Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4X9_LEIDO

TriTrypDb:

LdBPK_020050.1 , LdCL_020005700 , LDHU3_02.0120

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.708
CLV_C14_Caspase3-7	939	943	PF00656	0.661
CLV_NRD_NRD_1	145	147	PF00675	0.562
CLV_NRD_NRD_1	228	230	PF00675	0.494
CLV_NRD_NRD_1	450	452	PF00675	0.497
CLV_NRD_NRD_1	891	893	PF00675	0.543
CLV_PCSK_FUR_1	143	147	PF00082	0.546
CLV_PCSK_FUR_1	889	893	PF00082	0.567
CLV_PCSK_KEX2_1	143	145	PF00082	0.542
CLV_PCSK_KEX2_1	228	230	PF00082	0.488
CLV_PCSK_KEX2_1	450	452	PF00082	0.497
CLV_PCSK_KEX2_1	740	742	PF00082	0.743
CLV_PCSK_KEX2_1	891	893	PF00082	0.569
CLV_PCSK_KEX2_1	974	976	PF00082	0.661
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.537
CLV_PCSK_PC1ET2_1	974	976	PF00082	0.661
CLV_PCSK_PC7_1	140	146	PF00082	0.579
CLV_PCSK_SKI1_1	130	134	PF00082	0.528
CLV_PCSK_SKI1_1	228	232	PF00082	0.425
CLV_PCSK_SKI1_1	421	425	PF00082	0.465
CLV_PCSK_SKI1_1	482	486	PF00082	0.579
CLV_PCSK_SKI1_1	587	591	PF00082	0.448
CLV_PCSK_SKI1_1	592	596	PF00082	0.460
CLV_PCSK_SKI1_1	611	615	PF00082	0.363
CLV_PCSK_SKI1_1	740	744	PF00082	0.642
CLV_PCSK_SKI1_1	773	777	PF00082	0.408
CLV_PCSK_SKI1_1	824	828	PF00082	0.562
CLV_PCSK_SKI1_1	894	898	PF00082	0.578
CLV_Separin_Metazoa	112	116	PF03568	0.683
DEG_APCC_DBOX_1	420	428	PF00400	0.460
DEG_APCC_DBOX_1	823	831	PF00400	0.697
DEG_Kelch_actinfilin_1	645	649	PF01344	0.471
DEG_Kelch_Keap1_1	954	959	PF01344	0.744
DEG_SCF_FBW7_1	950	956	PF00400	0.734
DEG_SCF_FBW7_2	829	835	PF00400	0.734
DOC_CKS1_1	510	515	PF01111	0.598
DOC_CKS1_1	614	619	PF01111	0.560
DOC_CKS1_1	829	834	PF01111	0.737
DOC_CKS1_1	950	955	PF01111	0.733
DOC_CYCLIN_RxL_1	584	595	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	614	620	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.595
DOC_MAPK_MEF2A_6	248	255	PF00069	0.515
DOC_PP2B_LxvP_1	114	117	PF13499	0.697
DOC_PP2B_LxvP_1	750	753	PF13499	0.715
DOC_PP4_MxPP_1	1	4	PF00568	0.585
DOC_USP7_MATH_1	11	15	PF00917	0.627
DOC_USP7_MATH_1	340	344	PF00917	0.615
DOC_USP7_MATH_1	359	363	PF00917	0.669
DOC_USP7_MATH_1	43	47	PF00917	0.707
DOC_USP7_MATH_1	61	65	PF00917	0.380
DOC_USP7_MATH_1	678	682	PF00917	0.613
DOC_USP7_MATH_1	703	707	PF00917	0.796
DOC_USP7_MATH_1	806	810	PF00917	0.760
DOC_USP7_MATH_1	845	849	PF00917	0.667
