Nop14-like family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nop14-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H513_LEIDO

TriTrypDb:

LdBPK_020630.1 , LdCL_020011900 , LDHU3_02.0800

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0030684	preribosome	3	10
GO:0032040	small-subunit processome	4	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0030689	Noc complex	3	1
GO:0030692	Noc4p-Nop14p complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H513

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H513

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0042254	ribosome biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.755
CLV_C14_Caspase3-7	295	299	PF00656	0.612
CLV_NRD_NRD_1	130	132	PF00675	0.717
CLV_NRD_NRD_1	156	158	PF00675	0.662
CLV_NRD_NRD_1	223	225	PF00675	0.548
CLV_NRD_NRD_1	250	252	PF00675	0.628
CLV_NRD_NRD_1	377	379	PF00675	0.629
CLV_NRD_NRD_1	519	521	PF00675	0.351
CLV_NRD_NRD_1	559	561	PF00675	0.441
CLV_NRD_NRD_1	564	566	PF00675	0.444
CLV_NRD_NRD_1	845	847	PF00675	0.425
CLV_NRD_NRD_1	891	893	PF00675	0.705
CLV_PCSK_FUR_1	517	521	PF00082	0.272
CLV_PCSK_FUR_1	859	863	PF00082	0.485
CLV_PCSK_KEX2_1	130	132	PF00082	0.717
CLV_PCSK_KEX2_1	14	16	PF00082	0.588
CLV_PCSK_KEX2_1	156	158	PF00082	0.662
CLV_PCSK_KEX2_1	223	225	PF00082	0.569
CLV_PCSK_KEX2_1	250	252	PF00082	0.628
CLV_PCSK_KEX2_1	377	379	PF00082	0.631
CLV_PCSK_KEX2_1	519	521	PF00082	0.387
CLV_PCSK_KEX2_1	559	561	PF00082	0.441
CLV_PCSK_KEX2_1	564	566	PF00082	0.444
CLV_PCSK_KEX2_1	823	825	PF00082	0.379
CLV_PCSK_KEX2_1	831	833	PF00082	0.386
CLV_PCSK_KEX2_1	845	847	PF00082	0.369
CLV_PCSK_KEX2_1	850	852	PF00082	0.369
CLV_PCSK_KEX2_1	861	863	PF00082	0.369
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.629
CLV_PCSK_PC1ET2_1	823	825	PF00082	0.379
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.386
CLV_PCSK_PC1ET2_1	850	852	PF00082	0.369
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.304
CLV_PCSK_PC7_1	373	379	PF00082	0.551
CLV_PCSK_PC7_1	560	566	PF00082	0.429
CLV_PCSK_PC7_1	827	833	PF00082	0.369
CLV_PCSK_PC7_1	846	852	PF00082	0.369
CLV_PCSK_SKI1_1	11	15	PF00082	0.678
CLV_PCSK_SKI1_1	112	116	PF00082	0.702
CLV_PCSK_SKI1_1	203	207	PF00082	0.569
CLV_PCSK_SKI1_1	243	247	PF00082	0.567
CLV_PCSK_SKI1_1	256	260	PF00082	0.510
CLV_PCSK_SKI1_1	302	306	PF00082	0.630
CLV_PCSK_SKI1_1	384	388	PF00082	0.590
CLV_PCSK_SKI1_1	505	509	PF00082	0.272
CLV_PCSK_SKI1_1	544	548	PF00082	0.343
CLV_PCSK_SKI1_1	552	556	PF00082	0.344
CLV_PCSK_SKI1_1	565	569	PF00082	0.344
CLV_PCSK_SKI1_1	649	653	PF00082	0.344
CLV_PCSK_SKI1_1	710	714	PF00082	0.444
CLV_PCSK_SKI1_1	738	742	PF00082	0.485
CLV_PCSK_SKI1_1	820	824	PF00082	0.387
CLV_PCSK_SKI1_1	835	839	PF00082	0.318
DEG_APCC_DBOX_1	301	309	PF00400	0.639
DEG_APCC_DBOX_1	564	572	PF00400	0.346
DEG_COP1_1	403	411	PF00400	0.685
DEG_SCF_FBW7_2	506	512	PF00400	0.272
DEG_SPOP_SBC_1	275	279	PF00917	0.675
DEG_SPOP_SBC_1	57	61	PF00917	0.777
DEG_SPOP_SBC_1	750	754	PF00917	0.432
DEG_SPOP_SBC_1	898	902	PF00917	0.798
DOC_ANK_TNKS_1	61	68	PF00023	0.727
DOC_CKS1_1	506	511	PF01111	0.272
DOC_CKS1_1	587	592	PF01111	0.369
DOC_CYCLIN_RxL_1	250	263	PF00134	0.562
DOC_MAPK_DCC_7	405	413	PF00069	0.720
DOC_MAPK_gen_1	200	210	PF00069	0.632
DOC_MAPK_gen_1	517	526	PF00069	0.382
DOC_MAPK_gen_1	564	571	PF00069	0.429
DOC_MAPK_MEF2A_6	405	413	PF00069	0.720
DOC_MAPK_MEF2A_6	519	528	PF00069	0.350
DOC_MAPK_MEF2A_6	564	571	PF00069	0.444
DOC_PP2B_LxvP_1	169	172	PF13499	0.654
DOC_PP2B_LxvP_1	645	648	PF13499	0.344
DOC_PP2B_LxvP_1	662	665	PF13499	0.344
DOC_PP2B_LxvP_1	748	751	PF13499	0.477
DOC_USP7_MATH_1	147	151	PF00917	0.765
DOC_USP7_MATH_1	25	29	PF00917	0.548
DOC_USP7_MATH_1	274	278	PF00917	0.663
DOC_USP7_MATH_1	312	316	PF00917	0.618
DOC_USP7_MATH_1	550	554	PF00917	0.369
DOC_USP7_MATH_1	609	613	PF00917	0.444
DOC_USP7_MATH_1	751	755	PF00917	0.377
DOC_USP7_MATH_1	899	903	PF00917	0.795
DOC_USP7_UBL2_3	884	888	PF12436	0.694
DOC_WW_Pin1_4	145	150	PF00397	0.779
DOC_WW_Pin1_4	236	241	PF00397	0.549
DOC_WW_Pin1_4	322	327	PF00397	0.579
DOC_WW_Pin1_4	349	354	PF00397	0.553
DOC_WW_Pin1_4	505	510	PF00397	0.272
DOC_WW_Pin1_4	586	591	PF00397	0.369
DOC_WW_Pin1_4	704	709	PF00397	0.485
DOC_WW_Pin1_4	757	762	PF00397	0.449
DOC_WW_Pin1_4	785	790	PF00397	0.369
DOC_WW_Pin1_4	88	93	PF00397	0.773
LIG_14-3-3_CanoR_1	112	117	PF00244	0.523
LIG_14-3-3_CanoR_1	124	132	PF00244	0.759
LIG_14-3-3_CanoR_1	26	34	PF00244	0.632
LIG_14-3-3_CanoR_1	276	284	PF00244	0.686
LIG_14-3-3_CanoR_1	314	320	PF00244	0.608
LIG_14-3-3_CanoR_1	358	367	PF00244	0.604
LIG_14-3-3_CanoR_1	384	392	PF00244	0.636
LIG_14-3-3_CanoR_1	5	13	PF00244	0.585
LIG_14-3-3_CanoR_1	519	525	PF00244	0.348
LIG_14-3-3_CanoR_1	564	568	PF00244	0.347
LIG_14-3-3_CanoR_1	749	759	PF00244	0.438
LIG_14-3-3_CanoR_1	835	843	PF00244	0.485
LIG_14-3-3_CanoR_1	97	102	PF00244	0.745
LIG_Actin_WH2_2	540	558	PF00022	0.380
LIG_Actin_WH2_2	612	627	PF00022	0.444
LIG_BRCT_BRCA1_1	103	107	PF00533	0.801
