TPR repeat/Tetratricopeptide repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H509_LEIDO

TriTrypDb:

LdBPK_020560.1 , LdCL_020011200 , LDHU3_02.0730

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H509

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H509

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	276	278	PF00675	0.581
CLV_NRD_NRD_1	286	288	PF00675	0.633
CLV_NRD_NRD_1	338	340	PF00675	0.606
CLV_NRD_NRD_1	392	394	PF00675	0.756
CLV_NRD_NRD_1	444	446	PF00675	0.706
CLV_NRD_NRD_1	468	470	PF00675	0.720
CLV_NRD_NRD_1	516	518	PF00675	0.543
CLV_PCSK_FUR_1	274	278	PF00082	0.409
CLV_PCSK_KEX2_1	242	244	PF00082	0.408
CLV_PCSK_KEX2_1	276	278	PF00082	0.585
CLV_PCSK_KEX2_1	286	288	PF00082	0.637
CLV_PCSK_KEX2_1	338	340	PF00082	0.609
CLV_PCSK_KEX2_1	444	446	PF00082	0.706
CLV_PCSK_KEX2_1	467	469	PF00082	0.749
CLV_PCSK_KEX2_1	518	520	PF00082	0.567
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.408
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.658
CLV_PCSK_PC7_1	272	278	PF00082	0.411
CLV_PCSK_SKI1_1	101	105	PF00082	0.749
CLV_PCSK_SKI1_1	381	385	PF00082	0.770
CLV_PCSK_SKI1_1	398	402	PF00082	0.554
CLV_PCSK_SKI1_1	48	52	PF00082	0.814
CLV_PCSK_SKI1_1	519	523	PF00082	0.603
CLV_PCSK_SKI1_1	7	11	PF00082	0.541
DEG_SPOP_SBC_1	172	176	PF00917	0.560
DEG_SPOP_SBC_1	307	311	PF00917	0.700
DEG_SPOP_SBC_1	96	100	PF00917	0.745
DOC_CKS1_1	104	109	PF01111	0.656
DOC_MAPK_gen_1	276	285	PF00069	0.635
DOC_PP1_RVXF_1	106	113	PF00149	0.741
DOC_PP4_FxxP_1	104	107	PF00568	0.792
DOC_PP4_FxxP_1	486	489	PF00568	0.717
DOC_USP7_MATH_1	130	134	PF00917	0.647
DOC_USP7_MATH_1	187	191	PF00917	0.299
DOC_USP7_MATH_1	19	23	PF00917	0.486
DOC_USP7_MATH_1	307	311	PF00917	0.705
DOC_USP7_MATH_1	321	325	PF00917	0.604
DOC_USP7_MATH_1	377	381	PF00917	0.736
DOC_USP7_MATH_1	402	406	PF00917	0.755
DOC_USP7_MATH_1	409	413	PF00917	0.616
DOC_USP7_MATH_1	416	420	PF00917	0.635
DOC_USP7_MATH_1	457	461	PF00917	0.746
DOC_USP7_MATH_1	503	507	PF00917	0.643
DOC_USP7_MATH_1	55	59	PF00917	0.771
DOC_USP7_MATH_1	97	101	PF00917	0.701
DOC_USP7_MATH_2	497	503	PF00917	0.594
DOC_USP7_UBL2_3	394	398	PF12436	0.686
DOC_WW_Pin1_4	103	108	PF00397	0.660
DOC_WW_Pin1_4	381	386	PF00397	0.770
DOC_WW_Pin1_4	448	453	PF00397	0.739
DOC_WW_Pin1_4	470	475	PF00397	0.683
DOC_WW_Pin1_4	51	56	PF00397	0.730
DOC_WW_Pin1_4	86	91	PF00397	0.719
LIG_14-3-3_CanoR_1	101	107	PF00244	0.761
LIG_14-3-3_CanoR_1	219	224	PF00244	0.563
LIG_14-3-3_CanoR_1	260	265	PF00244	0.547
LIG_14-3-3_CanoR_1	290	299	PF00244	0.604
LIG_14-3-3_CanoR_1	422	431	PF00244	0.701
LIG_14-3-3_CanoR_1	467	474	PF00244	0.741
LIG_Actin_WH2_2	71	88	PF00022	0.681