DOC_USP7_MATH_1	914	918	PF00917	0.566
DOC_USP7_MATH_1	953	957	PF00917	0.841
DOC_USP7_MATH_1	973	977	PF00917	0.447
DOC_WW_Pin1_4	167	172	PF00397	0.687
DOC_WW_Pin1_4	221	226	PF00397	0.577
DOC_WW_Pin1_4	352	357	PF00397	0.732
DOC_WW_Pin1_4	39	44	PF00397	0.760
DOC_WW_Pin1_4	509	514	PF00397	0.594
DOC_WW_Pin1_4	613	618	PF00397	0.594
DOC_WW_Pin1_4	758	763	PF00397	0.575
DOC_WW_Pin1_4	813	818	PF00397	0.781
DOC_WW_Pin1_4	828	833	PF00397	0.561
DOC_WW_Pin1_4	843	848	PF00397	0.655
DOC_WW_Pin1_4	949	954	PF00397	0.767
DOC_WW_Pin1_4	962	967	PF00397	0.691
LIG_14-3-3_CanoR_1	360	366	PF00244	0.633
LIG_14-3-3_CanoR_1	450	454	PF00244	0.506
LIG_14-3-3_CanoR_1	472	480	PF00244	0.512
LIG_14-3-3_CanoR_1	482	487	PF00244	0.416
LIG_14-3-3_CanoR_1	521	526	PF00244	0.501
LIG_14-3-3_CanoR_1	592	597	PF00244	0.562
LIG_14-3-3_CanoR_1	636	641	PF00244	0.691
LIG_14-3-3_CanoR_1	781	788	PF00244	0.576
LIG_14-3-3_CanoR_1	89	97	PF00244	0.629
LIG_14-3-3_CanoR_1	920	924	PF00244	0.534
LIG_14-3-3_CanoR_1	961	966	PF00244	0.720
LIG_14-3-3_CanoR_1	984	990	PF00244	0.601
LIG_Actin_WH2_2	390	405	PF00022	0.586
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BIR_III_1	1	5	PF00653	0.583
LIG_BIR_III_3	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	318	322	PF00533	0.567
LIG_BRCT_BRCA1_1	556	560	PF00533	0.614
LIG_BRCT_BRCA1_1	670	674	PF00533	0.711
LIG_BRCT_BRCA1_1	931	935	PF00533	0.681
LIG_eIF4E_1	584	590	PF01652	0.356
LIG_FHA_1	158	164	PF00498	0.709
LIG_FHA_1	178	184	PF00498	0.549
LIG_FHA_1	34	40	PF00498	0.590
LIG_FHA_1	455	461	PF00498	0.548
LIG_FHA_1	512	518	PF00498	0.405
LIG_FHA_1	547	553	PF00498	0.655
LIG_FHA_1	586	592	PF00498	0.451
LIG_FHA_1	759	765	PF00498	0.774
LIG_FHA_1	853	859	PF00498	0.663
LIG_FHA_1	891	897	PF00498	0.542
LIG_FHA_1	978	984	PF00498	0.638
LIG_FHA_2	180	186	PF00498	0.631
LIG_FHA_2	289	295	PF00498	0.493
LIG_FHA_2	438	444	PF00498	0.462
LIG_FHA_2	45	51	PF00498	0.684
LIG_FHA_2	781	787	PF00498	0.746
LIG_GBD_Chelix_1	396	404	PF00786	0.470
LIG_LIR_Apic_2	717	722	PF02991	0.745
LIG_LIR_Gen_1	392	402	PF02991	0.437
LIG_LIR_Gen_1	438	448	PF02991	0.598
LIG_LIR_Gen_1	485	493	PF02991	0.498
LIG_LIR_Gen_1	557	568	PF02991	0.511
LIG_LIR_Gen_1	588	598	PF02991	0.558
LIG_LIR_Gen_1	768	777	PF02991	0.614
LIG_LIR_Gen_1	80	87	PF02991	0.451
LIG_LIR_Nem_3	392	397	PF02991	0.453
