LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase, putative (fragment)
Species:
Leishmania donovani
UniProt:
A0A3S5H4Y6_LEIDO
TriTrypDb:
LdBPK_020150.1 * , LdCL_020006800 , LDHU3_02.0240
Length:
807

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0016020 membrane 2 53
GO:0110165 cellular anatomical entity 1 53
GO:0000139 Golgi membrane 5 14
GO:0031090 organelle membrane 3 14
GO:0098588 bounding membrane of organelle 4 14

Expansion

Sequence features

A0A3S5H4Y6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Y6

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53
GO:0008194 UDP-glycosyltransferase activity 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 129 131 PF00675 0.610
CLV_NRD_NRD_1 160 162 PF00675 0.561
CLV_NRD_NRD_1 306 308 PF00675 0.544
CLV_NRD_NRD_1 361 363 PF00675 0.610
CLV_NRD_NRD_1 403 405 PF00675 0.674
CLV_NRD_NRD_1 408 410 PF00675 0.630
CLV_NRD_NRD_1 427 429 PF00675 0.562
CLV_NRD_NRD_1 486 488 PF00675 0.689
CLV_NRD_NRD_1 554 556 PF00675 0.583
CLV_NRD_NRD_1 586 588 PF00675 0.488
CLV_NRD_NRD_1 725 727 PF00675 0.565
CLV_NRD_NRD_1 746 748 PF00675 0.531
CLV_NRD_NRD_1 84 86 PF00675 0.465
CLV_NRD_NRD_1 88 90 PF00675 0.456
CLV_PCSK_KEX2_1 117 119 PF00082 0.634
CLV_PCSK_KEX2_1 129 131 PF00082 0.561
CLV_PCSK_KEX2_1 160 162 PF00082 0.561
CLV_PCSK_KEX2_1 306 308 PF00082 0.548
CLV_PCSK_KEX2_1 361 363 PF00082 0.626
CLV_PCSK_KEX2_1 403 405 PF00082 0.674
CLV_PCSK_KEX2_1 408 410 PF00082 0.629
CLV_PCSK_KEX2_1 427 429 PF00082 0.562
CLV_PCSK_KEX2_1 486 488 PF00082 0.617
CLV_PCSK_KEX2_1 556 558 PF00082 0.575
CLV_PCSK_KEX2_1 586 588 PF00082 0.502
CLV_PCSK_KEX2_1 659 661 PF00082 0.597
CLV_PCSK_KEX2_1 725 727 PF00082 0.622
CLV_PCSK_KEX2_1 745 747 PF00082 0.536
CLV_PCSK_KEX2_1 769 771 PF00082 0.585
CLV_PCSK_KEX2_1 795 797 PF00082 0.547
CLV_PCSK_KEX2_1 83 85 PF00082 0.479
CLV_PCSK_KEX2_1 90 92 PF00082 0.455
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.598
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.539
CLV_PCSK_PC1ET2_1 659 661 PF00082 0.518
CLV_PCSK_PC1ET2_1 725 727 PF00082 0.622
CLV_PCSK_PC1ET2_1 745 747 PF00082 0.509
CLV_PCSK_PC1ET2_1 769 771 PF00082 0.567
CLV_PCSK_PC1ET2_1 795 797 PF00082 0.508
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.415
CLV_PCSK_PC7_1 302 308 PF00082 0.519
CLV_PCSK_PC7_1 404 410 PF00082 0.550
CLV_PCSK_PC7_1 655 661 PF00082 0.510
CLV_PCSK_PC7_1 80 86 PF00082 0.403
CLV_PCSK_SKI1_1 114 118 PF00082 0.575
CLV_PCSK_SKI1_1 298 302 PF00082 0.572
CLV_PCSK_SKI1_1 376 380 PF00082 0.575
CLV_PCSK_SKI1_1 427 431 PF00082 0.557
