LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H504_LEIDO
TriTrypDb:
LdBPK_020460.1 , LdCL_020010100 , LDHU3_02.0580
Length:
709

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H504
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H504

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 5 9 PF00656 0.735
CLV_C14_Caspase3-7 533 537 PF00656 0.783
CLV_C14_Caspase3-7 88 92 PF00656 0.707
CLV_NRD_NRD_1 226 228 PF00675 0.719
CLV_NRD_NRD_1 254 256 PF00675 0.738
CLV_NRD_NRD_1 286 288 PF00675 0.841
CLV_NRD_NRD_1 414 416 PF00675 0.729
CLV_NRD_NRD_1 554 556 PF00675 0.771
CLV_NRD_NRD_1 558 560 PF00675 0.733
CLV_NRD_NRD_1 578 580 PF00675 0.512
CLV_NRD_NRD_1 676 678 PF00675 0.751
CLV_PCSK_FUR_1 224 228 PF00082 0.791
CLV_PCSK_FUR_1 411 415 PF00082 0.731
CLV_PCSK_FUR_1 555 559 PF00082 0.726
CLV_PCSK_KEX2_1 15 17 PF00082 0.815
CLV_PCSK_KEX2_1 188 190 PF00082 0.812
CLV_PCSK_KEX2_1 226 228 PF00082 0.748
CLV_PCSK_KEX2_1 254 256 PF00082 0.738
CLV_PCSK_KEX2_1 286 288 PF00082 0.841
CLV_PCSK_KEX2_1 413 415 PF00082 0.732
CLV_PCSK_KEX2_1 556 558 PF00082 0.785
CLV_PCSK_KEX2_1 578 580 PF00082 0.767
CLV_PCSK_KEX2_1 675 677 PF00082 0.751
CLV_PCSK_PC1ET2_1 15 17 PF00082 0.815
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.812
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.785
CLV_PCSK_PC1ET2_1 675 677 PF00082 0.694
CLV_PCSK_SKI1_1 200 204 PF00082 0.772
CLV_PCSK_SKI1_1 459 463 PF00082 0.691
CLV_PCSK_SKI1_1 569 573 PF00082 0.756
CLV_PCSK_SKI1_1 694 698 PF00082 0.624
DEG_SPOP_SBC_1 309 313 PF00917 0.802
DOC_ANK_TNKS_1 528 535 PF00023 0.783
DOC_CDC14_PxL_1 164 172 PF14671 0.691
DOC_CYCLIN_RxL_1 566 575 PF00134 0.806
DOC_CYCLIN_yClb5_NLxxxL_5 181 190 PF00134 0.681
DOC_CYCLIN_yCln2_LP_2 586 592 PF00134 0.818
DOC_CYCLIN_yCln2_LP_2 680 686 PF00134 0.724
DOC_MAPK_gen_1 578 587 PF00069 0.700
DOC_MAPK_RevD_3 662 677 PF00069 0.766
DOC_MIT_MIM_1 183 193 PF04212 0.682
DOC_PP2B_LxvP_1 392 395 PF13499 0.701
DOC_PP2B_LxvP_1 703 706 PF13499 0.688
DOC_PP4_FxxP_1 150 153 PF00568 0.805
DOC_PP4_FxxP_1 166 169 PF00568 0.560
DOC_PP4_FxxP_1 391 394 PF00568 0.716
DOC_USP7_MATH_1 130 134 PF00917 0.794
DOC_USP7_MATH_1 14 18 PF00917 0.750
DOC_USP7_MATH_1 142 146 PF00917 0.630