LIG_LIR_Nem_3	438	444	PF02991	0.608
LIG_LIR_Nem_3	485	490	PF02991	0.484
LIG_LIR_Nem_3	557	563	PF02991	0.500
LIG_LIR_Nem_3	588	593	PF02991	0.404
LIG_LIR_Nem_3	671	677	PF02991	0.702
LIG_LIR_Nem_3	724	730	PF02991	0.638
LIG_LIR_Nem_3	768	772	PF02991	0.612
LIG_LIR_Nem_3	80	84	PF02991	0.437
LIG_NRBOX	592	598	PF00104	0.562
LIG_NRBOX	771	777	PF00104	0.409
LIG_Pex14_1	197	201	PF04695	0.401
LIG_Pex14_1	365	369	PF04695	0.580
LIG_RPA_C_Fungi	299	311	PF08784	0.484
LIG_SH2_CRK	326	330	PF00017	0.440
LIG_SH2_GRB2like	147	150	PF00017	0.621
LIG_SH2_GRB2like	584	587	PF00017	0.509
LIG_SH2_SRC	328	331	PF00017	0.552
LIG_SH2_STAP1	201	205	PF00017	0.473
LIG_SH2_STAP1	285	289	PF00017	0.656
LIG_SH2_STAP1	293	297	PF00017	0.471
LIG_SH2_STAP1	326	330	PF00017	0.516
LIG_SH2_STAT3	201	204	PF00017	0.462
LIG_SH2_STAT3	898	901	PF00017	0.637
LIG_SH2_STAT5	147	150	PF00017	0.621
LIG_SH2_STAT5	315	318	PF00017	0.596
LIG_SH2_STAT5	328	331	PF00017	0.614
LIG_SH2_STAT5	401	404	PF00017	0.462
LIG_SH2_STAT5	441	444	PF00017	0.594
LIG_SH2_STAT5	719	722	PF00017	0.735
LIG_SH3_3	350	356	PF00018	0.726
LIG_SH3_3	672	678	PF00018	0.698
LIG_SH3_3	826	832	PF00018	0.648
LIG_SH3_3	861	867	PF00018	0.685
LIG_SH3_3	980	986	PF00018	0.600
LIG_SUMO_SIM_par_1	456	462	PF11976	0.546
LIG_TRAF2_1	159	162	PF00917	0.681
LIG_TRAF2_1	182	185	PF00917	0.621
LIG_TRAF2_1	499	502	PF00917	0.513
LIG_TRAF2_1	685	688	PF00917	0.607
LIG_TRAF2_1	783	786	PF00917	0.743
LIG_TYR_ITIM	324	329	PF00017	0.613
LIG_UBA3_1	565	569	PF00899	0.634
LIG_WRC_WIRS_1	366	371	PF05994	0.571
LIG_WRC_WIRS_1	78	83	PF05994	0.445
LIG_WRPW_2	88	91	PF00400	0.589
MOD_CDK_SPxxK_3	221	228	PF00069	0.572
MOD_CDK_SPxxK_3	758	765	PF00069	0.570
MOD_CK1_1	102	108	PF00069	0.528
MOD_CK1_1	164	170	PF00069	0.663
MOD_CK1_1	216	222	PF00069	0.694
MOD_CK1_1	260	266	PF00069	0.634
MOD_CK1_1	355	361	PF00069	0.688
MOD_CK1_1	364	370	PF00069	0.415
MOD_CK1_1	46	52	PF00069	0.676
MOD_CK1_1	511	517	PF00069	0.573
MOD_CK1_1	554	560	PF00069	0.508
MOD_CK1_1	639	645	PF00069	0.581
MOD_CK1_1	807	813	PF00069	0.787
MOD_CK1_1	954	960	PF00069	0.744
MOD_CK2_1	102	108	PF00069	0.691
MOD_CK2_1	125	131	PF00069	0.459
MOD_CK2_1	156	162	PF00069	0.665
MOD_CK2_1	179	185	PF00069	0.540
MOD_CK2_1	204	210	PF00069	0.633
MOD_CK2_1	221	227	PF00069	0.520
MOD_CK2_1	288	294	PF00069	0.541
MOD_CK2_1	626	632	PF00069	0.540
