Small_GTP_binding_protein_rab6-like_protein/GeneD B:LmjF.02.0260

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small GTP binding protein rab6-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H4Z2_LEIDO

TriTrypDb:

LdBPK_020230.1 , LdCL_020007700 , LDHU3_02.0330

Length:

274

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Small GTP binding rab6-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H4Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Z2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.371
CLV_PCSK_KEX2_1	146	148	PF00082	0.282
CLV_PCSK_SKI1_1	177	181	PF00082	0.295
CLV_PCSK_SKI1_1	26	30	PF00082	0.261
DEG_Nend_UBRbox_3	1	3	PF02207	0.657
DEG_SPOP_SBC_1	17	21	PF00917	0.617
DOC_CKS1_1	239	244	PF01111	0.570
DOC_PP2B_LxvP_1	187	190	PF13499	0.499
DOC_PP2B_PxIxI_1	54	60	PF00149	0.398
DOC_USP7_MATH_1	17	21	PF00917	0.554
DOC_USP7_MATH_1	202	206	PF00917	0.693
DOC_USP7_MATH_1	213	217	PF00917	0.690
DOC_WW_Pin1_4	200	205	PF00397	0.546
DOC_WW_Pin1_4	233	238	PF00397	0.563
LIG_14-3-3_CanoR_1	86	91	PF00244	0.284
LIG_14-3-3_CanoR_1	96	104	PF00244	0.303
LIG_FHA_1	36	42	PF00498	0.297
LIG_FHA_1	54	60	PF00498	0.280
LIG_FHA_1	63	69	PF00498	0.294
LIG_FHA_1	99	105	PF00498	0.277
LIG_LIR_Gen_1	112	120	PF02991	0.401
LIG_LIR_Gen_1	85	95	PF02991	0.398
LIG_LIR_Nem_3	112	117	PF02991	0.274
LIG_LIR_Nem_3	85	90	PF02991	0.261
LIG_Pex14_2	113	117	PF04695	0.276
LIG_REV1ctd_RIR_1	59	68	PF16727	0.277
LIG_SH2_STAT5	94	97	PF00017	0.261
LIG_SH3_3	231	237	PF00018	0.664
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.352
LIG_SUMO_SIM_par_1	100	106	PF11976	0.282
LIG_SUMO_SIM_par_1	26	32	PF11976	0.277
LIG_SxIP_EBH_1	86	97	PF03271	0.277
LIG_TRAF2_1	150	153	PF00917	0.277
LIG_TRAF2_1	82	85	PF00917	0.261
LIG_WRC_WIRS_1	46	51	PF05994	0.261
MOD_CK1_1	109	115	PF00069	0.262
MOD_CK1_1	16	22	PF00069	0.390
MOD_CK1_1	249	255	PF00069	0.654
MOD_CK1_1	3	9	PF00069	0.636
MOD_CK1_1	39	45	PF00069	0.277
MOD_CK1_1	98	104	PF00069	0.292
MOD_CK2_1	147	153	PF00069	0.261
MOD_GlcNHglycan	114	117	PF01048	0.358
MOD_GlcNHglycan	126	129	PF01048	0.347
MOD_GlcNHglycan	148	152	PF01048	0.398
MOD_GlcNHglycan	15	18	PF01048	0.421
MOD_GlcNHglycan	167	171	PF01048	0.261
MOD_GlcNHglycan	2	5	PF01048	0.664
MOD_GlcNHglycan	205	208	PF01048	0.658
MOD_GlcNHglycan	215	218	PF01048	0.677
MOD_GlcNHglycan	225	228	PF01048	0.729
MOD_GlcNHglycan	242	245	PF01048	0.610
MOD_GlcNHglycan	97	100	PF01048	0.273
MOD_GSK3_1	105	112	PF00069	0.113
MOD_GSK3_1	13	20	PF00069	0.672
MOD_GSK3_1	31	38	PF00069	0.194
MOD_GSK3_1	86	93	PF00069	0.277
MOD_N-GLC_1	249	254	PF02516	0.694
MOD_NEK2_1	166	171	PF00069	0.283
MOD_NEK2_1	62	67	PF00069	0.261
MOD_NEK2_1	78	83	PF00069	0.354
MOD_PKA_1	156	162	PF00069	0.352
MOD_PKA_2	109	115	PF00069	0.288
MOD_PKA_2	95	101	PF00069	0.282
MOD_Plk_1	31	37	PF00069	0.277
MOD_Plk_4	109	115	PF00069	0.277
MOD_Plk_4	36	42	PF00069	0.284
MOD_Plk_4	86	92	PF00069	0.277
MOD_Plk_4	98	104	PF00069	0.233
MOD_ProDKin_1	200	206	PF00069	0.546
