Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4V8_LEIDO

TriTrypDb:

LdBPK_010560.1 , LdCL_010010600 , LDHU3_01.0640

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.833
CLV_C14_Caspase3-7	592	596	PF00656	0.680
CLV_NRD_NRD_1	115	117	PF00675	0.672
CLV_NRD_NRD_1	142	144	PF00675	0.635
CLV_NRD_NRD_1	16	18	PF00675	0.616
CLV_NRD_NRD_1	168	170	PF00675	0.765
CLV_NRD_NRD_1	358	360	PF00675	0.744
CLV_NRD_NRD_1	363	365	PF00675	0.676
CLV_NRD_NRD_1	459	461	PF00675	0.667
CLV_NRD_NRD_1	50	52	PF00675	0.573
CLV_NRD_NRD_1	54	56	PF00675	0.553
CLV_NRD_NRD_1	590	592	PF00675	0.710
CLV_NRD_NRD_1	622	624	PF00675	0.618
CLV_NRD_NRD_1	665	667	PF00675	0.817
CLV_NRD_NRD_1	69	71	PF00675	0.711
CLV_NRD_NRD_1	99	101	PF00675	0.645
CLV_PCSK_FUR_1	356	360	PF00082	0.739
CLV_PCSK_FUR_1	588	592	PF00082	0.697
CLV_PCSK_KEX2_1	142	144	PF00082	0.635
CLV_PCSK_KEX2_1	16	18	PF00082	0.616
CLV_PCSK_KEX2_1	168	170	PF00082	0.765
CLV_PCSK_KEX2_1	220	222	PF00082	0.656
CLV_PCSK_KEX2_1	27	29	PF00082	0.482
CLV_PCSK_KEX2_1	358	360	PF00082	0.744
CLV_PCSK_KEX2_1	363	365	PF00082	0.676
CLV_PCSK_KEX2_1	459	461	PF00082	0.667
CLV_PCSK_KEX2_1	50	52	PF00082	0.573
CLV_PCSK_KEX2_1	54	56	PF00082	0.553
CLV_PCSK_KEX2_1	590	592	PF00082	0.703
CLV_PCSK_KEX2_1	622	624	PF00082	0.613
CLV_PCSK_KEX2_1	659	661	PF00082	0.752
CLV_PCSK_KEX2_1	665	667	PF00082	0.768
CLV_PCSK_KEX2_1	69	71	PF00082	0.711
CLV_PCSK_KEX2_1	99	101	PF00082	0.645
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.656
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.462
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.693
CLV_PCSK_PC7_1	23	29	PF00082	0.465
CLV_PCSK_PC7_1	359	365	PF00082	0.653
CLV_PCSK_PC7_1	50	56	PF00082	0.610
CLV_PCSK_SKI1_1	196	200	PF00082	0.531
CLV_PCSK_SKI1_1	427	431	PF00082	0.778
CLV_PCSK_SKI1_1	54	58	PF00082	0.654
CLV_PCSK_SKI1_1	626	630	PF00082	0.671
CLV_PCSK_SKI1_1	82	86	PF00082	0.616
CLV_Separin_Metazoa	662	666	PF03568	0.653
DEG_APCC_DBOX_1	49	57	PF00400	0.637
DEG_SPOP_SBC_1	230	234	PF00917	0.577
DOC_CKS1_1	189	194	PF01111	0.702
DOC_MAPK_gen_1	116	123	PF00069	0.617
DOC_MAPK_gen_1	139	148	PF00069	0.598
DOC_MAPK_gen_1	220	227	PF00069	0.603
DOC_MAPK_gen_1	638	647	PF00069	0.667
DOC_MAPK_gen_1	665	672	PF00069	0.693
DOC_MAPK_MEF2A_6	665	672	PF00069	0.693
DOC_PP4_FxxP_1	157	160	PF00568	0.673
