Protein kinase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitogen-activated kinase kinase kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4Z4_LEIDO

TriTrypDb:

LdBPK_020260.1 , LdCL_020008000 , LDHU3_02.0360

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H4Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Z4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0019538	protein metabolic process	3	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	23
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23
GO:0004674	protein serine/threonine kinase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.304
CLV_C14_Caspase3-7	58	62	PF00656	0.500
CLV_NRD_NRD_1	256	258	PF00675	0.309
CLV_NRD_NRD_1	448	450	PF00675	0.253
CLV_PCSK_KEX2_1	256	258	PF00082	0.309
CLV_PCSK_KEX2_1	448	450	PF00082	0.255
CLV_PCSK_PC7_1	444	450	PF00082	0.250
CLV_PCSK_SKI1_1	211	215	PF00082	0.223
CLV_PCSK_SKI1_1	317	321	PF00082	0.320
CLV_PCSK_SKI1_1	427	431	PF00082	0.391
CLV_PCSK_SKI1_1	448	452	PF00082	0.263
DEG_APCC_DBOX_1	443	451	PF00400	0.254
DEG_APCC_DBOX_1	456	464	PF00400	0.381
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DEG_SIAH_1	73	81	PF03145	0.479
DOC_ANK_TNKS_1	491	498	PF00023	0.383
DOC_CDC14_PxL_1	359	367	PF14671	0.288
DOC_CYCLIN_RxL_1	387	398	PF00134	0.227
DOC_MAPK_gen_1	317	326	PF00069	0.314
DOC_USP7_MATH_1	121	125	PF00917	0.765
DOC_USP7_MATH_1	304	308	PF00917	0.328
DOC_USP7_MATH_1	46	50	PF00917	0.638
DOC_USP7_MATH_1	484	488	PF00917	0.652
DOC_USP7_MATH_1	522	526	PF00917	0.418
DOC_USP7_MATH_1	54	58	PF00917	0.675
DOC_WW_Pin1_4	266	271	PF00397	0.266
DOC_WW_Pin1_4	354	359	PF00397	0.314
DOC_WW_Pin1_4	409	414	PF00397	0.330
DOC_WW_Pin1_4	88	93	PF00397	0.677
LIG_14-3-3_CanoR_1	492	499	PF00244	0.545
LIG_14-3-3_CterR_2	526	530	PF00244	0.561
LIG_Actin_WH2_2	196	213	PF00022	0.212
LIG_Actin_WH2_2	432	450	PF00022	0.244
LIG_BRCT_BRCA1_1	425	429	PF00533	0.283
LIG_Clathr_ClatBox_1	436	440	PF01394	0.357
LIG_deltaCOP1_diTrp_1	376	384	PF00928	0.328
LIG_deltaCOP1_diTrp_1	6	10	PF00928	0.624
LIG_eIF4E_1	360	366	PF01652	0.328
LIG_FHA_1	105	111	PF00498	0.520
LIG_FHA_1	178	184	PF00498	0.296
LIG_FHA_1	330	336	PF00498	0.315
LIG_FHA_2	25	31	PF00498	0.744
LIG_FHA_2	340	346	PF00498	0.328
LIG_FHA_2	348	354	PF00498	0.328
LIG_FHA_2	56	62	PF00498	0.492
LIG_FHA_2	7	13	PF00498	0.679
LIG_HOMEOBOX	5	8	PF00046	0.513
LIG_LIR_Apic_2	357	363	PF02991	0.314
LIG_LIR_Gen_1	2	10	PF02991	0.637
LIG_LIR_Gen_1	237	245	PF02991	0.223
LIG_LIR_Gen_1	296	305	PF02991	0.314
LIG_LIR_Nem_3	146	150	PF02991	0.454
LIG_LIR_Nem_3	296	301	PF02991	0.464
LIG_LIR_Nem_3	310	315	PF02991	0.273
LIG_LIR_Nem_3	426	432	PF02991	0.283
LIG_LIR_Nem_3	496	502	PF02991	0.463
LIG_LIR_Nem_3	6	10	PF02991	0.624
LIG_LYPXL_S_1	520	524	PF13949	0.350
LIG_LYPXL_yS_3	521	524	PF13949	0.365
LIG_Rb_pABgroove_1	221	229	PF01858	0.328
LIG_SH2_CRK	312	316	PF00017	0.328
LIG_SH2_CRK	385	389	PF00017	0.244
LIG_SH2_CRK	499	503	PF00017	0.306
LIG_SH2_SRC	222	225	PF00017	0.269
LIG_SH2_SRC	462	465	PF00017	0.284
LIG_SH2_STAP1	425	429	PF00017	0.356
LIG_SH2_STAT3	128	131	PF00017	0.569
LIG_SH2_STAT3	425	428	PF00017	0.328
LIG_SH2_STAT5	222	225	PF00017	0.306
LIG_SH2_STAT5	243	246	PF00017	0.312
LIG_SH2_STAT5	455	458	PF00017	0.336
LIG_SH2_STAT5	462	465	PF00017	0.296
LIG_SH3_2	473	478	PF14604	0.392
LIG_SH3_3	229	235	PF00018	0.474
LIG_SH3_3	264	270	PF00018	0.220
LIG_SH3_3	470	476	PF00018	0.375
LIG_SUMO_SIM_par_1	272	279	PF11976	0.178
LIG_SUMO_SIM_par_1	434	440	PF11976	0.355
LIG_TRAF2_1	196	199	PF00917	0.223
LIG_TYR_ITIM	383	388	PF00017	0.294
LIG_WW_1	231	234	PF00397	0.207
MOD_CK1_1	143	149	PF00069	0.537
MOD_CK1_1	260	266	PF00069	0.349
MOD_CK1_1	269	275	PF00069	0.344
MOD_CK1_1	307	313	PF00069	0.328
MOD_CK1_1	423	429	PF00069	0.416
MOD_CK1_1	435	441	PF00069	0.237
MOD_CK1_1	466	472	PF00069	0.608
MOD_CK1_1	49	55	PF00069	0.668
MOD_CK1_1	88	94	PF00069	0.550
MOD_CK2_1	347	353	PF00069	0.364
MOD_CK2_1	395	401	PF00069	0.403
MOD_Cter_Amidation	254	257	PF01082	0.207
MOD_GlcNHglycan	12	17	PF01048	0.755
MOD_GlcNHglycan	123	126	PF01048	0.679
MOD_GlcNHglycan	132	135	PF01048	0.586
MOD_GlcNHglycan	142	145	PF01048	0.473
MOD_GlcNHglycan	173	176	PF01048	0.243
MOD_GlcNHglycan	20	23	PF01048	0.657
MOD_GlcNHglycan	259	262	PF01048	0.409
MOD_GlcNHglycan	397	400	PF01048	0.359
MOD_GlcNHglycan	480	483	PF01048	0.567
MOD_GlcNHglycan	493	496	PF01048	0.666
MOD_GlcNHglycan	82	85	PF01048	0.688
MOD_GSK3_1	226	233	PF00069	0.465
MOD_GSK3_1	255	262	PF00069	0.305
MOD_GSK3_1	265	272	PF00069	0.394
MOD_GSK3_1	275	282	PF00069	0.353
MOD_GSK3_1	431	438	PF00069	0.310
MOD_GSK3_1	522	529	PF00069	0.567
MOD_GSK3_1	55	62	PF00069	0.504
MOD_GSK3_1	80	87	PF00069	0.616
MOD_NEK2_1	226	231	PF00069	0.361
MOD_NEK2_1	275	280	PF00069	0.311
MOD_NEK2_1	338	343	PF00069	0.234
MOD_NEK2_1	432	437	PF00069	0.223
MOD_NEK2_2	162	167	PF00069	0.244
MOD_NEK2_2	293	298	PF00069	0.383
MOD_NEK2_2	304	309	PF00069	0.281
MOD_NEK2_2	94	99	PF00069	0.525
MOD_PIKK_1	339	345	PF00454	0.223
MOD_PIKK_1	510	516	PF00454	0.298
MOD_PKA_2	255	261	PF00069	0.346
MOD_PKA_2	423	429	PF00069	0.460
MOD_PKA_2	443	449	PF00069	0.283
MOD_PKA_2	456	462	PF00069	0.385
MOD_PKA_2	491	497	PF00069	0.661
MOD_PKA_2	80	86	PF00069	0.482
MOD_Plk_2-3	6	12	PF00069	0.494
MOD_Plk_4	162	168	PF00069	0.303
MOD_Plk_4	189	195	PF00069	0.354
MOD_Plk_4	234	240	PF00069	0.445
MOD_Plk_4	293	299	PF00069	0.277
MOD_Plk_4	432	438	PF00069	0.226
MOD_Plk_4	463	469	PF00069	0.380
MOD_ProDKin_1	266	272	PF00069	0.266
MOD_ProDKin_1	354	360	PF00069	0.314
MOD_ProDKin_1	409	415	PF00069	0.330
MOD_ProDKin_1	88	94	PF00069	0.682
TRG_DiLeu_BaEn_1	401	406	PF01217	0.223
TRG_ENDOCYTIC_2	312	315	PF00928	0.280
TRG_ENDOCYTIC_2	385	388	PF00928	0.323
TRG_ENDOCYTIC_2	499	502	PF00928	0.311
TRG_ENDOCYTIC_2	521	524	PF00928	0.365
TRG_ER_diArg_1	152	155	PF00400	0.275
TRG_ER_diArg_1	447	449	PF00400	0.244
TRG_NES_CRM1_1	329	343	PF08389	0.223

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D3	Leptomonas seymouri	52%	100%
A0A0N1I9A0	Leptomonas seymouri	26%	82%
A0A0S4J757	Bodo saltans	25%	98%
A0A0S4J842	Bodo saltans	27%	99%
A0A0S4JIJ6	Bodo saltans	26%	94%
A0A0S4JMY6	Bodo saltans	24%	69%
A0A1X0NIX2	Trypanosomatidae	26%	100%
A0A1X0NKA1	Trypanosomatidae	39%	100%
