Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H515_LEIDO

TriTrypDb:

LdBPK_020660.1 , LdCL_020012200 , LDHU3_02.0830

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H515

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H515

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.510
CLV_NRD_NRD_1	16	18	PF00675	0.632
CLV_NRD_NRD_1	171	173	PF00675	0.573
CLV_NRD_NRD_1	211	213	PF00675	0.678
CLV_NRD_NRD_1	37	39	PF00675	0.669
CLV_NRD_NRD_1	391	393	PF00675	0.518
CLV_NRD_NRD_1	91	93	PF00675	0.706
CLV_PCSK_KEX2_1	16	18	PF00082	0.668
CLV_PCSK_KEX2_1	170	172	PF00082	0.573
CLV_PCSK_KEX2_1	210	212	PF00082	0.757
CLV_PCSK_KEX2_1	36	38	PF00082	0.639
CLV_PCSK_KEX2_1	391	393	PF00082	0.518
CLV_PCSK_KEX2_1	91	93	PF00082	0.706
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.610
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.477
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.622
CLV_PCSK_SKI1_1	305	309	PF00082	0.455
CLV_PCSK_SKI1_1	392	396	PF00082	0.597
DEG_Kelch_Keap1_1	110	115	PF01344	0.582
DEG_SPOP_SBC_1	108	112	PF00917	0.497
DEG_SPOP_SBC_1	289	293	PF00917	0.615
DEG_SPOP_SBC_1	94	98	PF00917	0.709
DOC_MAPK_gen_1	28	34	PF00069	0.672
DOC_MAPK_gen_1	436	443	PF00069	0.550
DOC_MAPK_MEF2A_6	418	425	PF00069	0.454
DOC_MAPK_NFAT4_5	418	426	PF00069	0.513
DOC_USP7_MATH_1	124	128	PF00917	0.710
DOC_USP7_MATH_1	143	147	PF00917	0.409
DOC_USP7_MATH_1	189	193	PF00917	0.688
DOC_USP7_MATH_1	254	258	PF00917	0.543
DOC_USP7_MATH_1	290	294	PF00917	0.653
DOC_USP7_MATH_1	41	45	PF00917	0.572
DOC_USP7_MATH_1	61	65	PF00917	0.375
DOC_USP7_UBL2_3	276	280	PF12436	0.480
DOC_WW_Pin1_4	196	201	PF00397	0.721
DOC_WW_Pin1_4	429	434	PF00397	0.482
LIG_14-3-3_CanoR_1	190	198	PF00244	0.713
LIG_14-3-3_CanoR_1	92	101	PF00244	0.657
LIG_AP2alpha_1	71	75	PF02296	0.583
LIG_FHA_1	111	117	PF00498	0.695
LIG_FHA_1	346	352	PF00498	0.511
LIG_LIR_Apic_2	427	433	PF02991	0.485
LIG_LIR_Gen_1	48	59	PF02991	0.494
LIG_LIR_Nem_3	48	54	PF02991	0.494
LIG_NRBOX	420	426	PF00104	0.427
LIG_PCNA_yPIPBox_3	327	338	PF02747	0.544
LIG_Pex14_2	71	75	PF04695	0.583
LIG_Rb_pABgroove_1	45	53	PF01858	0.551
LIG_SH2_STAP1	283	287	PF00017	0.611
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.457
LIG_TRAF2_1	394	397	PF00917	0.612
MOD_CDK_SPxK_1	196	202	PF00069	0.695
MOD_CDK_SPxxK_3	429	436	PF00069	0.423
MOD_CK1_1	109	115	PF00069	0.655
MOD_CK1_1	127	133	PF00069	0.677
MOD_CK1_1	192	198	PF00069	0.747
MOD_CK1_1	291	297	PF00069	0.642
MOD_CK1_1	325	331	PF00069	0.568
MOD_CK1_1	343	349	PF00069	0.390
MOD_CK1_1	448	454	PF00069	0.602
MOD_CK2_1	109	115	PF00069	0.583
MOD_CK2_1	190	196	PF00069	0.683
MOD_CK2_1	448	454	PF00069	0.582
MOD_GlcNHglycan	119	122	PF01048	0.644
MOD_GlcNHglycan	184	187	PF01048	0.740
MOD_GlcNHglycan	277	280	PF01048	0.473
MOD_GlcNHglycan	299	302	PF01048	0.550
MOD_GlcNHglycan	309	312	PF01048	0.484
MOD_GlcNHglycan	43	46	PF01048	0.590
MOD_GlcNHglycan	54	57	PF01048	0.611
MOD_GlcNHglycan	84	87	PF01048	0.757
MOD_GlcNHglycan	97	100	PF01048	0.643
MOD_GSK3_1	106	113	PF00069	0.645
MOD_GSK3_1	149	156	PF00069	0.655
MOD_GSK3_1	19	26	PF00069	0.691
MOD_GSK3_1	190	197	PF00069	0.747
MOD_GSK3_1	235	242	PF00069	0.595
MOD_GSK3_1	285	292	PF00069	0.622
MOD_GSK3_1	41	48	PF00069	0.535
MOD_GSK3_1	445	452	PF00069	0.519
MOD_N-GLC_1	19	24	PF02516	0.543
MOD_N-GLC_1	322	327	PF02516	0.475
MOD_N-GLC_1	340	345	PF02516	0.630
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	154	159	PF00069	0.545
MOD_NEK2_1	275	280	PF00069	0.475
MOD_NEK2_1	307	312	PF00069	0.527
MOD_NEK2_1	322	327	PF00069	0.525
MOD_NEK2_1	50	55	PF00069	0.495
MOD_NEK2_1	62	67	PF00069	0.453
MOD_NEK2_1	84	89	PF00069	0.629
MOD_NEK2_1	95	100	PF00069	0.722
MOD_PIKK_1	345	351	PF00454	0.467
MOD_PIKK_1	369	375	PF00454	0.477
MOD_PIKK_1	62	68	PF00454	0.656
MOD_PK_1	437	443	PF00069	0.524
MOD_PKA_2	189	195	PF00069	0.709
MOD_PKA_2	2	8	PF00069	0.671
MOD_PKB_1	188	196	PF00069	0.747
MOD_Plk_1	19	25	PF00069	0.628
MOD_Plk_1	239	245	PF00069	0.557
MOD_Plk_1	340	346	PF00069	0.637
MOD_Plk_1	437	443	PF00069	0.524
MOD_Plk_2-3	235	241	PF00069	0.558
MOD_Plk_4	437	443	PF00069	0.535
MOD_Plk_4	84	90	PF00069	0.677
MOD_ProDKin_1	196	202	PF00069	0.720
MOD_ProDKin_1	429	435	PF00069	0.481
MOD_SUMO_for_1	417	420	PF00179	0.521
MOD_SUMO_rev_2	300	310	PF00179	0.449
MOD_SUMO_rev_2	52	62	PF00179	0.449
TRG_DiLeu_BaEn_1	420	425	PF01217	0.424
TRG_ER_diArg_1	171	173	PF00400	0.583
TRG_ER_diArg_1	187	190	PF00400	0.707
TRG_ER_diArg_1	211	213	PF00400	0.666
TRG_ER_diArg_1	91	93	PF00400	0.706
TRG_NLS_MonoExtC_3	209	215	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB8	Leptomonas seymouri	49%	77%
A0A3S7X120	Leishmania donovani	99%	100%
A4HG32	Leishmania braziliensis	73%	100%
C9ZJ54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ACE3	Leishmania major	91%	100%
E9ACX2	Leishmania major	93%	100%
E9AG19	Leishmania infantum	99%	100%
E9AG20	Leishmania infantum	99%	100%
E9AJN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BA51	Trypanosoma cruzi	32%	100%