Serine peptidase, Clan S-, family S54, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhomboid-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H501_LEIDO

TriTrypDb:

LdBPK_020400.1 , LdCL_020009400 , LDHU3_02.0510

Length:

370

Annotations

LeishMANIAdb annotations

Despite the signature matches, it is both structurally and sequence-wise very dissimilar from rhomboids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 5
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S5H501

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H501

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006066	alcohol metabolic process	3	2
GO:0006071	glycerol metabolic process	5	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019400	alditol metabolic process	4	2
GO:0019751	polyol metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901615	organic hydroxy compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004371	glycerone kinase activity	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0004175	endopeptidase activity	4	4
GO:0004252	serine-type endopeptidase activity	5	4
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	4
GO:0016787	hydrolase activity	2	4
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.365
CLV_NRD_NRD_1	188	190	PF00675	0.465
CLV_NRD_NRD_1	298	300	PF00675	0.423
CLV_NRD_NRD_1	336	338	PF00675	0.618
CLV_NRD_NRD_1	340	342	PF00675	0.619
CLV_NRD_NRD_1	349	351	PF00675	0.585
CLV_NRD_NRD_1	98	100	PF00675	0.749
CLV_PCSK_KEX2_1	173	175	PF00082	0.312
CLV_PCSK_KEX2_1	188	190	PF00082	0.482
CLV_PCSK_KEX2_1	298	300	PF00082	0.423
CLV_PCSK_KEX2_1	340	342	PF00082	0.580
CLV_PCSK_KEX2_1	348	350	PF00082	0.582
CLV_PCSK_KEX2_1	97	99	PF00082	0.746
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.350
CLV_PCSK_SKI1_1	128	132	PF00082	0.610
CLV_PCSK_SKI1_1	189	193	PF00082	0.464
CLV_PCSK_SKI1_1	256	260	PF00082	0.352
CLV_PCSK_SKI1_1	298	302	PF00082	0.425
CLV_PCSK_SKI1_1	67	71	PF00082	0.571
CLV_PCSK_SKI1_1	98	102	PF00082	0.666
DOC_CDC14_PxL_1	11	19	PF14671	0.349
DOC_CYCLIN_RxL_1	337	347	PF00134	0.337
DOC_MAPK_gen_1	298	309	PF00069	0.534
DOC_MAPK_gen_1	337	344	PF00069	0.334
DOC_MAPK_gen_1	38	48	PF00069	0.413
DOC_MAPK_MEF2A_6	302	311	PF00069	0.525
DOC_MAPK_RevD_3	323	338	PF00069	0.282
DOC_PP2B_LxvP_1	263	266	PF13499	0.583
DOC_PP2B_LxvP_1	282	285	PF13499	0.623
DOC_USP7_MATH_1	108	112	PF00917	0.483
DOC_USP7_MATH_1	114	118	PF00917	0.460
DOC_USP7_MATH_1	217	221	PF00917	0.649
DOC_USP7_MATH_1	300	304	PF00917	0.617
DOC_USP7_MATH_1	310	314	PF00917	0.566
LIG_14-3-3_CanoR_1	122	131	PF00244	0.353
LIG_14-3-3_CanoR_1	189	194	PF00244	0.697
LIG_14-3-3_CanoR_1	199	205	PF00244	0.626
LIG_14-3-3_CanoR_1	256	265	PF00244	0.554
LIG_14-3-3_CanoR_1	299	309	PF00244	0.651
LIG_14-3-3_CanoR_1	41	47	PF00244	0.377
LIG_14-3-3_CanoR_1	52	57	PF00244	0.422
LIG_BRCT_BRCA1_1	70	74	PF00533	0.388
LIG_FHA_1	167	173	PF00498	0.574
LIG_FHA_1	270	276	PF00498	0.574
LIG_FHA_1	302	308	PF00498	0.659
LIG_FHA_2	29	35	PF00498	0.354
LIG_FHA_2	77	83	PF00498	0.287
LIG_FHA_2	99	105	PF00498	0.467
LIG_LIR_Gen_1	259	269	PF02991	0.564
LIG_LIR_Gen_1	58	69	PF02991	0.367
LIG_LIR_Nem_3	259	264	PF02991	0.558
LIG_LIR_Nem_3	303	308	PF02991	0.657
LIG_LIR_Nem_3	58	64	PF02991	0.367
LIG_LIR_Nem_3	82	86	PF02991	0.450
LIG_PDZ_Class_1	365	370	PF00595	0.462
LIG_Pex14_2	257	261	PF04695	0.461
LIG_RPA_C_Fungi	169	181	PF08784	0.494
LIG_SH2_PTP2	279	282	PF00017	0.516
LIG_SH2_SRC	363	366	PF00017	0.503
LIG_SH2_STAP1	292	296	PF00017	0.528
LIG_SH2_STAT5	279	282	PF00017	0.550
LIG_SH2_STAT5	331	334	PF00017	0.355
LIG_SH2_STAT5	363	366	PF00017	0.527
LIG_Sin3_3	261	268	PF02671	0.381
LIG_SUMO_SIM_par_1	15	21	PF11976	0.365
LIG_SUMO_SIM_par_1	220	225	PF11976	0.391
LIG_TRAF2_1	225	228	PF00917	0.449
LIG_UBA3_1	60	67	PF00899	0.406
LIG_WRC_WIRS_1	73	78	PF05994	0.418
MOD_CK1_1	247	253	PF00069	0.425
MOD_CK1_1	55	61	PF00069	0.417
MOD_CK2_1	222	228	PF00069	0.452
MOD_CK2_1	76	82	PF00069	0.335
MOD_CK2_1	86	92	PF00069	0.488
MOD_GlcNHglycan	105	111	PF01048	0.630
MOD_GlcNHglycan	117	120	PF01048	0.521
MOD_GlcNHglycan	142	145	PF01048	0.446
MOD_GlcNHglycan	224	227	PF01048	0.444
MOD_GlcNHglycan	239	242	PF01048	0.305
MOD_GlcNHglycan	246	249	PF01048	0.457
MOD_GlcNHglycan	25	28	PF01048	0.548
MOD_GlcNHglycan	88	91	PF01048	0.681
MOD_GSK3_1	18	25	PF00069	0.465
MOD_GSK3_1	189	196	PF00069	0.487
MOD_GSK3_1	283	290	PF00069	0.503
MOD_GSK3_1	68	75	PF00069	0.442
MOD_N-GLC_1	166	171	PF02516	0.431
MOD_NEK2_1	222	227	PF00069	0.518
MOD_NEK2_1	301	306	PF00069	0.623
MOD_NEK2_1	344	349	PF00069	0.528
MOD_NEK2_1	76	81	PF00069	0.332
MOD_PK_1	52	58	PF00069	0.448
MOD_PKA_1	189	195	PF00069	0.445
MOD_PKA_1	98	104	PF00069	0.595
MOD_PKA_2	301	307	PF00069	0.510
MOD_PKA_2	98	104	PF00069	0.728
MOD_PKB_1	97	105	PF00069	0.572
MOD_Plk_1	166	172	PF00069	0.430
MOD_Plk_4	217	223	PF00069	0.489
MOD_Plk_4	359	365	PF00069	0.440
MOD_Plk_4	52	58	PF00069	0.486
TRG_ENDOCYTIC_2	165	168	PF00928	0.491
TRG_ENDOCYTIC_2	254	257	PF00928	0.307
TRG_ENDOCYTIC_2	279	282	PF00928	0.553
TRG_ENDOCYTIC_2	331	334	PF00928	0.475
TRG_ER_diArg_1	134	137	PF00400	0.509
TRG_ER_diArg_1	172	174	PF00400	0.440
TRG_ER_diArg_1	211	214	PF00400	0.441
TRG_ER_diArg_1	340	343	PF00400	0.472
TRG_ER_diArg_1	348	350	PF00400	0.499
TRG_ER_diArg_1	367	370	PF00400	0.512
TRG_ER_diArg_1	97	99	PF00400	0.594
TRG_NLS_Bipartite_1	173	192	PF00514	0.332
TRG_NLS_MonoExtC_3	336	341	PF00514	0.523
TRG_PTS1	367	370	PF00515	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG61	Leptomonas seymouri	56%	100%
A0A1X0NK02	Trypanosomatidae	32%	100%
A0A3R7KGS4	Trypanosoma rangeli	32%	100%
A4H3C4	Leishmania braziliensis	66%	100%
A4HRP0	Leishmania infantum	100%	100%
C9ZJ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ACB8	Leishmania major	89%	100%
E9AJK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BCY2	Trypanosoma cruzi	31%	71%