MOD_CK2_1	780	786	PF00069	0.742
MOD_CK2_1	854	860	PF00069	0.662
MOD_CK2_1	953	959	PF00069	0.729
MOD_CK2_1	973	979	PF00069	0.739
MOD_GlcNHglycan	101	104	PF01048	0.720
MOD_GlcNHglycan	106	111	PF01048	0.772
MOD_GlcNHglycan	259	262	PF01048	0.647
MOD_GlcNHglycan	265	268	PF01048	0.685
MOD_GlcNHglycan	294	297	PF01048	0.605
MOD_GlcNHglycan	318	321	PF01048	0.553
MOD_GlcNHglycan	342	345	PF01048	0.727
MOD_GlcNHglycan	357	360	PF01048	0.641
MOD_GlcNHglycan	474	477	PF01048	0.378
MOD_GlcNHglycan	553	556	PF01048	0.612
MOD_GlcNHglycan	628	631	PF01048	0.514
MOD_GlcNHglycan	641	644	PF01048	0.636
MOD_GlcNHglycan	806	809	PF01048	0.781
MOD_GlcNHglycan	810	813	PF01048	0.711
MOD_GlcNHglycan	843	846	PF01048	0.653
MOD_GlcNHglycan	9	12	PF01048	0.688
MOD_GlcNHglycan	91	94	PF01048	0.573
MOD_GlcNHglycan	931	934	PF01048	0.636
MOD_GlcNHglycan	953	956	PF01048	0.839
MOD_GlcNHglycan	969	972	PF01048	0.559
MOD_GlcNHglycan	975	978	PF01048	0.627
MOD_GSK3_1	121	128	PF00069	0.537
MOD_GSK3_1	157	164	PF00069	0.687
MOD_GSK3_1	173	180	PF00069	0.666
MOD_GSK3_1	199	206	PF00069	0.606
MOD_GSK3_1	209	216	PF00069	0.612
MOD_GSK3_1	259	266	PF00069	0.612
MOD_GSK3_1	284	291	PF00069	0.528
MOD_GSK3_1	29	36	PF00069	0.621
MOD_GSK3_1	311	318	PF00069	0.675
MOD_GSK3_1	355	362	PF00069	0.628
MOD_GSK3_1	39	46	PF00069	0.695
MOD_GSK3_1	413	420	PF00069	0.557
MOD_GSK3_1	449	456	PF00069	0.561
MOD_GSK3_1	521	528	PF00069	0.616
MOD_GSK3_1	55	62	PF00069	0.483
MOD_GSK3_1	551	558	PF00069	0.539
MOD_GSK3_1	635	642	PF00069	0.603
MOD_GSK3_1	664	671	PF00069	0.722
MOD_GSK3_1	7	14	PF00069	0.644
MOD_GSK3_1	804	811	PF00069	0.756
MOD_GSK3_1	841	848	PF00069	0.667
MOD_GSK3_1	852	859	PF00069	0.633
MOD_GSK3_1	949	956	PF00069	0.770
MOD_GSK3_1	95	102	PF00069	0.585
MOD_GSK3_1	973	980	PF00069	0.756
MOD_N-GLC_1	585	590	PF02516	0.495
MOD_N-GLC_1	961	966	PF02516	0.761
MOD_N-GLC_2	714	716	PF02516	0.558
MOD_NEK2_1	199	204	PF00069	0.587
MOD_NEK2_1	292	297	PF00069	0.599
MOD_NEK2_1	309	314	PF00069	0.472
MOD_NEK2_1	324	329	PF00069	0.613
MOD_NEK2_1	453	458	PF00069	0.517
MOD_NEK2_1	551	556	PF00069	0.551
MOD_NEK2_1	60	65	PF00069	0.608
MOD_NEK2_1	841	846	PF00069	0.743
MOD_NEK2_1	858	863	PF00069	0.452
MOD_NEK2_1	919	924	PF00069	0.601
MOD_NEK2_1	927	932	PF00069	0.529
MOD_NEK2_2	555	560	PF00069	0.513
MOD_NEK2_2	585	590	PF00069	0.457
