Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4V1_LEIDO

TriTrypDb:

LdBPK_010450.1 , LdCL_010009500 , LDHU3_01.0480

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H4V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4V1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016787	hydrolase activity	2	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.546
CLV_C14_Caspase3-7	247	251	PF00656	0.758
CLV_C14_Caspase3-7	253	257	PF00656	0.727
CLV_C14_Caspase3-7	553	557	PF00656	0.694
CLV_C14_Caspase3-7	69	73	PF00656	0.553
CLV_NRD_NRD_1	150	152	PF00675	0.543
CLV_NRD_NRD_1	193	195	PF00675	0.638
CLV_NRD_NRD_1	308	310	PF00675	0.783
CLV_NRD_NRD_1	456	458	PF00675	0.291
CLV_NRD_NRD_1	602	604	PF00675	0.605
CLV_NRD_NRD_1	605	607	PF00675	0.588
CLV_NRD_NRD_1	619	621	PF00675	0.541
CLV_NRD_NRD_1	651	653	PF00675	0.534
CLV_NRD_NRD_1	655	657	PF00675	0.523
CLV_NRD_NRD_1	719	721	PF00675	0.630
CLV_NRD_NRD_1	85	87	PF00675	0.622
CLV_PCSK_FUR_1	454	458	PF00082	0.291
CLV_PCSK_FUR_1	603	607	PF00082	0.460
CLV_PCSK_FUR_1	652	656	PF00082	0.528
CLV_PCSK_KEX2_1	150	152	PF00082	0.543
CLV_PCSK_KEX2_1	193	195	PF00082	0.638
CLV_PCSK_KEX2_1	456	458	PF00082	0.291
CLV_PCSK_KEX2_1	601	603	PF00082	0.537
CLV_PCSK_KEX2_1	605	607	PF00082	0.490
CLV_PCSK_KEX2_1	619	621	PF00082	0.583
CLV_PCSK_KEX2_1	651	653	PF00082	0.534
CLV_PCSK_KEX2_1	654	656	PF00082	0.527
CLV_PCSK_PC7_1	597	603	PF00082	0.534
CLV_PCSK_PC7_1	651	657	PF00082	0.527
CLV_PCSK_SKI1_1	159	163	PF00082	0.461
CLV_PCSK_SKI1_1	486	490	PF00082	0.296
CLV_PCSK_SKI1_1	655	659	PF00082	0.520
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SCF_FBW7_1	332	339	PF00400	0.588
DEG_SPOP_SBC_1	525	529	PF00917	0.743
DEG_SPOP_SBC_1	96	100	PF00917	0.663
DOC_CKS1_1	292	297	PF01111	0.830
DOC_CKS1_1	352	357	PF01111	0.612
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	21	24	PF00134	0.526
DOC_MAPK_DCC_7	350	360	PF00069	0.613
DOC_MAPK_gen_1	363	371	PF00069	0.541
DOC_PP2B_LxvP_1	170	173	PF13499	0.625
DOC_PP2B_LxvP_1	21	24	PF13499	0.526
DOC_SPAK_OSR1_1	420	424	PF12202	0.476
DOC_USP7_MATH_1	103	107	PF00917	0.729
DOC_USP7_MATH_1	30	34	PF00917	0.582
DOC_USP7_MATH_1	302	306	PF00917	0.708
DOC_USP7_MATH_1	327	331	PF00917	0.684
DOC_USP7_MATH_1	336	340	PF00917	0.646
DOC_USP7_MATH_1	346	350	PF00917	0.625
DOC_USP7_MATH_1	410	414	PF00917	0.352
DOC_USP7_MATH_1	525	529	PF00917	0.772
DOC_USP7_MATH_1	624	628	PF00917	0.553
DOC_USP7_MATH_1	743	747	PF00917	0.644
DOC_USP7_MATH_1	80	84	PF00917	0.668
DOC_USP7_MATH_1	94	98	PF00917	0.569