DOC_USP7_MATH_1 264 268 PF00917 0.840
DOC_USP7_MATH_1 291 295 PF00917 0.734
DOC_USP7_MATH_1 309 313 PF00917 0.630
DOC_USP7_MATH_1 337 341 PF00917 0.612
DOC_USP7_MATH_1 366 370 PF00917 0.783
DOC_USP7_MATH_1 445 449 PF00917 0.794
DOC_USP7_MATH_1 487 491 PF00917 0.694
DOC_USP7_MATH_1 590 594 PF00917 0.769
DOC_USP7_MATH_1 606 610 PF00917 0.624
DOC_WW_Pin1_4 105 110 PF00397 0.660
DOC_WW_Pin1_4 143 148 PF00397 0.750
DOC_WW_Pin1_4 316 321 PF00397 0.790
DOC_WW_Pin1_4 430 435 PF00397 0.774
DOC_WW_Pin1_4 466 471 PF00397 0.811
DOC_WW_Pin1_4 474 479 PF00397 0.660
DOC_WW_Pin1_4 572 577 PF00397 0.665
DOC_WW_Pin1_4 617 622 PF00397 0.793
DOC_WW_Pin1_4 662 667 PF00397 0.785
DOC_WW_Pin1_4 94 99 PF00397 0.840
LIG_14-3-3_CanoR_1 397 406 PF00244 0.719
LIG_14-3-3_CanoR_1 569 577 PF00244 0.747
LIG_14-3-3_CanoR_1 578 587 PF00244 0.727
LIG_14-3-3_CanoR_1 635 644 PF00244 0.838
LIG_APCC_ABBA_1 483 488 PF00400 0.755
LIG_BIR_III_4 89 93 PF00653 0.709
LIG_BRCT_BRCA1_1 107 111 PF00533 0.715
LIG_BRCT_BRCA1_1 241 245 PF00533 0.748
LIG_BRCT_BRCA1_1 354 358 PF00533 0.674
LIG_deltaCOP1_diTrp_1 350 358 PF00928 0.668
LIG_EH1_1 338 346 PF00400 0.690
LIG_FHA_1 127 133 PF00498 0.734
LIG_FHA_1 218 224 PF00498 0.841
LIG_FHA_1 261 267 PF00498 0.708
LIG_FHA_1 30 36 PF00498 0.748
LIG_FHA_1 358 364 PF00498 0.614
LIG_FHA_1 398 404 PF00498 0.711
LIG_FHA_1 42 48 PF00498 0.598
LIG_FHA_1 478 484 PF00498 0.752
LIG_FHA_1 520 526 PF00498 0.694
LIG_FHA_1 669 675 PF00498 0.760
LIG_FHA_2 608 614 PF00498 0.636
LIG_GSK3_LRP6_1 430 435 PF00069 0.774
LIG_LIR_Apic_2 149 153 PF02991 0.811
LIG_LIR_Gen_1 350 358 PF02991 0.668
LIG_LIR_Gen_1 386 395 PF02991 0.711
LIG_LIR_Gen_1 547 554 PF02991 0.660
LIG_LIR_Nem_3 350 356 PF02991 0.663
LIG_LIR_Nem_3 386 392 PF02991 0.714
LIG_LIR_Nem_3 480 484 PF02991 0.746
LIG_LIR_Nem_3 547 553 PF02991 0.685
LIG_LIR_Nem_3 689 695 PF02991 0.738
LIG_LIR_Nem_3 70 74 PF02991 0.741
LIG_Pex14_1 498 502 PF04695 0.795
LIG_Pex14_2 354 358 PF04695 0.674
LIG_SH2_CRK 550 554 PF00017 0.719
LIG_SH2_CRK 692 696 PF00017 0.749
LIG_SH2_NCK_1 229 233 PF00017 0.719
LIG_SH2_NCK_1 550 554 PF00017 0.631
LIG_SH2_NCK_1 698 702 PF00017 0.755
LIG_SH2_PTP2 484 487 PF00017 0.748
LIG_SH2_SRC 135 138 PF00017 0.668
