CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4V9_LEIDO

TriTrypDb:

LdBPK_010570.1 , LdCL_010010700 , LDHU3_01.0650

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4V9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.745
CLV_C14_Caspase3-7	36	40	PF00656	0.458
CLV_NRD_NRD_1	52	54	PF00675	0.384
CLV_PCSK_KEX2_1	207	209	PF00082	0.736
CLV_PCSK_KEX2_1	222	224	PF00082	0.663
CLV_PCSK_KEX2_1	228	230	PF00082	0.622
CLV_PCSK_KEX2_1	5	7	PF00082	0.605
CLV_PCSK_KEX2_1	52	54	PF00082	0.402
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.736
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.663
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.622
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.572
CLV_PCSK_SKI1_1	335	339	PF00082	0.682
CLV_PCSK_SKI1_1	53	57	PF00082	0.375
DEG_SPOP_SBC_1	138	142	PF00917	0.514
DEG_SPOP_SBC_1	215	219	PF00917	0.581
DEG_SPOP_SBC_1	239	243	PF00917	0.712
DOC_CDC14_PxL_1	169	177	PF14671	0.506
DOC_MAPK_gen_1	178	186	PF00069	0.463
DOC_MAPK_gen_1	52	59	PF00069	0.435
DOC_MAPK_MEF2A_6	178	186	PF00069	0.534
DOC_MAPK_MEF2A_6	52	59	PF00069	0.506
DOC_MAPK_NFAT4_5	52	60	PF00069	0.509
DOC_PP2B_LxvP_1	133	136	PF13499	0.657
DOC_PP4_FxxP_1	134	137	PF00568	0.651
DOC_SPAK_OSR1_1	63	67	PF12202	0.436
DOC_USP7_MATH_1	13	17	PF00917	0.770
DOC_USP7_MATH_1	138	142	PF00917	0.620
DOC_USP7_MATH_1	215	219	PF00917	0.622
DOC_USP7_MATH_1	239	243	PF00917	0.723
DOC_USP7_MATH_1	244	248	PF00917	0.727
DOC_USP7_MATH_1	25	29	PF00917	0.446
DOC_USP7_MATH_1	256	260	PF00917	0.665
DOC_USP7_MATH_1	33	37	PF00917	0.373
DOC_USP7_MATH_1	38	42	PF00917	0.329
DOC_USP7_MATH_1	96	100	PF00917	0.633
DOC_USP7_UBL2_3	348	352	PF12436	0.471
DOC_WW_Pin1_4	23	28	PF00397	0.570
DOC_WW_Pin1_4	240	245	PF00397	0.771
DOC_WW_Pin1_4	306	311	PF00397	0.645
DOC_WW_Pin1_4	330	335	PF00397	0.685
LIG_14-3-3_CanoR_1	208	215	PF00244	0.643
LIG_14-3-3_CanoR_1	216	224	PF00244	0.727
LIG_14-3-3_CanoR_1	52	56	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.778
LIG_BRCT_BRCA1_1	165	169	PF00533	0.579
LIG_FHA_1	235	241	PF00498	0.761
LIG_FHA_2	127	133	PF00498	0.562
LIG_FHA_2	228	234	PF00498	0.678
LIG_FHA_2	344	350	PF00498	0.599
LIG_LIR_Apic_2	132	137	PF02991	0.637
LIG_LIR_Gen_1	122	133	PF02991	0.597
LIG_LIR_Gen_1	166	176	PF02991	0.543
LIG_LIR_Gen_1	39	47	PF02991	0.381
LIG_LIR_Nem_3	166	172	PF02991	0.542
LIG_LIR_Nem_3	26	32	PF02991	0.449
LIG_LIR_Nem_3	39	45	PF02991	0.347
LIG_LIR_Nem_3	54	59	PF02991	0.395
LIG_SH2_STAT5	174	177	PF00017	0.531
LIG_SH2_STAT5	353	356	PF00017	0.536
LIG_SH3_3	218	224	PF00018	0.799
LIG_SH3_3	304	310	PF00018	0.614
LIG_SH3_3	326	332	PF00018	0.565
LIG_SH3_3	7	13	PF00018	0.684
LIG_SH3_3	86	92	PF00018	0.541
LIG_SH3_4	340	347	PF00018	0.580
LIG_TRAF2_1	149	152	PF00917	0.701
LIG_TRAF2_1	20	23	PF00917	0.468
LIG_TRAF2_1	98	101	PF00917	0.628
MOD_CDK_SPK_2	330	335	PF00069	0.635
MOD_CK1_1	142	148	PF00069	0.727
MOD_Cter_Amidation	226	229	PF01082	0.672
MOD_GlcNHglycan	101	105	PF01048	0.748
MOD_GlcNHglycan	144	147	PF01048	0.722
MOD_GlcNHglycan	15	18	PF01048	0.743
MOD_GlcNHglycan	156	159	PF01048	0.659
MOD_GlcNHglycan	186	189	PF01048	0.528
MOD_GlcNHglycan	196	199	PF01048	0.589
MOD_GlcNHglycan	258	261	PF01048	0.763
MOD_GlcNHglycan	287	290	PF01048	0.478
MOD_GlcNHglycan	70	73	PF01048	0.547
MOD_GSK3_1	138	145	PF00069	0.686
MOD_GSK3_1	163	170	PF00069	0.526
MOD_GSK3_1	223	230	PF00069	0.756
MOD_GSK3_1	234	241	PF00069	0.665
MOD_GSK3_1	264	271	PF00069	0.679
MOD_GSK3_1	296	303	PF00069	0.557
MOD_GSK3_1	47	54	PF00069	0.479
MOD_GSK3_1	96	103	PF00069	0.622
MOD_LATS_1	205	211	PF00433	0.599
MOD_NEK2_1	1	6	PF00069	0.742
MOD_NEK2_1	167	172	PF00069	0.477
MOD_NEK2_1	194	199	PF00069	0.584
MOD_NEK2_1	47	52	PF00069	0.487
MOD_PIKK_1	139	145	PF00454	0.642
MOD_PIKK_1	244	250	PF00454	0.607
MOD_PIKK_1	96	102	PF00454	0.626
MOD_PKA_1	207	213	PF00069	0.802
MOD_PKA_1	222	228	PF00069	0.715
MOD_PKA_2	207	213	PF00069	0.672
MOD_PKA_2	215	221	PF00069	0.679
MOD_PKA_2	222	228	PF00069	0.806
MOD_PKA_2	344	350	PF00069	0.545
MOD_PKA_2	51	57	PF00069	0.464
MOD_Plk_1	167	173	PF00069	0.505
MOD_Plk_1	38	44	PF00069	0.367
MOD_Plk_2-3	126	132	PF00069	0.566
MOD_Plk_4	25	31	PF00069	0.447
MOD_Plk_4	38	44	PF00069	0.304
MOD_Plk_4	77	83	PF00069	0.348
MOD_ProDKin_1	23	29	PF00069	0.556
MOD_ProDKin_1	240	246	PF00069	0.771
MOD_ProDKin_1	306	312	PF00069	0.647
MOD_ProDKin_1	330	336	PF00069	0.684
TRG_ER_diArg_1	51	53	PF00400	0.385
TRG_ER_diArg_1	61	64	PF00400	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P578	Leptomonas seymouri	42%	95%
A0A3R7NL08	Trypanosoma rangeli	34%	100%
A4H378	Leishmania braziliensis	61%	100%
A4HRH8	Leishmania infantum	100%	100%
E9AC46	Leishmania major	85%	100%
E9AJE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
V5BH18	Trypanosoma cruzi	30%	98%