DOC_WW_Pin1_4	281	286	PF00397	0.705
DOC_WW_Pin1_4	291	296	PF00397	0.661
DOC_WW_Pin1_4	298	303	PF00397	0.715
DOC_WW_Pin1_4	328	333	PF00397	0.637
DOC_WW_Pin1_4	344	349	PF00397	0.676
DOC_WW_Pin1_4	351	356	PF00397	0.619
DOC_WW_Pin1_4	507	512	PF00397	0.764
DOC_WW_Pin1_4	539	544	PF00397	0.693
DOC_WW_Pin1_4	87	92	PF00397	0.626
LIG_14-3-3_CanoR_1	318	325	PF00244	0.649
LIG_14-3-3_CanoR_1	420	424	PF00244	0.486
LIG_14-3-3_CanoR_1	481	489	PF00244	0.613
LIG_14-3-3_CanoR_1	550	555	PF00244	0.575
LIG_14-3-3_CanoR_1	608	614	PF00244	0.584
LIG_APCC_ABBA_1	487	492	PF00400	0.491
LIG_APCC_ABBAyCdc20_2	486	492	PF00400	0.491
LIG_BIR_III_2	179	183	PF00653	0.537
LIG_BIR_III_4	201	205	PF00653	0.524
LIG_BRCT_BRCA1_1	375	379	PF00533	0.492
LIG_BRCT_BRCA1_1	484	488	PF00533	0.503
LIG_Clathr_ClatBox_1	54	58	PF01394	0.429
LIG_FHA_1	123	129	PF00498	0.607
LIG_FHA_1	14	20	PF00498	0.515
LIG_FHA_1	169	175	PF00498	0.511
LIG_FHA_1	379	385	PF00498	0.399
LIG_FHA_1	38	44	PF00498	0.477
LIG_FHA_1	4	10	PF00498	0.546
LIG_FHA_1	578	584	PF00498	0.447
LIG_FHA_1	663	669	PF00498	0.619
LIG_FHA_1	678	684	PF00498	0.395
LIG_FHA_1	713	719	PF00498	0.602
LIG_FHA_2	435	441	PF00498	0.505
LIG_FHA_2	525	531	PF00498	0.629
LIG_LIR_Gen_1	125	135	PF02991	0.509
LIG_LIR_Gen_1	227	237	PF02991	0.643
LIG_LIR_Gen_1	376	387	PF02991	0.325
LIG_LIR_Gen_1	404	414	PF02991	0.494
LIG_LIR_Gen_1	422	430	PF02991	0.352
LIG_LIR_Gen_1	437	446	PF02991	0.491
LIG_LIR_Nem_3	125	130	PF02991	0.565
LIG_LIR_Nem_3	227	232	PF02991	0.663
LIG_LIR_Nem_3	376	382	PF02991	0.461
LIG_LIR_Nem_3	404	409	PF02991	0.494
LIG_LIR_Nem_3	422	427	PF02991	0.389
LIG_LIR_Nem_3	437	441	PF02991	0.491
LIG_PCNA_PIPBox_1	693	702	PF02747	0.468
LIG_PDZ_Class_1	742	747	PF00595	0.474
LIG_SH2_CRK	143	147	PF00017	0.409
LIG_SH2_CRK	406	410	PF00017	0.334
LIG_SH2_CRK	424	428	PF00017	0.501
LIG_SH2_STAP1	438	442	PF00017	0.491
LIG_SH2_STAP1	579	583	PF00017	0.449
LIG_SH2_STAP1	594	598	PF00017	0.471
LIG_SH2_STAT3	279	282	PF00017	0.637
LIG_SH2_STAT3	578	581	PF00017	0.573
LIG_SH2_STAT5	135	138	PF00017	0.475
LIG_SH2_STAT5	143	146	PF00017	0.412
LIG_SH2_STAT5	176	179	PF00017	0.606
LIG_SH2_STAT5	388	391	PF00017	0.453
LIG_SH2_STAT5	579	582	PF00017	0.450
LIG_SH2_STAT5	661	664	PF00017	0.679
LIG_SH3_1	345	351	PF00018	0.753
LIG_SH3_3	289	295	PF00018	0.807
LIG_SH3_3	345	351	PF00018	0.777
LIG_SH3_3	353	359	PF00018	0.678
LIG_SUMO_SIM_anti_2	492	500	PF11976	0.494
LIG_SUMO_SIM_anti_2	665	670	PF11976	0.586
LIG_SUMO_SIM_par_1	181	186	PF11976	0.527
