Sidoreflexin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sidoreflexin

Gene product:

tricarboxylate carrier, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4W1_LEIDO

TriTrypDb:

LdBPK_010590.1 , LdCL_010010900 , LDHU3_01.0670

Length:

326

Annotations

Annotations by Jardim et al.

Transporters, Tricarboxylate transporter putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	6
GO:0031966	mitochondrial membrane	4	6
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	5
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H4W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4W1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006865	amino acid transport	5	11
GO:0015849	organic acid transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0009987	cellular process	1	1
GO:0055085	transmembrane transport	2	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.426
CLV_NRD_NRD_1	265	267	PF00675	0.282
CLV_NRD_NRD_1	311	313	PF00675	0.375
CLV_PCSK_KEX2_1	167	169	PF00082	0.226
CLV_PCSK_KEX2_1	265	267	PF00082	0.296
CLV_PCSK_KEX2_1	310	312	PF00082	0.371
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.226
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.367
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.408
DOC_MAPK_DCC_7	180	188	PF00069	0.284
DOC_MAPK_MEF2A_6	180	188	PF00069	0.284
DOC_MAPK_MEF2A_6	88	95	PF00069	0.492
DOC_MAPK_NFAT4_5	88	96	PF00069	0.492
DOC_PP1_RVXF_1	237	243	PF00149	0.265
DOC_PP2B_LxvP_1	282	285	PF13499	0.410
DOC_PP4_FxxP_1	98	101	PF00568	0.219
DOC_USP7_MATH_1	132	136	PF00917	0.212
DOC_USP7_MATH_1	70	74	PF00917	0.515
DOC_WW_Pin1_4	258	263	PF00397	0.475
DOC_WW_Pin1_4	312	317	PF00397	0.212
LIG_14-3-3_CanoR_1	134	141	PF00244	0.212
LIG_14-3-3_CanoR_1	180	184	PF00244	0.284
LIG_14-3-3_CanoR_1	221	229	PF00244	0.241
LIG_14-3-3_CanoR_1	23	32	PF00244	0.487
LIG_14-3-3_CanoR_1	265	274	PF00244	0.498
LIG_14-3-3_CanoR_1	66	75	PF00244	0.467
LIG_14-3-3_CanoR_1	88	92	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_3	1	5	PF00653	0.620
LIG_FHA_1	113	119	PF00498	0.212
LIG_FHA_1	147	153	PF00498	0.296
LIG_FHA_1	161	167	PF00498	0.227
LIG_FHA_1	173	179	PF00498	0.412
LIG_FHA_1	191	197	PF00498	0.182
LIG_FHA_1	252	258	PF00498	0.321
LIG_FHA_1	269	275	PF00498	0.491
LIG_FHA_1	279	285	PF00498	0.313
LIG_FHA_1	77	83	PF00498	0.428
LIG_FHA_2	67	73	PF00498	0.413
LIG_FHA_2	76	82	PF00498	0.387
LIG_LIR_Gen_1	182	192	PF02991	0.308
LIG_LIR_Gen_1	303	313	PF02991	0.241
LIG_LIR_Nem_3	182	188	PF02991	0.308
LIG_LIR_Nem_3	303	309	PF02991	0.222
LIG_LIR_Nem_3	90	95	PF02991	0.412
LIG_OCRL_FandH_1	262	274	PF00620	0.460
LIG_Pex14_2	98	102	PF04695	0.218
LIG_SH2_GRB2like	131	134	PF00017	0.212
LIG_SH2_STAP1	148	152	PF00017	0.319
LIG_SH2_STAT5	148	151	PF00017	0.265
LIG_SH2_STAT5	97	100	PF00017	0.377
LIG_SH3_3	79	85	PF00018	0.426
LIG_SUMO_SIM_par_1	31	36	PF11976	0.489
LIG_TRAF2_1	78	81	PF00917	0.515
LIG_TYR_ITIM	95	100	PF00017	0.362
LIG_UBA3_1	160	167	PF00899	0.410
LIG_WRC_WIRS_1	15	20	PF05994	0.492
MOD_CDK_SPxxK_3	258	265	PF00069	0.460
MOD_CK1_1	124	130	PF00069	0.242
MOD_CK1_1	268	274	PF00069	0.460
MOD_CK2_1	297	303	PF00069	0.211
MOD_CK2_1	66	72	PF00069	0.417
MOD_CK2_1	75	81	PF00069	0.442
MOD_CK2_1	8	14	PF00069	0.432
MOD_GlcNHglycan	126	129	PF01048	0.442
MOD_GlcNHglycan	170	173	PF01048	0.249
MOD_GlcNHglycan	206	209	PF01048	0.471
MOD_GlcNHglycan	267	270	PF01048	0.285
MOD_GlcNHglycan	60	63	PF01048	0.288
MOD_GSK3_1	104	111	PF00069	0.276
MOD_GSK3_1	156	163	PF00069	0.331
MOD_GSK3_1	168	175	PF00069	0.369
MOD_GSK3_1	186	193	PF00069	0.223
MOD_GSK3_1	217	224	PF00069	0.315
MOD_GSK3_1	293	300	PF00069	0.199
MOD_GSK3_1	312	319	PF00069	0.305
MOD_GSK3_1	4	11	PF00069	0.594
MOD_GSK3_1	66	73	PF00069	0.490
MOD_N-GLC_1	121	126	PF02516	0.412
MOD_N-GLC_1	132	137	PF02516	0.412
MOD_NEK2_1	121	126	PF00069	0.212
MOD_NEK2_1	160	165	PF00069	0.265
MOD_NEK2_1	186	191	PF00069	0.368
MOD_NEK2_1	278	283	PF00069	0.308
MOD_NEK2_1	293	298	PF00069	0.151
MOD_NEK2_1	8	13	PF00069	0.415
MOD_NEK2_1	87	92	PF00069	0.476
MOD_NEK2_2	228	233	PF00069	0.242
MOD_NEK2_2	316	321	PF00069	0.287
MOD_PIKK_1	76	82	PF00454	0.515
MOD_PK_1	233	239	PF00069	0.250
MOD_PKA_1	233	239	PF00069	0.264
MOD_PKA_1	265	271	PF00069	0.496
MOD_PKA_2	133	139	PF00069	0.212
MOD_PKA_2	179	185	PF00069	0.284
MOD_PKA_2	220	226	PF00069	0.282
MOD_PKA_2	265	271	PF00069	0.501
MOD_PKA_2	87	93	PF00069	0.485
MOD_PKB_1	21	29	PF00069	0.487
MOD_Plk_1	121	127	PF00069	0.212
MOD_Plk_1	13	19	PF00069	0.432
MOD_Plk_1	37	43	PF00069	0.491
MOD_Plk_4	105	111	PF00069	0.153
MOD_Plk_4	14	20	PF00069	0.426
MOD_Plk_4	156	162	PF00069	0.348
MOD_Plk_4	174	180	PF00069	0.344
MOD_Plk_4	87	93	PF00069	0.426
MOD_ProDKin_1	258	264	PF00069	0.475
MOD_ProDKin_1	312	318	PF00069	0.212
TRG_DiLeu_BaEn_2	13	19	PF01217	0.432
TRG_ENDOCYTIC_2	323	326	PF00928	0.212
TRG_ENDOCYTIC_2	97	100	PF00928	0.377
TRG_ER_diArg_1	21	24	PF00400	0.492
TRG_ER_diArg_1	65	68	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	29%	94%
A0A0N1I4E4	Leptomonas seymouri	73%	100%
A0A0S4IJR6	Bodo saltans	27%	100%
A0A1X0P3C3	Trypanosomatidae	59%	100%
A0A3R7KD90	Trypanosoma rangeli	58%	100%
A0A3S5H5J2	Leishmania donovani	28%	94%
A4H380	Leishmania braziliensis	81%	100%
A4H4B2	Leishmania braziliensis	28%	100%
A4HRI0	Leishmania infantum	100%	100%
A4HSJ0	Leishmania infantum	28%	100%
A5A761	Sus scrofa	28%	100%
A6QP55	Bos taurus	29%	100%
A8E7G5	Danio rerio	25%	100%
B2LU20	Ovis aries	28%	100%
C9ZXK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AC48	Leishmania major	96%	100%
E9AJE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AKH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O13793	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q09201	Caenorhabditis elegans	25%	99%
Q12029	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q3T0M2	Bos taurus	23%	100%
Q4QJD4	Leishmania major	29%	100%
Q54NQ9	Dictyostelium discoideum	34%	99%
Q5E9M8	Bos taurus	29%	100%
Q5EA43	Bos taurus	28%	100%
Q5FC79	Caenorhabditis elegans	31%	98%
Q5RD16	Pongo abelii	30%	100%
Q63965	Rattus norvegicus	29%	100%
Q6P4A7	Homo sapiens	23%	97%
Q8CFD0	Rattus norvegicus	32%	95%
Q8TD22	Homo sapiens	32%	96%
Q91V61	Mus musculus	29%	100%
Q925N0	Mus musculus	32%	95%
Q925N1	Mus musculus	22%	100%
Q925N2	Mus musculus	27%	100%
Q96NB2	Homo sapiens	27%	100%
Q99JR1	Mus musculus	29%	100%
Q9BWM7	Homo sapiens	30%	100%
Q9H9B4	Homo sapiens	28%	100%
Q9JHY2	Rattus norvegicus	29%	100%
Q9VN13	Drosophila melanogaster	26%	100%
Q9VVW3	Drosophila melanogaster	28%	100%
V5BCG0	Trypanosoma cruzi	57%	100%