LIG_BRCT_BRCA1_1	262	266	PF00533	0.629
LIG_BRCT_BRCA1_1	574	578	PF00533	0.369
LIG_BRCT_BRCA1_1	627	631	PF00533	0.408
LIG_Clathr_ClatBox_1	545	549	PF01394	0.352
LIG_CSL_BTD_1	758	761	PF09270	0.485
LIG_EH_1	92	96	PF12763	0.749
LIG_EH1_1	265	273	PF00400	0.535
LIG_FHA_1	113	119	PF00498	0.633
LIG_FHA_1	127	133	PF00498	0.739
LIG_FHA_1	205	211	PF00498	0.496
LIG_FHA_1	237	243	PF00498	0.543
LIG_FHA_1	521	527	PF00498	0.272
LIG_FHA_1	587	593	PF00498	0.392
LIG_FHA_1	616	622	PF00498	0.414
LIG_FHA_1	771	777	PF00498	0.455
LIG_FHA_2	137	143	PF00498	0.691
LIG_FHA_2	268	274	PF00498	0.670
LIG_FHA_2	383	389	PF00498	0.575
LIG_FHA_2	420	426	PF00498	0.541
LIG_FHA_2	681	687	PF00498	0.416
LIG_FHA_2	80	86	PF00498	0.749
LIG_FHA_2	903	909	PF00498	0.573
LIG_GBD_Chelix_1	616	624	PF00786	0.444
LIG_HP1_1	648	652	PF01393	0.444
LIG_LIR_Gen_1	363	372	PF02991	0.533
LIG_LIR_Gen_1	497	507	PF02991	0.589
LIG_LIR_Gen_1	589	599	PF02991	0.348
LIG_LIR_Gen_1	612	621	PF02991	0.378
LIG_LIR_Gen_1	860	870	PF02991	0.485
LIG_LIR_Nem_3	497	503	PF02991	0.585
LIG_LIR_Nem_3	540	546	PF02991	0.351
LIG_LIR_Nem_3	589	594	PF02991	0.349
LIG_LIR_Nem_3	612	616	PF02991	0.378
LIG_LIR_Nem_3	860	866	PF02991	0.369
LIG_MYND_3	664	668	PF01753	0.485
LIG_NRBOX	520	526	PF00104	0.401
LIG_NRBOX	615	621	PF00104	0.344
LIG_NRBOX	742	748	PF00104	0.444
LIG_PTAP_UEV_1	290	295	PF05743	0.710
LIG_RPA_C_Fungi	302	314	PF08784	0.527
LIG_SH2_CRK	863	867	PF00017	0.444
LIG_SH2_GRB2like	863	866	PF00017	0.485
LIG_SH2_SRC	570	573	PF00017	0.444
LIG_SH2_STAT5	570	573	PF00017	0.444
LIG_SH2_STAT5	613	616	PF00017	0.401
LIG_SH2_STAT5	81	84	PF00017	0.754
LIG_SH3_1	727	733	PF00018	0.444
LIG_SH3_3	288	294	PF00018	0.729
LIG_SH3_3	328	334	PF00018	0.732
LIG_SH3_3	448	454	PF00018	0.706
LIG_SH3_3	503	509	PF00018	0.395
LIG_SH3_3	584	590	PF00018	0.369
LIG_SH3_3	633	639	PF00018	0.380
LIG_SH3_3	727	733	PF00018	0.444
LIG_SH3_5	579	583	PF00018	0.344
LIG_Sin3_3	543	550	PF02671	0.352
LIG_SUMO_SIM_par_1	535	540	PF11976	0.485
LIG_SUMO_SIM_par_1	544	549	PF11976	0.352
LIG_TRAF2_1	315	318	PF00917	0.706
LIG_TRAF2_1	387	390	PF00917	0.540
LIG_UBA3_1	217	226	PF00899	0.632
LIG_UBA3_1	567	576	PF00899	0.444
LIG_UBA3_1	599	603	PF00899	0.321
LIG_UBA3_1	620	625	PF00899	0.444
LIG_WRC_WIRS_1	369	374	PF05994	0.632
LIG_WRC_WIRS_1	792	797	PF05994	0.401
MOD_CDC14_SPxK_1	707	710	PF00782	0.485
MOD_CDK_SPxK_1	704	710	PF00069	0.485
MOD_CDK_SPxxK_3	236	243	PF00069	0.547
MOD_CK1_1	140	146	PF00069	0.740
MOD_CK1_1	148	154	PF00069	0.651