LIG_SUMO_SIM_par_1	223	230	PF11976	0.578
LIG_SUMO_SIM_par_1	52	58	PF11976	0.439
LIG_TRAF2_1	161	164	PF00917	0.481
LIG_TRAF2_1	528	531	PF00917	0.625
LIG_TRAF2_1	570	573	PF00917	0.494
LIG_TRAF2_1	730	733	PF00917	0.594
MOD_CDC14_SPxK_1	296	299	PF00782	0.697
MOD_CDC14_SPxK_1	347	350	PF00782	0.698
MOD_CDK_SPK_2	328	333	PF00069	0.670
MOD_CDK_SPxK_1	293	299	PF00069	0.697
MOD_CDK_SPxK_1	344	350	PF00069	0.710
MOD_CK1_1	107	113	PF00069	0.489
MOD_CK1_1	284	290	PF00069	0.697
MOD_CK1_1	321	327	PF00069	0.658
MOD_CK1_1	467	473	PF00069	0.334
MOD_CK1_1	510	516	PF00069	0.698
MOD_CK1_1	60	66	PF00069	0.518
MOD_CK1_1	623	629	PF00069	0.590
MOD_CK1_1	638	644	PF00069	0.703
MOD_CK1_1	92	98	PF00069	0.689
MOD_CK1_1	99	105	PF00069	0.759
MOD_CK2_1	115	121	PF00069	0.678
MOD_CK2_1	123	129	PF00069	0.527
MOD_CK2_1	224	230	PF00069	0.622
MOD_CK2_1	524	530	PF00069	0.741
MOD_CK2_1	567	573	PF00069	0.642
MOD_CMANNOS	35	38	PF00535	0.477
MOD_Cter_Amidation	617	620	PF01082	0.625
MOD_GlcNHglycan	101	104	PF01048	0.577
MOD_GlcNHglycan	106	109	PF01048	0.517
MOD_GlcNHglycan	24	27	PF01048	0.562
MOD_GlcNHglycan	243	246	PF01048	0.769
MOD_GlcNHglycan	252	255	PF01048	0.826
MOD_GlcNHglycan	289	292	PF01048	0.698
MOD_GlcNHglycan	305	308	PF01048	0.676
MOD_GlcNHglycan	320	323	PF01048	0.658
MOD_GlcNHglycan	338	341	PF01048	0.645
MOD_GlcNHglycan	375	378	PF01048	0.488
MOD_GlcNHglycan	389	392	PF01048	0.376
MOD_GlcNHglycan	410	413	PF01048	0.337
MOD_GlcNHglycan	466	469	PF01048	0.334
MOD_GlcNHglycan	515	518	PF01048	0.627
MOD_GlcNHglycan	521	524	PF01048	0.681
MOD_GlcNHglycan	58	62	PF01048	0.543
MOD_GlcNHglycan	622	625	PF01048	0.584
MOD_GlcNHglycan	626	629	PF01048	0.546
MOD_GlcNHglycan	637	640	PF01048	0.592
MOD_GlcNHglycan	701	704	PF01048	0.456
MOD_GlcNHglycan	78	81	PF01048	0.577
MOD_GlcNHglycan	91	94	PF01048	0.674
MOD_GSK3_1	103	110	PF00069	0.621
MOD_GSK3_1	280	287	PF00069	0.730
MOD_GSK3_1	298	305	PF00069	0.730
MOD_GSK3_1	314	321	PF00069	0.634
MOD_GSK3_1	328	335	PF00069	0.618
MOD_GSK3_1	37	44	PF00069	0.544
MOD_GSK3_1	387	394	PF00069	0.503
MOD_GSK3_1	397	404	PF00069	0.363
MOD_GSK3_1	45	52	PF00069	0.442
MOD_GSK3_1	469	476	PF00069	0.356
MOD_GSK3_1	515	522	PF00069	0.737
MOD_GSK3_1	53	60	PF00069	0.447
MOD_GSK3_1	537	544	PF00069	0.701
MOD_GSK3_1	550	557	PF00069	0.562
MOD_GSK3_1	620	627	PF00069	0.594
MOD_GSK3_1	695	702	PF00069	0.467
MOD_GSK3_1	76	83	PF00069	0.726
MOD_GSK3_1	92	99	PF00069	0.632
MOD_N-GLC_1	481	486	PF02516	0.334
MOD_N-GLC_1	567	572	PF02516	0.503
MOD_NEK2_1	115	120	PF00069	0.544
MOD_NEK2_1	168	173	PF00069	0.506
MOD_NEK2_1	3	8	PF00069	0.532
MOD_NEK2_1	37	42	PF00069	0.406
MOD_NEK2_1	387	392	PF00069	0.449
MOD_NEK2_1	401	406	PF00069	0.263
MOD_NEK2_1	47	52	PF00069	0.441
MOD_NEK2_1	537	542	PF00069	0.725
MOD_NEK2_1	679	684	PF00069	0.428
MOD_NEK2_1	695	700	PF00069	0.469
MOD_NEK2_1	76	81	PF00069	0.562
MOD_NEK2_2	231	236	PF00069	0.620
MOD_NEK2_2	397	402	PF00069	0.317
MOD_NEK2_2	419	424	PF00069	0.472
MOD_PIKK_1	577	583	PF00454	0.564
MOD_PIKK_1	60	66	PF00454	0.438
MOD_PK_1	53	59	PF00069	0.442
MOD_PKA_2	113	119	PF00069	0.675
MOD_PKA_2	264	270	PF00069	0.666
MOD_PKA_2	419	425	PF00069	0.490
MOD_PKB_1	216	224	PF00069	0.530
MOD_PKB_1	479	487	PF00069	0.449
MOD_PKB_1	548	556	PF00069	0.657
MOD_PKB_1	654	662	PF00069	0.629
MOD_PKB_1	710	718	PF00069	0.512
MOD_Plk_1	122	128	PF00069	0.515
MOD_Plk_1	57	63	PF00069	0.509
MOD_Plk_2-3	123	129	PF00069	0.600
MOD_Plk_2-3	252	258	PF00069	0.786
MOD_Plk_4	123	129	PF00069	0.600
MOD_Plk_4	224	230	PF00069	0.538
MOD_Plk_4	231	237	PF00069	0.516
MOD_Plk_4	31	37	PF00069	0.527
MOD_Plk_4	554	560	PF00069	0.678
MOD_ProDKin_1	281	287	PF00069	0.706
MOD_ProDKin_1	291	297	PF00069	0.658
MOD_ProDKin_1	298	304	PF00069	0.716
MOD_ProDKin_1	328	334	PF00069	0.638
MOD_ProDKin_1	344	350	PF00069	0.676
MOD_ProDKin_1	351	357	PF00069	0.621
MOD_ProDKin_1	507	513	PF00069	0.764
MOD_ProDKin_1	539	545	PF00069	0.691
MOD_ProDKin_1	87	93	PF00069	0.627
MOD_SUMO_rev_2	79	88	PF00179	0.666
TRG_DiLeu_BaEn_1	492	497	PF01217	0.442
TRG_DiLeu_BaEn_1	735	740	PF01217	0.524
TRG_DiLeu_BaEn_4	163	169	PF01217	0.525
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.518
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.564
TRG_ENDOCYTIC_2	143	146	PF00928	0.412
TRG_ENDOCYTIC_2	406	409	PF00928	0.336
TRG_ENDOCYTIC_2	424	427	PF00928	0.605
TRG_ENDOCYTIC_2	438	441	PF00928	0.334
TRG_ENDOCYTIC_2	579	582	PF00928	0.562
TRG_ENDOCYTIC_2	676	679	PF00928	0.487
TRG_ER_diArg_1	112	115	PF00400	0.634
TRG_ER_diArg_1	193	196	PF00400	0.541
TRG_ER_diArg_1	213	216	PF00400	0.574
TRG_ER_diArg_1	454	457	PF00400	0.334
TRG_ER_diArg_1	548	551	PF00400	0.670
TRG_ER_diArg_1	601	603	PF00400	0.541
TRG_ER_diArg_1	651	654	PF00400	0.530
TRG_ER_diArg_1	655	657	PF00400	0.523
TRG_ER_diArg_1	711	714	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L0	Leptomonas seymouri	45%	88%
A4H369	Leishmania braziliensis	71%	98%
A4HRG6	Leishmania infantum	99%	100%
E9AC34	Leishmania major	89%	99%
E9AJD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%