A0A1X0NTN5	Trypanosomatidae	24%	70%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	25%	100%
A0A3Q8IAQ1	Leishmania donovani	33%	100%
A0A3Q8IFK8	Leishmania donovani	28%	100%
A0A3Q8IFW0	Leishmania donovani	31%	100%
A0A3Q8IIG1	Leishmania donovani	28%	100%
A0A3Q8IIY5	Leishmania donovani	24%	100%
A0A3Q8IPJ5	Leishmania donovani	26%	100%
A0A3R7NGF4	Trypanosoma rangeli	27%	94%
A0A3S5H789	Leishmania donovani	27%	100%
A0A3S7WWE7	Leishmania donovani	28%	100%
A0A3S7X6T8	Leishmania donovani	28%	100%
A0A422N701	Trypanosoma rangeli	41%	100%
A0A422NT89	Trypanosoma rangeli	23%	81%
A4H3C7	Leishmania braziliensis	77%	100%
A4HAS1	Leishmania braziliensis	24%	100%
A4HBL4	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	30%	100%
A4HFA1	Leishmania braziliensis	26%	100%
A4HH03	Leishmania braziliensis	30%	100%
A4HHP8	Leishmania braziliensis	28%	100%
A4HJT5	Leishmania braziliensis	28%	100%
A4HJW2	Leishmania braziliensis	31%	100%
A4HLR0	Leishmania braziliensis	28%	100%
A4HRM6	Leishmania infantum	100%	100%
A4HYX6	Leishmania infantum	27%	100%
A4HZA2	Leishmania infantum	29%	100%
A4HZW8	Leishmania infantum	33%	100%
A4I2H8	Leishmania infantum	26%	100%
A4I435	Leishmania infantum	28%	100%
A4I7A1	Leishmania infantum	28%	100%
A4I7C4	Leishmania infantum	31%	100%
A4I960	Leishmania infantum	28%	100%
A5GFW1	Sus scrofa	25%	100%
C9ZIZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZK32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
C9ZQL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	83%
E9ACA4	Leishmania major	94%	100%
E9AE77	Leishmania major	24%	100%
E9AEB1	Leishmania major	28%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AYN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
F4JBP3	Arabidopsis thaliana	28%	75%
P22209	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P31748	AKT8 murine leukemia virus	25%	100%
P31749	Homo sapiens	25%	100%
P31750	Mus musculus	25%	100%
P34101	Dictyostelium discoideum	24%	89%
P47196	Rattus norvegicus	25%	100%
P49101	Zea mays	26%	100%
P51956	Homo sapiens	26%	100%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	25%	100%
P62344	Plasmodium falciparum (isolate 3D7)	25%	100%
Q01314	Bos taurus	25%	100%
Q07832	Mus musculus	27%	88%
Q0VD22	Bos taurus	24%	100%
Q15349	Homo sapiens	25%	72%
Q38870	Arabidopsis thaliana	25%	82%
Q4Q3Y9	Leishmania major	27%	100%
Q4Q5T9	Leishmania major	31%	100%
Q4Q5W2	Leishmania major	29%	100%
Q4Q7W2	Leishmania major	28%	100%
Q4Q8T4	Leishmania major	26%	100%
Q4QBQ2	Leishmania major	34%	100%
Q4QCK0	Leishmania major	28%	100%
Q4QEJ2	Leishmania major	26%	96%
Q5UQ78	Acanthamoeba polyphaga mimivirus	24%	100%
Q5VQQ5	Oryza sativa subsp. japonica	28%	100%
Q60EY8	Oryza sativa subsp. japonica	27%	100%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q6Z2M9	Oryza sativa subsp. japonica	27%	100%
Q7XIM0	Oryza sativa subsp. japonica	29%	93%
Q852N6	Oryza sativa subsp. japonica	28%	92%
Q9H4B4	Homo sapiens	27%	82%
Q9NJU9	Plasmodium falciparum (isolate 3D7)	22%	94%
Q9WUT3	Mus musculus	27%	72%
Q9Y6E0	Homo sapiens	26%	100%
V5BHW8	Trypanosoma cruzi	25%	84%
V5DC27	Trypanosoma cruzi	29%	90%