CLV_PCSK_SKI1_1 511 515 PF00082 0.591
CLV_PCSK_SKI1_1 641 645 PF00082 0.475
CLV_PCSK_SKI1_1 788 792 PF00082 0.512
DEG_APCC_DBOX_1 361 369 PF00400 0.396
DEG_SCF_FBW7_1 447 454 PF00400 0.493
DEG_SCF_FBW7_2 416 423 PF00400 0.321
DOC_CKS1_1 280 285 PF01111 0.345
DOC_CKS1_1 448 453 PF01111 0.423
DOC_CYCLIN_yCln2_LP_2 134 140 PF00134 0.386
DOC_CYCLIN_yCln2_LP_2 445 451 PF00134 0.539
DOC_MAPK_gen_1 586 594 PF00069 0.282
DOC_MAPK_gen_1 89 97 PF00069 0.656
DOC_MAPK_JIP1_4 91 97 PF00069 0.458
DOC_MAPK_MEF2A_6 163 172 PF00069 0.372
DOC_MAPK_MEF2A_6 232 240 PF00069 0.366
DOC_MAPK_MEF2A_6 475 482 PF00069 0.355
DOC_MAPK_MEF2A_6 499 508 PF00069 0.336
DOC_MAPK_MEF2A_6 89 97 PF00069 0.694
DOC_PP1_RVXF_1 30 37 PF00149 0.607
DOC_PP1_RVXF_1 473 480 PF00149 0.333
DOC_PP1_RVXF_1 509 516 PF00149 0.435
DOC_PP2B_LxvP_1 445 448 PF13499 0.537
DOC_PP4_FxxP_1 453 456 PF00568 0.378
DOC_USP7_MATH_1 12 16 PF00917 0.590
DOC_USP7_MATH_1 168 172 PF00917 0.377
DOC_USP7_MATH_1 224 228 PF00917 0.522
DOC_USP7_MATH_1 239 243 PF00917 0.377
DOC_USP7_MATH_1 341 345 PF00917 0.481
DOC_USP7_MATH_1 433 437 PF00917 0.481
DOC_USP7_MATH_1 58 62 PF00917 0.629
DOC_USP7_UBL2_3 791 795 PF12436 0.298
DOC_WW_Pin1_4 179 184 PF00397 0.394
DOC_WW_Pin1_4 279 284 PF00397 0.388
DOC_WW_Pin1_4 39 44 PF00397 0.653
DOC_WW_Pin1_4 416 421 PF00397 0.504
DOC_WW_Pin1_4 447 452 PF00397 0.416
DOC_WW_Pin1_4 699 704 PF00397 0.303
DOC_WW_Pin1_4 768 773 PF00397 0.347
LIG_14-3-3_CanoR_1 204 211 PF00244 0.454
LIG_14-3-3_CanoR_1 306 310 PF00244 0.475
LIG_14-3-3_CanoR_1 32 37 PF00244 0.625
LIG_14-3-3_CanoR_1 352 360 PF00244 0.453
LIG_14-3-3_CanoR_1 362 370 PF00244 0.389
LIG_14-3-3_CanoR_1 427 432 PF00244 0.441
LIG_14-3-3_CanoR_1 49 53 PF00244 0.647
LIG_14-3-3_CanoR_1 586 590 PF00244 0.279
LIG_14-3-3_CanoR_1 641 650 PF00244 0.285
LIG_14-3-3_CanoR_1 746 754 PF00244 0.351
LIG_Actin_WH2_2 246 262 PF00022 0.383
LIG_APCC_ABBA_1 93 98 PF00400 0.409
LIG_BIR_II_1 1 5 PF00653 0.589
LIG_EH1_1 599 607 PF00400 0.248
LIG_eIF4E_1 102 108 PF01652 0.243
LIG_eIF4E_1 28 34 PF01652 0.590
LIG_FHA_1 107 113 PF00498 0.310
LIG_FHA_1 151 157 PF00498 0.380
LIG_FHA_1 188 194 PF00498 0.557
LIG_FHA_1 242 248 PF00498 0.508
LIG_FHA_1 280 286 PF00498 0.344
LIG_FHA_1 377 383 PF00498 0.367
LIG_FHA_1 433 439 PF00498 0.431
LIG_FHA_1 597 603 PF00498 0.284
LIG_FHA_2 309 315 PF00498 0.415
LIG_FHA_2 369 375 PF00498 0.502
LIG_FHA_2 642 648 PF00498 0.275
LIG_FHA_2 700 706 PF00498 0.288
LIG_FHA_2 747 753 PF00498 0.335
LIG_FHA_2 756 762 PF00498 0.293
LIG_IRF3_LxIS_1 97 104 PF10401 0.216
LIG_LIR_Apic_2 450 456 PF02991 0.382