MOD_ProDKin_1	233	239	PF00069	0.565
TRG_ENDOCYTIC_2	46	49	PF00928	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A0	Leptomonas seymouri	68%	100%
A0A0N0P6P8	Leptomonas seymouri	36%	100%
A0A0N0P8I1	Leptomonas seymouri	35%	100%
A0A0N0P971	Leptomonas seymouri	30%	100%
A0A0N1HU31	Leptomonas seymouri	31%	100%
A0A0N1HYV5	Leptomonas seymouri	37%	100%
A0A0N1I5E3	Leptomonas seymouri	32%	100%
A0A0N1IJ36	Leptomonas seymouri	36%	100%
A0A0S4IJB7	Bodo saltans	34%	100%
A0A0S4IRD6	Bodo saltans	30%	100%
A0A0S4IWG2	Bodo saltans	25%	79%
A0A0S4IY79	Bodo saltans	33%	100%
A0A0S4J1G8	Bodo saltans	38%	100%
A0A0S4J9T5	Bodo saltans	32%	100%
A0A0S4JBJ9	Bodo saltans	40%	100%
A0A0S4JDW3	Bodo saltans	60%	100%
A0A0S4JJX5	Bodo saltans	29%	100%
A0A0S4JKI9	Bodo saltans	32%	100%
A0A0S4JQT6	Bodo saltans	26%	100%
A0A0S4JR87	Bodo saltans	35%	100%
A0A0S4JVK4	Bodo saltans	35%	100%
A0A0S4KHE5	Bodo saltans	38%	100%
A0A1X0NLK7	Trypanosomatidae	33%	100%
A0A1X0NLM1	Trypanosomatidae	58%	100%
A0A1X0NN55	Trypanosomatidae	23%	100%
A0A1X0NN96	Trypanosomatidae	40%	100%
A0A1X0NQ87	Trypanosomatidae	34%	74%
A0A1X0NQG4	Trypanosomatidae	32%	100%
A0A1X0NVM5	Trypanosomatidae	35%	100%
A0A1X0NXM2	Trypanosomatidae	37%	81%
A0A1X0P1V3	Trypanosomatidae	36%	100%
A0A1X0P706	Trypanosomatidae	33%	100%
A0A3Q8I8T8	Leishmania donovani	38%	100%
A0A3Q8IC02	Leishmania donovani	37%	100%
A0A3Q8ICX9	Leishmania donovani	38%	100%
A0A3Q8ID64	Leishmania donovani	36%	100%
A0A3Q8IE68	Leishmania donovani	36%	100%
A0A3Q8IK84	Leishmania donovani	37%	100%
A0A3R7KA22	Trypanosoma rangeli	31%	100%
A0A3R7KBN3	Trypanosoma rangeli	35%	100%
A0A3R7LXW6	Trypanosoma rangeli	32%	100%
A0A3R7LYA6	Trypanosoma rangeli	28%	100%
A0A3R7N3U0	Trypanosoma rangeli	27%	100%
A0A3R7N6U0	Trypanosoma rangeli	56%	100%
A0A3R7RHV7	Trypanosoma rangeli	32%	100%
A0A3R7RKC1	Trypanosoma rangeli	32%	100%
A0A3S5H5Y5	Leishmania donovani	37%	100%
A0A3S5H6H3	Leishmania donovani	30%	100%
A0A3S5H7K4	Leishmania donovani	31%	100%
A0A3S7WRA9	Leishmania donovani	37%	100%
A0A3S7WV84	Leishmania donovani	38%	100%
A0A3S7X3D1	Leishmania donovani	35%	100%
A0A3S7X5J2	Leishmania donovani	30%	100%
A0A422MUR1	Trypanosoma rangeli	37%	100%
A0A422P0L6	Trypanosoma rangeli	39%	100%
A1KXP5	Leishmania donovani	44%	100%
A4D1S5	Homo sapiens	38%	100%
A4H506	Leishmania braziliensis	38%	100%
A4H679	Leishmania braziliensis	38%	100%
A4H6A4	Leishmania braziliensis	39%	100%
A4H6A5	Leishmania braziliensis	32%	100%
A4H9M3	Leishmania braziliensis	37%	100%
A4HBS6	Leishmania braziliensis	37%	100%
A4HEE8	Leishmania braziliensis	31%	100%
A4HFK0	Leishmania braziliensis	36%	100%
A4HH17	Leishmania braziliensis	30%	100%
A4HHR8	Leishmania braziliensis	42%	100%
A4HIB4	Leishmania braziliensis	34%	100%
A4HK33	Leishmania braziliensis	39%	100%
A4HKH2	Leishmania braziliensis	29%	100%
A4HKJ3	Leishmania braziliensis	38%	100%
A4HLP5	Leishmania braziliensis	35%	100%
A4HQE5	Leishmania braziliensis	33%	92%
A4HRM3	Leishmania infantum	100%	100%
A4HT72	Leishmania infantum	38%	100%