MOD_CK1_1	277	283	PF00069	0.721
MOD_CK1_1	285	291	PF00069	0.636
MOD_CK1_1	4	10	PF00069	0.706
MOD_CK1_1	677	683	PF00069	0.424
MOD_CK1_1	754	760	PF00069	0.425
MOD_CK1_1	902	908	PF00069	0.573
MOD_CK2_1	267	273	PF00069	0.663
MOD_CK2_1	312	318	PF00069	0.689
MOD_CK2_1	34	40	PF00069	0.633
MOD_CK2_1	382	388	PF00069	0.583
MOD_CK2_1	419	425	PF00069	0.552
MOD_CK2_1	452	458	PF00069	0.745
MOD_CK2_1	680	686	PF00069	0.410
MOD_CK2_1	79	85	PF00069	0.708
MOD_CK2_1	900	906	PF00069	0.743
MOD_DYRK1A_RPxSP_1	505	509	PF00069	0.272
MOD_GlcNHglycan	112	115	PF01048	0.665
MOD_GlcNHglycan	139	142	PF01048	0.717
MOD_GlcNHglycan	236	239	PF01048	0.606
MOD_GlcNHglycan	262	265	PF01048	0.605
MOD_GlcNHglycan	27	30	PF01048	0.585
MOD_GlcNHglycan	281	284	PF01048	0.573
MOD_GlcNHglycan	492	495	PF01048	0.509
MOD_GlcNHglycan	596	599	PF01048	0.444
MOD_GlcNHglycan	627	630	PF01048	0.466
MOD_GlcNHglycan	677	680	PF01048	0.446
MOD_GlcNHglycan	753	756	PF01048	0.405
MOD_GlcNHglycan	761	764	PF01048	0.310
MOD_GlcNHglycan	895	898	PF01048	0.722
MOD_GlcNHglycan	99	102	PF01048	0.735
MOD_GSK3_1	1	8	PF00069	0.750
MOD_GSK3_1	106	113	PF00069	0.622
MOD_GSK3_1	122	129	PF00069	0.745
MOD_GSK3_1	136	143	PF00069	0.665
MOD_GSK3_1	256	263	PF00069	0.616
MOD_GSK3_1	275	282	PF00069	0.446
MOD_GSK3_1	285	292	PF00069	0.789
MOD_GSK3_1	30	37	PF00069	0.658
MOD_GSK3_1	392	399	PF00069	0.557
MOD_GSK3_1	508	515	PF00069	0.334
MOD_GSK3_1	680	687	PF00069	0.386
MOD_GSK3_1	750	757	PF00069	0.426
MOD_GSK3_1	835	842	PF00069	0.485
MOD_GSK3_1	893	900	PF00069	0.801
MOD_GSK3_1	97	104	PF00069	0.688
MOD_LATS_1	16	22	PF00433	0.608
MOD_N-GLC_1	135	140	PF02516	0.780
MOD_N-GLC_1	512	517	PF02516	0.389
MOD_NEK2_1	1	6	PF00069	0.638
MOD_NEK2_1	107	112	PF00069	0.677
MOD_NEK2_1	135	140	PF00069	0.786
MOD_NEK2_1	234	239	PF00069	0.580
MOD_NEK2_1	24	29	PF00069	0.618
MOD_NEK2_1	245	250	PF00069	0.478
MOD_NEK2_1	260	265	PF00069	0.527
MOD_NEK2_1	34	39	PF00069	0.643
MOD_NEK2_1	368	373	PF00069	0.542
MOD_NEK2_1	555	560	PF00069	0.359
MOD_NEK2_1	563	568	PF00069	0.326
MOD_NEK2_1	594	599	PF00069	0.345
MOD_NEK2_1	674	679	PF00069	0.375
MOD_NEK2_1	701	706	PF00069	0.397
MOD_NEK2_1	725	730	PF00069	0.452
MOD_NEK2_2	791	796	PF00069	0.401
MOD_PIKK_1	34	40	PF00454	0.643
MOD_PIKK_1	416	422	PF00454	0.618
MOD_PIKK_1	689	695	PF00454	0.408
MOD_PIKK_1	865	871	PF00454	0.474
MOD_PKA_2	123	129	PF00069	0.665
MOD_PKA_2	25	31	PF00069	0.636
MOD_PKA_2	275	281	PF00069	0.740
MOD_PKA_2	313	319	PF00069	0.715
MOD_PKA_2	34	40	PF00069	0.607
MOD_PKA_2	4	10	PF00069	0.625
MOD_PKA_2	555	561	PF00069	0.370
MOD_PKA_2	563	569	PF00069	0.324
MOD_Plk_1	203	209	PF00069	0.567
MOD_Plk_1	382	388	PF00069	0.640
MOD_Plk_1	416	422	PF00069	0.640
MOD_Plk_1	550	556	PF00069	0.427
MOD_Plk_1	839	845	PF00069	0.485
MOD_Plk_2-3	267	273	PF00069	0.611
MOD_Plk_4	148	154	PF00069	0.746
MOD_Plk_4	292	298	PF00069	0.668
MOD_Plk_4	396	402	PF00069	0.572
MOD_Plk_4	520	526	PF00069	0.374
MOD_Plk_4	609	615	PF00069	0.408
MOD_Plk_4	657	663	PF00069	0.485
MOD_ProDKin_1	145	151	PF00069	0.780
MOD_ProDKin_1	236	242	PF00069	0.548
MOD_ProDKin_1	322	328	PF00069	0.580
MOD_ProDKin_1	349	355	PF00069	0.554
MOD_ProDKin_1	505	511	PF00069	0.272
MOD_ProDKin_1	586	592	PF00069	0.369
MOD_ProDKin_1	704	710	PF00069	0.485
MOD_ProDKin_1	757	763	PF00069	0.449
MOD_ProDKin_1	785	791	PF00069	0.369
MOD_ProDKin_1	88	94	PF00069	0.772
MOD_SUMO_for_1	227	230	PF00179	0.568
MOD_SUMO_for_1	815	818	PF00179	0.357
MOD_SUMO_rev_2	825	833	PF00179	0.369
TRG_DiLeu_BaEn_1	213	218	PF01217	0.582
TRG_DiLeu_BaEn_1	241	246	PF01217	0.561
TRG_DiLeu_BaEn_1	267	272	PF01217	0.529
TRG_DiLeu_BaEn_1	671	676	PF01217	0.449
TRG_DiLeu_BaEn_4	720	726	PF01217	0.485
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.444
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.385
TRG_DiLeu_BaLyEn_6	714	719	PF01217	0.315
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.369
TRG_DiLeu_BaLyEn_6	817	822	PF01217	0.357
TRG_DiLeu_BaLyEn_6	829	834	PF01217	0.415
TRG_ENDOCYTIC_2	613	616	PF00928	0.344
TRG_ENDOCYTIC_2	716	719	PF00928	0.344
TRG_ENDOCYTIC_2	863	866	PF00928	0.344
TRG_ER_diArg_1	130	132	PF00400	0.721
TRG_ER_diArg_1	155	157	PF00400	0.660
TRG_ER_diArg_1	222	224	PF00400	0.578
TRG_ER_diArg_1	249	251	PF00400	0.631
TRG_ER_diArg_1	376	378	PF00400	0.756
TRG_ER_diArg_1	517	520	PF00400	0.272
TRG_ER_diArg_1	563	565	PF00400	0.441
TRG_ER_diArg_1	795	798	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	717	721	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	798	802	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	820	825	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	835	840	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III2	Leptomonas seymouri	59%	100%
A0A1X0NK23	Trypanosomatidae	38%	92%
A4H3F7	Leishmania braziliensis	79%	98%
A4HRR1	Leishmania infantum	100%	100%
C9ZJ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
E9ACE0	Leishmania major	91%	100%
E9AJM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AQ76	Trypanosoma cruzi	40%	100%