Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4W8_LEIDO

TriTrypDb:

LdBPK_010760.1 , LdCL_010012600 , LDHU3_01.0860

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.628
CLV_C14_Caspase3-7	231	235	PF00656	0.832
CLV_C14_Caspase3-7	394	398	PF00656	0.814
CLV_C14_Caspase3-7	560	564	PF00656	0.638
CLV_C14_Caspase3-7	727	731	PF00656	0.516
CLV_NRD_NRD_1	14	16	PF00675	0.629
CLV_NRD_NRD_1	173	175	PF00675	0.704
CLV_NRD_NRD_1	284	286	PF00675	0.635
CLV_NRD_NRD_1	408	410	PF00675	0.799
CLV_NRD_NRD_1	493	495	PF00675	0.590
CLV_NRD_NRD_1	519	521	PF00675	0.735
CLV_NRD_NRD_1	522	524	PF00675	0.656
CLV_NRD_NRD_1	527	529	PF00675	0.599
CLV_NRD_NRD_1	532	534	PF00675	0.607
CLV_NRD_NRD_1	711	713	PF00675	0.525
CLV_NRD_NRD_1	736	738	PF00675	0.628
CLV_PCSK_FUR_1	520	524	PF00082	0.642
CLV_PCSK_FUR_1	751	755	PF00082	0.577
CLV_PCSK_KEX2_1	14	16	PF00082	0.629
CLV_PCSK_KEX2_1	173	175	PF00082	0.704
CLV_PCSK_KEX2_1	284	286	PF00082	0.635
CLV_PCSK_KEX2_1	308	310	PF00082	0.585
CLV_PCSK_KEX2_1	408	410	PF00082	0.799
CLV_PCSK_KEX2_1	521	523	PF00082	0.682
CLV_PCSK_KEX2_1	527	529	PF00082	0.627
CLV_PCSK_KEX2_1	532	534	PF00082	0.609
CLV_PCSK_KEX2_1	581	583	PF00082	0.630
CLV_PCSK_KEX2_1	674	676	PF00082	0.615
CLV_PCSK_KEX2_1	679	681	PF00082	0.603
CLV_PCSK_KEX2_1	710	712	PF00082	0.518
CLV_PCSK_KEX2_1	736	738	PF00082	0.628
CLV_PCSK_KEX2_1	753	755	PF00082	0.564
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.639
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.550
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.464
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.641
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.626
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.639
CLV_PCSK_PC7_1	169	175	PF00082	0.694
CLV_PCSK_PC7_1	523	529	PF00082	0.745
CLV_PCSK_PC7_1	675	681	PF00082	0.619
CLV_PCSK_PC7_1	749	755	PF00082	0.567
CLV_PCSK_SKI1_1	169	173	PF00082	0.691
CLV_PCSK_SKI1_1	275	279	PF00082	0.587
CLV_PCSK_SKI1_1	284	288	PF00082	0.630
CLV_PCSK_SKI1_1	339	343	PF00082	0.543
CLV_PCSK_SKI1_1	4	8	PF00082	0.626
CLV_PCSK_SKI1_1	523	527	PF00082	0.742
CLV_PCSK_SKI1_1	671	675	PF00082	0.604
CLV_PCSK_SKI1_1	712	716	PF00082	0.612
CLV_Separin_Metazoa	622	626	PF03568	0.628
DEG_SCF_FBW7_2	615	622	PF00400	0.593
DOC_ANK_TNKS_1	484	491	PF00023	0.735
DOC_CKS1_1	260	265	PF01111	0.770
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.669
DOC_MAPK_gen_1	14	20	PF00069	0.626
DOC_MAPK_gen_1	581	588	PF00069	0.592
DOC_MAPK_HePTP_8	322	334	PF00069	0.568
DOC_MAPK_MEF2A_6	325	334	PF00069	0.562
DOC_MAPK_MEF2A_6	616	623	PF00069	0.597
DOC_PP1_RVXF_1	571	578	PF00149	0.578
DOC_PP1_RVXF_1	665	671	PF00149	0.577
DOC_PP2B_LxvP_1	624	627	PF13499	0.526
DOC_PP4_FxxP_1	260	263	PF00568	0.773
DOC_USP7_MATH_1	153	157	PF00917	0.801
DOC_USP7_MATH_1	208	212	PF00917	0.801
DOC_USP7_MATH_1	213	217	PF00917	0.746
DOC_USP7_MATH_1	223	227	PF00917	0.616
DOC_USP7_MATH_1	232	236	PF00917	0.534
DOC_USP7_MATH_1	239	243	PF00917	0.590
DOC_USP7_MATH_1	249	253	PF00917	0.599
DOC_USP7_MATH_1	270	274	PF00917	0.707
DOC_USP7_MATH_1	489	493	PF00917	0.836
DOC_USP7_MATH_1	553	557	PF00917	0.598
DOC_USP7_MATH_1	627	631	PF00917	0.656
DOC_USP7_MATH_1	660	664	PF00917	0.654
DOC_WW_Pin1_4	158	163	PF00397	0.765
DOC_WW_Pin1_4	195	200	PF00397	0.741
DOC_WW_Pin1_4	206	211	PF00397	0.702
DOC_WW_Pin1_4	22	27	PF00397	0.613
DOC_WW_Pin1_4	259	264	PF00397	0.762
DOC_WW_Pin1_4	597	602	PF00397	0.748
DOC_WW_Pin1_4	615	620	PF00397	0.609
DOC_WW_Pin1_4	70	75	PF00397	0.725
DOC_WW_Pin1_4	720	725	PF00397	0.564
LIG_14-3-3_CanoR_1	173	177	PF00244	0.771
LIG_14-3-3_CanoR_1	197	206	PF00244	0.678
LIG_14-3-3_CanoR_1	291	300	PF00244	0.683
LIG_14-3-3_CanoR_1	552	558	PF00244	0.721
LIG_14-3-3_CanoR_1	602	607	PF00244	0.682
LIG_14-3-3_CanoR_1	696	701	PF00244	0.529
LIG_deltaCOP1_diTrp_1	569	578	PF00928	0.649
LIG_eIF4E_1	678	684	PF01652	0.717
LIG_FHA_1	103	109	PF00498	0.681
LIG_FHA_1	26	32	PF00498	0.713
LIG_FHA_1	295	301	PF00498	0.640
LIG_FHA_1	616	622	PF00498	0.619
LIG_FHA_1	679	685	PF00498	0.668
LIG_FHA_1	721	727	PF00498	0.575
LIG_FHA_2	229	235	PF00498	0.834
LIG_FHA_2	260	266	PF00498	0.622
LIG_FHA_2	324	330	PF00498	0.531
LIG_FHA_2	367	373	PF00498	0.716
LIG_FHA_2	514	520	PF00498	0.679
LIG_FHA_2	558	564	PF00498	0.690
LIG_FHA_2	98	104	PF00498	0.635
LIG_Integrin_RGD_1	675	677	PF01839	0.749
LIG_LIR_Apic_2	258	263	PF02991	0.783
LIG_LIR_Apic_2	55	60	PF02991	0.628
LIG_LIR_Gen_1	324	334	PF02991	0.565
LIG_LIR_Gen_1	633	640	PF02991	0.646
LIG_LIR_Gen_1	654	661	PF02991	0.625
LIG_LIR_Nem_3	110	115	PF02991	0.692
LIG_LIR_Nem_3	268	274	PF02991	0.551
LIG_LIR_Nem_3	314	320	PF02991	0.608
LIG_LIR_Nem_3	324	330	PF02991	0.663
LIG_LIR_Nem_3	450	454	PF02991	0.673
LIG_LIR_Nem_3	569	575	PF02991	0.643
LIG_LIR_Nem_3	633	638	PF02991	0.496
LIG_LIR_Nem_3	654	658	PF02991	0.635
LIG_MAD2	113	121	PF02301	0.548
LIG_MAD2	339	347	PF02301	0.545
LIG_MYND_1	742	746	PF01753	0.572
LIG_NRP_CendR_1	753	755	PF00754	0.692
LIG_Pex14_1	358	362	PF04695	0.537
LIG_REV1ctd_RIR_1	27	35	PF16727	0.724
LIG_REV1ctd_RIR_1	575	586	PF16727	0.625
LIG_RPA_C_Fungi	470	482	PF08784	0.645
LIG_SH2_CRK	112	116	PF00017	0.576
LIG_SH2_CRK	274	278	PF00017	0.587
LIG_SH2_CRK	313	317	PF00017	0.564
LIG_SH2_NCK_1	317	321	PF00017	0.590
LIG_SH2_NCK_1	57	61	PF00017	0.643
LIG_SH2_PTP2	17	20	PF00017	0.623
LIG_SH2_PTP2	635	638	PF00017	0.558
LIG_SH2_SRC	57	60	PF00017	0.644
LIG_SH2_STAP1	313	317	PF00017	0.564
LIG_SH2_STAT5	17	20	PF00017	0.623
LIG_SH2_STAT5	276	279	PF00017	0.682
LIG_SH2_STAT5	313	316	PF00017	0.553
LIG_SH2_STAT5	61	64	PF00017	0.668
LIG_SH2_STAT5	635	638	PF00017	0.475
LIG_SH3_3	118	124	PF00018	0.528
LIG_SH3_3	128	134	PF00018	0.815
LIG_SH3_3	20	26	PF00018	0.609
LIG_SH3_3	344	350	PF00018	0.585
LIG_SH3_3	371	377	PF00018	0.771
LIG_SH3_3	418	424	PF00018	0.706
LIG_SH3_3	595	601	PF00018	0.622
LIG_SH3_3	604	610	PF00018	0.669
LIG_SH3_3	66	72	PF00018	0.703
LIG_SH3_3	740	746	PF00018	0.510
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.662
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.529
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.655
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.668
LIG_SUMO_SIM_anti_2	697	703	PF11976	0.636
LIG_SUMO_SIM_par_1	105	111	PF11976	0.727
LIG_SUMO_SIM_par_1	318	324	PF11976	0.586
LIG_TRAF2_1	606	609	PF00917	0.662
LIG_TRAF2_1	631	634	PF00917	0.580
LIG_TYR_ITIM	315	320	PF00017	0.677
LIG_TYR_ITSM	108	115	PF00017	0.592
MOD_CDK_SPK_2	597	602	PF00069	0.674
MOD_CK1_1	198	204	PF00069	0.761
MOD_CK1_1	211	217	PF00069	0.634
MOD_CK1_1	235	241	PF00069	0.821
MOD_CK1_1	25	31	PF00069	0.567
MOD_CK1_1	395	401	PF00069	0.821
MOD_CK1_1	558	564	PF00069	0.748
MOD_CK1_1	576	582	PF00069	0.626
MOD_CK1_1	67	73	PF00069	0.710
MOD_CK2_1	221	227	PF00069	0.759
MOD_CK2_1	323	329	PF00069	0.581
MOD_CK2_1	366	372	PF00069	0.709
MOD_CK2_1	447	453	PF00069	0.669
MOD_CK2_1	513	519	PF00069	0.777
MOD_CK2_1	627	633	PF00069	0.651
MOD_Cter_Amidation	282	285	PF01082	0.619
MOD_Cter_Amidation	492	495	PF01082	0.556
MOD_DYRK1A_RPxSP_1	597	601	PF00069	0.568
MOD_GlcNHglycan	155	158	PF01048	0.814
MOD_GlcNHglycan	200	203	PF01048	0.808
MOD_GlcNHglycan	210	213	PF01048	0.651
MOD_GlcNHglycan	223	226	PF01048	0.773
MOD_GlcNHglycan	236	240	PF01048	0.707
MOD_GlcNHglycan	241	244	PF01048	0.570
MOD_GlcNHglycan	251	254	PF01048	0.585
MOD_GlcNHglycan	369	372	PF01048	0.617
MOD_GlcNHglycan	385	388	PF01048	0.620
MOD_GlcNHglycan	394	397	PF01048	0.717
MOD_GlcNHglycan	484	488	PF01048	0.789
MOD_GlcNHglycan	491	494	PF01048	0.692
MOD_GlcNHglycan	557	560	PF01048	0.643
MOD_GlcNHglycan	563	566	PF01048	0.638
MOD_GlcNHglycan	604	607	PF01048	0.615
MOD_GlcNHglycan	629	632	PF01048	0.666
MOD_GlcNHglycan	702	705	PF01048	0.620
MOD_GlcNHglycan	718	721	PF01048	0.584
MOD_GlcNHglycan	726	729	PF01048	0.643
MOD_GlcNHglycan	89	92	PF01048	0.634
MOD_GSK3_1	153	160	PF00069	0.753
MOD_GSK3_1	18	25	PF00069	0.617
MOD_GSK3_1	211	218	PF00069	0.760
MOD_GSK3_1	228	235	PF00069	0.817
MOD_GSK3_1	245	252	PF00069	0.611
MOD_GSK3_1	255	262	PF00069	0.651
MOD_GSK3_1	553	560	PF00069	0.571
MOD_GSK3_1	641	648	PF00069	0.528
MOD_GSK3_1	696	703	PF00069	0.548
MOD_GSK3_1	716	723	PF00069	0.656
MOD_N-GLC_1	561	566	PF02516	0.739
MOD_NEK2_1	102	107	PF00069	0.647
MOD_NEK2_1	172	177	PF00069	0.806
MOD_NEK2_1	193	198	PF00069	0.658
MOD_NEK2_1	221	226	PF00069	0.718
MOD_NEK2_1	557	562	PF00069	0.648
MOD_NEK2_2	731	736	PF00069	0.615
MOD_PIKK_1	177	183	PF00454	0.789
MOD_PIKK_1	67	73	PF00454	0.710
MOD_PIKK_1	79	85	PF00454	0.646
MOD_PK_1	119	125	PF00069	0.703
MOD_PK_1	696	702	PF00069	0.569
MOD_PKA_2	172	178	PF00069	0.808
MOD_PKA_2	292	298	PF00069	0.713
MOD_PKA_2	404	410	PF00069	0.741
MOD_PKA_2	474	480	PF00069	0.642
MOD_PKA_2	588	594	PF00069	0.634
MOD_PKB_1	291	299	PF00069	0.559
MOD_Plk_1	102	108	PF00069	0.647
MOD_Plk_1	323	329	PF00069	0.581
MOD_Plk_1	573	579	PF00069	0.648
MOD_Plk_4	102	108	PF00069	0.647
MOD_Plk_4	25	31	PF00069	0.709
MOD_Plk_4	311	317	PF00069	0.611
MOD_Plk_4	573	579	PF00069	0.640
MOD_Plk_4	660	666	PF00069	0.588
MOD_Plk_4	696	702	PF00069	0.646
MOD_ProDKin_1	158	164	PF00069	0.757
MOD_ProDKin_1	195	201	PF00069	0.742
MOD_ProDKin_1	206	212	PF00069	0.702
MOD_ProDKin_1	22	28	PF00069	0.609
MOD_ProDKin_1	259	265	PF00069	0.759
MOD_ProDKin_1	597	603	PF00069	0.752
MOD_ProDKin_1	615	621	PF00069	0.634
MOD_ProDKin_1	70	76	PF00069	0.724
MOD_ProDKin_1	720	726	PF00069	0.563
TRG_DiLeu_BaEn_1	633	638	PF01217	0.567
TRG_DiLeu_BaEn_3	80	86	PF01217	0.641
TRG_DiLeu_BaEn_4	633	639	PF01217	0.568
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.666
TRG_ENDOCYTIC_2	112	115	PF00928	0.601
TRG_ENDOCYTIC_2	17	20	PF00928	0.623
TRG_ENDOCYTIC_2	257	260	PF00928	0.709
TRG_ENDOCYTIC_2	274	277	PF00928	0.591
TRG_ENDOCYTIC_2	313	316	PF00928	0.553
TRG_ENDOCYTIC_2	317	320	PF00928	0.587
TRG_ENDOCYTIC_2	635	638	PF00928	0.534
TRG_ENDOCYTIC_2	655	658	PF00928	0.410
TRG_ENDOCYTIC_2	687	690	PF00928	0.571
TRG_ER_diArg_1	13	15	PF00400	0.627
TRG_ER_diArg_1	172	174	PF00400	0.700
TRG_ER_diArg_1	31	34	PF00400	0.646
TRG_ER_diArg_1	408	411	PF00400	0.791
TRG_ER_diArg_1	520	523	PF00400	0.706
TRG_ER_diArg_1	526	528	PF00400	0.620
TRG_ER_diArg_1	594	597	PF00400	0.625
TRG_ER_diArg_1	710	712	PF00400	0.522
TRG_ER_diArg_1	735	737	PF00400	0.621
TRG_ER_diArg_1	753	755	PF00400	0.545
TRG_NLS_Bipartite_1	520	536	PF00514	0.535
TRG_NLS_MonoExtC_3	531	536	PF00514	0.532
TRG_NLS_MonoExtN_4	520	525	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II66	Leptomonas seymouri	56%	100%
A4H391	Leishmania braziliensis	76%	97%
A4HRJ7	Leishmania infantum	100%	100%
E9AC65	Leishmania major	91%	100%
E9AJG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%