Metallo-peptidase, Clan MA(E), Family M3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-dipeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4X4_LEIDO

TriTrypDb:

LdBPK_020710.1 , LdCL_010013600 , LDHU3_01.0970

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4X4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0019538	protein metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004175	endopeptidase activity	4	6
GO:0004180	carboxypeptidase activity	5	2
GO:0004222	metalloendopeptidase activity	5	6
GO:0005488	binding	1	6
GO:0008233	peptidase activity	3	6
GO:0008237	metallopeptidase activity	4	6
GO:0008238	exopeptidase activity	4	2
GO:0016787	hydrolase activity	2	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.195
CLV_NRD_NRD_1	375	377	PF00675	0.307
CLV_NRD_NRD_1	54	56	PF00675	0.301
CLV_NRD_NRD_1	94	96	PF00675	0.307
CLV_PCSK_KEX2_1	131	133	PF00082	0.450
CLV_PCSK_KEX2_1	23	25	PF00082	0.195
CLV_PCSK_KEX2_1	94	96	PF00082	0.307
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.307
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.195
CLV_PCSK_SKI1_1	205	209	PF00082	0.425
CLV_PCSK_SKI1_1	337	341	PF00082	0.195
CLV_PCSK_SKI1_1	381	385	PF00082	0.327
CLV_PCSK_SKI1_1	78	82	PF00082	0.273
DOC_MAPK_gen_1	131	139	PF00069	0.307
DOC_MAPK_gen_1	94	100	PF00069	0.307
DOC_USP7_MATH_1	127	131	PF00917	0.195
DOC_USP7_MATH_1	17	21	PF00917	0.335
DOC_USP7_MATH_1	170	174	PF00917	0.195
DOC_USP7_MATH_1	290	294	PF00917	0.195
DOC_USP7_MATH_1	360	364	PF00917	0.195
DOC_USP7_UBL2_3	377	381	PF12436	0.307
DOC_WW_Pin1_4	141	146	PF00397	0.209
LIG_14-3-3_CanoR_1	94	101	PF00244	0.307
LIG_BIR_II_1	1	5	PF00653	0.319
LIG_BIR_III_1	1	5	PF00653	0.319
LIG_BIR_III_3	1	5	PF00653	0.319
LIG_BRCT_BRCA1_1	306	310	PF00533	0.307
LIG_FHA_1	256	262	PF00498	0.311
LIG_LIR_Gen_1	107	114	PF02991	0.195
LIG_LIR_Gen_1	176	186	PF02991	0.273
LIG_LIR_Gen_1	206	214	PF02991	0.273
LIG_LIR_Gen_1	268	279	PF02991	0.205
LIG_LIR_Gen_1	380	390	PF02991	0.195
LIG_LIR_Nem_3	107	111	PF02991	0.272
LIG_LIR_Nem_3	176	182	PF02991	0.292
LIG_LIR_Nem_3	206	210	PF02991	0.273
LIG_LIR_Nem_3	216	221	PF02991	0.282
LIG_LIR_Nem_3	268	274	PF02991	0.210
LIG_LIR_Nem_3	307	312	PF02991	0.276
LIG_LIR_Nem_3	320	325	PF02991	0.283
LIG_LIR_Nem_3	334	339	PF02991	0.214
LIG_LIR_Nem_3	380	386	PF02991	0.195
LIG_LIR_Nem_3	46	50	PF02991	0.466
LIG_LIR_Nem_3	66	72	PF02991	0.196
LIG_MLH1_MIPbox_1	306	310	PF16413	0.307
LIG_Pex14_1	135	139	PF04695	0.195
LIG_Pex14_2	310	314	PF04695	0.199
LIG_PTB_Apo_2	189	196	PF02174	0.307
LIG_PTB_Phospho_1	189	195	PF10480	0.307
LIG_SH2_CRK	195	199	PF00017	0.307
LIG_SH2_CRK	221	225	PF00017	0.307
LIG_SH2_NCK_1	126	130	PF00017	0.307
LIG_SH2_STAP1	228	232	PF00017	0.268
LIG_SH2_STAP1	318	322	PF00017	0.307
LIG_SH2_STAP1	370	374	PF00017	0.307
LIG_SH2_STAP1	50	54	PF00017	0.307
LIG_SH2_STAT3	140	143	PF00017	0.195
LIG_SH2_STAT3	323	326	PF00017	0.195
LIG_SH2_STAT5	266	269	PF00017	0.440
LIG_SH2_STAT5	309	312	PF00017	0.469
LIG_SH2_STAT5	323	326	PF00017	0.385
LIG_SH2_STAT5	69	72	PF00017	0.273
LIG_SH2_STAT5	82	85	PF00017	0.273
LIG_SH3_2	167	172	PF14604	0.195
LIG_SH3_3	156	162	PF00018	0.310
LIG_SH3_3	164	170	PF00018	0.380
LIG_SH3_3	97	103	PF00018	0.307
LIG_SH3_4	236	243	PF00018	0.195
LIG_Sin3_3	7	14	PF02671	0.307
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.195
LIG_TRFH_1	121	125	PF08558	0.195
LIG_TRFH_1	40	44	PF08558	0.275
LIG_WRC_WIRS_1	291	296	PF05994	0.195
LIG_WRC_WIRS_1	311	316	PF05994	0.195
LIG_WW_1	302	305	PF00397	0.307
LIG_WW_3	301	305	PF00397	0.335
MOD_CK1_1	173	179	PF00069	0.195
MOD_CK1_1	196	202	PF00069	0.307
MOD_Cter_Amidation	374	377	PF01082	0.307
MOD_GlcNHglycan	198	201	PF01048	0.307
MOD_GlcNHglycan	306	309	PF01048	0.307
MOD_GlcNHglycan	314	317	PF01048	0.256
MOD_GlcNHglycan	358	361	PF01048	0.206
MOD_GlcNHglycan	5	8	PF01048	0.396
MOD_GSK3_1	170	177	PF00069	0.195
MOD_GSK3_1	194	201	PF00069	0.289
MOD_GSK3_1	356	363	PF00069	0.206
MOD_N-GLC_1	63	68	PF02516	0.198
MOD_NEK2_1	114	119	PF00069	0.195
MOD_NEK2_1	198	203	PF00069	0.298
MOD_NEK2_1	310	315	PF00069	0.195
MOD_NEK2_2	135	140	PF00069	0.195
MOD_PIKK_1	209	215	PF00454	0.273
MOD_PKA_2	127	133	PF00069	0.195
MOD_PKA_2	165	171	PF00069	0.195
MOD_PKA_2	93	99	PF00069	0.307
MOD_Plk_1	173	179	PF00069	0.273
MOD_Plk_2-3	104	110	PF00069	0.307
MOD_Plk_4	135	141	PF00069	0.296
MOD_Plk_4	174	180	PF00069	0.319
MOD_ProDKin_1	141	147	PF00069	0.209
MOD_SUMO_for_1	22	25	PF00179	0.195
MOD_SUMO_rev_2	25	32	PF00179	0.195
MOD_SUMO_rev_2	332	339	PF00179	0.195
MOD_SUMO_rev_2	60	68	PF00179	0.307
TRG_DiLeu_BaEn_2	334	340	PF01217	0.195
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.195
TRG_ENDOCYTIC_2	195	198	PF00928	0.307
TRG_ENDOCYTIC_2	221	224	PF00928	0.307
TRG_ENDOCYTIC_2	266	269	PF00928	0.383
TRG_ENDOCYTIC_2	370	373	PF00928	0.307
TRG_ENDOCYTIC_2	69	72	PF00928	0.273
TRG_NES_CRM1_1	109	124	PF08389	0.195
TRG_NLS_MonoExtC_3	54	60	PF00514	0.195
TRG_NLS_MonoExtN_4	53	59	PF00514	0.195
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFS7	Leishmania braziliensis	80%	100%
A4HFS8	Leishmania braziliensis	79%	100%
A4HG37	Leishmania braziliensis	80%	100%
V5B1A3	Trypanosoma cruzi	26%	100%