MOD_NEK2_2	914	919	PF00069	0.550
MOD_PIKK_1	177	183	PF00454	0.553
MOD_PIKK_1	435	441	PF00454	0.552
MOD_PIKK_1	664	670	PF00454	0.739
MOD_PIKK_1	781	787	PF00454	0.746
MOD_PKA_2	359	365	PF00069	0.649
MOD_PKA_2	449	455	PF00069	0.503
MOD_PKA_2	635	641	PF00069	0.607
MOD_PKA_2	780	786	PF00069	0.536
MOD_PKA_2	890	896	PF00069	0.648
MOD_PKA_2	919	925	PF00069	0.530
MOD_Plk_1	214	220	PF00069	0.506
MOD_Plk_1	417	423	PF00069	0.520
MOD_Plk_1	585	591	PF00069	0.455
MOD_Plk_2-3	273	279	PF00069	0.617
MOD_Plk_2-3	288	294	PF00069	0.392
MOD_Plk_4	204	210	PF00069	0.633
MOD_Plk_4	288	294	PF00069	0.535
MOD_Plk_4	311	317	PF00069	0.676
MOD_Plk_4	324	330	PF00069	0.464
MOD_Plk_4	361	367	PF00069	0.522
MOD_Plk_4	437	443	PF00069	0.511
MOD_Plk_4	482	488	PF00069	0.583
MOD_Plk_4	521	527	PF00069	0.542
MOD_Plk_4	555	561	PF00069	0.553
MOD_Plk_4	592	598	PF00069	0.494
MOD_Plk_4	61	67	PF00069	0.586
MOD_Plk_4	678	684	PF00069	0.644
MOD_Plk_4	714	720	PF00069	0.746
MOD_Plk_4	745	751	PF00069	0.694
MOD_Plk_4	77	83	PF00069	0.370
MOD_Plk_4	914	920	PF00069	0.545
MOD_Plk_4	977	983	PF00069	0.655
MOD_Plk_4	985	991	PF00069	0.600
MOD_ProDKin_1	167	173	PF00069	0.688
MOD_ProDKin_1	221	227	PF00069	0.566
MOD_ProDKin_1	352	358	PF00069	0.728
MOD_ProDKin_1	39	45	PF00069	0.758
MOD_ProDKin_1	509	515	PF00069	0.593
MOD_ProDKin_1	613	619	PF00069	0.587
MOD_ProDKin_1	758	764	PF00069	0.573
MOD_ProDKin_1	813	819	PF00069	0.777
MOD_ProDKin_1	828	834	PF00069	0.556
MOD_ProDKin_1	843	849	PF00069	0.657
MOD_ProDKin_1	949	955	PF00069	0.768
MOD_ProDKin_1	962	968	PF00069	0.689
MOD_SUMO_rev_2	564	571	PF00179	0.634
MOD_SUMO_rev_2	733	742	PF00179	0.540
MOD_SUMO_rev_2	932	941	PF00179	0.696
TRG_DiLeu_BaEn_3	737	743	PF01217	0.740
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.487
TRG_ENDOCYTIC_2	326	329	PF00928	0.498
TRG_ENDOCYTIC_2	401	404	PF00928	0.419
TRG_ENDOCYTIC_2	441	444	PF00928	0.594
TRG_ER_diArg_1	143	146	PF00400	0.545
TRG_ER_diArg_1	228	230	PF00400	0.488
TRG_ER_diArg_1	889	892	PF00400	0.572
TRG_NES_CRM1_1	520	535	PF08389	0.555
TRG_Pf-PMV_PEXEL_1	925	929	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K8	Leptomonas seymouri	38%	83%
A4H3A4	Leishmania braziliensis	71%	100%
A4HRL0	Leishmania infantum	99%	100%
E9AC82	Leishmania major	91%	100%
E9AJH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%