DNA-directed RNA polymerase III subunit RPC3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H514_LEIDO

TriTrypDb:

LdBPK_020650.1 , LdCL_020012100 , LDHU3_02.0820

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	4
GO:0005666	RNA polymerase III complex	4	4
GO:0030880	RNA polymerase complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	4
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	4
GO:0140513	nuclear protein-containing complex	2	4
GO:0140535	intracellular protein-containing complex	2	4
GO:1902494	catalytic complex	2	4
GO:1990234	transferase complex	3	4

Expansion

Sequence features

A0A3S5H514

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H514

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003697	single-stranded DNA binding	5	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	124	128	PF00082	0.414
CLV_PCSK_SKI1_1	150	154	PF00082	0.634
CLV_PCSK_SKI1_1	174	178	PF00082	0.479
CLV_PCSK_SKI1_1	53	57	PF00082	0.687
CLV_PCSK_SKI1_1	96	100	PF00082	0.529
CLV_Separin_Metazoa	140	144	PF03568	0.621
DEG_APCC_DBOX_1	123	131	PF00400	0.411
DEG_SPOP_SBC_1	6	10	PF00917	0.649
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.602
DOC_MAPK_gen_1	150	158	PF00069	0.599
DOC_MAPK_gen_1	172	181	PF00069	0.483
DOC_MAPK_MEF2A_6	89	97	PF00069	0.552
DOC_USP7_MATH_1	142	146	PF00917	0.656
DOC_USP7_MATH_1	152	156	PF00917	0.408
DOC_USP7_MATH_1	35	39	PF00917	0.732
DOC_USP7_MATH_1	7	11	PF00917	0.493
DOC_WW_Pin1_4	40	45	PF00397	0.736
LIG_14-3-3_CanoR_1	174	180	PF00244	0.456
LIG_AP2alpha_1	131	135	PF02296	0.575
LIG_BRCT_BRCA1_1	42	46	PF00533	0.741
LIG_FHA_1	1	7	PF00498	0.720
LIG_FHA_1	142	148	PF00498	0.531
LIG_FHA_1	176	182	PF00498	0.485
LIG_FHA_1	50	56	PF00498	0.728
LIG_FHA_2	109	115	PF00498	0.586
LIG_LIR_Gen_1	119	127	PF02991	0.537
LIG_LIR_Gen_1	180	189	PF02991	0.496
LIG_LIR_Gen_1	43	54	PF02991	0.733
LIG_LIR_Nem_3	119	123	PF02991	0.554
LIG_LIR_Nem_3	180	186	PF02991	0.492
LIG_LIR_Nem_3	63	68	PF02991	0.573
LIG_LIR_Nem_3	88	93	PF02991	0.533
LIG_Pex14_2	131	135	PF04695	0.575
LIG_SH2_CRK	90	94	PF00017	0.526
LIG_SH2_PTP2	120	123	PF00017	0.546
LIG_SH2_STAP1	28	32	PF00017	0.640
LIG_SH2_STAT5	120	123	PF00017	0.585
LIG_SH2_STAT5	157	160	PF00017	0.540
LIG_SH3_4	58	65	PF00018	0.632
MOD_CK1_1	45	51	PF00069	0.665
MOD_CK2_1	108	114	PF00069	0.531
MOD_CK2_1	6	12	PF00069	0.635
MOD_GlcNHglycan	144	147	PF01048	0.681
MOD_GlcNHglycan	149	153	PF01048	0.575
MOD_GlcNHglycan	163	166	PF01048	0.277
MOD_GlcNHglycan	37	40	PF01048	0.713
MOD_GSK3_1	148	155	PF00069	0.469
MOD_GSK3_1	159	166	PF00069	0.391
MOD_GSK3_1	40	47	PF00069	0.744
MOD_NEK2_1	161	166	PF00069	0.446
MOD_NEK2_1	175	180	PF00069	0.350
MOD_NEK2_2	152	157	PF00069	0.591
MOD_PIKK_1	58	64	PF00454	0.634
MOD_PKA_2	142	148	PF00069	0.668
MOD_Plk_1	108	114	PF00069	0.581
MOD_Plk_2-3	108	114	PF00069	0.581
MOD_Plk_4	116	122	PF00069	0.518
MOD_Plk_4	152	158	PF00069	0.536
MOD_Plk_4	163	169	PF00069	0.364
MOD_ProDKin_1	40	46	PF00069	0.733
TRG_ENDOCYTIC_2	120	123	PF00928	0.546
TRG_ENDOCYTIC_2	90	93	PF00928	0.534
TRG_NES_CRM1_1	125	140	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRR3	Leishmania infantum	99%	100%
E9AJN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%