LeishMANIAdb
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Cytochrome b-domain protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome b-domain protein, putative
Gene product:
cytochrome b-domain protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H4X7_LEIDO
TriTrypDb:
LdBPK_020020.1 * , LdCL_020005400 , LDHU3_02.0080
Length:
218

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S5H4X7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4X7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 9
GO:0020037 heme binding 4 9
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0046906 tetrapyrrole binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 162 164 PF00675 0.399
CLV_NRD_NRD_1 168 170 PF00675 0.521
CLV_NRD_NRD_1 67 69 PF00675 0.242
CLV_PCSK_KEX2_1 67 69 PF00082 0.231
CLV_PCSK_PC7_1 63 69 PF00082 0.212
CLV_PCSK_SKI1_1 122 126 PF00082 0.265
CLV_PCSK_SKI1_1 169 173 PF00082 0.518
CLV_PCSK_SKI1_1 41 45 PF00082 0.273
CLV_PCSK_SKI1_1 84 88 PF00082 0.416
DOC_MAPK_gen_1 67 74 PF00069 0.453
DOC_MAPK_MEF2A_6 201 210 PF00069 0.337
DOC_MAPK_NFAT4_5 201 209 PF00069 0.314
DOC_USP7_MATH_1 93 97 PF00917 0.519
DOC_WW_Pin1_4 109 114 PF00397 0.503
LIG_14-3-3_CanoR_1 163 167 PF00244 0.719
LIG_14-3-3_CanoR_1 84 89 PF00244 0.586
LIG_APCC_ABBA_1 111 116 PF00400 0.503
LIG_FHA_1 110 116 PF00498 0.477
LIG_FHA_1 178 184 PF00498 0.668
LIG_LIR_Gen_1 112 119 PF02991 0.491
LIG_LIR_Gen_1 144 155 PF02991 0.537
LIG_LIR_Gen_1 17 28 PF02991 0.524
LIG_LIR_Nem_3 112 117 PF02991 0.521
LIG_LIR_Nem_3 17 23 PF02991 0.455
LIG_LIR_Nem_3 53 59 PF02991 0.452
LIG_PTB_Apo_2 103 110 PF02174 0.452
LIG_PTB_Apo_2 22 29 PF02174 0.519
LIG_PTB_Phospho_1 103 109 PF10480 0.452
LIG_PTB_Phospho_1 22 28 PF10480 0.519
LIG_SH2_PTP2 85 88 PF00017 0.512
LIG_SH2_SRC 34 37 PF00017 0.477
LIG_SH2_STAT5 153 156 PF00017 0.489
LIG_SH2_STAT5 5 8 PF00017 0.457
LIG_SH2_STAT5 85 88 PF00017 0.570
MOD_CK1_1 15 21 PF00069 0.465
MOD_GlcNHglycan 127 130 PF01048 0.250
MOD_GlcNHglycan 17 20 PF01048 0.317
MOD_GlcNHglycan 95 98 PF01048 0.376
MOD_GSK3_1 131 138 PF00069 0.519
MOD_GSK3_1 158 165 PF00069 0.649
MOD_N-GLC_1 188 193 PF02516 0.400
MOD_N-GLC_1 59 64 PF02516 0.277
MOD_NEK2_1 125 130 PF00069 0.459
MOD_PIKK_1 131 137 PF00454 0.519
MOD_PIKK_1 177 183 PF00454 0.692
MOD_PKA_1 169 175 PF00069 0.697
MOD_PKA_2 162 168 PF00069 0.637
MOD_PKB_1 82 90 PF00069 0.587
MOD_Plk_1 188 194 PF00069 0.581
MOD_Plk_4 162 168 PF00069 0.612
MOD_Plk_4 188 194 PF00069 0.631
MOD_ProDKin_1 109 115 PF00069 0.503
MOD_SUMO_for_1 185 188 PF00179 0.642
MOD_SUMO_rev_2 157 166 PF00179 0.612
TRG_DiLeu_BaEn_1 162 167 PF01217 0.586
TRG_DiLeu_BaEn_1 17 22 PF01217 0.462
TRG_DiLeu_BaEn_1 188 193 PF01217 0.606
TRG_DiLeu_BaEn_1 198 203 PF01217 0.453
TRG_DiLeu_LyEn_5 198 203 PF01217 0.412
TRG_ENDOCYTIC_2 147 150 PF00928 0.519
TRG_ENDOCYTIC_2 85 88 PF00928 0.570
TRG_ER_diArg_1 66 68 PF00400 0.426
TRG_ER_diArg_1 82 85 PF00400 0.542

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4I5 Leptomonas seymouri 72% 100%
A0A1X0NJR3 Trypanosomatidae 50% 98%
A0A422N6Z2 Trypanosoma rangeli 51% 96%
A4H3A1 Leishmania braziliensis 74% 100%
A4HRK7 Leishmania infantum 99% 100%
E9AC79 Leishmania major 88% 100%
E9AJH1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS