Voltage-dependent_anion-selective_channel_putativ e/GeneDB:LmjF.02.0460

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial outer membrane protein porin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H503_LEIDO

TriTrypDb:

LdBPK_020430.1 , LdCL_020009800 , LDHU3_02.0550

Length:

291

Annotations

Annotations by Jardim et al.

Pyruvate metabolism, Mitochondrial outer membrane porin, putative (VDAC) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	17
GO:0016020	membrane	2	17
GO:0019867	outer membrane	3	17
GO:0031090	organelle membrane	3	17
GO:0031966	mitochondrial membrane	4	17
GO:0031968	organelle outer membrane	4	17
GO:0098588	bounding membrane of organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:0005739	mitochondrion	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046930	pore complex	3	1
GO:0098796	membrane protein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H503

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H503

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	1
GO:0006839	mitochondrial transport	4	2
GO:0009987	cellular process	1	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	17
GO:0005216	monoatomic ion channel activity	4	17
GO:0005244	voltage-gated monoatomic ion channel activity	4	17
GO:0005253	monoatomic anion channel activity	5	17
GO:0008308	voltage-gated monoatomic anion channel activity	5	17
GO:0008509	monoatomic anion transmembrane transporter activity	4	17
GO:0015075	monoatomic ion transmembrane transporter activity	3	17
GO:0015103	inorganic anion transmembrane transporter activity	4	17
GO:0015267	channel activity	4	17
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	17
GO:0022803	passive transmembrane transporter activity	3	17
GO:0022832	voltage-gated channel activity	6	17
GO:0022836	gated channel activity	5	17
GO:0022857	transmembrane transporter activity	2	17
GO:0015288	porin activity	6	1
GO:0022829	wide pore channel activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	131	133	PF00082	0.439
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.439
CLV_PCSK_SKI1_1	256	260	PF00082	0.584
CLV_PCSK_SKI1_1	29	33	PF00082	0.397
CLV_PCSK_SKI1_1	41	45	PF00082	0.392
CLV_PCSK_SKI1_1	91	95	PF00082	0.614
CLV_Separin_Metazoa	88	92	PF03568	0.469
DOC_CKS1_1	15	20	PF01111	0.567
DOC_MAPK_gen_1	225	234	PF00069	0.598
DOC_PP4_FxxP_1	56	59	PF00568	0.447
DOC_USP7_MATH_1	59	63	PF00917	0.518
DOC_USP7_MATH_1	7	11	PF00917	0.682
DOC_USP7_UBL2_3	22	26	PF12436	0.430
DOC_WW_Pin1_4	137	142	PF00397	0.571
DOC_WW_Pin1_4	14	19	PF00397	0.592
DOC_WW_Pin1_4	83	88	PF00397	0.516
LIG_14-3-3_CanoR_1	192	197	PF00244	0.480
LIG_14-3-3_CanoR_1	212	216	PF00244	0.260
LIG_Actin_WH2_2	67	84	PF00022	0.523
LIG_BRCT_BRCA1_1	204	208	PF00533	0.575
LIG_eIF4E_1	15	21	PF01652	0.558
LIG_FHA_1	15	21	PF00498	0.489
LIG_FHA_1	161	167	PF00498	0.468
LIG_FHA_1	188	194	PF00498	0.460
LIG_FHA_1	239	245	PF00498	0.513
LIG_FHA_1	26	32	PF00498	0.507
LIG_FHA_1	271	277	PF00498	0.458
LIG_FHA_1	52	58	PF00498	0.563
LIG_FHA_1	84	90	PF00498	0.531
LIG_FHA_2	140	146	PF00498	0.436
LIG_Integrin_RGD_1	227	229	PF01839	0.624
LIG_LIR_Apic_2	45	51	PF02991	0.412
LIG_LIR_Apic_2	53	59	PF02991	0.433
LIG_LIR_Gen_1	23	32	PF02991	0.397
LIG_LIR_Nem_3	19	24	PF02991	0.449
LIG_Pex14_1	260	264	PF04695	0.420
LIG_RPA_C_Fungi	207	219	PF08784	0.400
LIG_SH2_CRK	15	19	PF00017	0.578
LIG_SH2_CRK	24	28	PF00017	0.528
LIG_SH2_CRK	48	52	PF00017	0.551
LIG_SH2_NCK_1	15	19	PF00017	0.578
LIG_SH2_SRC	119	122	PF00017	0.514
LIG_SH2_SRC	164	167	PF00017	0.582
LIG_SH2_STAT3	99	102	PF00017	0.447
LIG_SH2_STAT5	264	267	PF00017	0.422
LIG_SH2_STAT5	73	76	PF00017	0.413
LIG_SH2_STAT5	99	102	PF00017	0.580
LIG_SH3_3	240	246	PF00018	0.576
LIG_UBA3_1	89	94	PF00899	0.501
MOD_CK1_1	122	128	PF00069	0.505
MOD_CK1_1	16	22	PF00069	0.386
MOD_CK2_1	131	137	PF00069	0.516
MOD_CK2_1	139	145	PF00069	0.529
MOD_CK2_1	274	280	PF00069	0.437
MOD_GlcNHglycan	198	201	PF01048	0.522
MOD_GlcNHglycan	5	8	PF01048	0.602
MOD_GlcNHglycan	67	70	PF01048	0.476
MOD_GlcNHglycan	9	12	PF01048	0.554
MOD_GSK3_1	127	134	PF00069	0.534
MOD_GSK3_1	192	199	PF00069	0.455
MOD_GSK3_1	270	277	PF00069	0.451
MOD_GSK3_1	3	10	PF00069	0.718
MOD_GSK3_1	93	100	PF00069	0.549
MOD_N-GLC_1	270	275	PF02516	0.403
MOD_N-GLC_2	169	171	PF02516	0.553
MOD_N-GLC_2	211	213	PF02516	0.465
MOD_NEK2_1	238	243	PF00069	0.545
MOD_NEK2_1	81	86	PF00069	0.544
MOD_NEK2_2	246	251	PF00069	0.561
MOD_NEK2_2	51	56	PF00069	0.519
MOD_PK_1	131	137	PF00069	0.556
MOD_PKA_1	131	137	PF00069	0.422
MOD_PKA_2	131	137	PF00069	0.562
MOD_PKA_2	211	217	PF00069	0.388
MOD_Plk_4	16	22	PF00069	0.428
MOD_Plk_4	202	208	PF00069	0.573
MOD_Plk_4	51	57	PF00069	0.509
MOD_ProDKin_1	137	143	PF00069	0.570
MOD_ProDKin_1	14	20	PF00069	0.581
MOD_ProDKin_1	83	89	PF00069	0.526
MOD_SUMO_rev_2	255	261	PF00179	0.367
MOD_SUMO_rev_2	62	68	PF00179	0.480
MOD_SUMO_rev_2	88	96	PF00179	0.585
TRG_ENDOCYTIC_2	24	27	PF00928	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUD3	Leptomonas seymouri	68%	98%
A0A0N1IIR1	Leptomonas seymouri	32%	100%
A0A0S4JQ02	Bodo saltans	35%	100%
A0A1X0NJX9	Trypanosomatidae	44%	100%
A0A3R7M1M0	Trypanosoma rangeli	43%	100%
A0A3S5H502	Leishmania donovani	30%	99%
A0A422NPQ5	Trypanosoma rangeli	44%	100%
A4H3D7	Leishmania braziliensis	78%	100%
A4HRP1	Leishmania infantum	30%	99%
A4HRP2	Leishmania infantum	100%	100%
C9ZJ24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACB9	Leishmania major	28%	99%
E9ACC0	Leishmania major	97%	100%
E9AJK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9AJK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%