Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4Y1_LEIDO

TriTrypDb:

LdBPK_020070.1 , LdCL_020005900 , LDHU3_02.0140

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S5H4Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Y1

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.679
CLV_NRD_NRD_1	118	120	PF00675	0.546
CLV_NRD_NRD_1	301	303	PF00675	0.583
CLV_NRD_NRD_1	69	71	PF00675	0.731
CLV_NRD_NRD_1	74	76	PF00675	0.665
CLV_NRD_NRD_1	8	10	PF00675	0.720
CLV_PCSK_KEX2_1	117	119	PF00082	0.554
CLV_PCSK_KEX2_1	351	353	PF00082	0.744
CLV_PCSK_KEX2_1	69	71	PF00082	0.727
CLV_PCSK_KEX2_1	73	75	PF00082	0.689

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM5	Leptomonas seymouri	60%	100%
A0A0S4JHT8	Bodo saltans	28%	99%
A0A1X0NKG5	Trypanosomatidae	37%	90%
A0A422N6Z1	Trypanosoma rangeli	39%	91%
A4H3B2	Leishmania braziliensis	77%	100%
A4HRL2	Leishmania infantum	99%	100%
C9ZJ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AC84	Leishmania major	89%	99%
E9AJH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B685	Trypanosoma cruzi	38%	91%

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