Glycerate kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerate kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H505_LEIDO

TriTrypDb:

LdBPK_020470.1 , LdCL_020010200 , LDHU3_02.0590

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H505

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H505

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0031388	organic acid phosphorylation	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008887	glycerate kinase activity	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.421
CLV_C14_Caspase3-7	609	613	PF00656	0.504
CLV_NRD_NRD_1	269	271	PF00675	0.350
CLV_NRD_NRD_1	279	281	PF00675	0.308
CLV_NRD_NRD_1	395	397	PF00675	0.623
CLV_NRD_NRD_1	626	628	PF00675	0.464
CLV_NRD_NRD_1	679	681	PF00675	0.647
CLV_NRD_NRD_1	782	784	PF00675	0.499
CLV_NRD_NRD_1	928	930	PF00675	0.510
CLV_PCSK_KEX2_1	269	271	PF00082	0.359
CLV_PCSK_KEX2_1	279	281	PF00082	0.308
CLV_PCSK_KEX2_1	395	397	PF00082	0.623
CLV_PCSK_KEX2_1	55	57	PF00082	0.627
CLV_PCSK_KEX2_1	626	628	PF00082	0.464
CLV_PCSK_KEX2_1	679	681	PF00082	0.663
CLV_PCSK_KEX2_1	688	690	PF00082	0.609
CLV_PCSK_KEX2_1	782	784	PF00082	0.499
CLV_PCSK_KEX2_1	928	930	PF00082	0.510
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.605
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.703
CLV_PCSK_SKI1_1	279	283	PF00082	0.315
CLV_PCSK_SKI1_1	316	320	PF00082	0.443
CLV_PCSK_SKI1_1	352	356	PF00082	0.329
CLV_PCSK_SKI1_1	501	505	PF00082	0.324
CLV_PCSK_SKI1_1	640	644	PF00082	0.376
CLV_PCSK_SKI1_1	786	790	PF00082	0.508
CLV_PCSK_SKI1_1	881	885	PF00082	0.544
CLV_PCSK_SKI1_1	928	932	PF00082	0.616
DEG_APCC_DBOX_1	315	323	PF00400	0.421
DEG_COP1_1	153	161	PF00400	0.614
DEG_SPOP_SBC_1	832	836	PF00917	0.591
DOC_CKS1_1	194	199	PF01111	0.365
DOC_CKS1_1	661	666	PF01111	0.439
DOC_CKS1_1	896	901	PF01111	0.514
DOC_MAPK_gen_1	782	793	PF00069	0.458
DOC_MAPK_MEF2A_6	279	286	PF00069	0.324
DOC_MAPK_MEF2A_6	68	76	PF00069	0.687
DOC_MAPK_RevD_3	664	680	PF00069	0.465
DOC_PP1_RVXF_1	267	274	PF00149	0.306
DOC_PP2B_LxvP_1	168	171	PF13499	0.703
DOC_PP2B_LxvP_1	698	701	PF13499	0.620
DOC_PP2B_LxvP_1	821	824	PF13499	0.506
DOC_PP4_FxxP_1	902	905	PF00568	0.638
DOC_USP7_MATH_1	22	26	PF00917	0.516
DOC_USP7_MATH_1	35	39	PF00917	0.513
DOC_USP7_MATH_1	397	401	PF00917	0.712
DOC_USP7_MATH_1	40	44	PF00917	0.616
DOC_USP7_MATH_1	472	476	PF00917	0.692
DOC_USP7_MATH_1	6	10	PF00917	0.624
DOC_USP7_MATH_1	605	609	PF00917	0.635
DOC_USP7_MATH_1	706	710	PF00917	0.604
DOC_USP7_MATH_1	832	836	PF00917	0.673
DOC_USP7_MATH_2	152	158	PF00917	0.647
DOC_WW_Pin1_4	157	162	PF00397	0.652
DOC_WW_Pin1_4	193	198	PF00397	0.365
DOC_WW_Pin1_4	224	229	PF00397	0.497
DOC_WW_Pin1_4	26	31	PF00397	0.630
DOC_WW_Pin1_4	335	340	PF00397	0.460
DOC_WW_Pin1_4	43	48	PF00397	0.684
DOC_WW_Pin1_4	451	456	PF00397	0.595
DOC_WW_Pin1_4	474	479	PF00397	0.663
DOC_WW_Pin1_4	519	524	PF00397	0.324
DOC_WW_Pin1_4	526	531	PF00397	0.644
DOC_WW_Pin1_4	660	665	PF00397	0.432
DOC_WW_Pin1_4	895	900	PF00397	0.507
DOC_WW_Pin1_4	97	102	PF00397	0.524
LIG_14-3-3_CanoR_1	136	146	PF00244	0.596
LIG_14-3-3_CanoR_1	269	274	PF00244	0.306
LIG_14-3-3_CanoR_1	305	310	PF00244	0.407
LIG_14-3-3_CanoR_1	396	404	PF00244	0.582
LIG_14-3-3_CanoR_1	501	506	PF00244	0.329
LIG_14-3-3_CanoR_1	569	576	PF00244	0.469
LIG_14-3-3_CanoR_1	7	16	PF00244	0.637
LIG_14-3-3_CanoR_1	75	83	PF00244	0.631
LIG_14-3-3_CanoR_1	786	794	PF00244	0.462
LIG_14-3-3_CanoR_1	891	895	PF00244	0.406
LIG_14-3-3_CanoR_1	928	938	PF00244	0.636
LIG_Actin_WH2_2	663	681	PF00022	0.533
LIG_APCC_ABBA_1	375	380	PF00400	0.421
LIG_BIR_III_2	696	700	PF00653	0.650
LIG_BIR_III_4	939	943	PF00653	0.499
LIG_BRCT_BRCA1_1	635	639	PF00533	0.343
LIG_BRCT_BRCA1_1	859	863	PF00533	0.469
LIG_EH1_1	308	316	PF00400	0.324
LIG_eIF4E_1	309	315	PF01652	0.324
LIG_FHA_1	245	251	PF00498	0.303
LIG_FHA_1	336	342	PF00498	0.267
LIG_FHA_1	39	45	PF00498	0.695
LIG_FHA_1	661	667	PF00498	0.459
LIG_FHA_1	725	731	PF00498	0.486
LIG_FHA_1	787	793	PF00498	0.548
LIG_FHA_1	814	820	PF00498	0.518
LIG_FHA_1	832	838	PF00498	0.490
LIG_FHA_1	896	902	PF00498	0.550
LIG_FHA_2	409	415	PF00498	0.592
LIG_FHA_2	459	465	PF00498	0.705
LIG_FHA_2	682	688	PF00498	0.553
LIG_FHA_2	834	840	PF00498	0.624
LIG_IRF3_LxIS_1	70	77	PF10401	0.680
LIG_LIR_Apic_2	885	890	PF02991	0.547
LIG_LIR_Apic_2	900	905	PF02991	0.489
LIG_LIR_Gen_1	802	811	PF02991	0.578
LIG_LIR_Nem_3	578	583	PF02991	0.462
LIG_LIR_Nem_3	636	642	PF02991	0.380
LIG_LIR_Nem_3	802	806	PF02991	0.648
LIG_MAD2	574	582	PF02301	0.454
LIG_MLH1_MIPbox_1	635	639	PF16413	0.343
LIG_MYND_1	224	228	PF01753	0.337
LIG_MYND_1	899	903	PF01753	0.668
LIG_NRBOX	619	625	PF00104	0.415
LIG_NRBOX	879	885	PF00104	0.417
LIG_PDZ_Class_1	944	949	PF00595	0.538
LIG_REV1ctd_RIR_1	636	644	PF16727	0.361
LIG_SH2_CRK	887	891	PF00017	0.530
LIG_SH2_CRK	912	916	PF00017	0.513
LIG_SH2_NCK_1	317	321	PF00017	0.393
LIG_SH2_NCK_1	661	665	PF00017	0.464
LIG_SH2_SRC	239	242	PF00017	0.324
LIG_SH2_SRC	647	650	PF00017	0.384
LIG_SH2_STAP1	317	321	PF00017	0.393
LIG_SH2_STAP1	912	916	PF00017	0.475
LIG_SH2_STAT5	239	242	PF00017	0.324
LIG_SH2_STAT5	448	451	PF00017	0.571
LIG_SH2_STAT5	483	486	PF00017	0.475
LIG_SH2_STAT5	641	644	PF00017	0.429
LIG_SH2_STAT5	647	650	PF00017	0.377
LIG_SH2_STAT5	768	771	PF00017	0.484
LIG_SH2_STAT5	803	806	PF00017	0.499
LIG_SH2_STAT5	853	856	PF00017	0.470
LIG_SH2_STAT5	882	885	PF00017	0.465
LIG_SH2_STAT5	887	890	PF00017	0.438
LIG_SH3_3	146	152	PF00018	0.630
LIG_SH3_3	153	159	PF00018	0.652
LIG_SH3_3	166	172	PF00018	0.478
LIG_SH3_3	235	241	PF00018	0.324
LIG_SH3_3	24	30	PF00018	0.561
LIG_SH3_3	444	450	PF00018	0.519
LIG_SH3_3	46	52	PF00018	0.703
LIG_SH3_3	517	523	PF00018	0.358
LIG_SH3_3	576	582	PF00018	0.460
LIG_SH3_3	63	69	PF00018	0.581
LIG_SH3_3	893	899	PF00018	0.463
LIG_SUMO_SIM_anti_2	789	795	PF11976	0.386
LIG_SUMO_SIM_par_1	14	19	PF11976	0.646
LIG_SUMO_SIM_par_1	280	285	PF11976	0.324
LIG_TRAF2_1	152	155	PF00917	0.719
LIG_TRAF2_1	932	935	PF00917	0.593
MOD_CDC14_SPxK_1	477	480	PF00782	0.502
MOD_CDK_SPxK_1	474	480	PF00069	0.516
MOD_CDK_SPxxK_3	43	50	PF00069	0.601
MOD_CK1_1	137	143	PF00069	0.534
MOD_CK1_1	157	163	PF00069	0.650
MOD_CK1_1	176	182	PF00069	0.481
MOD_CK1_1	340	346	PF00069	0.480
MOD_CK1_1	38	44	PF00069	0.672
MOD_CK1_1	474	480	PF00069	0.544
MOD_CK1_1	522	528	PF00069	0.628
MOD_CK1_1	672	678	PF00069	0.594
MOD_CK1_1	745	751	PF00069	0.426
MOD_CK1_1	77	83	PF00069	0.593
MOD_CK2_1	610	616	PF00069	0.520
MOD_CK2_1	681	687	PF00069	0.548
MOD_CK2_1	734	740	PF00069	0.461
MOD_CK2_1	833	839	PF00069	0.599
MOD_CK2_1	869	875	PF00069	0.538
MOD_CK2_1	929	935	PF00069	0.634
MOD_CMANNOS	129	132	PF00535	0.576
MOD_GlcNHglycan	137	140	PF01048	0.619
MOD_GlcNHglycan	178	181	PF01048	0.568
MOD_GlcNHglycan	228	231	PF01048	0.366
MOD_GlcNHglycan	262	265	PF01048	0.324
MOD_GlcNHglycan	342	345	PF01048	0.365
MOD_GlcNHglycan	37	40	PF01048	0.609
MOD_GlcNHglycan	537	540	PF01048	0.792
MOD_GlcNHglycan	553	556	PF01048	0.389
MOD_GlcNHglycan	571	574	PF01048	0.428
MOD_GlcNHglycan	589	592	PF01048	0.595
MOD_GlcNHglycan	635	638	PF01048	0.343
MOD_GlcNHglycan	703	707	PF01048	0.682
MOD_GlcNHglycan	708	711	PF01048	0.622
MOD_GlcNHglycan	732	735	PF01048	0.374
MOD_GlcNHglycan	76	79	PF01048	0.671
MOD_GlcNHglycan	807	810	PF01048	0.484
MOD_GlcNHglycan	860	863	PF01048	0.446
MOD_GlcNHglycan	871	874	PF01048	0.619
MOD_GlcNHglycan	884	887	PF01048	0.459
MOD_GlcNHglycan	9	12	PF01048	0.636
MOD_GlcNHglycan	916	919	PF01048	0.466
MOD_GlcNHglycan	931	934	PF01048	0.544
MOD_GSK3_1	107	114	PF00069	0.508
MOD_GSK3_1	150	157	PF00069	0.627
MOD_GSK3_1	16	23	PF00069	0.648
MOD_GSK3_1	207	214	PF00069	0.331
MOD_GSK3_1	240	247	PF00069	0.322
MOD_GSK3_1	265	272	PF00069	0.381
MOD_GSK3_1	333	340	PF00069	0.316
MOD_GSK3_1	454	461	PF00069	0.662
MOD_GSK3_1	522	529	PF00069	0.641
MOD_GSK3_1	702	709	PF00069	0.637
MOD_GSK3_1	730	737	PF00069	0.379
