-3-3_CanoR_1 585 592 PF00244 0.707
LIG_14-3-3_CanoR_1 617 623 PF00244 0.797
LIG_14-3-3_CanoR_1 692 698 PF00244 0.616
LIG_14-3-3_CanoR_1 769 775 PF00244 0.647
LIG_14-3-3_CanoR_1 875 881 PF00244 0.788
LIG_Actin_WH2_2 771 789 PF00022 0.611
LIG_BRCT_BRCA1_1 118 122 PF00533 0.632
LIG_CaM_IQ_9 681 697 PF13499 0.647
LIG_CaM_NSCaTE_8 562 569 PF13499 0.669
LIG_FHA_1 100 106 PF00498 0.448
LIG_FHA_1 129 135 PF00498 0.577
LIG_FHA_1 140 146 PF00498 0.409
LIG_FHA_1 159 165 PF00498 0.328
LIG_FHA_1 2 8 PF00498 0.636
LIG_FHA_1 268 274 PF00498 0.866
LIG_FHA_1 453 459 PF00498 0.652
LIG_FHA_1 517 523 PF00498 0.709
LIG_FHA_1 527 533 PF00498 0.571
LIG_FHA_1 736 742 PF00498 0.653
LIG_FHA_1 876 882 PF00498 0.833
LIG_FHA_2 168 174 PF00498 0.663
LIG_FHA_2 528 534 PF00498 0.731
LIG_FHA_2 751 757 PF00498 0.578
LIG_GBD_Chelix_1 733 741 PF00786 0.572
LIG_Integrin_RGD_1 446 448 PF01839 0.831
LIG_LIR_Apic_2 231 235 PF02991 0.584
LIG_LIR_Apic_2 84 88 PF02991 0.484
LIG_LIR_Gen_1 27 37 PF02991 0.498
LIG_LIR_Gen_1 625 631 PF02991 0.582
LIG_LIR_Gen_1 653 664 PF02991 0.494
LIG_LIR_Gen_1 806 814 PF02991 0.598
LIG_LIR_Gen_1 97 108 PF02991 0.556
LIG_LIR_Nem_3 27 32 PF02991 0.533
LIG_LIR_Nem_3 625 629 PF02991 0.587
LIG_LIR_Nem_3 653 659 PF02991 0.496
LIG_LIR_Nem_3 691 697 PF02991 0.618
LIG_LIR_Nem_3 70 76 PF02991 0.455
LIG_LIR_Nem_3 728 734 PF02991 0.654
LIG_LIR_Nem_3 806 811 PF02991 0.598
LIG_LIR_Nem_3 97 103 PF02991 0.561
LIG_MYND_1 497 501 PF01753 0.633
LIG_NRBOX 406 412 PF00104 0.682
LIG_NRBOX 876 882 PF00104 0.833
LIG_PCNA_yPIPBox_3 401 415 PF02747 0.665
LIG_PDZ_Class_2 886 891 PF00595 0.732
LIG_Pex14_1 69 73 PF04695 0.566
LIG_Pex14_2 118 122 PF04695 0.632
LIG_Pex14_2 42 46 PF04695 0.528
LIG_PTB_Apo_2 40 47 PF02174 0.563
LIG_SH2_CRK 29 33 PF00017 0.580
LIG_SH2_SRC 808 811 PF00017 0.603
LIG_SH2_STAP1 29 33 PF00017 0.503
LIG_SH2_STAP1 462 466 PF00017 0.675
LIG_SH2_STAP1 808 812 PF00017 0.645
LIG_SH2_STAP1 824 828 PF00017 0.721
LIG_SH2_STAT5 107 110 PF00017 0.511
LIG_SH2_STAT5 133 136 PF00017 0.497
LIG_SH3_3 151 157 PF00018 0.646
LIG_SH3_3 250 256 PF00018 0.833
LIG_SH3_3 303 309 PF00018 0.777
LIG_SH3_3 490 496 PF00018 0.807
LIG_Sin3_3 141 148 PF02671 0.577
LIG_SUMO_SIM_par_1 529 536 PF11976 0.639
LIG_TRAF2_1 177 180 PF00917 0.657
LIG_TRAF2_1 716 719 PF00917 0.674
LIG_WRC_WIRS_1 14 19 PF05994 0.566
LIG_WW_2 497 500 PF00397 0.635
LIG_WW_3 252 256 PF00397 0.819
MOD_CDK_SPK_2 431 436 PF00069 0.827
MOD_CDK_SPxxK_3 239 246 PF00069 0.761
MOD_CDK_SPxxK_3 248 255 PF00069 0.650
MOD_CDK_SPxxK_3 429 436 PF00069 0.838
