Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H507_LEIDO

TriTrypDb:

LdBPK_020530.1 , LdCL_020010900 , LDHU3_02.0670

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H507

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H507

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.804
CLV_C14_Caspase3-7	722	726	PF00656	0.748
CLV_C14_Caspase3-7	819	823	PF00656	0.707
CLV_NRD_NRD_1	240	242	PF00675	0.644
CLV_NRD_NRD_1	361	363	PF00675	0.799
CLV_NRD_NRD_1	383	385	PF00675	0.678
CLV_NRD_NRD_1	432	434	PF00675	0.635
CLV_NRD_NRD_1	563	565	PF00675	0.766
CLV_NRD_NRD_1	595	597	PF00675	0.815
CLV_NRD_NRD_1	627	629	PF00675	0.738
CLV_NRD_NRD_1	661	663	PF00675	0.633
CLV_NRD_NRD_1	835	837	PF00675	0.725
CLV_PCSK_FUR_1	359	363	PF00082	0.801
CLV_PCSK_KEX2_1	240	242	PF00082	0.636
CLV_PCSK_KEX2_1	359	361	PF00082	0.803
CLV_PCSK_KEX2_1	383	385	PF00082	0.670
CLV_PCSK_KEX2_1	432	434	PF00082	0.635
CLV_PCSK_KEX2_1	562	564	PF00082	0.767
CLV_PCSK_KEX2_1	595	597	PF00082	0.815
CLV_PCSK_KEX2_1	627	629	PF00082	0.738
CLV_PCSK_KEX2_1	661	663	PF00082	0.633
CLV_PCSK_KEX2_1	835	837	PF00082	0.734
CLV_PCSK_SKI1_1	179	183	PF00082	0.554
CLV_PCSK_SKI1_1	332	336	PF00082	0.747
CLV_PCSK_SKI1_1	82	86	PF00082	0.586
CLV_Separin_Metazoa	493	497	PF03568	0.710
DEG_APCC_DBOX_1	178	186	PF00400	0.561
DEG_APCC_DBOX_1	636	644	PF00400	0.683
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DEG_SCF_FBW7_1	680	687	PF00400	0.824
DEG_SPOP_SBC_1	812	816	PF00917	0.746
DOC_ANK_TNKS_1	497	504	PF00023	0.807
DOC_ANK_TNKS_1	660	667	PF00023	0.623
DOC_CKS1_1	229	234	PF01111	0.709
DOC_CKS1_1	681	686	PF01111	0.825
DOC_MAPK_gen_1	732	740	PF00069	0.706
DOC_MAPK_gen_1	832	840	PF00069	0.733
DOC_PP1_RVXF_1	423	430	PF00149	0.670
DOC_PP1_RVXF_1	834	841	PF00149	0.731
DOC_PP4_FxxP_1	491	494	PF00568	0.721
DOC_PP4_FxxP_1	840	843	PF00568	0.723
DOC_USP7_MATH_1	260	264	PF00917	0.625
DOC_USP7_MATH_1	312	316	PF00917	0.769
DOC_USP7_MATH_1	36	40	PF00917	0.649
DOC_USP7_MATH_1	363	367	PF00917	0.709
DOC_USP7_MATH_1	434	438	PF00917	0.731
DOC_USP7_MATH_1	463	467	PF00917	0.797
DOC_USP7_MATH_1	527	531	PF00917	0.749
DOC_USP7_MATH_1	649	653	PF00917	0.727
DOC_USP7_MATH_1	684	688	PF00917	0.745
DOC_USP7_MATH_1	691	695	PF00917	0.795
DOC_USP7_MATH_1	704	708	PF00917	0.519
DOC_USP7_MATH_1	728	732	PF00917	0.650
DOC_USP7_MATH_1	775	779	PF00917	0.846
DOC_USP7_MATH_1	781	785	PF00917	0.785
DOC_USP7_MATH_1	793	797	PF00917	0.605
DOC_WW_Pin1_4	200	205	PF00397	0.672
DOC_WW_Pin1_4	228	233	PF00397	0.693
DOC_WW_Pin1_4	284	289	PF00397	0.637
DOC_WW_Pin1_4	332	337	PF00397	0.804
DOC_WW_Pin1_4	338	343	PF00397	0.753
