Mitochondrial protein 81

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid RNA editing protein 1, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S5H4Z9_LEIDO

TriTrypDb:

LdBPK_020380.1 , LdCL_020009200 , LDHU3_02.0480

Length:

1148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S5H4Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Z9

Function

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Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045294	alpha-catenin binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1004	1008	PF00656	0.752
CLV_C14_Caspase3-7	1066	1070	PF00656	0.556
CLV_C14_Caspase3-7	193	197	PF00656	0.638
CLV_C14_Caspase3-7	345	349	PF00656	0.563
CLV_C14_Caspase3-7	897	901	PF00656	0.587
CLV_NRD_NRD_1	1126	1128	PF00675	0.465
CLV_NRD_NRD_1	120	122	PF00675	0.562
CLV_NRD_NRD_1	127	129	PF00675	0.583
CLV_NRD_NRD_1	26	28	PF00675	0.469
CLV_NRD_NRD_1	335	337	PF00675	0.636

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0H5	Leptomonas seymouri	42%	100%
A4H3D6	Leishmania braziliensis	65%	98%
A4HRN8	Leishmania infantum	96%	100%
E9AJK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q6T446	Leishmania major	89%	99%

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