Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H519_LEIDO

TriTrypDb:

LdBPK_030020.1 , LdCL_030005200 , LDHU3_03.0020

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H519

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H519

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.500
CLV_NRD_NRD_1	208	210	PF00675	0.475
CLV_NRD_NRD_1	236	238	PF00675	0.537
CLV_NRD_NRD_1	34	36	PF00675	0.475
CLV_NRD_NRD_1	92	94	PF00675	0.608
CLV_PCSK_KEX2_1	208	210	PF00082	0.463
CLV_PCSK_KEX2_1	236	238	PF00082	0.559
CLV_PCSK_KEX2_1	34	36	PF00082	0.566
CLV_PCSK_KEX2_1	94	96	PF00082	0.598
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.576
CLV_PCSK_SKI1_1	208	212	PF00082	0.477
DEG_APCC_DBOX_1	198	206	PF00400	0.503
DEG_SPOP_SBC_1	67	71	PF00917	0.606
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.547
DOC_MAPK_DCC_7	8	17	PF00069	0.500
DOC_MAPK_gen_1	240	249	PF00069	0.587
DOC_MAPK_gen_1	8	14	PF00069	0.506
DOC_MAPK_MEF2A_6	8	17	PF00069	0.476
DOC_PP4_FxxP_1	211	214	PF00568	0.470
DOC_USP7_MATH_1	170	174	PF00917	0.513
DOC_USP7_MATH_1	46	50	PF00917	0.627
DOC_USP7_MATH_1	67	71	PF00917	0.637
DOC_USP7_MATH_1	76	80	PF00917	0.553
DOC_USP7_UBL2_3	154	158	PF12436	0.512
DOC_WW_Pin1_4	190	195	PF00397	0.477
DOC_WW_Pin1_4	238	243	PF00397	0.547
DOC_WW_Pin1_4	255	260	PF00397	0.662
DOC_WW_Pin1_4	72	77	PF00397	0.778
LIG_14-3-3_CanoR_1	24	33	PF00244	0.553
LIG_14-3-3_CanoR_1	95	102	PF00244	0.625
LIG_BRCT_BRCA1_1	128	132	PF00533	0.593
LIG_deltaCOP1_diTrp_1	203	211	PF00928	0.476
LIG_EH1_1	225	233	PF00400	0.441
LIG_eIF4E_1	131	137	PF01652	0.515
LIG_FHA_1	151	157	PF00498	0.508
LIG_FHA_1	170	176	PF00498	0.402
LIG_FHA_1	187	193	PF00498	0.372
LIG_FHA_2	250	256	PF00498	0.488
LIG_LIR_Gen_1	133	142	PF02991	0.421
LIG_LIR_Gen_1	16	21	PF02991	0.455
LIG_LIR_Gen_1	203	211	PF02991	0.397
LIG_LIR_Nem_3	128	134	PF02991	0.487
LIG_LIR_Nem_3	16	20	PF02991	0.454
LIG_LIR_Nem_3	203	207	PF02991	0.372
LIG_LIR_Nem_3	241	247	PF02991	0.602
LIG_MLH1_MIPbox_1	128	132	PF16413	0.593
LIG_MYND_3	12	16	PF01753	0.571
LIG_SH2_PTP2	167	170	PF00017	0.480
LIG_SH2_STAP1	68	72	PF00017	0.656
LIG_SH2_STAT5	131	134	PF00017	0.456
LIG_SH2_STAT5	167	170	PF00017	0.370
LIG_SH3_3	256	262	PF00018	0.629
LIG_SH3_3	82	88	PF00018	0.559
LIG_SUMO_SIM_par_1	179	184	PF11976	0.458
LIG_SUMO_SIM_par_1	187	193	PF11976	0.464
LIG_TRAF2_1	252	255	PF00917	0.687
LIG_TRAF2_1	88	91	PF00917	0.536
MOD_CDC14_SPxK_1	193	196	PF00782	0.512
MOD_CDK_SPK_2	238	243	PF00069	0.574
MOD_CDK_SPxK_1	190	196	PF00069	0.491
MOD_CK1_1	184	190	PF00069	0.518
MOD_CK1_1	258	264	PF00069	0.643
MOD_CK2_1	227	233	PF00069	0.391
MOD_CK2_1	249	255	PF00069	0.561
MOD_CK2_1	46	52	PF00069	0.730
MOD_CK2_1	95	101	PF00069	0.692
MOD_GlcNHglycan	109	112	PF01048	0.581
MOD_GlcNHglycan	76	79	PF01048	0.692
MOD_GSK3_1	170	177	PF00069	0.475
MOD_GSK3_1	186	193	PF00069	0.322
MOD_GSK3_1	238	245	PF00069	0.573
MOD_GSK3_1	254	261	PF00069	0.642
MOD_GSK3_1	68	75	PF00069	0.676
MOD_NEK2_1	119	124	PF00069	0.470
MOD_NEK2_1	132	137	PF00069	0.453
MOD_PIKK_1	24	30	PF00454	0.544
MOD_PIKK_1	261	267	PF00454	0.603
MOD_PK_1	227	233	PF00069	0.336
MOD_PKA_1	93	99	PF00069	0.627
MOD_PKB_1	93	101	PF00069	0.593
MOD_Plk_1	132	138	PF00069	0.463
MOD_Plk_1	181	187	PF00069	0.529
MOD_Plk_1	47	53	PF00069	0.641
MOD_Plk_4	170	176	PF00069	0.465
MOD_Plk_4	186	192	PF00069	0.453
MOD_Plk_4	227	233	PF00069	0.336
MOD_ProDKin_1	190	196	PF00069	0.491
MOD_ProDKin_1	238	244	PF00069	0.545
MOD_ProDKin_1	255	261	PF00069	0.666
MOD_ProDKin_1	72	78	PF00069	0.778
MOD_SUMO_for_1	42	45	PF00179	0.736
MOD_SUMO_for_1	58	61	PF00179	0.530
TRG_DiLeu_BaEn_2	15	21	PF01217	0.550
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.550
TRG_ENDOCYTIC_2	131	134	PF00928	0.462
TRG_ER_diArg_1	207	209	PF00400	0.494
TRG_ER_diArg_1	33	35	PF00400	0.493
TRG_ER_diArg_1	92	95	PF00400	0.587
TRG_NLS_MonoExtC_3	92	97	PF00514	0.693
TRG_NLS_MonoExtN_4	93	98	PF00514	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W5	Leptomonas seymouri	46%	100%
A0A1X0P8M5	Trypanosomatidae	31%	100%
A0A3R7KU56	Trypanosoma rangeli	29%	100%
A4H3H5	Leishmania braziliensis	73%	100%
E9ACF0	Leishmania major	89%	100%
E9AG22	Leishmania infantum	99%	100%
E9AJN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5ANT9	Trypanosoma cruzi	32%	100%