Mis18 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4Y0_LEIDO

TriTrypDb:

LdBPK_020060.1 , LdCL_020005800 , LDHU3_02.0130

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.533
CLV_NRD_NRD_1	240	242	PF00675	0.640
CLV_NRD_NRD_1	31	33	PF00675	0.731
CLV_NRD_NRD_1	42	44	PF00675	0.649
CLV_PCSK_KEX2_1	145	147	PF00082	0.533
CLV_PCSK_KEX2_1	242	244	PF00082	0.658
CLV_PCSK_KEX2_1	31	33	PF00082	0.732
CLV_PCSK_KEX2_1	42	44	PF00082	0.647
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.586
CLV_PCSK_PC7_1	27	33	PF00082	0.625
DOC_CKS1_1	176	181	PF01111	0.550
DOC_CYCLIN_RxL_1	145	155	PF00134	0.392
DOC_CYCLIN_RxL_1	27	39	PF00134	0.559
DOC_MAPK_gen_1	145	152	PF00069	0.450
DOC_MAPK_gen_1	214	223	PF00069	0.578
DOC_MAPK_gen_1	241	249	PF00069	0.616
DOC_MAPK_MEF2A_6	214	223	PF00069	0.582
DOC_MAPK_MEF2A_6	266	275	PF00069	0.580
DOC_PP1_RVXF_1	146	153	PF00149	0.442
DOC_PP1_RVXF_1	160	166	PF00149	0.544
DOC_PP2B_LxvP_1	122	125	PF13499	0.482
DOC_PP4_FxxP_1	173	176	PF00568	0.395
DOC_PP4_MxPP_1	1	4	PF00568	0.556
DOC_USP7_MATH_1	102	106	PF00917	0.659
DOC_USP7_MATH_1	158	162	PF00917	0.503
DOC_USP7_MATH_1	17	21	PF00917	0.669
DOC_USP7_MATH_1	274	278	PF00917	0.474
DOC_USP7_MATH_1	46	50	PF00917	0.628
DOC_WW_Pin1_4	133	138	PF00397	0.515
DOC_WW_Pin1_4	175	180	PF00397	0.537
DOC_WW_Pin1_4	196	201	PF00397	0.663
DOC_WW_Pin1_4	278	283	PF00397	0.499
DOC_WW_Pin1_4	308	313	PF00397	0.593
DOC_WW_Pin1_4	71	76	PF00397	0.681
DOC_WW_Pin1_4	98	103	PF00397	0.737
LIG_14-3-3_CanoR_1	183	188	PF00244	0.574
LIG_14-3-3_CanoR_1	203	212	PF00244	0.443
LIG_14-3-3_CanoR_1	214	220	PF00244	0.636
LIG_14-3-3_CanoR_1	231	236	PF00244	0.570
LIG_14-3-3_CanoR_1	295	304	PF00244	0.447
LIG_14-3-3_CanoR_1	43	53	PF00244	0.703
LIG_14-3-3_CanoR_1	57	67	PF00244	0.685
LIG_14-3-3_CanoR_1	77	81	PF00244	0.768
LIG_BIR_III_2	113	117	PF00653	0.545
LIG_BRCT_BRCA1_1	153	157	PF00533	0.432
LIG_EVH1_2	116	120	PF00568	0.601
LIG_FHA_1	158	164	PF00498	0.543
LIG_FHA_1	216	222	PF00498	0.662
LIG_FHA_1	244	250	PF00498	0.604
LIG_FHA_1	292	298	PF00498	0.492
LIG_FHA_1	7	13	PF00498	0.618
LIG_FHA_1	76	82	PF00498	0.660
LIG_FHA_2	128	134	PF00498	0.593
LIG_FHA_2	197	203	PF00498	0.609
LIG_FHA_2	252	258	PF00498	0.544
LIG_LIR_Apic_2	172	176	PF02991	0.426
LIG_LIR_Gen_1	123	133	PF02991	0.631
LIG_LIR_Nem_3	123	129	PF02991	0.488
LIG_LIR_Nem_3	168	173	PF02991	0.390
LIG_SH2_STAT5	142	145	PF00017	0.411
LIG_SH2_STAT5	296	299	PF00017	0.373
LIG_SH3_1	32	38	PF00018	0.594
LIG_SH3_3	173	179	PF00018	0.538
LIG_SH3_3	32	38	PF00018	0.707
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.515
LIG_SUMO_SIM_par_1	245	252	PF11976	0.598
LIG_SUMO_SIM_par_1	271	277	PF11976	0.453
LIG_TRAF2_1	130	133	PF00917	0.509
LIG_TRAF2_1	248	251	PF00917	0.590
LIG_TRFH_1	120	124	PF08558	0.605
