Soluble NSF attachment protein, SNAP, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Soluble NSF attachment protein, SNAP, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4Z6_LEIDO

TriTrypDb:

LdBPK_020280.1 , LdCL_020008200 , LDHU3_02.0390

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A0A3S5H4Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	7
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0033036	macromolecule localization	2	7
GO:0045184	establishment of protein localization	3	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0070727	cellular macromolecule localization	3	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0035494	SNARE complex disassembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005483	soluble NSF attachment protein activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019905	syntaxin binding	4	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.668
CLV_C14_Caspase3-7	28	32	PF00656	0.597
CLV_C14_Caspase3-7	304	308	PF00656	0.367
CLV_C14_Caspase3-7	516	520	PF00656	0.392
CLV_MEL_PAP_1	241	247	PF00089	0.585
CLV_NRD_NRD_1	189	191	PF00675	0.619
CLV_NRD_NRD_1	264	266	PF00675	0.351
CLV_NRD_NRD_1	411	413	PF00675	0.524
CLV_NRD_NRD_1	573	575	PF00675	0.504
CLV_NRD_NRD_1	679	681	PF00675	0.418
CLV_PCSK_KEX2_1	188	190	PF00082	0.587
CLV_PCSK_KEX2_1	264	266	PF00082	0.351
CLV_PCSK_KEX2_1	411	413	PF00082	0.664
CLV_PCSK_KEX2_1	679	681	PF00082	0.421
CLV_PCSK_KEX2_1	90	92	PF00082	0.635
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.635
CLV_PCSK_SKI1_1	289	293	PF00082	0.318
CLV_PCSK_SKI1_1	310	314	PF00082	0.318
CLV_PCSK_SKI1_1	393	397	PF00082	0.403
CLV_PCSK_SKI1_1	557	561	PF00082	0.356
CLV_PCSK_SKI1_1	616	620	PF00082	0.474
CLV_PCSK_SKI1_1	638	642	PF00082	0.390
CLV_PCSK_SKI1_1	680	684	PF00082	0.388
DEG_APCC_DBOX_1	521	529	PF00400	0.356
DEG_APCC_KENBOX_2	631	635	PF00400	0.402
DOC_ANK_TNKS_1	272	279	PF00023	0.246
DOC_CYCLIN_RxL_1	307	316	PF00134	0.403
DOC_CYCLIN_RxL_1	551	563	PF00134	0.384
DOC_CYCLIN_RxL_1	677	687	PF00134	0.385
DOC_MAPK_gen_1	522	531	PF00069	0.362
DOC_MAPK_MEF2A_6	340	348	PF00069	0.318
DOC_MAPK_MEF2A_6	522	531	PF00069	0.362
DOC_MAPK_MEF2A_6	591	598	PF00069	0.518
DOC_PP1_RVXF_1	287	294	PF00149	0.318
DOC_PP2B_PxIxI_1	343	349	PF00149	0.318
DOC_PP4_FxxP_1	468	471	PF00568	0.628
DOC_USP7_MATH_1	111	115	PF00917	0.662
DOC_USP7_MATH_1	165	169	PF00917	0.737
DOC_USP7_MATH_1	194	198	PF00917	0.565
DOC_USP7_MATH_1	217	221	PF00917	0.681
DOC_USP7_MATH_1	243	247	PF00917	0.588
DOC_USP7_MATH_1	25	29	PF00917	0.609
DOC_USP7_MATH_1	294	298	PF00917	0.439
DOC_USP7_MATH_1	347	351	PF00917	0.297
DOC_USP7_MATH_1	439	443	PF00917	0.708
DOC_USP7_MATH_1	77	81	PF00917	0.713
DOC_WW_Pin1_4	220	225	PF00397	0.741
DOC_WW_Pin1_4	232	237	PF00397	0.534
DOC_WW_Pin1_4	247	252	PF00397	0.618
DOC_WW_Pin1_4	429	434	PF00397	0.654
DOC_WW_Pin1_4	447	452	PF00397	0.648
DOC_WW_Pin1_4	467	472	PF00397	0.643
DOC_WW_Pin1_4	590	595	PF00397	0.613
LIG_14-3-3_CanoR_1	244	251	PF00244	0.596
LIG_14-3-3_CanoR_1	264	274	PF00244	0.401
LIG_14-3-3_CanoR_1	508	514	PF00244	0.535
LIG_14-3-3_CanoR_1	569	574	PF00244	0.548