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_FHA_1	163	169	PF00498	0.436
LIG_FHA_1	218	224	PF00498	0.555
LIG_FHA_1	294	300	PF00498	0.703
LIG_FHA_1	41	47	PF00498	0.725
LIG_FHA_1	80	86	PF00498	0.754
LIG_FHA_2	1	7	PF00498	0.590
LIG_FHA_2	15	21	PF00498	0.458
LIG_FHA_2	309	315	PF00498	0.793
LIG_FHA_2	327	333	PF00498	0.764
LIG_FHA_2	356	362	PF00498	0.697
LIG_FHA_2	425	431	PF00498	0.697
LIG_FHA_2	82	88	PF00498	0.799
LIG_LIR_Apic_2	485	489	PF02991	0.660
LIG_LIR_Nem_3	225	231	PF02991	0.448
LIG_LIR_Nem_3	236	241	PF02991	0.282
LIG_MYND_1	462	466	PF01753	0.790
LIG_Pex14_1	227	231	PF04695	0.344
LIG_PTB_Apo_2	146	153	PF02174	0.496
LIG_RPA_C_Fungi	267	279	PF08784	0.548
LIG_SH2_CRK	52	56	PF00017	0.786
LIG_SH2_NCK_1	52	56	PF00017	0.786
LIG_SH2_STAP1	164	168	PF00017	0.401
LIG_SH2_STAP1	210	214	PF00017	0.568
LIG_SH2_STAP1	251	255	PF00017	0.344
LIG_SH2_STAT3	231	234	PF00017	0.344
LIG_SH2_STAT3	367	370	PF00017	0.677
LIG_SH2_STAT5	164	167	PF00017	0.425
LIG_SH2_STAT5	196	199	PF00017	0.424
LIG_SH2_STAT5	238	241	PF00017	0.454
LIG_SH3_2	462	467	PF14604	0.797
LIG_SH3_3	18	24	PF00018	0.537
LIG_SH3_3	459	465	PF00018	0.716
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.453
LIG_SUMO_SIM_par_1	181	186	PF11976	0.485
LIG_SUMO_SIM_par_1	218	226	PF11976	0.489
LIG_TRAF2_1	279	282	PF00917	0.575
LIG_WRC_WIRS_1	483	488	PF05994	0.629
LIG_WW_3	464	468	PF00397	0.812
MOD_CDK_SPK_2	103	108	PF00069	0.660
MOD_CK1_1	116	122	PF00069	0.699
MOD_CK1_1	133	139	PF00069	0.470
MOD_CK1_1	190	196	PF00069	0.392
MOD_CK1_1	222	228	PF00069	0.499
MOD_CK1_1	291	297	PF00069	0.606
MOD_CK1_1	298	304	PF00069	0.643
MOD_CK1_1	310	316	PF00069	0.805
MOD_CK1_1	34	40	PF00069	0.739
MOD_CK1_1	421	427	PF00069	0.769
MOD_CK1_1	470	476	PF00069	0.756
MOD_CK2_1	175	181	PF00069	0.618
MOD_CK2_1	308	314	PF00069	0.788
MOD_CK2_1	355	361	PF00069	0.712
MOD_CK2_1	409	415	PF00069	0.598
MOD_Cter_Amidation	336	339	PF01082	0.650
MOD_GlcNHglycan	132	135	PF01048	0.714
MOD_GlcNHglycan	178	181	PF01048	0.559
MOD_GlcNHglycan	185	188	PF01048	0.384
MOD_GlcNHglycan	192	195	PF01048	0.308
MOD_GlcNHglycan	340	343	PF01048	0.629
MOD_GlcNHglycan	404	407	PF01048	0.741
MOD_GlcNHglycan	418	421	PF01048	0.695
MOD_GlcNHglycan	470	473	PF01048	0.796
MOD_GlcNHglycan	501	504	PF01048	0.723
MOD_GlcNHglycan	505	508	PF01048	0.597
MOD_GlcNHglycan	65	68	PF01048	0.699
MOD_GlcNHglycan	93	96	PF01048	0.758
MOD_GSK3_1	102	109	PF00069	0.663
MOD_GSK3_1	113	120	PF00069	0.756
MOD_GSK3_1	171	178	PF00069	0.617
MOD_GSK3_1	183	190	PF00069	0.465
MOD_GSK3_1	219	226	PF00069	0.512
MOD_GSK3_1	285	292	PF00069	0.541
MOD_GSK3_1	294	301	PF00069	0.607
MOD_GSK3_1	306	313	PF00069	0.639