LIG_WW_1	2	5	PF00397	0.554
MOD_CDC14_SPxK_1	101	104	PF00782	0.732
MOD_CDC14_SPxK_1	74	77	PF00782	0.683
MOD_CDK_SPK_2	196	201	PF00069	0.660
MOD_CDK_SPK_2	308	313	PF00069	0.497
MOD_CDK_SPxK_1	71	77	PF00069	0.683
MOD_CDK_SPxK_1	98	104	PF00069	0.714
MOD_CDK_SPxxK_3	196	203	PF00069	0.590
MOD_CK1_1	206	212	PF00069	0.775
MOD_CK1_1	49	55	PF00069	0.716
MOD_CK1_1	83	89	PF00069	0.692
MOD_CK2_1	127	133	PF00069	0.590
MOD_CK2_1	245	251	PF00069	0.648
MOD_CK2_1	308	314	PF00069	0.611
MOD_GlcNHglycan	14	17	PF01048	0.685
MOD_GlcNHglycan	167	170	PF01048	0.456
MOD_GlcNHglycan	179	182	PF01048	0.444
MOD_GlcNHglycan	19	22	PF01048	0.647
MOD_GlcNHglycan	208	211	PF01048	0.718
MOD_GlcNHglycan	276	279	PF01048	0.495
MOD_GlcNHglycan	288	291	PF01048	0.604
MOD_GlcNHglycan	61	64	PF01048	0.770
MOD_GlcNHglycan	86	89	PF01048	0.778
MOD_GSK3_1	165	172	PF00069	0.469
MOD_GSK3_1	206	213	PF00069	0.744
MOD_GSK3_1	245	252	PF00069	0.678
MOD_GSK3_1	274	281	PF00069	0.475
MOD_GSK3_1	291	298	PF00069	0.582
MOD_GSK3_1	45	52	PF00069	0.723
MOD_GSK3_1	71	78	PF00069	0.679
MOD_GSK3_1	80	87	PF00069	0.569
MOD_GSK3_1	98	105	PF00069	0.722
MOD_NEK2_1	12	17	PF00069	0.711
MOD_NEK2_1	157	162	PF00069	0.524
MOD_NEK2_1	182	187	PF00069	0.511
MOD_NEK2_1	188	193	PF00069	0.565
MOD_NEK2_1	22	27	PF00069	0.665
MOD_NEK2_1	249	254	PF00069	0.721
MOD_NEK2_1	45	50	PF00069	0.717
MOD_NEK2_1	53	58	PF00069	0.626
MOD_NEK2_1	66	71	PF00069	0.492
MOD_NEK2_2	6	11	PF00069	0.583
MOD_PIKK_1	284	290	PF00454	0.555
MOD_PK_1	231	237	PF00069	0.506
MOD_PKA_2	127	133	PF00069	0.537
MOD_PKA_2	182	188	PF00069	0.600
MOD_PKA_2	194	200	PF00069	0.581
MOD_PKA_2	23	29	PF00069	0.766
MOD_PKA_2	255	261	PF00069	0.607
MOD_PKA_2	49	55	PF00069	0.719
MOD_PKA_2	76	82	PF00069	0.775
MOD_PKB_1	201	209	PF00069	0.598
MOD_PKB_1	241	249	PF00069	0.717
MOD_Plk_1	158	164	PF00069	0.514
MOD_Plk_2-3	251	257	PF00069	0.661
MOD_Plk_4	169	175	PF00069	0.513
MOD_Plk_4	183	189	PF00069	0.510
MOD_Plk_4	76	82	PF00069	0.721
MOD_ProDKin_1	133	139	PF00069	0.513
MOD_ProDKin_1	175	181	PF00069	0.531
MOD_ProDKin_1	196	202	PF00069	0.664
MOD_ProDKin_1	278	284	PF00069	0.496
MOD_ProDKin_1	308	314	PF00069	0.610
MOD_ProDKin_1	71	77	PF00069	0.683
MOD_ProDKin_1	98	104	PF00069	0.737
TRG_ENDOCYTIC_2	5	8	PF00928	0.660
TRG_ER_diArg_1	145	148	PF00400	0.474
TRG_ER_diArg_1	240	243	PF00400	0.639
TRG_ER_diArg_1	30	32	PF00400	0.725
TRG_ER_diArg_1	42	44	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NLG5	Trypanosomatidae	36%	100%
A0A3R7LQ19	Trypanosoma rangeli	33%	100%
A4H3B3	Leishmania braziliensis	63%	100%
A4HRL1	Leishmania infantum	99%	100%
C9ZIZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AC83	Leishmania major	88%	100%
E9AJH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%