MOD_CK1_1 197 203 PF00069 0.828
MOD_CK1_1 212 218 PF00069 0.617
MOD_CK1_1 231 237 PF00069 0.590
MOD_CK1_1 239 245 PF00069 0.718
MOD_CK1_1 262 268 PF00069 0.861
MOD_CK1_1 27 33 PF00069 0.566
MOD_CK1_1 271 277 PF00069 0.724
MOD_CK1_1 318 324 PF00069 0.778
MOD_CK1_1 325 331 PF00069 0.656
MOD_CK1_1 334 340 PF00069 0.597
MOD_CK1_1 343 349 PF00069 0.553
MOD_CK1_1 361 367 PF00069 0.649
MOD_CK1_1 371 377 PF00069 0.644
MOD_CK1_1 421 427 PF00069 0.728
MOD_CK1_1 487 493 PF00069 0.814
MOD_CK1_1 502 508 PF00069 0.546
MOD_CK1_1 618 624 PF00069 0.774
MOD_CK1_1 627 633 PF00069 0.664
MOD_CK1_1 770 776 PF00069 0.648
MOD_CK1_1 820 826 PF00069 0.695
MOD_CK1_1 862 868 PF00069 0.831
MOD_CK2_1 167 173 PF00069 0.655
MOD_CK2_1 713 719 PF00069 0.673
MOD_CK2_1 750 756 PF00069 0.571
MOD_Cter_Amidation 9 12 PF01082 0.602
MOD_DYRK1A_RPxSP_1 248 252 PF00069 0.632
MOD_DYRK1A_RPxSP_1 431 435 PF00069 0.657
MOD_GlcNHglycan 117 121 PF01048 0.536
MOD_GlcNHglycan 196 199 PF01048 0.805
MOD_GlcNHglycan 218 221 PF01048 0.797
MOD_GlcNHglycan 235 238 PF01048 0.600
MOD_GlcNHglycan 299 302 PF01048 0.788
MOD_GlcNHglycan 320 323 PF01048 0.861
MOD_GlcNHglycan 327 330 PF01048 0.740
MOD_GlcNHglycan 343 346 PF01048 0.612
MOD_GlcNHglycan 360 363 PF01048 0.597
MOD_GlcNHglycan 365 368 PF01048 0.761
MOD_GlcNHglycan 373 376 PF01048 0.625
MOD_GlcNHglycan 420 423 PF01048 0.778
MOD_GlcNHglycan 425 428 PF01048 0.744
MOD_GlcNHglycan 501 504 PF01048 0.833
MOD_GlcNHglycan 604 607 PF01048 0.704
MOD_GlcNHglycan 626 629 PF01048 0.773
MOD_GlcNHglycan 639 642 PF01048 0.528
MOD_GlcNHglycan 652 655 PF01048 0.525
MOD_GlcNHglycan 715 718 PF01048 0.470
MOD_GlcNHglycan 805 808 PF01048 0.570
MOD_GlcNHglycan 840 843 PF01048 0.682
MOD_GSK3_1 129 136 PF00069 0.604
MOD_GSK3_1 20 27 PF00069 0.469
MOD_GSK3_1 212 219 PF00069 0.792
MOD_GSK3_1 233 240 PF00069 0.784
MOD_GSK3_1 259 266 PF00069 0.858
MOD_GSK3_1 267 274 PF00069 0.749
MOD_GSK3_1 291 298 PF00069 0.785
MOD_GSK3_1 314 321 PF00069 0.840
MOD_GSK3_1 324 331 PF00069 0.665
MOD_GSK3_1 337 344 PF00069 0.592
MOD_GSK3_1 371 378 PF00069 0.759
MOD_GSK3_1 418 425 PF00069 0.740
MOD_GSK3_1 447 454 PF00069 0.679
MOD_GSK3_1 53 60 PF00069 0.659
MOD_GSK3_1 618 625 PF00069 0.697
MOD_GSK3_1 646 653 PF00069 0.557
MOD_GSK3_1 693 700 PF00069 0.609
MOD_GSK3_1 705 712 PF00069 0.433
MOD_GSK3_1 815 822 PF00069 0.724
MOD_GSK3_1 823 830 PF00069 0.644
MOD_GSK3_1 845 852 PF00069 0.652
MOD_GSK3_1 860 867 PF00069 0.664
MOD_N-GLC_1 259 264 PF02516 0.777
MOD_N-GLC_1 602 607 PF02516 0.675
MOD_NEK2_1 158 163 PF00069 0.634