MOD_GSK3_1	31	38	PF00069	0.777
MOD_GSK3_1	377	384	PF00069	0.751
MOD_GSK3_1	398	405	PF00069	0.680
MOD_GSK3_1	414	421	PF00069	0.715
MOD_GSK3_1	453	460	PF00069	0.740
MOD_GSK3_1	499	506	PF00069	0.634
MOD_GSK3_1	51	58	PF00069	0.784
MOD_GSK3_1	61	68	PF00069	0.674
MOD_GSK3_1	74	81	PF00069	0.670
MOD_GSK3_1	91	98	PF00069	0.753
MOD_N-GLC_1	148	153	PF02516	0.495
MOD_N-GLC_1	190	195	PF02516	0.390
MOD_N-GLC_1	260	265	PF02516	0.543
MOD_N-GLC_1	398	403	PF02516	0.715
MOD_N-GLC_1	40	45	PF02516	0.766
MOD_N-GLC_1	79	84	PF02516	0.749
MOD_NEK2_1	171	176	PF00069	0.530
MOD_NEK2_1	183	188	PF00069	0.497
MOD_NEK2_1	223	228	PF00069	0.545
MOD_NEK2_1	268	273	PF00069	0.505
MOD_NEK2_1	285	290	PF00069	0.602
MOD_NEK2_1	299	304	PF00069	0.691
MOD_NEK2_1	453	458	PF00069	0.722
MOD_NEK2_1	63	68	PF00069	0.708
MOD_NEK2_1	78	83	PF00069	0.610
MOD_NEK2_1	85	90	PF00069	0.741
MOD_NEK2_2	409	414	PF00069	0.576
MOD_PIKK_1	121	127	PF00454	0.775
MOD_PIKK_1	31	37	PF00454	0.804
MOD_PIKK_1	321	327	PF00454	0.727
MOD_PK_1	414	420	PF00069	0.716
MOD_PKA_1	338	344	PF00069	0.634
MOD_PKA_1	467	473	PF00069	0.819
MOD_PKA_2	223	229	PF00069	0.442
MOD_PKA_2	285	291	PF00069	0.516
MOD_PKA_2	338	344	PF00069	0.613
MOD_PKA_2	377	383	PF00069	0.707
MOD_PKA_2	392	398	PF00069	0.723
MOD_PKA_2	421	427	PF00069	0.711
MOD_PKA_2	467	473	PF00069	0.782
MOD_PKA_2	85	91	PF00069	0.809
MOD_Plk_1	113	119	PF00069	0.709
MOD_Plk_1	148	154	PF00069	0.501
MOD_Plk_1	217	223	PF00069	0.547
MOD_Plk_1	260	266	PF00069	0.547
MOD_Plk_1	355	361	PF00069	0.560
MOD_Plk_1	398	404	PF00069	0.785
MOD_Plk_1	414	420	PF00069	0.741
MOD_Plk_4	223	229	PF00069	0.450
MOD_Plk_4	260	266	PF00069	0.498
MOD_ProDKin_1	103	109	PF00069	0.658
MOD_ProDKin_1	381	387	PF00069	0.770
MOD_ProDKin_1	448	454	PF00069	0.741
MOD_ProDKin_1	470	476	PF00069	0.681
MOD_ProDKin_1	51	57	PF00069	0.730
MOD_ProDKin_1	86	92	PF00069	0.719
MOD_SUMO_for_1	351	354	PF00179	0.592
MOD_SUMO_rev_2	141	147	PF00179	0.492
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.528
TRG_ENDOCYTIC_2	238	241	PF00928	0.477
TRG_ER_diArg_1	274	277	PF00400	0.561
TRG_ER_diArg_1	285	287	PF00400	0.635
TRG_ER_diArg_1	375	378	PF00400	0.643
TRG_ER_diArg_1	466	469	PF00400	0.742
TRG_ER_diArg_1	516	519	PF00400	0.557
TRG_NLS_MonoCore_2	516	521	PF00514	0.620
TRG_NLS_MonoExtN_4	517	522	PF00514	0.534
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B2	Leptomonas seymouri	49%	93%
A0A1X0NJW2	Trypanosomatidae	34%	100%
A0A422NAY7	Trypanosoma rangeli	29%	100%
A4H3F0	Leishmania braziliensis	73%	100%
A4HRQ4	Leishmania infantum	100%	100%
E9ACD3	Leishmania major	93%	98%
E9AJM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B5N7	Trypanosoma cruzi	33%	100%