Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4Y2_LEIDO

TriTrypDb:

LdBPK_020080.1 , LdCL_020006000 , LDHU3_02.0160

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Y2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.689
CLV_C14_Caspase3-7	422	426	PF00656	0.783
CLV_C14_Caspase3-7	492	496	PF00656	0.505
CLV_C14_Caspase3-7	503	507	PF00656	0.528
CLV_NRD_NRD_1	17	19	PF00675	0.573
CLV_NRD_NRD_1	306	308	PF00675	0.856
CLV_NRD_NRD_1	969	971	PF00675	0.697
CLV_PCSK_KEX2_1	17	19	PF00082	0.573
CLV_PCSK_KEX2_1	305	307	PF00082	0.859
CLV_PCSK_KEX2_1	699	701	PF00082	0.578
CLV_PCSK_KEX2_1	969	971	PF00082	0.691
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.578
CLV_PCSK_SKI1_1	840	844	PF00082	0.667
CLV_PCSK_SKI1_1	911	915	PF00082	0.677
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SCF_TRCP1_1	131	137	PF00400	0.697
DEG_SPOP_SBC_1	735	739	PF00917	0.589
DEG_SPOP_SBC_1	93	97	PF00917	0.841
DOC_CKS1_1	273	278	PF01111	0.676
DOC_CKS1_1	428	433	PF01111	0.772
DOC_CKS1_1	915	920	PF01111	0.673
DOC_CYCLIN_RxL_1	906	917	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	810	816	PF00134	0.749
DOC_MAPK_gen_1	539	547	PF00069	0.451
DOC_MAPK_gen_1	906	915	PF00069	0.679
DOC_MAPK_MEF2A_6	720	729	PF00069	0.581
DOC_PP2B_LxvP_1	136	139	PF13499	0.825
DOC_PP2B_LxvP_1	800	803	PF13499	0.792
DOC_PP4_MxPP_1	877	880	PF00568	0.668
DOC_USP7_MATH_1	129	133	PF00917	0.862
DOC_USP7_MATH_1	151	155	PF00917	0.658
DOC_USP7_MATH_1	173	177	PF00917	0.769
DOC_USP7_MATH_1	200	204	PF00917	0.718
DOC_USP7_MATH_1	269	273	PF00917	0.813
DOC_USP7_MATH_1	310	314	PF00917	0.855
DOC_USP7_MATH_1	352	356	PF00917	0.797
DOC_USP7_MATH_1	366	370	PF00917	0.609
DOC_USP7_MATH_1	390	394	PF00917	0.771
DOC_USP7_MATH_1	419	423	PF00917	0.759
DOC_USP7_MATH_1	476	480	PF00917	0.659
DOC_USP7_MATH_1	48	52	PF00917	0.716
DOC_USP7_MATH_1	481	485	PF00917	0.515
DOC_USP7_MATH_1	522	526	PF00917	0.638
DOC_USP7_MATH_1	735	739	PF00917	0.589
DOC_USP7_MATH_1	823	827	PF00917	0.699
DOC_USP7_MATH_2	205	211	PF00917	0.692
DOC_WW_Pin1_4	101	106	PF00397	0.750
DOC_WW_Pin1_4	119	124	PF00397	0.855
DOC_WW_Pin1_4	196	201	PF00397	0.742
DOC_WW_Pin1_4	272	277	PF00397	0.678
DOC_WW_Pin1_4	311	316	PF00397	0.852
DOC_WW_Pin1_4	427	432	PF00397	0.770
DOC_WW_Pin1_4	44	49	PF00397	0.580
DOC_WW_Pin1_4	646	651	PF00397	0.611
DOC_WW_Pin1_4	875	880	PF00397	0.620
DOC_WW_Pin1_4	914	919	PF00397	0.673
LIG_14-3-3_CanoR_1	114	123	PF00244	0.855
LIG_14-3-3_CanoR_1	135	139	PF00244	0.693
LIG_14-3-3_CanoR_1	17	22	PF00244	0.562
LIG_14-3-3_CanoR_1	228	236	PF00244	0.668
LIG_14-3-3_CanoR_1	267	276	PF00244	0.761
LIG_14-3-3_CanoR_1	307	315	PF00244	0.707
LIG_14-3-3_CanoR_1	539	547	PF00244	0.460
LIG_14-3-3_CanoR_1	577	587	PF00244	0.603
LIG_14-3-3_CanoR_1	624	628	PF00244	0.651
LIG_14-3-3_CanoR_1	895	900	PF00244	0.613