LIG_LIR_Apic_2 497 503 PF02991 0.464
LIG_LIR_Gen_1 135 142 PF02991 0.479
LIG_LIR_Gen_1 282 291 PF02991 0.336
LIG_LIR_Gen_1 311 316 PF02991 0.326
LIG_LIR_Gen_1 517 528 PF02991 0.345
LIG_LIR_Gen_1 534 544 PF02991 0.311
LIG_LIR_Gen_1 675 683 PF02991 0.349
LIG_LIR_Gen_1 692 698 PF02991 0.362
LIG_LIR_Nem_3 109 113 PF02991 0.247
LIG_LIR_Nem_3 135 141 PF02991 0.477
LIG_LIR_Nem_3 282 287 PF02991 0.327
LIG_LIR_Nem_3 308 312 PF02991 0.476
LIG_LIR_Nem_3 517 523 PF02991 0.367
LIG_LIR_Nem_3 534 540 PF02991 0.293
LIG_LIR_Nem_3 675 680 PF02991 0.351
LIG_LIR_Nem_3 692 696 PF02991 0.367
LIG_LIR_Nem_3 705 709 PF02991 0.274
LIG_NRBOX 649 655 PF00104 0.283
LIG_REV1ctd_RIR_1 710 719 PF16727 0.281
LIG_SH2_GRB2like 785 788 PF00017 0.305
LIG_SH2_PTP2 537 540 PF00017 0.310
LIG_SH2_SRC 312 315 PF00017 0.339
LIG_SH2_SRC 518 521 PF00017 0.371
LIG_SH2_SRC 708 711 PF00017 0.266
LIG_SH2_STAP1 518 522 PF00017 0.462
LIG_SH2_STAP1 571 575 PF00017 0.352
LIG_SH2_STAT5 102 105 PF00017 0.264
LIG_SH2_STAT5 284 287 PF00017 0.389
LIG_SH2_STAT5 330 333 PF00017 0.420
LIG_SH2_STAT5 440 443 PF00017 0.380
LIG_SH2_STAT5 459 462 PF00017 0.339
LIG_SH2_STAT5 537 540 PF00017 0.336
LIG_SH2_STAT5 549 552 PF00017 0.366
LIG_SH2_STAT5 672 675 PF00017 0.353
LIG_SH2_STAT5 708 711 PF00017 0.443
LIG_SH2_STAT5 789 792 PF00017 0.320
LIG_SH3_3 277 283 PF00018 0.459
LIG_SH3_3 445 451 PF00018 0.510
LIG_SH3_3 535 541 PF00018 0.314
LIG_SH3_3 555 561 PF00018 0.347
LIG_SH3_3 607 613 PF00018 0.327
LIG_SH3_3 801 807 PF00018 0.285
LIG_SUMO_SIM_anti_2 588 593 PF11976 0.253
LIG_SUMO_SIM_anti_2 621 626 PF11976 0.316
LIG_SUMO_SIM_par_1 621 626 PF11976 0.337
LIG_TRAF2_1 311 314 PF00917 0.350
LIG_TYR_ITIM 310 315 PF00017 0.549
LIG_TYR_ITSM 280 287 PF00017 0.394
LIG_UBA3_1 112 117 PF00899 0.407
LIG_WRC_WIRS_1 33 38 PF05994 0.487
MOD_CK1_1 19 25 PF00069 0.557
MOD_CK1_1 344 350 PF00069 0.631
MOD_CK1_1 35 41 PF00069 0.610
MOD_CK1_1 4 10 PF00069 0.471
MOD_CK1_1 436 442 PF00069 0.581
MOD_CK1_1 48 54 PF00069 0.587
MOD_CK1_1 585 591 PF00069 0.322
MOD_CK2_1 206 212 PF00069 0.538
MOD_CK2_1 308 314 PF00069 0.497
MOD_CK2_1 353 359 PF00069 0.580
MOD_CK2_1 368 374 PF00069 0.655
MOD_CK2_1 452 458 PF00069 0.450
MOD_CK2_1 725 731 PF00069 0.511
MOD_CK2_1 746 752 PF00069 0.357
MOD_CK2_1 755 761 PF00069 0.339
MOD_GlcNHglycan 165 168 PF01048 0.470
MOD_GlcNHglycan 18 21 PF01048 0.584
MOD_GlcNHglycan 208 211 PF01048 0.656
MOD_GlcNHglycan 226 229 PF01048 0.639
MOD_GlcNHglycan 347 350 PF01048 0.614
MOD_GlcNHglycan 355 358 PF01048 0.561
MOD_GlcNHglycan 365 368 PF01048 0.474
MOD_GlcNHglycan 434 438 PF01048 0.592
MOD_GlcNHglycan 441 444 PF01048 0.537
MOD_GlcNHglycan 464 467 PF01048 0.561
MOD_GlcNHglycan 551 554 PF01048 0.375
MOD_GSK3_1 116 123 PF00069 0.483
MOD_GSK3_1 12 19 PF00069 0.487
MOD_GSK3_1 175 182 PF00069 0.509
MOD_GSK3_1 199 206 PF00069 0.576
MOD_GSK3_1 32 39 PF00069 0.590
MOD_GSK3_1 341 348 PF00069 0.695
MOD_GSK3_1 423 430 PF00069 0.554
MOD_GSK3_1 43 50 PF00069 0.641
MOD_GSK3_1 432 439 PF00069 0.530
MOD_GSK3_1 443 450 PF00069 0.462
MOD_GSK3_1 637 644 PF00069 0.316
MOD_GSK3_1 717 724 PF00069 0.395
MOD_N-GLC_1 175 180 PF02516 0.448
MOD_N-GLC_1 341 346 PF02516 0.525
MOD_N-GLC_1 352 357 PF02516 0.555
MOD_N-GLC_1 39 44 PF02516 0.529
MOD_N-GLC_1 575 580 PF02516 0.317
MOD_N-GLC_1 615 620 PF02516 0.389
MOD_N-GLC_1 689 694 PF02516 0.342
MOD_NEK2_1 1 6 PF00069 0.471
MOD_NEK2_1 101 106 PF00069 0.368
MOD_NEK2_1 116 121 PF00069 0.449
MOD_NEK2_1 16 21 PF00069 0.532
MOD_NEK2_1 238 243 PF00069 0.435
MOD_NEK2_1 36 41 PF00069 0.556
MOD_NEK2_1 383 388 PF00069 0.444
MOD_NEK2_1 615 620 PF00069 0.478
MOD_NEK2_1 717 722 PF00069 0.355
MOD_NEK2_1 76 81 PF00069 0.422
MOD_NEK2_2 12 17 PF00069 0.469
MOD_NEK2_2 187 192 PF00069 0.707
MOD_OFUCOSY 18 25 PF10250 0.473
MOD_PIKK_1 506 512 PF00454 0.548
MOD_PIKK_1 615 621 PF00454 0.378
MOD_PIKK_1 733 739 PF00454 0.429
MOD_PKA_1 427 433 PF00069 0.418
MOD_PKA_1 486 492 PF00069 0.632
MOD_PKA_1 725 731 PF00069 0.388
MOD_PKA_1 745 751 PF00069 0.375
MOD_PKA_2 16 22 PF00069 0.489
MOD_PKA_2 203 209 PF00069 0.580
MOD_PKA_2 305 311 PF00069 0.588
MOD_PKA_2 363 369 PF00069 0.489
MOD_PKA_2 427 433 PF00069 0.548
MOD_PKA_2 48 54 PF00069 0.582
MOD_PKA_2 486 492 PF00069 0.581
MOD_PKA_2 585 591 PF00069 0.292
MOD_PKA_2 725 731 PF00069 0.415
MOD_PKA_2 745 751 PF00069 0.390
MOD_PKB_1 161 169 PF00069 0.440
MOD_PKB_1 639 647 PF00069 0.265
MOD_Plk_1 175 181 PF00069 0.449
MOD_Plk_1 433 439 PF00069 0.434
MOD_Plk_1 689 695 PF00069 0.404
MOD_Plk_4 106 112 PF00069 0.327
MOD_Plk_4 175 181 PF00069 0.501
MOD_Plk_4 436 442 PF00069 0.418
MOD_Plk_4 596 602 PF00069 0.337
MOD_Plk_4 692 698 PF00069 0.508
MOD_ProDKin_1 179 185 PF00069 0.464
MOD_ProDKin_1 279 285 PF00069 0.452
MOD_ProDKin_1 39 45 PF00069 0.555
MOD_ProDKin_1 416 422 PF00069 0.625
MOD_ProDKin_1 447 453 PF00069 0.496
MOD_ProDKin_1 699 705 PF00069 0.341
MOD_ProDKin_1 768 774 PF00069 0.402
TRG_DiLeu_BaLyEn_6 601 606 PF01217 0.398
TRG_DiLeu_BaLyEn_6 649 654 PF01217 0.246
TRG_ENDOCYTIC_2 284 287 PF00928 0.465
TRG_ENDOCYTIC_2 312 315 PF00928 0.588
TRG_ENDOCYTIC_2 520 523 PF00928 0.451
TRG_ENDOCYTIC_2 537 540 PF00928 0.265
TRG_ENDOCYTIC_2 706 709 PF00928 0.279
TRG_ER_diArg_1 128 130 PF00400 0.468
TRG_ER_diArg_1 160 163 PF00400 0.440
TRG_ER_diArg_1 360 362 PF00400 0.512
TRG_ER_diArg_1 403 405 PF00400 0.586
TRG_ER_diArg_1 407 409 PF00400 0.559
TRG_ER_diArg_1 427 429 PF00400 0.427
TRG_ER_diArg_1 486 488 PF00400 0.477
TRG_ER_diArg_1 554 557 PF00400 0.435
TRG_ER_diArg_1 638 641 PF00400 0.315
TRG_ER_diArg_1 82 85 PF00400 0.555
TRG_ER_diArg_1 88 91 PF00400 0.556
TRG_NLS_MonoExtC_3 554 559 PF00514 0.347
TRG_NLS_MonoExtC_3 724 729 PF00514 0.414
TRG_NLS_MonoExtN_4 725 730 PF00514 0.399
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.428
TRG_Pf-PMV_PEXEL_1 604 608 PF00026 0.448
TRG_Pf-PMV_PEXEL_1 641 646 PF00026 0.287
TRG_Pf-PMV_PEXEL_1 652 657 PF00026 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 38% 100%
A0A3S5H4Y9 Leishmania donovani 35% 81%
A0A3S7WT86 Leishmania donovani 44% 79%
A0A3S7WWA6 Leishmania donovani 41% 99%
A0A451EJD9 Leishmania donovani 40% 99%
A0A451EJF4 Leishmania donovani 74% 99%
A0A451EJF6 Leishmania donovani 75% 100%
A0A451EJF8 Leishmania donovani 66% 100%
A0A451EJF9 Leishmania donovani 62% 94%
A4H3A9 Leishmania braziliensis 62% 100%
A4H3B4 Leishmania braziliensis 59% 100%
A4H3B6 Leishmania braziliensis 63% 100%
A4H3B8 Leishmania braziliensis 59% 100%
A4H3B9 Leishmania braziliensis 41% 100%
A4H4W8 Leishmania braziliensis 37% 100%
A4HJ20 Leishmania braziliensis 60% 100%
A4HNK3 Leishmania braziliensis 41% 99%
A4HNK6 Leishmania braziliensis 37% 100%
A4HRL9 Leishmania infantum 84% 100%
A4HRM0 Leishmania infantum 88% 99%
A4HRM1 Leishmania infantum 76% 100%
A4HRS1 Leishmania infantum 63% 100%
A4HRS3 Leishmania infantum 35% 100%
A4HRS5 Leishmania infantum 66% 99%
A4HZM0 Leishmania infantum 37% 100%
A4I7C7 Leishmania infantum 40% 100%
A4IAQ2 Leishmania infantum 39% 100%
E9AC91 Leishmania major 79% 100%
E9AC92 Leishmania major 77% 100%
E9AC94 Leishmania major 35% 100%
E9AC95 Leishmania major 64% 98%
E9AC96 Leishmania major 65% 100%
E9AC98 Leishmania major 35% 100%
E9AEH8 Leishmania major 39% 100%
E9AHA6 Leishmania infantum 37% 100%
E9AIP8 Leishmania braziliensis 38% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 99%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 99%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
Q4Q5T6 Leishmania major 40% 100%
Q4QCL8 Leishmania major 40% 100%
Q4QFJ3 Leishmania major 44% 100%
Q4QIG9 Leishmania major 40% 100%
Q7YXU9 Leishmania major 39% 100%
Q7YXV1 Leishmania major 40% 100%
Q7YXV2 Leishmania major 38% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS