Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4X8_LEIDO

TriTrypDb:

LdBPK_020040.1 , LdCL_020005600 , LDHU3_02.0100

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.605
CLV_C14_Caspase3-7	215	219	PF00656	0.619
CLV_C14_Caspase3-7	230	234	PF00656	0.627
CLV_C14_Caspase3-7	330	334	PF00656	0.497
CLV_C14_Caspase3-7	344	348	PF00656	0.458
CLV_C14_Caspase3-7	383	387	PF00656	0.593
CLV_C14_Caspase3-7	67	71	PF00656	0.546
CLV_NRD_NRD_1	270	272	PF00675	0.370
CLV_NRD_NRD_1	286	288	PF00675	0.426
CLV_NRD_NRD_1	363	365	PF00675	0.638
CLV_PCSK_KEX2_1	24	26	PF00082	0.337
CLV_PCSK_KEX2_1	286	288	PF00082	0.430
CLV_PCSK_KEX2_1	293	295	PF00082	0.322
CLV_PCSK_KEX2_1	363	365	PF00082	0.590
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.337
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.375
CLV_PCSK_SKI1_1	14	18	PF00082	0.359
CLV_PCSK_SKI1_1	205	209	PF00082	0.576
CLV_PCSK_SKI1_1	237	241	PF00082	0.501
CLV_PCSK_SKI1_1	24	28	PF00082	0.486
CLV_PCSK_SKI1_1	286	290	PF00082	0.377
CLV_PCSK_SKI1_1	297	301	PF00082	0.451
CLV_PCSK_SKI1_1	3	7	PF00082	0.511
CLV_PCSK_SKI1_1	309	313	PF00082	0.435
CLV_Separin_Metazoa	277	281	PF03568	0.436
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DEG_SPOP_SBC_1	225	229	PF00917	0.657
DEG_SPOP_SBC_1	97	101	PF00917	0.706
DOC_MAPK_gen_1	293	300	PF00069	0.337
DOC_MAPK_RevD_3	257	272	PF00069	0.323
DOC_PP1_RVXF_1	295	301	PF00149	0.474
DOC_PP2B_LxvP_1	155	158	PF13499	0.396
DOC_USP7_MATH_1	178	182	PF00917	0.507
DOC_USP7_MATH_1	251	255	PF00917	0.497
DOC_USP7_MATH_1	261	265	PF00917	0.318
DOC_USP7_MATH_1	301	305	PF00917	0.454
DOC_USP7_MATH_1	95	99	PF00917	0.652
DOC_USP7_UBL2_3	3	7	PF12436	0.621
DOC_WW_Pin1_4	198	203	PF00397	0.481
DOC_WW_Pin1_4	217	222	PF00397	0.452
DOC_WW_Pin1_4	249	254	PF00397	0.480
DOC_WW_Pin1_4	365	370	PF00397	0.686
LIG_14-3-3_CanoR_1	127	136	PF00244	0.589
LIG_14-3-3_CanoR_1	363	369	PF00244	0.694
LIG_Actin_WH2_2	303	319	PF00022	0.533
LIG_BIR_III_2	218	222	PF00653	0.648
LIG_BIR_III_4	333	337	PF00653	0.511
LIG_Clathr_ClatBox_1	172	176	PF01394	0.351
LIG_FHA_1	13	19	PF00498	0.435
LIG_FHA_1	322	328	PF00498	0.472
LIG_FHA_1	44	50	PF00498	0.476
LIG_FHA_1	91	97	PF00498	0.681
LIG_FHA_2	108	114	PF00498	0.647
LIG_FHA_2	208	214	PF00498	0.583
LIG_FHA_2	226	232	PF00498	0.650
LIG_FHA_2	368	374	PF00498	0.627
LIG_FHA_2	65	71	PF00498	0.660
LIG_GBD_Chelix_1	147	155	PF00786	0.340
LIG_LIR_Apic_2	388	393	PF02991	0.662
LIG_LIR_Gen_1	113	122	PF02991	0.620
LIG_LIR_Gen_1	252	262	PF02991	0.400
LIG_LIR_Gen_1	275	283	PF02991	0.520
LIG_LIR_Nem_3	113	117	PF02991	0.631
LIG_LIR_Nem_3	135	139	PF02991	0.549
LIG_LIR_Nem_3	166	172	PF02991	0.310
LIG_LIR_Nem_3	220	226	PF02991	0.564
LIG_LIR_Nem_3	252	258	PF02991	0.410
LIG_NRBOX	203	209	PF00104	0.537
LIG_Pex14_1	136	140	PF04695	0.507
LIG_Pex14_2	164	168	PF04695	0.431
LIG_SH2_CRK	144	148	PF00017	0.398
LIG_SH2_CRK	169	173	PF00017	0.322
LIG_SH2_CRK	255	259	PF00017	0.407
LIG_SH2_CRK	270	274	PF00017	0.284
LIG_SH2_GRB2like	57	60	PF00017	0.602
LIG_SH2_STAP1	144	148	PF00017	0.419
LIG_SH2_STAP1	255	259	PF00017	0.359
LIG_SH2_STAT5	140	143	PF00017	0.366
LIG_SH2_STAT5	238	241	PF00017	0.377
LIG_SH2_STAT5	28	31	PF00017	0.384
LIG_SH2_STAT5	320	323	PF00017	0.543
LIG_SH2_STAT5	57	60	PF00017	0.506
LIG_SH3_3	218	224	PF00018	0.612
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.443
LIG_SUMO_SIM_par_1	171	176	PF11976	0.467
LIG_SUMO_SIM_par_1	287	292	PF11976	0.353
LIG_TYR_ITIM	236	241	PF00017	0.393
LIG_TYR_ITIM	268	273	PF00017	0.402
LIG_UBA3_1	288	293	PF00899	0.415
LIG_UBA3_1	77	84	PF00899	0.581
MOD_CDK_SPxxK_3	198	205	PF00069	0.504
MOD_CK1_1	335	341	PF00069	0.713
MOD_CK1_1	367	373	PF00069	0.662
MOD_CK1_1	98	104	PF00069	0.629
MOD_CK2_1	147	153	PF00069	0.404
MOD_CK2_1	209	215	PF00069	0.612
MOD_CK2_1	367	373	PF00069	0.679
MOD_GlcNHglycan	101	104	PF01048	0.670
MOD_GlcNHglycan	131	134	PF01048	0.563
MOD_GlcNHglycan	180	183	PF01048	0.449
MOD_GlcNHglycan	333	337	PF01048	0.603
MOD_GlcNHglycan	340	343	PF01048	0.631
MOD_GlcNHglycan	90	93	PF01048	0.642
MOD_GSK3_1	178	185	PF00069	0.553
MOD_GSK3_1	203	210	PF00069	0.480
MOD_GSK3_1	213	220	PF00069	0.533
MOD_GSK3_1	34	41	PF00069	0.534
MOD_GSK3_1	363	370	PF00069	0.622
MOD_GSK3_1	95	102	PF00069	0.616
MOD_N-GLC_1	115	120	PF02516	0.494
MOD_NEK2_1	147	152	PF00069	0.336
MOD_NEK2_1	207	212	PF00069	0.568
MOD_NEK2_1	96	101	PF00069	0.651
MOD_NEK2_2	43	48	PF00069	0.492
MOD_PK_1	287	293	PF00069	0.358
MOD_PKA_1	363	369	PF00069	0.560
MOD_PKA_2	128	134	PF00069	0.528
MOD_PKA_2	363	369	PF00069	0.699
MOD_PKB_1	127	135	PF00069	0.578
MOD_Plk_1	115	121	PF00069	0.623
MOD_Plk_2-3	213	219	PF00069	0.440
MOD_Plk_2-3	34	40	PF00069	0.573
MOD_Plk_4	203	209	PF00069	0.502
MOD_Plk_4	261	267	PF00069	0.357
MOD_Plk_4	38	44	PF00069	0.648
MOD_Plk_4	385	391	PF00069	0.733
MOD_ProDKin_1	198	204	PF00069	0.475
MOD_ProDKin_1	217	223	PF00069	0.454
MOD_ProDKin_1	249	255	PF00069	0.467
MOD_ProDKin_1	365	371	PF00069	0.689
MOD_SUMO_rev_2	367	377	PF00179	0.628
TRG_ENDOCYTIC_2	144	147	PF00928	0.323
TRG_ENDOCYTIC_2	169	172	PF00928	0.304
TRG_ENDOCYTIC_2	238	241	PF00928	0.373
TRG_ENDOCYTIC_2	255	258	PF00928	0.360
TRG_ENDOCYTIC_2	270	273	PF00928	0.431
TRG_ENDOCYTIC_2	276	279	PF00928	0.397
TRG_ENDOCYTIC_2	57	60	PF00928	0.557
TRG_ER_diArg_1	126	129	PF00400	0.599
TRG_ER_diArg_1	285	287	PF00400	0.419
TRG_NES_CRM1_1	231	243	PF08389	0.452
TRG_NES_CRM1_1	50	62	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV1	Leptomonas seymouri	61%	95%
A0A0S4JHJ5	Bodo saltans	29%	100%
A0A1X0NJT7	Trypanosomatidae	34%	100%
A0A3S5IQM7	Trypanosoma rangeli	35%	98%
A4H3A3	Leishmania braziliensis	83%	100%
A4HRK9	Leishmania infantum	100%	100%
E9AC81	Leishmania major	95%	100%
E9AJH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BAQ0	Trypanosoma cruzi	36%	100%