MOD_GSK3_1	801	808	PF00069	0.491
MOD_GSK3_1	827	834	PF00069	0.694
MOD_N-GLC_1	224	229	PF02516	0.267
MOD_N-GLC_2	825	827	PF02516	0.493
MOD_NEK2_1	111	116	PF00069	0.490
MOD_NEK2_1	173	178	PF00069	0.586
MOD_NEK2_1	20	25	PF00069	0.642
MOD_NEK2_1	205	210	PF00069	0.324
MOD_NEK2_1	74	79	PF00069	0.674
MOD_NEK2_1	857	862	PF00069	0.445
MOD_NEK2_1	89	94	PF00069	0.531
MOD_NEK2_1	923	928	PF00069	0.468
MOD_NEK2_2	107	112	PF00069	0.520
MOD_NEK2_2	833	838	PF00069	0.700
MOD_OFUCOSY	723	728	PF10250	0.378
MOD_OFUCOSY	941	948	PF10250	0.499
MOD_PK_1	610	616	PF00069	0.441
MOD_PKA_1	269	275	PF00069	0.267
MOD_PKA_1	928	934	PF00069	0.570
MOD_PKA_2	135	141	PF00069	0.560
MOD_PKA_2	269	275	PF00069	0.296
MOD_PKA_2	304	310	PF00069	0.407
MOD_PKA_2	397	403	PF00069	0.574
MOD_PKA_2	6	12	PF00069	0.687
MOD_PKA_2	74	80	PF00069	0.772
MOD_PKA_2	890	896	PF00069	0.431
MOD_PKA_2	928	934	PF00069	0.570
MOD_PKB_1	396	404	PF00069	0.557
MOD_Plk_1	154	160	PF00069	0.643
MOD_Plk_1	493	499	PF00069	0.436
MOD_Plk_1	672	678	PF00069	0.507
MOD_Plk_1	739	745	PF00069	0.473
MOD_Plk_1	801	807	PF00069	0.494
MOD_Plk_1	845	851	PF00069	0.458
MOD_Plk_1	923	929	PF00069	0.572
MOD_Plk_1	934	940	PF00069	0.526
MOD_Plk_4	173	179	PF00069	0.588
MOD_Plk_4	181	187	PF00069	0.554
MOD_Plk_4	493	499	PF00069	0.345
MOD_Plk_4	575	581	PF00069	0.501
MOD_Plk_4	739	745	PF00069	0.514
MOD_Plk_4	814	820	PF00069	0.455
MOD_Plk_4	890	896	PF00069	0.418
MOD_Plk_4	897	903	PF00069	0.542
MOD_ProDKin_1	157	163	PF00069	0.651
MOD_ProDKin_1	193	199	PF00069	0.365
MOD_ProDKin_1	224	230	PF00069	0.497
MOD_ProDKin_1	26	32	PF00069	0.636
MOD_ProDKin_1	335	341	PF00069	0.460
MOD_ProDKin_1	43	49	PF00069	0.679
MOD_ProDKin_1	451	457	PF00069	0.603
MOD_ProDKin_1	474	480	PF00069	0.655
MOD_ProDKin_1	519	525	PF00069	0.324
MOD_ProDKin_1	526	532	PF00069	0.644
MOD_ProDKin_1	660	666	PF00069	0.432
MOD_ProDKin_1	895	901	PF00069	0.520
MOD_ProDKin_1	97	103	PF00069	0.508
TRG_DiLeu_BaEn_1	278	283	PF01217	0.421
TRG_DiLeu_BaLyEn_6	748	753	PF01217	0.383
TRG_ENDOCYTIC_2	641	644	PF00928	0.392
TRG_ENDOCYTIC_2	803	806	PF00928	0.591
TRG_ENDOCYTIC_2	912	915	PF00928	0.522
TRG_ER_diArg_1	269	271	PF00400	0.350
TRG_ER_diArg_1	279	281	PF00400	0.308
TRG_ER_diArg_1	395	398	PF00400	0.556
TRG_ER_diArg_1	625	627	PF00400	0.480
TRG_ER_diArg_1	678	680	PF00400	0.590
TRG_ER_diArg_1	927	929	PF00400	0.507
TRG_NES_CRM1_1	428	441	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L9	Leptomonas seymouri	47%	100%
A4H3E1	Leishmania braziliensis	69%	100%
A4HRP5	Leishmania infantum	99%	100%
E9ACC4	Leishmania major	90%	100%
E9AJL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%