LIG_14-3-3_CanoR_1	645	650	PF00244	0.396
LIG_14-3-3_CanoR_1	679	683	PF00244	0.443
LIG_Actin_WH2_2	325	342	PF00022	0.403
LIG_APCC_ABBA_1	396	401	PF00400	0.318
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_4	226	230	PF00653	0.635
LIG_BRCT_BRCA1_1	177	181	PF00533	0.552
LIG_BRCT_BRCA1_1	191	195	PF00533	0.588
LIG_BRCT_BRCA1_1	495	499	PF00533	0.709
LIG_BRCT_BRCA1_1	79	83	PF00533	0.640
LIG_deltaCOP1_diTrp_1	283	292	PF00928	0.318
LIG_FHA_1	144	150	PF00498	0.578
LIG_FHA_1	199	205	PF00498	0.657
LIG_FHA_1	286	292	PF00498	0.318
LIG_FHA_1	420	426	PF00498	0.551
LIG_FHA_1	430	436	PF00498	0.635
LIG_FHA_1	472	478	PF00498	0.782
LIG_FHA_1	484	490	PF00498	0.649
LIG_FHA_1	554	560	PF00498	0.388
LIG_FHA_1	561	567	PF00498	0.351
LIG_FHA_1	591	597	PF00498	0.562
LIG_FHA_2	125	131	PF00498	0.585
LIG_FHA_2	198	204	PF00498	0.616
LIG_FHA_2	266	272	PF00498	0.377
LIG_FHA_2	442	448	PF00498	0.703
LIG_FHA_2	648	654	PF00498	0.459
LIG_LIR_Apic_2	465	471	PF02991	0.622
LIG_LIR_Gen_1	235	245	PF02991	0.578
LIG_LIR_Gen_1	297	306	PF02991	0.297
LIG_LIR_Gen_1	605	612	PF02991	0.399
LIG_LIR_Gen_1	615	625	PF02991	0.437
LIG_LIR_Gen_1	681	690	PF02991	0.477
LIG_LIR_Gen_1	89	100	PF02991	0.634
LIG_LIR_Nem_3	192	198	PF02991	0.574
LIG_LIR_Nem_3	235	241	PF02991	0.572
LIG_LIR_Nem_3	297	302	PF02991	0.297
LIG_LIR_Nem_3	556	561	PF02991	0.431
LIG_LIR_Nem_3	605	611	PF02991	0.398
LIG_LIR_Nem_3	615	621	PF02991	0.423
LIG_LIR_Nem_3	89	95	PF02991	0.636
LIG_LYPXL_SIV_4	266	274	PF13949	0.377
LIG_MYND_1	433	437	PF01753	0.615
LIG_NRBOX	524	530	PF00104	0.353
LIG_PCNA_yPIPBox_3	23	34	PF02747	0.623
LIG_PCNA_yPIPBox_3	630	641	PF02747	0.370
LIG_PTAP_UEV_1	450	455	PF05743	0.666
LIG_PTB_Apo_2	316	323	PF02174	0.351
LIG_SH2_CRK	159	163	PF00017	0.519
LIG_SH2_CRK	238	242	PF00017	0.575
LIG_SH2_CRK	561	565	PF00017	0.424
LIG_SH2_NCK_1	238	242	PF00017	0.575
LIG_SH2_NCK_1	267	271	PF00017	0.308
LIG_SH2_SRC	535	538	PF00017	0.468
LIG_SH2_STAT3	358	361	PF00017	0.351
LIG_SH2_STAT5	267	270	PF00017	0.436
LIG_SH2_STAT5	558	561	PF00017	0.436
LIG_SH2_STAT5	607	610	PF00017	0.423
LIG_SH3_1	591	597	PF00018	0.520
LIG_SH3_3	11	17	PF00018	0.815
LIG_SH3_3	230	236	PF00018	0.579
LIG_SH3_3	430	436	PF00018	0.605
LIG_SH3_3	448	454	PF00018	0.665
LIG_SH3_3	461	467	PF00018	0.542
LIG_SH3_3	494	500	PF00018	0.624
LIG_SH3_3	575	581	PF00018	0.570
LIG_SH3_3	591	597	PF00018	0.455
LIG_SUMO_SIM_par_1	230	235	PF11976	0.555
LIG_SUMO_SIM_par_1	525	530	PF11976	0.469
LIG_TRAF2_1	269	272	PF00917	0.351
LIG_TRAF2_1	384	387	PF00917	0.351
LIG_TYR_ITIM	559	564	PF00017	0.426
LIG_UBA3_1	377	385	PF00899	0.450
LIG_WW_1	504	507	PF00397	0.555
LIG_WW_2	433	436	PF00397	0.611
MOD_CDK_SPK_2	467	472	PF00069	0.624
MOD_CK1_1	118	124	PF00069	0.632
MOD_CK1_1	197	203	PF00069	0.586
MOD_CK1_1	220	226	PF00069	0.652
MOD_CK1_1	470	476	PF00069	0.614
MOD_CK1_1	484	490	PF00069	0.732
MOD_CK1_1	76	82	PF00069	0.712
MOD_CK2_1	124	130	PF00069	0.588
MOD_CK2_1	197	203	PF00069	0.645
MOD_CK2_1	213	219	PF00069	0.653
MOD_CK2_1	265	271	PF00069	0.386
MOD_CK2_1	452	458	PF00069	0.578
MOD_CK2_1	660	666	PF00069	0.413
MOD_CK2_1	678	684	PF00069	0.474
MOD_GlcNHglycan	117	120	PF01048	0.719
MOD_GlcNHglycan	164	168	PF01048	0.733
MOD_GlcNHglycan	191	194	PF01048	0.667
MOD_GlcNHglycan	215	218	PF01048	0.639
MOD_GlcNHglycan	219	222	PF01048	0.658
MOD_GlcNHglycan	226	230	PF01048	0.699
MOD_GlcNHglycan	3	6	PF01048	0.629
MOD_GlcNHglycan	42	45	PF01048	0.653
MOD_GlcNHglycan	437	440	PF01048	0.656
MOD_GlcNHglycan	454	457	PF01048	0.772
MOD_GlcNHglycan	479	482	PF01048	0.693
MOD_GlcNHglycan	600	603	PF01048	0.485
MOD_GlcNHglycan	61	64	PF01048	0.673
MOD_GlcNHglycan	75	78	PF01048	0.642
MOD_GlcNHglycan	83	86	PF01048	0.670
MOD_GSK3_1	1	8	PF00069	0.762
MOD_GSK3_1	111	118	PF00069	0.676
MOD_GSK3_1	194	201	PF00069	0.597
MOD_GSK3_1	213	220	PF00069	0.623
MOD_GSK3_1	243	250	PF00069	0.603
MOD_GSK3_1	328	335	PF00069	0.327
MOD_GSK3_1	435	442	PF00069	0.690
MOD_GSK3_1	467	474	PF00069	0.613
MOD_GSK3_1	477	484	PF00069	0.701
MOD_GSK3_1	48	55	PF00069	0.722
MOD_GSK3_1	509	516	PF00069	0.468
MOD_GSK3_1	549	556	PF00069	0.420
MOD_GSK3_1	592	599	PF00069	0.699
MOD_GSK3_1	607	614	PF00069	0.298
MOD_GSK3_1	73	80	PF00069	0.665
MOD_GSK3_1	98	105	PF00069	0.622
MOD_N-GLC_1	143	148	PF02516	0.525
MOD_N-GLC_1	323	328	PF02516	0.397
MOD_NEK2_1	1	6	PF00069	0.647
MOD_NEK2_1	124	129	PF00069	0.615
MOD_NEK2_1	143	148	PF00069	0.584
MOD_NEK2_1	313	318	PF00069	0.327
MOD_NEK2_1	339	344	PF00069	0.444
MOD_NEK2_1	485	490	PF00069	0.648
MOD_NEK2_1	517	522	PF00069	0.409
MOD_NEK2_1	560	565	PF00069	0.340
MOD_NEK2_1	598	603	PF00069	0.609
MOD_NEK2_2	294	299	PF00069	0.351
MOD_NEK2_2	602	607	PF00069	0.438
MOD_NEK2_2	678	683	PF00069	0.437
MOD_PIKK_1	118	124	PF00454	0.824
MOD_PIKK_1	6	12	PF00454	0.721
MOD_PK_1	493	499	PF00069	0.593
MOD_PK_1	569	575	PF00069	0.509
MOD_PKA_1	189	195	PF00069	0.559
MOD_PKA_1	574	580	PF00069	0.544
MOD_PKA_2	124	130	PF00069	0.614
MOD_PKA_2	189	195	PF00069	0.606
MOD_PKA_2	243	249	PF00069	0.568
MOD_PKA_2	507	513	PF00069	0.593
MOD_PKA_2	59	65	PF00069	0.779
MOD_PKA_2	678	684	PF00069	0.440
MOD_Plk_1	457	463	PF00069	0.694
MOD_Plk_1	624	630	PF00069	0.525
MOD_Plk_4	25	31	PF00069	0.662
MOD_Plk_4	294	300	PF00069	0.461
MOD_Plk_4	313	319	PF00069	0.318
MOD_Plk_4	347	353	PF00069	0.297
MOD_Plk_4	527	533	PF00069	0.440
MOD_Plk_4	602	608	PF00069	0.470
MOD_ProDKin_1	220	226	PF00069	0.741
MOD_ProDKin_1	232	238	PF00069	0.535
MOD_ProDKin_1	247	253	PF00069	0.609
MOD_ProDKin_1	429	435	PF00069	0.657
MOD_ProDKin_1	447	453	PF00069	0.648
MOD_ProDKin_1	467	473	PF00069	0.643
MOD_ProDKin_1	590	596	PF00069	0.611
MOD_SUMO_for_1	384	387	PF00179	0.351
MOD_SUMO_rev_2	397	405	PF00179	0.331
TRG_DiLeu_BaEn_1	255	260	PF01217	0.318
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.284
TRG_ENDOCYTIC_2	159	162	PF00928	0.515
TRG_ENDOCYTIC_2	238	241	PF00928	0.574
TRG_ENDOCYTIC_2	561	564	PF00928	0.424
TRG_ER_diArg_1	188	190	PF00400	0.625
TRG_ER_diArg_1	411	413	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	680	684	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E1	Leptomonas seymouri	45%	89%
A4H3C9	Leishmania braziliensis	63%	100%
A4HRM8	Leishmania infantum	100%	100%
E9ACA6	Leishmania major	89%	100%
E9AJJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	96%