MOD_NEK2_1 411 416 PF00069 0.694
MOD_NEK2_1 586 591 PF00069 0.548
MOD_NEK2_1 693 698 PF00069 0.610
MOD_PIKK_1 204 210 PF00454 0.721
MOD_PIKK_1 260 266 PF00454 0.759
MOD_PIKK_1 304 310 PF00454 0.858
MOD_PIKK_1 468 474 PF00454 0.672
MOD_PIKK_1 53 59 PF00454 0.616
MOD_PIKK_1 615 621 PF00454 0.799
MOD_PIKK_1 735 741 PF00454 0.654
MOD_PKA_1 192 198 PF00069 0.714
MOD_PKA_1 24 30 PF00069 0.538
MOD_PKA_2 19 25 PF00069 0.624
MOD_PKA_2 192 198 PF00069 0.714
MOD_PKA_2 212 218 PF00069 0.534
MOD_PKA_2 266 272 PF00069 0.856
MOD_PKA_2 295 301 PF00069 0.723
MOD_PKA_2 314 320 PF00069 0.662
MOD_PKA_2 325 331 PF00069 0.673
MOD_PKA_2 371 377 PF00069 0.723
MOD_PKA_2 838 844 PF00069 0.754
MOD_PKB_1 192 200 PF00069 0.801
MOD_Plk_1 128 134 PF00069 0.606
MOD_Plk_1 27 33 PF00069 0.517
MOD_Plk_1 646 652 PF00069 0.700
MOD_Plk_1 787 793 PF00069 0.581
MOD_Plk_2-3 13 19 PF00069 0.570
MOD_Plk_2-3 28 34 PF00069 0.507
MOD_Plk_4 129 135 PF00069 0.606
MOD_Plk_4 139 145 PF00069 0.403
MOD_Plk_4 406 412 PF00069 0.682
MOD_Plk_4 527 533 PF00069 0.659
MOD_Plk_4 697 703 PF00069 0.604
MOD_Plk_4 770 776 PF00069 0.636
MOD_Plk_4 81 87 PF00069 0.495
MOD_Plk_4 876 882 PF00069 0.833
MOD_Plk_4 99 105 PF00069 0.335
MOD_ProDKin_1 1 7 PF00069 0.536
MOD_ProDKin_1 231 237 PF00069 0.821
MOD_ProDKin_1 239 245 PF00069 0.688
MOD_ProDKin_1 248 254 PF00069 0.546
MOD_ProDKin_1 429 435 PF00069 0.834
MOD_ProDKin_1 485 491 PF00069 0.840
MOD_ProDKin_1 627 633 PF00069 0.766
MOD_ProDKin_1 761 767 PF00069 0.710
MOD_ProDKin_1 815 821 PF00069 0.595
MOD_ProDKin_1 827 833 PF00069 0.566
MOD_ProDKin_1 864 870 PF00069 0.658
MOD_SUMO_rev_2 853 862 PF00179 0.710
TRG_DiLeu_BaEn_1 536 541 PF01217 0.666
TRG_DiLeu_BaEn_1 781 786 PF01217 0.583
TRG_DiLeu_BaEn_4 646 652 PF01217 0.603
TRG_ENDOCYTIC_2 186 189 PF00928 0.661
TRG_ENDOCYTIC_2 29 32 PF00928 0.582
TRG_ENDOCYTIC_2 656 659 PF00928 0.569
TRG_ENDOCYTIC_2 731 734 PF00928 0.646
TRG_ENDOCYTIC_2 808 811 PF00928 0.603
TRG_ER_diArg_1 192 194 PF00400 0.783
TRG_ER_diArg_1 24 26 PF00400 0.544
TRG_ER_diArg_1 296 299 PF00400 0.835
TRG_ER_diArg_1 49 52 PF00400 0.615
TRG_ER_diArg_1 553 556 PF00400 0.734
TRG_ER_diArg_1 688 690 PF00400 0.645
TRG_ER_diArg_1 724 727 PF00400 0.658
TRG_ER_diArg_1 73 75 PF00400 0.561
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.625

Homologs

Protein Taxonomy Sequence identity Coverage
A4H3I3 Leishmania braziliensis 74% 100%
E9ACF8 Leishmania major 89% 100%
E9AG30 Leishmania infantum 99% 100%
E9AJP6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS