Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4Y1_LEIDO

TriTrypDb:

LdBPK_020070.1 , LdCL_020005900 , LDHU3_02.0140

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H4Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.679
CLV_NRD_NRD_1	118	120	PF00675	0.546
CLV_NRD_NRD_1	301	303	PF00675	0.583
CLV_NRD_NRD_1	69	71	PF00675	0.731
CLV_NRD_NRD_1	74	76	PF00675	0.665
CLV_NRD_NRD_1	8	10	PF00675	0.720
CLV_PCSK_KEX2_1	117	119	PF00082	0.554
CLV_PCSK_KEX2_1	351	353	PF00082	0.744
CLV_PCSK_KEX2_1	69	71	PF00082	0.727
CLV_PCSK_KEX2_1	73	75	PF00082	0.689
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.681
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.747
CLV_PCSK_PC7_1	69	75	PF00082	0.789
CLV_PCSK_SKI1_1	111	115	PF00082	0.695
CLV_PCSK_SKI1_1	15	19	PF00082	0.599
DEG_SPOP_SBC_1	321	325	PF00917	0.670
DOC_CKS1_1	333	338	PF01111	0.785
DOC_MAPK_gen_1	73	84	PF00069	0.691
DOC_MAPK_MEF2A_6	78	86	PF00069	0.637
DOC_PP2B_LxvP_1	168	171	PF13499	0.654
DOC_USP7_MATH_1	162	166	PF00917	0.597
DOC_USP7_MATH_1	228	232	PF00917	0.586
DOC_USP7_MATH_1	321	325	PF00917	0.789
DOC_USP7_MATH_1	342	346	PF00917	0.789
DOC_USP7_MATH_1	46	50	PF00917	0.743
DOC_USP7_UBL2_3	29	33	PF12436	0.694
DOC_USP7_UBL2_3	59	63	PF12436	0.747
DOC_WW_Pin1_4	145	150	PF00397	0.685
DOC_WW_Pin1_4	226	231	PF00397	0.689
DOC_WW_Pin1_4	332	337	PF00397	0.851
LIG_14-3-3_CanoR_1	223	230	PF00244	0.641
LIG_14-3-3_CanoR_1	73	82	PF00244	0.649
LIG_BRCT_BRCA1_1	21	25	PF00533	0.676
LIG_FHA_1	264	270	PF00498	0.602
LIG_FHA_1	279	285	PF00498	0.533
LIG_FHA_1	99	105	PF00498	0.722
LIG_FHA_2	146	152	PF00498	0.664
LIG_FHA_2	204	210	PF00498	0.615
LIG_FHA_2	231	237	PF00498	0.684
LIG_FHA_2	62	68	PF00498	0.770
LIG_Integrin_isoDGR_2	37	39	PF01839	0.747
LIG_LIR_Gen_1	131	142	PF02991	0.467
LIG_LIR_Gen_1	208	218	PF02991	0.528
LIG_LIR_Gen_1	22	30	PF02991	0.673
LIG_LIR_Gen_1	81	90	PF02991	0.606
LIG_LIR_Nem_3	131	137	PF02991	0.444
LIG_LIR_Nem_3	208	213	PF02991	0.547
LIG_LIR_Nem_3	22	28	PF02991	0.588
LIG_LIR_Nem_3	295	300	PF02991	0.604
LIG_LIR_Nem_3	5	11	PF02991	0.657
LIG_LIR_Nem_3	81	86	PF02991	0.625
LIG_NRP_CendR_1	351	354	PF00754	0.859
LIG_Pex14_2	293	297	PF04695	0.601
LIG_SH2_NCK_1	161	165	PF00017	0.497
LIG_SH2_SRC	129	132	PF00017	0.563
LIG_SH2_STAT5	129	132	PF00017	0.538
LIG_SH2_STAT5	156	159	PF00017	0.511
LIG_SH2_STAT5	203	206	PF00017	0.706
LIG_SH2_STAT5	224	227	PF00017	0.509
LIG_SH2_STAT5	237	240	PF00017	0.659
LIG_SH2_STAT5	292	295	PF00017	0.584
LIG_SH3_3	55	61	PF00018	0.800
LIG_UBA3_1	17	23	PF00899	0.579
LIG_UBA3_1	24	33	PF00899	0.634
MOD_CK1_1	19	25	PF00069	0.680
MOD_CK1_1	324	330	PF00069	0.845
MOD_CK1_1	94	100	PF00069	0.773
MOD_CK2_1	145	151	PF00069	0.624
MOD_CK2_1	203	209	PF00069	0.589
MOD_Cter_Amidation	347	350	PF01082	0.838
MOD_GlcNHglycan	108	111	PF01048	0.689
MOD_GlcNHglycan	131	134	PF01048	0.563
MOD_GlcNHglycan	186	189	PF01048	0.682
MOD_GlcNHglycan	226	229	PF01048	0.622
MOD_GlcNHglycan	230	233	PF01048	0.646
MOD_GlcNHglycan	304	308	PF01048	0.698
MOD_GlcNHglycan	337	340	PF01048	0.768
MOD_GSK3_1	180	187	PF00069	0.687
MOD_GSK3_1	201	208	PF00069	0.651
MOD_GSK3_1	224	231	PF00069	0.640
MOD_GSK3_1	278	285	PF00069	0.577
MOD_GSK3_1	320	327	PF00069	0.792
MOD_GSK3_1	331	338	PF00069	0.725
MOD_GSK3_1	61	68	PF00069	0.779
MOD_GSK3_1	69	76	PF00069	0.688
MOD_GSK3_1	94	101	PF00069	0.679
MOD_N-GLC_1	342	347	PF02516	0.813
MOD_NEK2_1	180	185	PF00069	0.688
MOD_NEK2_1	305	310	PF00069	0.678
MOD_PIKK_1	272	278	PF00454	0.701
MOD_PIKK_1	73	79	PF00454	0.810
MOD_PK_1	78	84	PF00069	0.741
MOD_PKA_1	69	75	PF00069	0.721
MOD_PKA_2	106	112	PF00069	0.630
MOD_PKA_2	272	278	PF00069	0.603
MOD_PKA_2	69	75	PF00069	0.728
MOD_Plk_1	201	207	PF00069	0.686
MOD_Plk_4	78	84	PF00069	0.618
MOD_ProDKin_1	145	151	PF00069	0.687
MOD_ProDKin_1	226	232	PF00069	0.691
MOD_ProDKin_1	332	338	PF00069	0.852
TRG_DiLeu_BaEn_1	13	18	PF01217	0.636
TRG_DiLeu_BaEn_4	13	19	PF01217	0.658
TRG_ER_diArg_1	270	273	PF00400	0.589
TRG_ER_diArg_1	352	354	PF00400	0.794
TRG_ER_diArg_1	73	75	PF00400	0.830
TRG_ER_diLys_1	349	354	PF00400	0.811
TRG_NLS_MonoCore_2	348	353	PF00514	0.854
TRG_NLS_MonoExtC_3	348	353	PF00514	0.780
TRG_NLS_MonoExtC_3	61	67	PF00514	0.786
TRG_NLS_MonoExtN_4	349	354	PF00514	0.803
TRG_NLS_MonoExtN_4	59	66	PF00514	0.803
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	60%	100%
A0A0S4JHT8	Bodo saltans	28%	99%
A0A1X0NKG5	Trypanosomatidae	37%	90%
A0A422N6Z1	Trypanosoma rangeli	39%	91%
A4H3B2	Leishmania braziliensis	77%	100%
A4HRL2	Leishmania infantum	99%	100%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AC84	Leishmania major	89%	99%
E9AJH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B685	Trypanosoma cruzi	38%	91%