A4HUK3	Leishmania infantum	37%	100%
A4HUM8	Leishmania infantum	38%	100%
A4HUM9	Leishmania infantum	31%	100%
A4HVF7	Leishmania infantum	44%	100%
A4HXY7	Leishmania infantum	38%	100%
A4HZ80	Leishmania infantum	37%	100%
A4I1I6	Leishmania infantum	31%	100%
A4I446	Leishmania infantum	31%	100%
A4I5J8	Leishmania infantum	35%	100%
A4I7N3	Leishmania infantum	38%	100%
A4I7Z9	Leishmania infantum	31%	100%
A4I825	Leishmania infantum	36%	100%
A4I946	Leishmania infantum	37%	100%
B1A5Z4	Leishmania donovani	31%	100%
B6DT76	Bodo saltans	36%	100%
C9ZIZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
C9ZQX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZUL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZVR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZZR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	81%
D0A3U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A6V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E2RQ15	Canis lupus familiaris	33%	100%
E9ACA1	Leishmania major	95%	100%
E9AD53	Leishmania major	37%	100%
E9ADL1	Leishmania major	30%	100%
E9AHE8	Leishmania infantum	36%	100%
E9AJI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AM70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AV47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
M0RC99	Rattus norvegicus	41%	100%
O01803	Caenorhabditis elegans	33%	100%
O04486	Arabidopsis thaliana	32%	100%
O14966	Homo sapiens	32%	100%
O23561	Arabidopsis thaliana	38%	100%
O23657	Arabidopsis thaliana	39%	100%
P01123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P07560	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P11023	Bos taurus	34%	100%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P17609	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P17610	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P18066	Canis lupus familiaris	41%	100%
P20336	Homo sapiens	34%	100%
P20339	Homo sapiens	41%	100%
P22125	Diplobatis ommata	37%	100%
P22127	Diplobatis ommata	38%	100%
P24409	Canis lupus familiaris	39%	100%
P25228	Drosophila melanogaster	36%	100%
P28186	Arabidopsis thaliana	34%	100%
P28188	Arabidopsis thaliana	37%	100%
P31583	Nicotiana plumbaginifolia	43%	100%
P33723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
P34140	Dictyostelium discoideum	36%	100%
P35276	Mus musculus	36%	100%
P35278	Mus musculus	43%	100%
P35281	Rattus norvegicus	37%	100%
P35282	Mus musculus	35%	100%
P35293	Mus musculus	38%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P36412	Dictyostelium discoideum	34%	100%
P36862	Volvox carteri	37%	100%
P36863	Volvox carteri	35%	100%
P41924	Yarrowia lipolytica (strain CLIB 122 / E 150)	35%	100%
P46629	Oryctolagus cuniculus	35%	100%
P51147	Canis lupus familiaris	42%	100%
P51148	Homo sapiens	43%	100%
P55745	Canis lupus familiaris	35%	100%
P61020	Homo sapiens	42%	100%
P61021	Mus musculus	42%	100%
P61026	Homo sapiens	39%	100%
P61027	Mus musculus	39%	100%
P61028	Mus musculus	38%	100%
P61271	Macaca fascicularis	41%	100%
P63011	Mus musculus	34%	100%
P63012	Rattus norvegicus	34%	100%
P70550	Rattus norvegicus	38%	100%
P91580	Ciona intestinalis	35%	100%
P97950	Mus musculus	37%	100%
Q01387	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q01890	Phytophthora infestans	36%	100%
Q05974	Lymnaea stagnalis	35%	100%
Q06AU3	Sus scrofa	34%	100%
Q06AU6	Sus scrofa	42%	100%
Q06AU7	Sus scrofa	35%	100%
Q0IIG7	Bos taurus	42%	100%
Q13636	Homo sapiens	39%	100%
Q14964	Homo sapiens	34%	100%
Q17R06	Bos taurus	36%	100%
Q1ZXE7	Dictyostelium discoideum	32%	100%
Q2HJH2	Bos taurus	36%	100%
Q2HJI8	Bos taurus	38%	100%
Q39433	Beta vulgaris	34%	100%
Q39434	Beta vulgaris	33%	100%
Q3ZC27	Bos taurus	38%	100%
Q40191	Lotus japonicus	34%	100%
Q40193	Lotus japonicus	33%	100%
Q40194	Lotus japonicus	35%	100%
Q4Q404	Leishmania major	36%	100%
Q4Q573	Leishmania major	36%	100%
Q4Q595	Leishmania major	31%	100%
Q4Q5N4	Leishmania major	38%	100%
Q4Q7C3	Leishmania major	34%	100%
Q4Q9V1	Leishmania major	31%	100%
Q4QCD4	Leishmania major	37%	100%
Q4QDS9	Leishmania major	38%	100%
Q4QGD2	Leishmania major	44%	100%
Q4QH97	Leishmania major	30%	100%
Q4QH98	Leishmania major	38%	100%
Q4QHC3	Leishmania major	38%	100%
Q4QIN6	Leishmania major	38%	100%
Q4R4R9	Macaca fascicularis	34%	100%
Q4R8X3	Macaca fascicularis	36%	100%
Q4UB16	Theileria annulata	32%	100%
Q54DA7	Dictyostelium discoideum	38%	100%
Q54P07	Dictyostelium discoideum	32%	100%
Q54RX9	Dictyostelium discoideum	38%	100%
Q55E31	Dictyostelium discoideum	33%	100%
Q55FU9	Dictyostelium discoideum	32%	100%
Q58DS9	Bos taurus	43%	100%
Q5EB77	Rattus norvegicus	38%	100%
Q5M7D1	Xenopus laevis	27%	99%
Q5R4W9	Pongo abelii	33%	100%
Q5R5U1	Pongo abelii	39%	100%
Q5R7A4	Pongo abelii	32%	100%
Q5R7L7	Pongo abelii	43%	100%
Q5RBG1	Pongo abelii	42%	100%
Q5RE13	Pongo abelii	36%	100%
Q5ZHW4	Gallus gallus	45%	100%
Q5ZIT5	Gallus gallus	38%	100%
Q63481	Rattus norvegicus	32%	100%
Q63942	Rattus norvegicus	34%	100%
Q6AXT5	Rattus norvegicus	35%	100%
Q6DHC1	Danio rerio	38%	100%
Q6GQP4	Rattus norvegicus	40%	100%
Q6IMM1	Gallus gallus	29%	100%
Q7ZYF1	Xenopus laevis	30%	100%
Q86JP3	Dictyostelium discoideum	41%	100%
Q8BHD0	Mus musculus	34%	100%
Q94148	Caenorhabditis elegans	42%	100%
Q94986	Caenorhabditis elegans	36%	100%
Q98932	Gallus gallus	42%	100%
Q99260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
Q99P74	Rattus norvegicus	30%	100%
Q9CB01	Arabidopsis thaliana	41%	100%
Q9CQD1	Mus musculus	41%	100%
Q9DD03	Mus musculus	39%	100%
Q9FJH0	Arabidopsis thaliana	33%	100%
Q9H0U4	Homo sapiens	36%	100%
Q9NP90	Homo sapiens	33%	100%
Q9UL25	Homo sapiens	36%	100%
Q9ULC3	Homo sapiens	33%	100%
Q9WTL2	Mus musculus	35%	100%
Q9ZRE2	Arabidopsis thaliana	35%	100%
V5BJM4	Trypanosoma cruzi	34%	100%
V5C1F1	Trypanosoma cruzi	28%	100%
V5C2R1	Trypanosoma cruzi	34%	75%
V5D027	Trypanosoma cruzi	36%	100%
V5D1K6	Trypanosoma cruzi	34%	100%
V5D6P4	Trypanosoma cruzi	62%	100%
V5DF70	Trypanosoma cruzi	28%	81%
V5DKQ7	Trypanosoma cruzi	35%	86%