Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H512_LEIDO

TriTrypDb:

LdBPK_020620.1 , LdCL_020011800 , LDHU3_02.0790

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H512

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H512

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.560
CLV_NRD_NRD_1	171	173	PF00675	0.641
CLV_PCSK_KEX2_1	123	125	PF00082	0.778
CLV_PCSK_KEX2_1	171	173	PF00082	0.666
CLV_PCSK_KEX2_1	47	49	PF00082	0.665
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.689
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.666
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.665
CLV_PCSK_SKI1_1	123	127	PF00082	0.753
CLV_PCSK_SKI1_1	182	186	PF00082	0.582
CLV_PCSK_SKI1_1	202	206	PF00082	0.441
CLV_PCSK_SKI1_1	47	51	PF00082	0.548
DEG_SCF_FBW7_1	140	147	PF00400	0.677
DOC_CKS1_1	11	16	PF01111	0.788
DOC_CKS1_1	141	146	PF01111	0.685
DOC_CYCLIN_RxL_1	197	207	PF00134	0.582
DOC_MAPK_DCC_7	171	181	PF00069	0.581
DOC_MAPK_gen_1	197	205	PF00069	0.565
DOC_MAPK_gen_1	80	90	PF00069	0.697
DOC_MAPK_MEF2A_6	172	181	PF00069	0.577
DOC_USP7_MATH_1	267	271	PF00917	0.713
DOC_USP7_MATH_1	30	34	PF00917	0.754
DOC_USP7_MATH_1	40	44	PF00917	0.595
DOC_WW_Pin1_4	115	120	PF00397	0.578
DOC_WW_Pin1_4	140	145	PF00397	0.635
DOC_WW_Pin1_4	190	195	PF00397	0.612
DOC_WW_Pin1_4	5	10	PF00397	0.719
LIG_14-3-3_CanoR_1	136	140	PF00244	0.775
LIG_14-3-3_CanoR_1	182	189	PF00244	0.537
LIG_14-3-3_CanoR_1	296	305	PF00244	0.517
LIG_14-3-3_CanoR_1	48	56	PF00244	0.629
LIG_FHA_1	11	17	PF00498	0.771
LIG_FHA_1	191	197	PF00498	0.575
LIG_FHA_1	52	58	PF00498	0.578
LIG_FHA_2	145	151	PF00498	0.811
LIG_FHA_2	183	189	PF00498	0.556
LIG_FHA_2	297	303	PF00498	0.382
LIG_LIR_Nem_3	219	225	PF02991	0.581
LIG_NRBOX	51	57	PF00104	0.502
LIG_NRBOX	83	89	PF00104	0.494
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.611
LIG_SH2_CRK	222	226	PF00017	0.582
LIG_SH2_STAT5	224	227	PF00017	0.530
LIG_SH3_3	11	17	PF00018	0.756
LIG_SH3_3	138	144	PF00018	0.810
LIG_SH3_3	150	156	PF00018	0.749
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.592
LIG_TRAF2_1	185	188	PF00917	0.639
LIG_TRAF2_1	42	45	PF00917	0.568
LIG_TRAF2_1	62	65	PF00917	0.605
LIG_WRPW_2	105	108	PF00400	0.638
LIG_WW_2	14	17	PF00397	0.608
MOD_CDK_SPxxK_3	190	197	PF00069	0.636
MOD_CK1_1	146	152	PF00069	0.732
MOD_CK1_1	26	32	PF00069	0.761
MOD_CK1_1	7	13	PF00069	0.787
MOD_CK2_1	144	150	PF00069	0.810
MOD_CK2_1	18	24	PF00069	0.794
MOD_CK2_1	182	188	PF00069	0.541
MOD_CK2_1	296	302	PF00069	0.377
MOD_CK2_1	35	41	PF00069	0.686
MOD_CMANNOS	108	111	PF00535	0.640
MOD_GlcNHglycan	112	115	PF01048	0.550
MOD_GlcNHglycan	128	133	PF01048	0.648
MOD_GlcNHglycan	26	29	PF01048	0.734
MOD_GlcNHglycan	274	277	PF01048	0.719
MOD_GlcNHglycan	72	75	PF01048	0.622
MOD_GSK3_1	1	8	PF00069	0.721
MOD_GSK3_1	106	113	PF00069	0.527
MOD_GSK3_1	124	131	PF00069	0.667
MOD_GSK3_1	140	147	PF00069	0.682
MOD_GSK3_1	26	33	PF00069	0.687
MOD_GSK3_1	296	303	PF00069	0.526
MOD_GSK3_1	35	42	PF00069	0.744
MOD_GSK3_1	47	54	PF00069	0.547
MOD_N-GLC_1	18	23	PF02516	0.763
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	217	222	PF00069	0.652
MOD_PIKK_1	144	150	PF00454	0.738
MOD_PKA_1	47	53	PF00069	0.640
MOD_PKA_2	135	141	PF00069	0.727
MOD_PKA_2	272	278	PF00069	0.638
MOD_PKA_2	47	53	PF00069	0.640
MOD_Plk_1	217	223	PF00069	0.597
MOD_Plk_4	300	306	PF00069	0.610
MOD_Plk_4	51	57	PF00069	0.583
MOD_ProDKin_1	115	121	PF00069	0.581
MOD_ProDKin_1	140	146	PF00069	0.637
MOD_ProDKin_1	190	196	PF00069	0.609
MOD_ProDKin_1	5	11	PF00069	0.720
MOD_SUMO_for_1	231	234	PF00179	0.620
MOD_SUMO_rev_2	309	315	PF00179	0.473
MOD_SUMO_rev_2	41	49	PF00179	0.662
MOD_SUMO_rev_2	63	68	PF00179	0.637
TRG_DiLeu_BaEn_1	199	204	PF01217	0.523
TRG_DiLeu_BaEn_4	187	193	PF01217	0.636
TRG_DiLeu_BaEn_4	44	50	PF01217	0.587
TRG_ENDOCYTIC_2	222	225	PF00928	0.587
TRG_NLS_MonoCore_2	170	175	PF00514	0.681
TRG_NLS_MonoExtN_4	169	176	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W5	Leptomonas seymouri	53%	100%
A0A0S4JF25	Bodo saltans	24%	100%
A0A1X0NJL7	Trypanosomatidae	39%	95%
A0A422NAY0	Trypanosoma rangeli	35%	95%
A4H3F6	Leishmania braziliensis	77%	96%
A4HRR0	Leishmania infantum	100%	100%
C9ZJ49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ACD9	Leishmania major	91%	100%
E9AJM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D620	Trypanosoma cruzi	35%	98%