Proteasome_regulatory_non-ATPase_subunit_6_putati ve/GeneDB:LmjF.02.0370

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATPase subunit 6, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4Z8_LEIDO

TriTrypDb:

LdBPK_020340.1 , LdCL_020008800 , LDHU3_02.0450

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	10
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	11
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1

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Expansion

Sequence features

A0A3S5H4Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Z8

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.605
CLV_C14_Caspase3-7	288	292	PF00656	0.538
CLV_C14_Caspase3-7	43	47	PF00656	0.604
CLV_C14_Caspase3-7	503	507	PF00656	0.785
CLV_NRD_NRD_1	122	124	PF00675	0.410
CLV_NRD_NRD_1	126	128	PF00675	0.397
CLV_NRD_NRD_1	146	148	PF00675	0.563
CLV_NRD_NRD_1	163	165	PF00675	0.383
CLV_NRD_NRD_1	254	256	PF00675	0.474
CLV_NRD_NRD_1	339	341	PF00675	0.384

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L4	Leptomonas seymouri	79%	100%
A0A0S4JHD2	Bodo saltans	55%	100%
A0A1X0NKK6	Trypanosomatidae	60%	93%
A0A3R7KIY0	Trypanosoma rangeli	58%	100%
A4H3D3	Leishmania braziliensis	93%	100%
A4HRN4	Leishmania infantum	100%	100%
A8X379	Caenorhabditis briggsae	30%	100%
C9ZJ16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ACB2	Leishmania major	97%	100%
E9AJK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%

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