LIG_14-3-3_CterR_2	969	974	PF00244	0.642
LIG_BIR_III_4	674	678	PF00653	0.617
LIG_BIR_III_4	751	755	PF00653	0.652
LIG_BRCT_BRCA1_1	352	356	PF00533	0.677
LIG_BRCT_BRCA1_1	706	710	PF00533	0.588
LIG_EH1_1	708	716	PF00400	0.420
LIG_EVH1_1	800	804	PF00568	0.685
LIG_FHA_1	37	43	PF00498	0.572
LIG_FHA_1	489	495	PF00498	0.638
LIG_FHA_1	607	613	PF00498	0.593
LIG_FHA_1	632	638	PF00498	0.481
LIG_FHA_1	683	689	PF00498	0.596
LIG_FHA_1	735	741	PF00498	0.587
LIG_FHA_1	88	94	PF00498	0.743
LIG_FHA_1	931	937	PF00498	0.545
LIG_FHA_2	298	304	PF00498	0.686
LIG_FHA_2	791	797	PF00498	0.761
LIG_IBAR_NPY_1	111	113	PF08397	0.828
LIG_LIR_Gen_1	667	676	PF02991	0.571
LIG_LIR_LC3C_4	591	594	PF02991	0.489
LIG_LIR_Nem_3	626	632	PF02991	0.611
LIG_LIR_Nem_3	667	671	PF02991	0.526
LIG_LYPXL_S_1	857	861	PF13949	0.748
LIG_LYPXL_yS_3	629	632	PF13949	0.579
LIG_LYPXL_yS_3	858	861	PF13949	0.747
LIG_MYND_1	436	440	PF01753	0.694
LIG_MYND_1	462	466	PF01753	0.722
LIG_MYND_1	650	654	PF01753	0.438
LIG_PROFILIN_1	801	807	PF00235	0.678
LIG_REV1ctd_RIR_1	889	899	PF16727	0.673
LIG_SH2_CRK	113	117	PF00017	0.705
LIG_SH2_CRK	195	199	PF00017	0.699
LIG_SH2_CRK	554	558	PF00017	0.586
LIG_SH2_CRK	668	672	PF00017	0.489
LIG_SH2_NCK_1	279	283	PF00017	0.813
LIG_SH2_NCK_1	37	41	PF00017	0.576
LIG_SH2_SRC	451	454	PF00017	0.722
LIG_SH2_SRC	588	591	PF00017	0.480
LIG_SH2_STAP1	530	534	PF00017	0.474
LIG_SH2_STAT3	180	183	PF00017	0.845
LIG_SH2_STAT3	453	456	PF00017	0.748
LIG_SH2_STAT5	195	198	PF00017	0.701
LIG_SH2_STAT5	37	40	PF00017	0.571
LIG_SH2_STAT5	575	578	PF00017	0.498
LIG_SH2_STAT5	588	591	PF00017	0.366
LIG_SH3_1	799	805	PF00018	0.687
LIG_SH3_3	270	276	PF00018	0.680
LIG_SH3_3	393	399	PF00018	0.804
LIG_SH3_3	42	48	PF00018	0.562
LIG_SH3_3	425	431	PF00018	0.837
LIG_SH3_3	516	522	PF00018	0.659
LIG_SH3_3	637	643	PF00018	0.586
LIG_SH3_3	719	725	PF00018	0.716
LIG_SH3_3	740	746	PF00018	0.579
LIG_SH3_3	779	785	PF00018	0.727
LIG_SH3_3	798	804	PF00018	0.550
LIG_SH3_3	912	918	PF00018	0.672
LIG_SH3_3	919	925	PF00018	0.617
LIG_SH3_3	926	932	PF00018	0.546
LIG_SUMO_SIM_anti_2	237	242	PF11976	0.764
LIG_SUMO_SIM_anti_2	248	255	PF11976	0.683
LIG_SUMO_SIM_anti_2	917	924	PF11976	0.692
LIG_SUMO_SIM_par_1	341	347	PF11976	0.649
LIG_SUMO_SIM_par_1	727	732	PF11976	0.595
LIG_SUMO_SIM_par_1	87	97	PF11976	0.688
LIG_SUMO_SIM_par_1	911	917	PF11976	0.675
LIG_SxIP_EBH_1	708	720	PF03271	0.449
LIG_TRAF2_1	794	797	PF00917	0.816
LIG_TYR_ITIM	552	557	PF00017	0.599
LIG_TYR_ITIM	627	632	PF00017	0.600
LIG_WW_2	725	728	PF00397	0.714
MOD_CDK_SPK_2	123	128	PF00069	0.852
MOD_CDK_SPK_2	196	201	PF00069	0.837
MOD_CK1_1	117	123	PF00069	0.707
MOD_CK1_1	166	172	PF00069	0.678
MOD_CK1_1	176	182	PF00069	0.682
MOD_CK1_1	187	193	PF00069	0.592
MOD_CK1_1	199	205	PF00069	0.641
MOD_CK1_1	210	216	PF00069	0.748
MOD_CK1_1	220	226	PF00069	0.653
MOD_CK1_1	272	278	PF00069	0.810
MOD_CK1_1	308	314	PF00069	0.854
MOD_CK1_1	357	363	PF00069	0.668
MOD_CK1_1	369	375	PF00069	0.602
MOD_CK1_1	401	407	PF00069	0.865
MOD_CK1_1	47	53	PF00069	0.688
MOD_CK1_1	525	531	PF00069	0.600
MOD_CK1_1	595	601	PF00069	0.628
MOD_CK1_1	606	612	PF00069	0.534
MOD_CK1_1	734	740	PF00069	0.594
MOD_CK1_1	762	768	PF00069	0.673
MOD_CK1_1	96	102	PF00069	0.841
MOD_CK2_1	171	177	PF00069	0.835
MOD_CK2_1	352	358	PF00069	0.653
MOD_CK2_1	401	407	PF00069	0.865
MOD_CK2_1	48	54	PF00069	0.696
MOD_CK2_1	553	559	PF00069	0.602
MOD_CK2_1	790	796	PF00069	0.757
MOD_GlcNHglycan	130	134	PF01048	0.843
MOD_GlcNHglycan	145	148	PF01048	0.553
MOD_GlcNHglycan	149	152	PF01048	0.636
MOD_GlcNHglycan	170	173	PF01048	0.688
MOD_GlcNHglycan	189	192	PF01048	0.663
MOD_GlcNHglycan	213	216	PF01048	0.838
MOD_GlcNHglycan	222	225	PF01048	0.777
MOD_GlcNHglycan	230	233	PF01048	0.511
MOD_GlcNHglycan	247	250	PF01048	0.649
MOD_GlcNHglycan	269	272	PF01048	0.674
MOD_GlcNHglycan	307	310	PF01048	0.826
MOD_GlcNHglycan	323	326	PF01048	0.587
MOD_GlcNHglycan	352	355	PF01048	0.648
MOD_GlcNHglycan	372	375	PF01048	0.684
MOD_GlcNHglycan	417	420	PF01048	0.765
MOD_GlcNHglycan	478	481	PF01048	0.750
MOD_GlcNHglycan	502	505	PF01048	0.552
MOD_GlcNHglycan	581	584	PF01048	0.515
MOD_GlcNHglycan	609	612	PF01048	0.742
MOD_GlcNHglycan	671	674	PF01048	0.678
MOD_GlcNHglycan	732	736	PF01048	0.704
MOD_GlcNHglycan	761	764	PF01048	0.701
MOD_GlcNHglycan	810	813	PF01048	0.756
MOD_GlcNHglycan	845	848	PF01048	0.651
MOD_GlcNHglycan	942	945	PF01048	0.647
MOD_GlcNHglycan	96	99	PF01048	0.742
MOD_GSK3_1	114	121	PF00069	0.719
MOD_GSK3_1	134	141	PF00069	0.722
MOD_GSK3_1	143	150	PF00069	0.775
MOD_GSK3_1	183	190	PF00069	0.839
MOD_GSK3_1	196	203	PF00069	0.625
MOD_GSK3_1	207	214	PF00069	0.735
MOD_GSK3_1	216	223	PF00069	0.579
MOD_GSK3_1	241	248	PF00069	0.673
MOD_GSK3_1	263	270	PF00069	0.703
MOD_GSK3_1	271	278	PF00069	0.666
MOD_GSK3_1	297	304	PF00069	0.683
MOD_GSK3_1	350	357	PF00069	0.716
MOD_GSK3_1	366	373	PF00069	0.660
MOD_GSK3_1	382	389	PF00069	0.606
MOD_GSK3_1	390	397	PF00069	0.699
MOD_GSK3_1	398	405	PF00069	0.567
MOD_GSK3_1	415	422	PF00069	0.608
MOD_GSK3_1	423	430	PF00069	0.728
MOD_GSK3_1	44	51	PF00069	0.569
MOD_GSK3_1	481	488	PF00069	0.589
MOD_GSK3_1	525	532	PF00069	0.604
MOD_GSK3_1	588	595	PF00069	0.510
MOD_GSK3_1	603	610	PF00069	0.437
MOD_GSK3_1	727	734	PF00069	0.596
MOD_GSK3_1	92	99	PF00069	0.765
MOD_LATS_1	537	543	PF00433	0.468
MOD_N-GLC_1	147	152	PF02516	0.670
MOD_N-GLC_1	228	233	PF02516	0.660
MOD_N-GLC_1	23	28	PF02516	0.582
MOD_N-GLC_1	646	651	PF02516	0.508
MOD_N-GLC_1	823	828	PF02516	0.685
MOD_N-GLC_1	831	836	PF02516	0.618
MOD_N-GLC_1	843	848	PF02516	0.628
MOD_N-GLC_1	93	98	PF02516	0.783