DOC_WW_Pin1_4	345	350	PF00397	0.615
DOC_WW_Pin1_4	386	391	PF00397	0.777
DOC_WW_Pin1_4	47	52	PF00397	0.766
DOC_WW_Pin1_4	478	483	PF00397	0.641
DOC_WW_Pin1_4	680	685	PF00397	0.754
LIG_14-3-3_CanoR_1	15	24	PF00244	0.768
LIG_14-3-3_CanoR_1	152	161	PF00244	0.677
LIG_14-3-3_CanoR_1	190	200	PF00244	0.595
LIG_14-3-3_CanoR_1	360	366	PF00244	0.717
LIG_14-3-3_CanoR_1	425	430	PF00244	0.690
LIG_14-3-3_CanoR_1	627	635	PF00244	0.642
LIG_14-3-3_CanoR_1	754	760	PF00244	0.791
LIG_14-3-3_CanoR_1	803	812	PF00244	0.783
LIG_14-3-3_CanoR_1	835	839	PF00244	0.732
LIG_BIR_III_2	725	729	PF00653	0.615
LIG_BRCT_BRCA1_1	134	138	PF00533	0.596
LIG_BRCT_BRCA1_1	651	655	PF00533	0.808
LIG_eIF4E_1	155	161	PF01652	0.553
LIG_FHA_1	154	160	PF00498	0.661
LIG_FHA_1	196	202	PF00498	0.599
LIG_FHA_1	221	227	PF00498	0.652
LIG_FHA_1	229	235	PF00498	0.598
LIG_FHA_1	48	54	PF00498	0.738
LIG_FHA_1	61	67	PF00498	0.634
LIG_FHA_1	681	687	PF00498	0.822
LIG_FHA_2	373	379	PF00498	0.651
LIG_FHA_2	784	790	PF00498	0.824
LIG_FHA_2	813	819	PF00498	0.833
LIG_Integrin_RGD_1	305	307	PF01839	0.661
LIG_LIR_Apic_2	644	648	PF02991	0.744
LIG_LIR_Apic_2	837	843	PF02991	0.726
LIG_LIR_Gen_1	202	211	PF02991	0.620
LIG_LIR_Gen_1	603	612	PF02991	0.818
LIG_LIR_Nem_3	135	141	PF02991	0.702
LIG_LIR_Nem_3	148	154	PF02991	0.520
LIG_LIR_Nem_3	202	208	PF02991	0.632
LIG_LIR_Nem_3	379	385	PF02991	0.760
LIG_LIR_Nem_3	603	607	PF02991	0.824
LIG_NRBOX	233	239	PF00104	0.590
LIG_NRBOX	85	91	PF00104	0.584
LIG_Pex14_1	151	155	PF04695	0.619
LIG_Pex14_1	431	435	PF04695	0.662
LIG_Pex14_1	534	538	PF04695	0.649
LIG_PTAP_UEV_1	458	463	PF05743	0.644
LIG_SH2_CRK	282	286	PF00017	0.635
LIG_SH2_CRK	525	529	PF00017	0.652
LIG_SH2_CRK	604	608	PF00017	0.758
LIG_SH2_NCK_1	264	268	PF00017	0.733
LIG_SH2_NCK_1	525	529	PF00017	0.652
LIG_SH2_PTP2	371	374	PF00017	0.699
LIG_SH2_PTP2	540	543	PF00017	0.745
LIG_SH2_SRC	371	374	PF00017	0.699
LIG_SH2_SRC	492	495	PF00017	0.779
LIG_SH2_STAP1	155	159	PF00017	0.657
LIG_SH2_STAP1	282	286	PF00017	0.635
LIG_SH2_STAP1	292	296	PF00017	0.629
LIG_SH2_STAT5	139	142	PF00017	0.601
LIG_SH2_STAT5	155	158	PF00017	0.554
LIG_SH2_STAT5	205	208	PF00017	0.655
LIG_SH2_STAT5	228	231	PF00017	0.693
LIG_SH2_STAT5	273	276	PF00017	0.667
LIG_SH2_STAT5	371	374	PF00017	0.777
LIG_SH2_STAT5	540	543	PF00017	0.745
LIG_SH3_2	147	152	PF14604	0.741
LIG_SH3_2	557	562	PF14604	0.840
LIG_SH3_3	141	147	PF00018	0.635
LIG_SH3_3	204	210	PF00018	0.682
LIG_SH3_3	212	218	PF00018	0.627
LIG_SH3_3	285	291	PF00018	0.737
LIG_SH3_3	313	319	PF00018	0.710
LIG_SH3_3	384	390	PF00018	0.658
LIG_SH3_3	450	456	PF00018	0.810
LIG_SH3_3	46	52	PF00018	0.770
LIG_SH3_3	473	479	PF00018	0.771
LIG_SH3_3	554	560	PF00018	0.761
LIG_SH3_3	645	651	PF00018	0.792
LIG_SH3_3	69	75	PF00018	0.707
LIG_SUMO_SIM_par_1	372	380	PF11976	0.639
LIG_TRAF2_1	375	378	PF00917	0.649
LIG_TRFH_1	214	218	PF08558	0.655
LIG_WW_1	270	273	PF00397	0.745
LIG_WW_3	493	497	PF00397	0.719
MOD_CDC14_SPxK_1	389	392	PF00782	0.706
MOD_CDK_SPK_2	228	233	PF00069	0.722
MOD_CDK_SPxK_1	386	392	PF00069	0.701
MOD_CDK_SPxxK_3	47	54	PF00069	0.691
MOD_CK1_1	130	136	PF00069	0.421
MOD_CK1_1	192	198	PF00069	0.765
MOD_CK1_1	287	293	PF00069	0.720
MOD_CK1_1	412	418	PF00069	0.674
MOD_CK1_1	447	453	PF00069	0.719
MOD_CK1_1	530	536	PF00069	0.747
MOD_CK1_1	576	582	PF00069	0.689
MOD_CK1_1	603	609	PF00069	0.760
MOD_CK1_1	629	635	PF00069	0.744
MOD_CK1_1	758	764	PF00069	0.734
MOD_CK1_1	773	779	PF00069	0.679
MOD_CK1_1	831	837	PF00069	0.734
MOD_CK2_1	125	131	PF00069	0.682
MOD_CK2_1	162	168	PF00069	0.650
MOD_CK2_1	256	262	PF00069	0.719
MOD_CK2_1	29	35	PF00069	0.810
MOD_CK2_1	312	318	PF00069	0.771
MOD_CK2_1	372	378	PF00069	0.656
MOD_CK2_1	436	442	PF00069	0.662
MOD_CK2_1	576	582	PF00069	0.731
MOD_CK2_1	702	708	PF00069	0.808
MOD_GlcNHglycan	134	137	PF01048	0.591
MOD_GlcNHglycan	156	159	PF01048	0.554
MOD_GlcNHglycan	17	20	PF01048	0.719
MOD_GlcNHglycan	191	194	PF01048	0.663
MOD_GlcNHglycan	25	28	PF01048	0.775
MOD_GlcNHglycan	258	261	PF01048	0.723
MOD_GlcNHglycan	276	279	PF01048	0.451
MOD_GlcNHglycan	3	6	PF01048	0.653
MOD_GlcNHglycan	31	34	PF01048	0.740
MOD_GlcNHglycan	365	368	PF01048	0.713
MOD_GlcNHglycan	438	441	PF01048	0.708
MOD_GlcNHglycan	446	449	PF01048	0.674
MOD_GlcNHglycan	459	462	PF01048	0.627
MOD_GlcNHglycan	465	468	PF01048	0.814
MOD_GlcNHglycan	529	532	PF01048	0.673
MOD_GlcNHglycan	574	578	PF01048	0.746
MOD_GlcNHglycan	589	592	PF01048	0.614
MOD_GlcNHglycan	618	621	PF01048	0.782
MOD_GlcNHglycan	773	776	PF01048	0.838
MOD_GlcNHglycan	777	780	PF01048	0.769
MOD_GlcNHglycan	783	786	PF01048	0.712
MOD_GlcNHglycan	795	798	PF01048	0.615
MOD_GlcNHglycan	81	85	PF01048	0.639
MOD_GSK3_1	1	8	PF00069	0.676
MOD_GSK3_1	126	133	PF00069	0.478
MOD_GSK3_1	191	198	PF00069	0.640
MOD_GSK3_1	220	227	PF00069	0.651
MOD_GSK3_1	256	263	PF00069	0.660
MOD_GSK3_1	386	393	PF00069	0.783
MOD_GSK3_1	444	451	PF00069	0.661
MOD_GSK3_1	572	579	PF00069	0.699
MOD_GSK3_1	626	633	PF00069	0.683
MOD_GSK3_1	676	683	PF00069	0.790
MOD_GSK3_1	685	692	PF00069	0.688
MOD_GSK3_1	704	711	PF00069	0.733
MOD_GSK3_1	766	773	PF00069	0.742
MOD_GSK3_1	812	819	PF00069	0.810
MOD_GSK3_1	827	834	PF00069	0.614
MOD_N-GLC_1	5	10	PF02516	0.561
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	274	279	PF00069	0.629
MOD_NEK2_1	544	549	PF00069	0.660
MOD_NEK2_1	552	557	PF00069	0.724
MOD_NEK2_1	573	578	PF00069	0.697
MOD_NEK2_1	616	621	PF00069	0.701
MOD_NEK2_1	685	690	PF00069	0.695
MOD_NEK2_1	715	720	PF00069	0.749
MOD_NEK2_1	770	775	PF00069	0.756
MOD_PIKK_1	649	655	PF00454	0.809
MOD_PK_1	361	367	PF00069	0.714
MOD_PK_1	399	405	PF00069	0.792
MOD_PKA_1	361	367	PF00069	0.714
MOD_PKA_1	827	833	PF00069	0.833
MOD_PKA_2	14	20	PF00069	0.731
MOD_PKA_2	189	195	PF00069	0.715
MOD_PKA_2	361	367	PF00069	0.714
MOD_PKA_2	412	418	PF00069	0.658
MOD_PKA_2	626	632	PF00069	0.735
MOD_PKA_2	781	787	PF00069	0.791
MOD_PKA_2	812	818	PF00069	0.843
MOD_PKA_2	831	837	PF00069	0.533
MOD_PKB_1	359	367	PF00069	0.717
MOD_PKB_1	397	405	PF00069	0.795
MOD_Plk_1	312	318	PF00069	0.771
MOD_Plk_1	573	579	PF00069	0.696
MOD_Plk_1	629	635	PF00069	0.644
MOD_Plk_1	708	714	PF00069	0.782
MOD_Plk_1	761	767	PF00069	0.698
MOD_Plk_1	80	86	PF00069	0.600
MOD_Plk_1	838	844	PF00069	0.826
MOD_Plk_4	224	230	PF00069	0.642
MOD_Plk_4	312	318	PF00069	0.771
MOD_Plk_4	412	418	PF00069	0.624
MOD_Plk_4	425	431	PF00069	0.587
MOD_Plk_4	530	536	PF00069	0.645
MOD_Plk_4	676	682	PF00069	0.827
MOD_ProDKin_1	200	206	PF00069	0.661
MOD_ProDKin_1	228	234	PF00069	0.688
MOD_ProDKin_1	284	290	PF00069	0.632
MOD_ProDKin_1	332	338	PF00069	0.805
MOD_ProDKin_1	345	351	PF00069	0.616
MOD_ProDKin_1	386	392	PF00069	0.779
MOD_ProDKin_1	47	53	PF00069	0.767
MOD_ProDKin_1	478	484	PF00069	0.641
MOD_ProDKin_1	680	686	PF00069	0.756
MOD_SUMO_rev_2	112	121	PF00179	0.725
MOD_SUMO_rev_2	32	39	PF00179	0.817
MOD_SUMO_rev_2	822	830	PF00179	0.754
TRG_DiLeu_BaEn_4	568	574	PF01217	0.756
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.803
TRG_ENDOCYTIC_2	205	208	PF00928	0.714
TRG_ENDOCYTIC_2	282	285	PF00928	0.634
TRG_ENDOCYTIC_2	371	374	PF00928	0.777
TRG_ENDOCYTIC_2	435	438	PF00928	0.733
TRG_ENDOCYTIC_2	525	528	PF00928	0.662
TRG_ENDOCYTIC_2	604	607	PF00928	0.756
TRG_ER_diArg_1	239	241	PF00400	0.617
TRG_ER_diArg_1	359	362	PF00400	0.803
TRG_ER_diArg_1	382	384	PF00400	0.671
TRG_ER_diArg_1	431	433	PF00400	0.624
TRG_ER_diArg_1	495	498	PF00400	0.731
TRG_ER_diArg_1	562	564	PF00400	0.767
TRG_ER_diArg_1	594	596	PF00400	0.818
TRG_ER_diArg_1	626	628	PF00400	0.735
TRG_ER_diArg_1	660	662	PF00400	0.623
TRG_ER_diArg_1	716	719	PF00400	0.711
TRG_ER_diArg_1	802	805	PF00400	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI3	Leptomonas seymouri	43%	95%
A4H3E6	Leishmania braziliensis	73%	99%
A4HRQ1	Leishmania infantum	100%	100%
E9ACD0	Leishmania major	92%	100%
E9AJL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%