Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA processing factor 3 (PRP3)/Protein of unknown function (DUF1115), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4W0_LEIDO

TriTrypDb:

LdBPK_010580.1 , LdCL_010010800 , LDHU3_01.0660

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	11
GO:0097525	spliceosomal snRNP complex	4	11
GO:0097526	spliceosomal tri-snRNP complex	5	11
GO:0120114	Sm-like protein family complex	2	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3S5H4W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4W0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	564	568	PF00656	0.496
CLV_NRD_NRD_1	126	128	PF00675	0.630
CLV_NRD_NRD_1	195	197	PF00675	0.241
CLV_NRD_NRD_1	21	23	PF00675	0.684
CLV_NRD_NRD_1	336	338	PF00675	0.245
CLV_NRD_NRD_1	423	425	PF00675	0.244
CLV_NRD_NRD_1	445	447	PF00675	0.475
CLV_NRD_NRD_1	591	593	PF00675	0.266
CLV_NRD_NRD_1	86	88	PF00675	0.676
CLV_PCSK_KEX2_1	125	127	PF00082	0.615
CLV_PCSK_KEX2_1	195	197	PF00082	0.227
CLV_PCSK_KEX2_1	336	338	PF00082	0.266
CLV_PCSK_KEX2_1	423	425	PF00082	0.244
CLV_PCSK_KEX2_1	439	441	PF00082	0.427
CLV_PCSK_KEX2_1	445	447	PF00082	0.438
CLV_PCSK_KEX2_1	550	552	PF00082	0.271
CLV_PCSK_KEX2_1	558	560	PF00082	0.361
CLV_PCSK_KEX2_1	591	593	PF00082	0.266
CLV_PCSK_KEX2_1	86	88	PF00082	0.676
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.438
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.271
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.361
CLV_PCSK_PC7_1	82	88	PF00082	0.648
CLV_PCSK_SKI1_1	128	132	PF00082	0.753
CLV_PCSK_SKI1_1	243	247	PF00082	0.337
CLV_PCSK_SKI1_1	343	347	PF00082	0.282
CLV_PCSK_SKI1_1	446	450	PF00082	0.452
CLV_PCSK_SKI1_1	608	612	PF00082	0.420
DEG_SPOP_SBC_1	17	21	PF00917	0.587
DOC_CKS1_1	149	154	PF01111	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	386	395	PF00134	0.441
DOC_MAPK_gen_1	125	131	PF00069	0.712
DOC_MAPK_gen_1	522	531	PF00069	0.538
DOC_PP1_RVXF_1	125	132	PF00149	0.582
DOC_PP2B_LxvP_1	593	596	PF13499	0.571
DOC_PP4_MxPP_1	1	4	PF00568	0.724
DOC_USP7_MATH_1	11	15	PF00917	0.624
DOC_USP7_MATH_1	115	119	PF00917	0.683
DOC_USP7_MATH_1	17	21	PF00917	0.594
DOC_USP7_MATH_1	269	273	PF00917	0.412
DOC_USP7_MATH_1	352	356	PF00917	0.536
DOC_USP7_MATH_1	372	376	PF00917	0.517
DOC_USP7_MATH_1	42	46	PF00917	0.724
DOC_USP7_MATH_1	48	52	PF00917	0.694
DOC_USP7_MATH_1	58	62	PF00917	0.678
DOC_USP7_MATH_1	594	598	PF00917	0.579
DOC_USP7_MATH_1	6	10	PF00917	0.656
DOC_USP7_UBL2_3	23	27	PF12436	0.575
DOC_USP7_UBL2_3	346	350	PF12436	0.513
DOC_WW_Pin1_4	148	153	PF00397	0.705
DOC_WW_Pin1_4	278	283	PF00397	0.465
DOC_WW_Pin1_4	595	600	PF00397	0.573
LIG_14-3-3_CanoR_1	18	24	PF00244	0.597
LIG_14-3-3_CanoR_1	258	264	PF00244	0.555
LIG_14-3-3_CanoR_1	385	393	PF00244	0.538
LIG_14-3-3_CanoR_1	445	454	PF00244	0.424
LIG_14-3-3_CanoR_1	525	530	PF00244	0.444
LIG_Actin_WH2_2	426	441	PF00022	0.602
LIG_APCC_Cbox_2	427	433	PF00515	0.501
LIG_BRCT_BRCA1_1	535	539	PF00533	0.501
LIG_Clathr_ClatBox_2	254	259	PF01394	0.444
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.444
LIG_deltaCOP1_diTrp_1	507	516	PF00928	0.444
LIG_FHA_1	107	113	PF00498	0.517
LIG_FHA_1	236	242	PF00498	0.485
LIG_FHA_1	282	288	PF00498	0.465
LIG_FHA_1	386	392	PF00498	0.538
LIG_FHA_1	406	412	PF00498	0.538
LIG_FHA_1	519	525	PF00498	0.446
LIG_FHA_2	580	586	PF00498	0.571
LIG_LIR_Gen_1	35	43	PF02991	0.511
LIG_LIR_Gen_1	573	583	PF02991	0.457
LIG_LIR_Gen_1	597	606	PF02991	0.546
LIG_LIR_Nem_3	313	317	PF02991	0.554
LIG_LIR_Nem_3	35	41	PF02991	0.504
LIG_LIR_Nem_3	597	603	PF02991	0.424
LIG_Pex14_1	607	611	PF04695	0.519
LIG_PROFILIN_1	2	8	PF00235	0.629
LIG_SH2_CRK	88	92	PF00017	0.684
LIG_SH2_STAP1	108	112	PF00017	0.650
LIG_SH2_STAP1	308	312	PF00017	0.444
LIG_SH2_STAT3	199	202	PF00017	0.500
LIG_SH2_STAT5	108	111	PF00017	0.635
LIG_SH2_STAT5	199	202	PF00017	0.538
LIG_SH2_STAT5	308	311	PF00017	0.511
LIG_SH2_STAT5	486	489	PF00017	0.545
LIG_SH3_3	146	152	PF00018	0.763
LIG_SH3_3	157	163	PF00018	0.611
LIG_SH3_3	2	8	PF00018	0.636
LIG_SH3_3	276	282	PF00018	0.585
LIG_SH3_3	295	301	PF00018	0.387
LIG_SH3_3	397	403	PF00018	0.450
LIG_SH3_3	593	599	PF00018	0.568
LIG_SH3_4	23	30	PF00018	0.613
LIG_SUMO_SIM_anti_2	491	497	PF11976	0.457
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.494
LIG_SUMO_SIM_par_1	27	33	PF11976	0.581
LIG_TRAF2_1	143	146	PF00917	0.599
LIG_TRAF2_1	582	585	PF00917	0.441
LIG_WRC_WIRS_1	203	208	PF05994	0.479
LIG_WW_2	5	8	PF00397	0.634
MOD_CK1_1	281	287	PF00069	0.454
MOD_CK1_1	376	382	PF00069	0.472
MOD_CK1_1	53	59	PF00069	0.660
MOD_CK1_1	598	604	PF00069	0.482
MOD_CK1_1	9	15	PF00069	0.667
MOD_CK2_1	140	146	PF00069	0.593
MOD_CK2_1	161	167	PF00069	0.573
MOD_CK2_1	579	585	PF00069	0.452
MOD_CMANNOS	256	259	PF00535	0.244
MOD_Cter_Amidation	556	559	PF01082	0.266
MOD_Cter_Amidation	84	87	PF01082	0.680
MOD_GlcNHglycan	13	16	PF01048	0.622
MOD_GlcNHglycan	142	145	PF01048	0.651
MOD_GlcNHglycan	187	190	PF01048	0.379
MOD_GlcNHglycan	219	222	PF01048	0.326
MOD_GlcNHglycan	267	270	PF01048	0.391
MOD_GlcNHglycan	271	274	PF01048	0.374
MOD_GlcNHglycan	37	41	PF01048	0.545
MOD_GlcNHglycan	375	378	PF01048	0.338
MOD_GlcNHglycan	44	47	PF01048	0.598
MOD_GlcNHglycan	463	466	PF01048	0.334
MOD_GlcNHglycan	52	55	PF01048	0.592
MOD_GlcNHglycan	9	12	PF01048	0.654
MOD_GSK3_1	150	157	PF00069	0.739
MOD_GSK3_1	162	169	PF00069	0.582
MOD_GSK3_1	265	272	PF00069	0.464
MOD_GSK3_1	32	39	PF00069	0.591
MOD_GSK3_1	360	367	PF00069	0.499
MOD_GSK3_1	368	375	PF00069	0.472
MOD_GSK3_1	42	49	PF00069	0.634
MOD_GSK3_1	594	601	PF00069	0.567
MOD_GSK3_1	6	13	PF00069	0.661
MOD_LATS_1	383	389	PF00433	0.538
MOD_LATS_1	549	555	PF00433	0.465
MOD_NEK2_1	166	171	PF00069	0.647
MOD_NEK2_1	283	288	PF00069	0.536
MOD_NEK2_1	360	365	PF00069	0.547
MOD_NEK2_1	373	378	PF00069	0.453
MOD_NEK2_1	395	400	PF00069	0.484
MOD_NEK2_2	535	540	PF00069	0.430
MOD_PIKK_1	166	172	PF00454	0.560
MOD_PIKK_1	306	312	PF00454	0.457
MOD_PK_1	27	33	PF00069	0.646
MOD_PK_1	525	531	PF00069	0.501
MOD_PKA_2	106	112	PF00069	0.777
MOD_PKA_2	17	23	PF00069	0.578
MOD_PKA_2	257	263	PF00069	0.525
MOD_PKA_2	384	390	PF00069	0.444
MOD_Plk_1	32	38	PF00069	0.522
MOD_Plk_2-3	32	38	PF00069	0.550
MOD_Plk_4	237	243	PF00069	0.457
MOD_Plk_4	396	402	PF00069	0.444
MOD_Plk_4	58	64	PF00069	0.615
MOD_ProDKin_1	148	154	PF00069	0.706
MOD_ProDKin_1	278	284	PF00069	0.465
MOD_ProDKin_1	595	601	PF00069	0.577
TRG_DiLeu_BaEn_3	584	590	PF01217	0.538
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.501
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.471
TRG_ENDOCYTIC_2	314	317	PF00928	0.510
TRG_ENDOCYTIC_2	457	460	PF00928	0.459
TRG_ENDOCYTIC_2	88	91	PF00928	0.689
TRG_ER_diArg_1	125	127	PF00400	0.636
TRG_ER_diArg_1	590	592	PF00400	0.465
TRG_ER_diArg_1	86	88	PF00400	0.742
TRG_NLS_MonoExtN_4	548	554	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXQ4	Leptomonas seymouri	56%	100%
A0A1X0P2M3	Trypanosomatidae	44%	100%
A0A3R7KZ00	Trypanosoma rangeli	44%	100%
A4H379	Leishmania braziliensis	75%	93%
A4HRH9	Leishmania infantum	99%	100%
C9ZXK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AC47	Leishmania major	92%	100%
E9AJE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BLJ6	Trypanosoma cruzi	37%	100%