MOD_NEK2_1	142	147	PF00069	0.673
MOD_NEK2_1	209	214	PF00069	0.849
MOD_NEK2_1	286	291	PF00069	0.791
MOD_NEK2_1	343	348	PF00069	0.696
MOD_NEK2_1	356	361	PF00069	0.602
MOD_NEK2_1	370	375	PF00069	0.588
MOD_NEK2_1	485	490	PF00069	0.639
MOD_NEK2_1	592	597	PF00069	0.656
MOD_NEK2_1	704	709	PF00069	0.578
MOD_NEK2_1	710	715	PF00069	0.463
MOD_NEK2_1	736	741	PF00069	0.587
MOD_NEK2_1	80	85	PF00069	0.671
MOD_OFUCOSY	702	708	PF10250	0.568
MOD_PIKK_1	151	157	PF00454	0.668
MOD_PIKK_1	200	206	PF00454	0.679
MOD_PIKK_1	485	491	PF00454	0.639
MOD_PIKK_1	522	528	PF00454	0.627
MOD_PIKK_1	595	601	PF00454	0.628
MOD_PIKK_1	680	686	PF00454	0.673
MOD_PIKK_1	831	837	PF00454	0.811
MOD_PIKK_1	930	936	PF00454	0.670
MOD_PK_1	398	404	PF00069	0.707
MOD_PKA_1	17	23	PF00069	0.565
MOD_PKA_1	305	311	PF00069	0.854
MOD_PKA_2	134	140	PF00069	0.738
MOD_PKA_2	16	22	PF00069	0.562
MOD_PKA_2	166	172	PF00069	0.677
MOD_PKA_2	210	216	PF00069	0.808
MOD_PKA_2	227	233	PF00069	0.649
MOD_PKA_2	305	311	PF00069	0.854
MOD_PKA_2	394	400	PF00069	0.847
MOD_PKA_2	578	584	PF00069	0.620
MOD_PKA_2	623	629	PF00069	0.513
MOD_PKB_1	265	273	PF00069	0.678
MOD_PKB_1	498	506	PF00069	0.588
MOD_PKB_1	577	585	PF00069	0.478
MOD_Plk_1	176	182	PF00069	0.697
MOD_Plk_1	357	363	PF00069	0.668
MOD_Plk_1	603	609	PF00069	0.519
MOD_Plk_1	731	737	PF00069	0.534
MOD_Plk_1	795	801	PF00069	0.709
MOD_Plk_1	87	93	PF00069	0.682
MOD_Plk_2-3	87	93	PF00069	0.682
MOD_Plk_4	138	144	PF00069	0.663
MOD_Plk_4	193	199	PF00069	0.842
MOD_Plk_4	398	404	PF00069	0.707
MOD_Plk_4	525	531	PF00069	0.396
MOD_Plk_4	588	594	PF00069	0.610
MOD_Plk_4	710	716	PF00069	0.562
MOD_ProDKin_1	101	107	PF00069	0.752
MOD_ProDKin_1	119	125	PF00069	0.856
MOD_ProDKin_1	196	202	PF00069	0.741
MOD_ProDKin_1	272	278	PF00069	0.678
MOD_ProDKin_1	311	317	PF00069	0.853
MOD_ProDKin_1	427	433	PF00069	0.772
MOD_ProDKin_1	44	50	PF00069	0.582
MOD_ProDKin_1	646	652	PF00069	0.608
MOD_ProDKin_1	875	881	PF00069	0.621
MOD_ProDKin_1	914	920	PF00069	0.674
MOD_SUMO_for_1	540	543	PF00179	0.528
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.650
TRG_DiLeu_BaLyEn_6	909	914	PF01217	0.676
TRG_ENDOCYTIC_2	113	116	PF00928	0.705
TRG_ENDOCYTIC_2	195	198	PF00928	0.701
TRG_ENDOCYTIC_2	554	557	PF00928	0.529
TRG_ENDOCYTIC_2	629	632	PF00928	0.579
TRG_ENDOCYTIC_2	668	671	PF00928	0.490
TRG_ENDOCYTIC_2	858	861	PF00928	0.706
TRG_ER_diArg_1	305	307	PF00400	0.782
TRG_ER_diArg_1	564	567	PF00400	0.497
TRG_ER_diArg_1	576	579	PF00400	0.383
TRG_ER_diArg_1	66	69	PF00400	0.607
TRG_ER_diArg_1	688	691	PF00400	0.643
TRG_ER_diArg_1	968	970	PF00400	0.697
TRG_NES_CRM1_1	44	56	PF08389	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRL3	Leishmania infantum	99%	100%
E8NHD4	Leishmania braziliensis	56%	100%
E9AI19	Leishmania braziliensis	56%	100%