Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H506_LEIDO

TriTrypDb:

LdBPK_020520.1 , LdCL_020010800 , LDHU3_02.0660

Length:

163

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 59, 64

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H506

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H506

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.498
CLV_PCSK_SKI1_1	52	56	PF00082	0.505
DOC_CYCLIN_RxL_1	46	59	PF00134	0.651
DOC_MAPK_gen_1	104	113	PF00069	0.618
DOC_MAPK_gen_1	151	160	PF00069	0.544
DOC_MAPK_MEF2A_6	123	130	PF00069	0.394
DOC_MAPK_NFAT4_5	123	131	PF00069	0.416
DOC_PP4_FxxP_1	10	13	PF00568	0.388
DOC_USP7_MATH_1	13	17	PF00917	0.318
DOC_USP7_MATH_1	90	94	PF00917	0.568
DOC_WW_Pin1_4	86	91	PF00397	0.603
LIG_14-3-3_CanoR_1	142	148	PF00244	0.488
LIG_Actin_WH2_2	127	144	PF00022	0.385
LIG_Clathr_ClatBox_1	128	132	PF01394	0.412
LIG_FHA_1	142	148	PF00498	0.496
LIG_FHA_1	153	159	PF00498	0.462
LIG_FHA_1	37	43	PF00498	0.579
LIG_LIR_Apic_2	7	13	PF02991	0.382
LIG_SH2_STAT3	117	120	PF00017	0.415
LIG_SH2_STAT5	117	120	PF00017	0.445
LIG_SH3_2	47	52	PF14604	0.506
LIG_SH3_3	44	50	PF00018	0.523
LIG_SUMO_SIM_par_1	127	132	PF11976	0.494
LIG_TRAF2_1	133	136	PF00917	0.500
MOD_CK1_1	41	47	PF00069	0.546
MOD_GlcNHglycan	58	61	PF01048	0.678
MOD_GlcNHglycan	63	66	PF01048	0.722
MOD_GlcNHglycan	71	76	PF01048	0.782
MOD_GSK3_1	37	44	PF00069	0.502
MOD_GSK3_1	81	88	PF00069	0.773
MOD_N-GLC_1	56	61	PF02516	0.670
MOD_N-GLC_1	86	91	PF02516	0.591
MOD_NEK2_1	141	146	PF00069	0.446
MOD_NEK2_1	53	58	PF00069	0.513
MOD_NEK2_2	13	18	PF00069	0.276
MOD_PIKK_1	153	159	PF00454	0.552
MOD_PIKK_1	41	47	PF00454	0.630
MOD_PIKK_1	81	87	PF00454	0.569
MOD_PKA_2	141	147	PF00069	0.449
MOD_Plk_1	153	159	PF00069	0.494
MOD_Plk_4	143	149	PF00069	0.599
MOD_ProDKin_1	86	92	PF00069	0.604
MOD_SUMO_rev_2	101	108	PF00179	0.460
TRG_DiLeu_BaEn_2	48	54	PF01217	0.498
TRG_DiLeu_BaEn_4	136	142	PF01217	0.518
TRG_NES_CRM1_1	119	135	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D0	Leptomonas seymouri	64%	100%
A0A0N1HW96	Leptomonas seymouri	29%	100%
A0A0S4IPF2	Bodo saltans	30%	100%
A0A0S4JFI1	Bodo saltans	35%	100%
A0A1X0NKC2	Trypanosomatidae	34%	100%
A0A1X0P259	Trypanosomatidae	31%	100%
A0A3R7K0R9	Trypanosoma rangeli	29%	100%
A0A3S7X3W3	Leishmania donovani	29%	100%
A0A422NFX4	Trypanosoma rangeli	38%	100%
A4H3E5	Leishmania braziliensis	76%	99%
A4HIL9	Leishmania braziliensis	29%	70%
A4HRQ0	Leishmania infantum	100%	100%
A4I5W4	Leishmania infantum	29%	70%
C9ZR85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACC9	Leishmania major	96%	100%
E9AJL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B159	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	70%
Q4Q707	Leishmania major	29%	70%
V5BMX8	Trypanosoma cruzi	29%	100%