Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4W5_LEIDO

TriTrypDb:

LdBPK_010690.1 , LdCL_010011900 , LDHU3_01.0770

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.476
CLV_PCSK_SKI1_1	16	20	PF00082	0.568
DEG_SCF_FBW7_1	163	170	PF00400	0.691
DOC_CKS1_1	140	145	PF01111	0.665
DOC_CKS1_1	164	169	PF01111	0.694
DOC_CYCLIN_yClb3_PxF_3	163	169	PF00134	0.623
DOC_MAPK_gen_1	124	134	PF00069	0.621
DOC_PP1_RVXF_1	14	20	PF00149	0.550
DOC_PP4_FxxP_1	19	22	PF00568	0.523
DOC_USP7_MATH_1	123	127	PF00917	0.595
DOC_USP7_MATH_1	196	200	PF00917	0.627
DOC_USP7_MATH_1	40	44	PF00917	0.743
DOC_USP7_MATH_1	77	81	PF00917	0.608
DOC_WW_Pin1_4	139	144	PF00397	0.698
DOC_WW_Pin1_4	159	164	PF00397	0.617
DOC_WW_Pin1_4	167	172	PF00397	0.685
DOC_WW_Pin1_4	209	214	PF00397	0.646
DOC_WW_Pin1_4	221	226	PF00397	0.696
DOC_WW_Pin1_4	233	238	PF00397	0.581
DOC_WW_Pin1_4	273	278	PF00397	0.650
DOC_WW_Pin1_4	63	68	PF00397	0.629
LIG_14-3-3_CanoR_1	127	132	PF00244	0.712
LIG_14-3-3_CanoR_1	16	22	PF00244	0.558
LIG_14-3-3_CanoR_1	291	300	PF00244	0.606
LIG_14-3-3_CanoR_1	50	55	PF00244	0.579
LIG_14-3-3_CanoR_1	83	91	PF00244	0.626
LIG_14-3-3_CanoR_1	93	102	PF00244	0.476
LIG_BRCT_BRCA1_1	293	297	PF00533	0.603
LIG_FHA_2	186	192	PF00498	0.586
LIG_FHA_2	22	28	PF00498	0.643
LIG_LIR_Gen_1	181	192	PF02991	0.599
LIG_LIR_Gen_1	294	300	PF02991	0.595
LIG_LIR_Gen_1	45	54	PF02991	0.602
LIG_LIR_Gen_1	8	18	PF02991	0.454
LIG_LIR_LC3C_4	12	15	PF02991	0.443
LIG_LIR_Nem_3	181	187	PF02991	0.608
LIG_LIR_Nem_3	217	223	PF02991	0.589
LIG_LIR_Nem_3	294	300	PF02991	0.595
LIG_LIR_Nem_3	45	51	PF02991	0.600
LIG_LIR_Nem_3	8	13	PF02991	0.449
LIG_PDZ_Class_3	295	300	PF00595	0.663
LIG_SH2_CRK	204	208	PF00017	0.647
LIG_SH3_3	161	167	PF00018	0.681
LIG_SUMO_SIM_par_1	129	136	PF11976	0.632
LIG_TRAF2_1	188	191	PF00917	0.596
MOD_CDK_SPK_2	139	144	PF00069	0.668
MOD_CDK_SPxK_1	233	239	PF00069	0.655
MOD_CK1_1	126	132	PF00069	0.588
MOD_CK1_1	133	139	PF00069	0.602
MOD_CK1_1	157	163	PF00069	0.746
MOD_CK1_1	232	238	PF00069	0.710
MOD_CK1_1	246	252	PF00069	0.811
MOD_CK1_1	289	295	PF00069	0.622
MOD_CK1_1	42	48	PF00069	0.596
MOD_CK1_1	92	98	PF00069	0.579
MOD_CK2_1	185	191	PF00069	0.664
MOD_CK2_1	28	34	PF00069	0.646
MOD_CK2_1	290	296	PF00069	0.699
MOD_GlcNHglycan	144	147	PF01048	0.685
MOD_GlcNHglycan	156	159	PF01048	0.755
MOD_GlcNHglycan	198	201	PF01048	0.614
MOD_GlcNHglycan	216	219	PF01048	0.780
MOD_GlcNHglycan	42	45	PF01048	0.583
MOD_GlcNHglycan	79	82	PF01048	0.604
MOD_GlcNHglycan	95	98	PF01048	0.618
MOD_GSK3_1	123	130	PF00069	0.625
MOD_GSK3_1	138	145	PF00069	0.600
MOD_GSK3_1	159	166	PF00069	0.699
MOD_GSK3_1	17	24	PF00069	0.630
MOD_GSK3_1	172	179	PF00069	0.636
MOD_GSK3_1	229	236	PF00069	0.664
MOD_GSK3_1	243	250	PF00069	0.709
MOD_GSK3_1	275	282	PF00069	0.632
MOD_GSK3_1	286	293	PF00069	0.616
MOD_GSK3_1	42	49	PF00069	0.581
MOD_GSK3_1	77	84	PF00069	0.792
MOD_GSK3_1	85	92	PF00069	0.525
MOD_N-GLC_1	138	143	PF02516	0.669
MOD_N-GLC_1	232	237	PF02516	0.612
MOD_N-GLC_1	279	284	PF02516	0.656
MOD_N-GLC_1	40	45	PF02516	0.651
MOD_NEK2_1	154	159	PF00069	0.624
MOD_NEK2_1	177	182	PF00069	0.664
MOD_NEK2_1	244	249	PF00069	0.629
MOD_NEK2_1	265	270	PF00069	0.702
MOD_NEK2_1	68	73	PF00069	0.596
MOD_PIKK_1	157	163	PF00454	0.686
MOD_PIKK_1	275	281	PF00454	0.671
MOD_PIKK_1	286	292	PF00454	0.618
MOD_PIKK_1	42	48	PF00454	0.571
MOD_PK_1	127	133	PF00069	0.620
MOD_PKA_2	123	129	PF00069	0.670
MOD_PKA_2	286	292	PF00069	0.616
MOD_PKA_2	82	88	PF00069	0.659
MOD_PKA_2	92	98	PF00069	0.499
MOD_Plk_4	127	133	PF00069	0.592
MOD_Plk_4	180	186	PF00069	0.617
MOD_ProDKin_1	139	145	PF00069	0.696
MOD_ProDKin_1	159	165	PF00069	0.621
MOD_ProDKin_1	167	173	PF00069	0.678
MOD_ProDKin_1	209	215	PF00069	0.647
MOD_ProDKin_1	221	227	PF00069	0.695
MOD_ProDKin_1	233	239	PF00069	0.581
MOD_ProDKin_1	273	279	PF00069	0.653
MOD_ProDKin_1	63	69	PF00069	0.632
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.542
TRG_ENDOCYTIC_2	204	207	PF00928	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I318	Leptomonas seymouri	43%	93%
A4H385	Leishmania braziliensis	70%	92%
A4HRJ0	Leishmania infantum	99%	100%
E9AC58	Leishmania major	90%	100%
E9AJF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	96%