Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H510_LEIDO

TriTrypDb:

LdBPK_020580.1 , LdCL_020011400 , LDHU3_02.0750

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H510

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H510

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.547
CLV_NRD_NRD_1	136	138	PF00675	0.510
CLV_NRD_NRD_1	150	152	PF00675	0.380
CLV_NRD_NRD_1	187	189	PF00675	0.717
CLV_NRD_NRD_1	308	310	PF00675	0.589
CLV_NRD_NRD_1	33	35	PF00675	0.440
CLV_NRD_NRD_1	41	43	PF00675	0.411
CLV_PCSK_KEX2_1	11	13	PF00082	0.542
CLV_PCSK_KEX2_1	136	138	PF00082	0.545
CLV_PCSK_KEX2_1	150	152	PF00082	0.434
CLV_PCSK_KEX2_1	187	189	PF00082	0.698
CLV_PCSK_KEX2_1	310	312	PF00082	0.567
CLV_PCSK_KEX2_1	33	35	PF00082	0.384
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.542
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.567
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.519
CLV_PCSK_SKI1_1	102	106	PF00082	0.541
CLV_PCSK_SKI1_1	202	206	PF00082	0.660
CLV_PCSK_SKI1_1	311	315	PF00082	0.615
CLV_PCSK_SKI1_1	34	38	PF00082	0.436
DEG_APCC_DBOX_1	135	143	PF00400	0.462
DOC_ANK_TNKS_1	277	284	PF00023	0.662
DOC_CKS1_1	195	200	PF01111	0.692
DOC_CKS1_1	232	237	PF01111	0.687
DOC_CYCLIN_RxL_1	31	40	PF00134	0.465
DOC_MAPK_gen_1	172	182	PF00069	0.548
DOC_USP7_MATH_1	203	207	PF00917	0.699
DOC_USP7_MATH_1	211	215	PF00917	0.581
DOC_USP7_MATH_1	222	226	PF00917	0.544
DOC_USP7_MATH_1	227	231	PF00917	0.599
DOC_USP7_MATH_1	263	267	PF00917	0.667
DOC_USP7_MATH_1	271	275	PF00917	0.550
DOC_USP7_UBL2_3	229	233	PF12436	0.628
DOC_USP7_UBL2_3	31	35	PF12436	0.533
DOC_WW_Pin1_4	194	199	PF00397	0.650
DOC_WW_Pin1_4	231	236	PF00397	0.684
LIG_14-3-3_CanoR_1	12	20	PF00244	0.545
LIG_14-3-3_CanoR_1	188	198	PF00244	0.778
LIG_14-3-3_CanoR_1	250	259	PF00244	0.666
LIG_14-3-3_CanoR_1	261	268	PF00244	0.534
LIG_14-3-3_CanoR_1	296	301	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_FHA_2	125	131	PF00498	0.532
LIG_FHA_2	203	209	PF00498	0.756
LIG_FHA_2	55	61	PF00498	0.588
LIG_FHA_2	74	80	PF00498	0.529
LIG_LIR_Apic_2	299	303	PF02991	0.691
LIG_LIR_Gen_1	92	101	PF02991	0.425
LIG_LIR_Nem_3	92	97	PF02991	0.535
LIG_MAD2	188	196	PF02301	0.673
LIG_PTB_Apo_2	93	100	PF02174	0.525
LIG_SH2_CRK	300	304	PF00017	0.692
LIG_SH2_GRB2like	94	97	PF00017	0.524
LIG_SH2_SRC	44	47	PF00017	0.532
LIG_SH2_STAP1	44	48	PF00017	0.425
LIG_SH3_3	195	201	PF00018	0.685
LIG_TRAF2_1	129	132	PF00917	0.440
LIG_TRAF2_1	16	19	PF00917	0.549
LIG_TRAF2_1	206	209	PF00917	0.727
MOD_CDK_SPK_2	197	202	PF00069	0.739
MOD_CK1_1	237	243	PF00069	0.740
MOD_CK1_1	266	272	PF00069	0.655
MOD_CK2_1	11	17	PF00069	0.540
MOD_CK2_1	124	130	PF00069	0.504
MOD_CK2_1	162	168	PF00069	0.591
MOD_CK2_1	202	208	PF00069	0.774
MOD_CK2_1	54	60	PF00069	0.584
MOD_CK2_1	73	79	PF00069	0.502
MOD_GlcNHglycan	205	208	PF01048	0.672
MOD_GlcNHglycan	213	216	PF01048	0.634
MOD_GlcNHglycan	224	227	PF01048	0.673
MOD_GlcNHglycan	236	239	PF01048	0.556
MOD_GlcNHglycan	255	258	PF01048	0.635
MOD_GlcNHglycan	273	276	PF01048	0.751
MOD_GSK3_1	190	197	PF00069	0.629
MOD_GSK3_1	227	234	PF00069	0.641
MOD_GSK3_1	239	246	PF00069	0.622
MOD_GSK3_1	249	256	PF00069	0.661
MOD_GSK3_1	257	264	PF00069	0.582
MOD_PIKK_1	261	267	PF00454	0.605
MOD_PKA_1	11	17	PF00069	0.540
MOD_PKA_2	11	17	PF00069	0.540
MOD_PKA_2	122	128	PF00069	0.517
MOD_PKA_2	249	255	PF00069	0.745
MOD_Plk_1	73	79	PF00069	0.547
MOD_Plk_2-3	124	130	PF00069	0.530
MOD_Plk_4	263	269	PF00069	0.603
MOD_ProDKin_1	194	200	PF00069	0.651
MOD_ProDKin_1	231	237	PF00069	0.687
TRG_DiLeu_BaEn_1	51	56	PF01217	0.487
TRG_DiLeu_BaEn_2	207	213	PF01217	0.708
TRG_DiLeu_BaEn_2	94	100	PF01217	0.526
TRG_DiLeu_BaEn_4	130	136	PF01217	0.469
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.621
TRG_ENDOCYTIC_2	44	47	PF00928	0.426
TRG_ENDOCYTIC_2	94	97	PF00928	0.425
TRG_ER_diArg_1	135	137	PF00400	0.570
TRG_ER_diArg_1	187	189	PF00400	0.747
TRG_NLS_MonoExtN_4	31	37	PF00514	0.361
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT89	Leptomonas seymouri	64%	98%
A0A1X0NQ36	Trypanosomatidae	37%	93%
A0A3R7LN24	Trypanosoma rangeli	40%	95%
A4H3F2	Leishmania braziliensis	85%	100%
A4HRQ6	Leishmania infantum	100%	100%
C9ZUN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
E9ACD5	Leishmania major	97%	100%
E9AJM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DPV7	Trypanosoma cruzi	39%	94%