LIG_SH2_SRC 229 232 PF00017 0.729
LIG_SH2_SRC 484 487 PF00017 0.748
LIG_SH2_STAP1 399 403 PF00017 0.705
LIG_SH2_STAP1 550 554 PF00017 0.755
LIG_SH2_STAT5 135 138 PF00017 0.668
LIG_SH2_STAT5 353 356 PF00017 0.668
LIG_SH2_STAT5 389 392 PF00017 0.702
LIG_SH2_STAT5 399 402 PF00017 0.544
LIG_SH2_STAT5 484 487 PF00017 0.748
LIG_SH2_STAT5 71 74 PF00017 0.742
LIG_SH3_2 272 277 PF14604 0.814
LIG_SH3_3 145 151 PF00018 0.817
LIG_SH3_3 268 274 PF00018 0.719
LIG_SH3_3 277 283 PF00018 0.642
LIG_SH3_3 317 323 PF00018 0.659
LIG_SH3_3 360 366 PF00018 0.695
LIG_SH3_3 428 434 PF00018 0.765
LIG_SH3_3 464 470 PF00018 0.813
LIG_SH3_3 660 666 PF00018 0.665
LIG_TRAF2_1 513 516 PF00917 0.789
LIG_TYR_ITIM 690 695 PF00017 0.747
LIG_WW_3 575 579 PF00397 0.813
MOD_CDK_SPxK_1 572 578 PF00069 0.747
MOD_CDK_SPxK_1 617 623 PF00069 0.690
MOD_CDK_SPxxK_3 572 579 PF00069 0.812
MOD_CDK_SPxxK_3 662 669 PF00069 0.785
MOD_CDK_SPxxK_3 94 101 PF00069 0.837
MOD_CK1_1 146 152 PF00069 0.811
MOD_CK1_1 260 266 PF00069 0.765
MOD_CK1_1 311 317 PF00069 0.800
MOD_CK1_1 369 375 PF00069 0.771
MOD_CK1_1 379 385 PF00069 0.594
MOD_CK1_1 448 454 PF00069 0.720
MOD_CK1_1 477 483 PF00069 0.756
MOD_CK1_1 490 496 PF00069 0.562
MOD_CK1_1 507 513 PF00069 0.630
MOD_CK1_1 619 625 PF00069 0.787
MOD_CK1_1 629 635 PF00069 0.631
MOD_CK2_1 291 297 PF00069 0.721
MOD_CK2_1 696 702 PF00069 0.687
MOD_GlcNHglycan 114 117 PF01048 0.805
MOD_GlcNHglycan 126 129 PF01048 0.593
MOD_GlcNHglycan 2 5 PF01048 0.775
MOD_GlcNHglycan 293 296 PF01048 0.729
MOD_GlcNHglycan 330 333 PF01048 0.753
MOD_GlcNHglycan 335 338 PF01048 0.671
MOD_GlcNHglycan 368 371 PF01048 0.777
MOD_GlcNHglycan 455 459 PF01048 0.790
MOD_GlcNHglycan 464 467 PF01048 0.697
MOD_GlcNHglycan 509 512 PF01048 0.847
MOD_GlcNHglycan 582 585 PF01048 0.831
MOD_GlcNHglycan 594 597 PF01048 0.634
MOD_GlcNHglycan 638 641 PF01048 0.842
MOD_GSK3_1 120 127 PF00069 0.730
MOD_GSK3_1 14 21 PF00069 0.693
MOD_GSK3_1 142 149 PF00069 0.709
MOD_GSK3_1 235 242 PF00069 0.761
MOD_GSK3_1 253 260 PF00069 0.512
MOD_GSK3_1 333 340 PF00069 0.627
MOD_GSK3_1 365 372 PF00069 0.731
MOD_GSK3_1 379 386 PF00069 0.571
MOD_GSK3_1 462 469 PF00069 0.763
MOD_GSK3_1 503 510 PF00069 0.701
MOD_GSK3_1 607 614 PF00069 0.812
