Sidoreflexin

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sidoreflexin

Gene product:

tricarboxylate carrier, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4W1_LEIDO

TriTrypDb:

LdBPK_010590.1 , LdCL_010010900 , LDHU3_01.0670

Length:

326

Annotations

Annotations by Jardim et al.

Transporters, Tricarboxylate transporter putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0016020	membrane	2	10
GO:0020023	kinetoplast	2	1
GO:0031090	organelle membrane	3	6
GO:0031966	mitochondrial membrane	4	6
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	11

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H4W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4W1

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006865	amino acid transport	5	11
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:1990542	mitochondrial transmembrane transport	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.426
CLV_NRD_NRD_1	265	267	PF00675	0.282
CLV_NRD_NRD_1	311	313	PF00675	0.375
CLV_PCSK_KEX2_1	167	169	PF00082	0.226
CLV_PCSK_KEX2_1	265	267	PF00082	0.296
CLV_PCSK_KEX2_1	310	312	PF00082	0.371
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.226
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.367
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.408
DOC_MAPK_DCC_7	180	188	PF00069	0.284

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	29%	94%
A0A0N1I4E4	Leptomonas seymouri	73%	100%
A0A0S4IJR6	Bodo saltans	27%	100%
A0A1X0P3C3	Trypanosomatidae	59%	100%
A0A3R7KD90	Trypanosoma rangeli	58%	100%
A0A3S5H5J2	Leishmania donovani	28%	94%
A4H380	Leishmania braziliensis	81%	100%
A4H4B2	Leishmania braziliensis	28%	100%
A4HRI0	Leishmania infantum	100%	100%
A4HSJ0	Leishmania infantum	28%	100%

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