DOC_PP4_FxxP_1	227	230	PF00568	0.557
DOC_PP4_FxxP_1	9	12	PF00568	0.645
DOC_PP4_MxPP_1	671	674	PF00568	0.638
DOC_USP7_MATH_1	128	132	PF00917	0.689
DOC_USP7_MATH_1	205	209	PF00917	0.727
DOC_USP7_MATH_1	230	234	PF00917	0.577
DOC_USP7_MATH_1	405	409	PF00917	0.694
DOC_USP7_MATH_1	465	469	PF00917	0.672
DOC_USP7_MATH_1	530	534	PF00917	0.720
DOC_USP7_MATH_1	569	573	PF00917	0.726
DOC_USP7_MATH_1	575	579	PF00917	0.748
DOC_USP7_MATH_1	634	638	PF00917	0.800
DOC_USP7_MATH_1	653	657	PF00917	0.655
DOC_USP7_MATH_1	91	95	PF00917	0.605
DOC_WW_Pin1_4	188	193	PF00397	0.714
DOC_WW_Pin1_4	398	403	PF00397	0.797
DOC_WW_Pin1_4	429	434	PF00397	0.736
DOC_WW_Pin1_4	476	481	PF00397	0.748
DOC_WW_Pin1_4	492	497	PF00397	0.688
DOC_WW_Pin1_4	505	510	PF00397	0.620
DOC_WW_Pin1_4	526	531	PF00397	0.681
DOC_WW_Pin1_4	556	561	PF00397	0.707
DOC_WW_Pin1_4	596	601	PF00397	0.737
LIG_14-3-3_CanoR_1	116	123	PF00244	0.653
LIG_14-3-3_CanoR_1	127	137	PF00244	0.592
LIG_14-3-3_CanoR_1	190	199	PF00244	0.667
LIG_14-3-3_CanoR_1	363	371	PF00244	0.716
LIG_14-3-3_CanoR_1	380	386	PF00244	0.505
LIG_14-3-3_CanoR_1	500	509	PF00244	0.701
LIG_14-3-3_CanoR_1	552	562	PF00244	0.658
LIG_14-3-3_CanoR_1	626	634	PF00244	0.766
LIG_14-3-3_CanoR_1	82	87	PF00244	0.616
LIG_Actin_WH2_2	643	661	PF00022	0.630
LIG_ActinCP_TwfCPI_2	227	236	PF01115	0.575
LIG_BIR_III_4	568	572	PF00653	0.671
LIG_CtBP_PxDLS_1	480	484	PF00389	0.653
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.615
LIG_FHA_1	192	198	PF00498	0.615
LIG_FHA_1	274	280	PF00498	0.584
LIG_FHA_1	314	320	PF00498	0.606
LIG_FHA_1	339	345	PF00498	0.679
LIG_FHA_1	371	377	PF00498	0.638
LIG_FHA_1	468	474	PF00498	0.615
LIG_FHA_1	83	89	PF00498	0.731
LIG_FHA_2	107	113	PF00498	0.651
LIG_FHA_2	256	262	PF00498	0.685
LIG_FHA_2	290	296	PF00498	0.657
LIG_FHA_2	333	339	PF00498	0.551
LIG_FHA_2	563	569	PF00498	0.837
LIG_LIR_Apic_2	154	160	PF02991	0.660
LIG_LIR_Apic_2	629	634	PF02991	0.662
LIG_LIR_Apic_2	8	13	PF02991	0.673
LIG_LIR_Gen_1	106	115	PF02991	0.590
LIG_LIR_Gen_1	312	320	PF02991	0.653
LIG_LIR_Nem_3	106	111	PF02991	0.581
LIG_LIR_Nem_3	312	318	PF02991	0.653
LIG_MYND_1	476	480	PF01753	0.700
LIG_Pex14_1	34	38	PF04695	0.614
LIG_SH2_CRK	631	635	PF00017	0.637
LIG_SH2_GRB2like	281	284	PF00017	0.582
LIG_SH2_SRC	248	251	PF00017	0.636
LIG_SH2_STAP1	315	319	PF00017	0.630
LIG_SH2_STAP1	381	385	PF00017	0.686
LIG_SH2_STAP1	643	647	PF00017	0.666
LIG_SH2_STAT5	114	117	PF00017	0.671
LIG_SH2_STAT5	147	150	PF00017	0.664
LIG_SH2_STAT5	248	251	PF00017	0.636
LIG_SH2_STAT5	257	260	PF00017	0.547
LIG_SH2_STAT5	281	284	PF00017	0.582
LIG_SH2_STAT5	315	318	PF00017	0.608
LIG_SH2_STAT5	352	355	PF00017	0.676
LIG_SH2_STAT5	562	565	PF00017	0.784
LIG_SH3_3	293	299	PF00018	0.678
LIG_SH3_3	417	423	PF00018	0.696
LIG_SH3_3	470	476	PF00018	0.587
LIG_SH3_3	601	607	PF00018	0.667
LIG_SH3_3	667	673	PF00018	0.685
LIG_SH3_3	8	14	PF00018	0.588
LIG_SUMO_SIM_par_1	197	202	PF11976	0.552
LIG_TRFH_1	346	350	PF08558	0.684
LIG_WW_3	662	666	PF00397	0.593
MOD_CDC14_SPxK_1	603	606	PF00782	0.692
MOD_CDK_SPxK_1	600	606	PF00069	0.689
MOD_CK1_1	106	112	PF00069	0.555
MOD_CK1_1	164	170	PF00069	0.590
MOD_CK1_1	228	234	PF00069	0.678
MOD_CK1_1	365	371	PF00069	0.713
MOD_CK1_1	390	396	PF00069	0.757
MOD_CK1_1	461	467	PF00069	0.794
MOD_CK1_1	468	474	PF00069	0.707
MOD_CK1_1	505	511	PF00069	0.719
MOD_CK1_1	526	532	PF00069	0.779
MOD_CK1_1	554	560	PF00069	0.680
MOD_CK1_1	637	643	PF00069	0.665
MOD_CK2_1	106	112	PF00069	0.646
MOD_CK2_1	332	338	PF00069	0.552
MOD_CK2_1	381	387	PF00069	0.702
MOD_CK2_1	476	482	PF00069	0.726
MOD_Cter_Amidation	361	364	PF01082	0.656
MOD_GlcNHglycan	105	108	PF01048	0.606
MOD_GlcNHglycan	117	120	PF01048	0.664
MOD_GlcNHglycan	130	133	PF01048	0.608
MOD_GlcNHglycan	139	142	PF01048	0.571
MOD_GlcNHglycan	326	329	PF01048	0.667
MOD_GlcNHglycan	365	368	PF01048	0.627
MOD_GlcNHglycan	381	384	PF01048	0.632
MOD_GlcNHglycan	389	392	PF01048	0.678
MOD_GlcNHglycan	407	410	PF01048	0.639
MOD_GlcNHglycan	420	423	PF01048	0.618
MOD_GlcNHglycan	460	463	PF01048	0.734
MOD_GlcNHglycan	581	584	PF01048	0.779
MOD_GlcNHglycan	66	69	PF01048	0.612
MOD_GlcNHglycan	79	82	PF01048	0.695
MOD_GlcNHglycan	93	96	PF01048	0.664
MOD_GSK3_1	123	130	PF00069	0.705
MOD_GSK3_1	225	232	PF00069	0.717
MOD_GSK3_1	268	275	PF00069	0.645
MOD_GSK3_1	324	331	PF00069	0.644
MOD_GSK3_1	334	341	PF00069	0.604
MOD_GSK3_1	344	351	PF00069	0.498
MOD_GSK3_1	375	382	PF00069	0.693
MOD_GSK3_1	389	396	PF00069	0.679
MOD_GSK3_1	418	425	PF00069	0.797
MOD_GSK3_1	461	468	PF00069	0.708
MOD_GSK3_1	501	508	PF00069	0.781
MOD_GSK3_1	526	533	PF00069	0.708
MOD_GSK3_1	550	557	PF00069	0.714
MOD_GSK3_1	558	565	PF00069	0.642
MOD_GSK3_1	575	582	PF00069	0.791
MOD_GSK3_1	596	603	PF00069	0.747
MOD_GSK3_1	64	71	PF00069	0.605
MOD_GSK3_1	73	80	PF00069	0.562
MOD_N-GLC_1	434	439	PF02516	0.699
MOD_N-GLC_1	554	559	PF02516	0.682
MOD_NEK2_1	115	120	PF00069	0.800
MOD_NEK2_1	137	142	PF00069	0.660
MOD_NEK2_1	151	156	PF00069	0.538
MOD_NEK2_1	199	204	PF00069	0.620
MOD_NEK2_1	225	230	PF00069	0.681
MOD_NEK2_1	344	349	PF00069	0.684
MOD_NEK2_1	357	362	PF00069	0.586
MOD_NEK2_1	389	394	PF00069	0.721
MOD_NEK2_1	451	456	PF00069	0.638
MOD_NEK2_1	458	463	PF00069	0.582
MOD_NEK2_1	487	492	PF00069	0.643
MOD_NEK2_1	502	507	PF00069	0.670
MOD_NEK2_1	524	529	PF00069	0.674
MOD_NEK2_1	550	555	PF00069	0.720
MOD_PIKK_1	121	127	PF00454	0.681
MOD_PIKK_1	231	237	PF00454	0.613
MOD_PIKK_1	365	371	PF00454	0.710
MOD_PIKK_1	390	396	PF00454	0.648
MOD_PKA_1	363	369	PF00069	0.648
MOD_PKA_2	115	121	PF00069	0.645
MOD_PKA_2	348	354	PF00069	0.683
MOD_PKA_2	357	363	PF00069	0.629
MOD_PKA_2	379	385	PF00069	0.647
MOD_PKA_2	458	464	PF00069	0.657
MOD_PKA_2	551	557	PF00069	0.610
MOD_PKA_2	68	74	PF00069	0.684
MOD_Plk_1	434	440	PF00069	0.700
MOD_Plk_1	653	659	PF00069	0.625
MOD_Plk_4	151	157	PF00069	0.650
MOD_Plk_4	244	250	PF00069	0.589
MOD_Plk_4	348	354	PF00069	0.683
MOD_Plk_4	558	564	PF00069	0.667
MOD_Plk_4	653	659	PF00069	0.692
MOD_ProDKin_1	188	194	PF00069	0.706
MOD_ProDKin_1	398	404	PF00069	0.797
MOD_ProDKin_1	429	435	PF00069	0.735
MOD_ProDKin_1	476	482	PF00069	0.747
MOD_ProDKin_1	492	498	PF00069	0.688
MOD_ProDKin_1	505	511	PF00069	0.620
MOD_ProDKin_1	526	532	PF00069	0.677
MOD_ProDKin_1	556	562	PF00069	0.711
MOD_ProDKin_1	596	602	PF00069	0.740
MOD_SUMO_rev_2	212	222	PF00179	0.655
MOD_SUMO_rev_2	256	266	PF00179	0.553
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.670
TRG_ENDOCYTIC_2	315	318	PF00928	0.632
TRG_ER_diArg_1	168	171	PF00400	0.786
TRG_ER_diArg_1	356	359	PF00400	0.748
TRG_ER_diArg_1	458	460	PF00400	0.638
TRG_ER_diArg_1	50	52	PF00400	0.571
TRG_ER_diArg_1	53	55	PF00400	0.534
TRG_ER_diArg_1	588	591	PF00400	0.710
TRG_ER_diArg_1	605	608	PF00400	0.563
TRG_ER_diArg_1	645	648	PF00400	0.635
TRG_ER_diArg_1	664	666	PF00400	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H377	Leishmania braziliensis	62%	98%
A4HRH7	Leishmania infantum	99%	100%
E9AC45	Leishmania major	85%	95%
E9AJE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%