MOD_GSK3_1 615 622 PF00069 0.673
MOD_GSK3_1 626 633 PF00069 0.531
MOD_N-GLC_1 184 189 PF02516 0.635
MOD_N-GLC_1 29 34 PF02516 0.684
MOD_N-GLC_1 379 384 PF02516 0.692
MOD_N-GLC_1 507 512 PF02516 0.781
MOD_NEK2_1 181 186 PF00069 0.810
MOD_NEK2_1 310 315 PF00069 0.805
MOD_NEK2_1 335 340 PF00069 0.729
MOD_NEK2_1 357 362 PF00069 0.660
MOD_NEK2_1 383 388 PF00069 0.731
MOD_NEK2_1 462 467 PF00069 0.752
MOD_NEK2_1 571 576 PF00069 0.743
MOD_NEK2_1 61 66 PF00069 0.782
MOD_PIKK_1 18 24 PF00454 0.699
MOD_PIKK_1 630 636 PF00454 0.696
MOD_PKA_1 579 585 PF00069 0.702
MOD_PKA_2 22 28 PF00069 0.767
MOD_PKA_2 253 259 PF00069 0.798
MOD_PKA_2 260 266 PF00069 0.717
MOD_PKA_2 366 372 PF00069 0.779
MOD_PKA_2 448 454 PF00069 0.793
MOD_PKA_2 668 674 PF00069 0.761
MOD_PKB_1 16 24 PF00069 0.697
MOD_Plk_1 379 385 PF00069 0.740
MOD_Plk_1 41 47 PF00069 0.751
MOD_Plk_1 487 493 PF00069 0.589
MOD_Plk_1 51 57 PF00069 0.718
MOD_Plk_1 590 596 PF00069 0.756
MOD_Plk_4 477 483 PF00069 0.623
MOD_Plk_4 545 551 PF00069 0.726
MOD_ProDKin_1 105 111 PF00069 0.663
MOD_ProDKin_1 143 149 PF00069 0.753
MOD_ProDKin_1 316 322 PF00069 0.789
MOD_ProDKin_1 430 436 PF00069 0.772
MOD_ProDKin_1 466 472 PF00069 0.809
MOD_ProDKin_1 474 480 PF00069 0.658
MOD_ProDKin_1 572 578 PF00069 0.668
MOD_ProDKin_1 617 623 PF00069 0.795
MOD_ProDKin_1 662 668 PF00069 0.783
MOD_ProDKin_1 94 100 PF00069 0.838
MOD_SUMO_rev_2 242 250 PF00179 0.747
TRG_DiLeu_BaLyEn_6 421 426 PF01217 0.699
TRG_ENDOCYTIC_2 229 232 PF00928 0.729
TRG_ENDOCYTIC_2 353 356 PF00928 0.668
TRG_ENDOCYTIC_2 389 392 PF00928 0.709
TRG_ENDOCYTIC_2 550 553 PF00928 0.723
TRG_ENDOCYTIC_2 692 695 PF00928 0.757
TRG_ER_diArg_1 223 226 PF00400 0.732
TRG_ER_diArg_1 285 287 PF00400 0.840
TRG_ER_diArg_1 413 415 PF00400 0.732
TRG_ER_diArg_1 555 558 PF00400 0.783
TRG_ER_diArg_1 577 579 PF00400 0.759
TRG_ER_diArg_1 601 604 PF00400 0.801
TRG_NLS_MonoCore_2 554 559 PF00514 0.783
TRG_NLS_MonoExtC_3 554 559 PF00514 0.723
TRG_NLS_MonoExtN_4 555 560 PF00514 0.722
TRG_Pf-PMV_PEXEL_1 226 230 PF00026 0.747

Homologs

Protein Taxonomy Sequence identity Coverage
A4HRP4 Leishmania infantum 99% 100%
E9ACC3 Leishmania major 89% 100%
E9AJL1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS