Dymeclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

Dyggve-Melchior-Clausen syndrome protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4V0_LEIDO

TriTrypDb:

LdBPK_010400.1 , LdCL_010009000 , LDHU3_01.0430

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H4V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4V0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.346
CLV_C14_Caspase3-7	633	637	PF00656	0.431
CLV_NRD_NRD_1	5	7	PF00675	0.428
CLV_NRD_NRD_1	615	617	PF00675	0.319
CLV_NRD_NRD_1	684	686	PF00675	0.277
CLV_NRD_NRD_1	722	724	PF00675	0.257
CLV_NRD_NRD_1	80	82	PF00675	0.358
CLV_NRD_NRD_1	806	808	PF00675	0.327
CLV_PCSK_KEX2_1	615	617	PF00082	0.319
CLV_PCSK_KEX2_1	684	686	PF00082	0.275
CLV_PCSK_KEX2_1	722	724	PF00082	0.257
CLV_PCSK_KEX2_1	80	82	PF00082	0.358
CLV_PCSK_KEX2_1	806	808	PF00082	0.327
CLV_PCSK_PC7_1	611	617	PF00082	0.318
CLV_PCSK_SKI1_1	105	109	PF00082	0.322
CLV_PCSK_SKI1_1	148	152	PF00082	0.291
CLV_PCSK_SKI1_1	172	176	PF00082	0.339
CLV_PCSK_SKI1_1	313	317	PF00082	0.291
CLV_PCSK_SKI1_1	412	416	PF00082	0.457
CLV_PCSK_SKI1_1	433	437	PF00082	0.494
CLV_PCSK_SKI1_1	475	479	PF00082	0.351
CLV_PCSK_SKI1_1	600	604	PF00082	0.379
CLV_PCSK_SKI1_1	650	654	PF00082	0.306
CLV_PCSK_SKI1_1	69	73	PF00082	0.262
CLV_Separin_Metazoa	169	173	PF03568	0.527
CLV_Separin_Metazoa	77	81	PF03568	0.474
DEG_APCC_DBOX_1	599	607	PF00400	0.440
DEG_SPOP_SBC_1	268	272	PF00917	0.440
DEG_SPOP_SBC_1	562	566	PF00917	0.530
DOC_CYCLIN_RxL_1	167	179	PF00134	0.539
DOC_MAPK_FxFP_2	441	444	PF00069	0.262
DOC_MAPK_gen_1	806	813	PF00069	0.507
DOC_MAPK_MEF2A_6	439	448	PF00069	0.339
DOC_PP1_RVXF_1	431	437	PF00149	0.291
DOC_PP2B_LxvP_1	266	269	PF13499	0.491
DOC_PP4_FxxP_1	441	444	PF00568	0.248
DOC_PP4_FxxP_1	783	786	PF00568	0.501
DOC_USP7_MATH_1	158	162	PF00917	0.518
DOC_USP7_MATH_1	16	20	PF00917	0.542
DOC_USP7_MATH_1	25	29	PF00917	0.345
DOC_USP7_MATH_1	277	281	PF00917	0.427
DOC_USP7_MATH_1	483	487	PF00917	0.513
DOC_USP7_MATH_1	57	61	PF00917	0.587
DOC_USP7_MATH_1	578	582	PF00917	0.546
DOC_WW_Pin1_4	200	205	PF00397	0.539
DOC_WW_Pin1_4	226	231	PF00397	0.483
DOC_WW_Pin1_4	342	347	PF00397	0.480
DOC_WW_Pin1_4	467	472	PF00397	0.539
DOC_WW_Pin1_4	672	677	PF00397	0.504
DOC_WW_Pin1_4	90	95	PF00397	0.539
LIG_14-3-3_CanoR_1	148	154	PF00244	0.526
LIG_14-3-3_CanoR_1	172	178	PF00244	0.575
LIG_14-3-3_CanoR_1	313	322	PF00244	0.522
LIG_14-3-3_CanoR_1	357	366	PF00244	0.587
LIG_14-3-3_CanoR_1	439	444	PF00244	0.317
LIG_Actin_WH2_2	532	547	PF00022	0.453
LIG_Actin_WH2_2	584	602	PF00022	0.539
LIG_Actin_WH2_2	92	107	PF00022	0.504
LIG_APCC_ABBA_1	193	198	PF00400	0.444
LIG_BRCT_BRCA1_1	441	445	PF00533	0.248
LIG_BRCT_BRCA1_1	779	783	PF00533	0.532
LIG_BRCT_BRCA1_1	9	13	PF00533	0.539
LIG_FHA_1	12	18	PF00498	0.539
LIG_FHA_1	140	146	PF00498	0.537
LIG_FHA_1	190	196	PF00498	0.483
LIG_FHA_1	214	220	PF00498	0.576
LIG_FHA_1	314	320	PF00498	0.558
LIG_FHA_1	404	410	PF00498	0.352
LIG_FHA_1	450	456	PF00498	0.318
LIG_FHA_1	468	474	PF00498	0.545
LIG_FHA_1	539	545	PF00498	0.503
LIG_FHA_1	63	69	PF00498	0.455
LIG_FHA_1	647	653	PF00498	0.537
LIG_FHA_1	91	97	PF00498	0.463
LIG_FHA_2	164	170	PF00498	0.457
LIG_FHA_2	415	421	PF00498	0.261
LIG_FHA_2	563	569	PF00498	0.560
LIG_FHA_2	578	584	PF00498	0.558
LIG_GBD_Chelix_1	392	400	PF00786	0.457
LIG_LIR_Apic_2	780	786	PF02991	0.512
LIG_LIR_Gen_1	194	204	PF02991	0.448
LIG_LIR_Gen_1	240	248	PF02991	0.541
LIG_LIR_Gen_1	306	315	PF02991	0.539
LIG_LIR_Gen_1	348	356	PF02991	0.509
LIG_LIR_Gen_1	376	385	PF02991	0.328
LIG_LIR_Gen_1	442	453	PF02991	0.331
LIG_LIR_Gen_1	773	778	PF02991	0.578
LIG_LIR_Nem_3	194	199	PF02991	0.452
LIG_LIR_Nem_3	240	244	PF02991	0.481
LIG_LIR_Nem_3	306	311	PF02991	0.539
LIG_LIR_Nem_3	348	352	PF02991	0.509
LIG_LIR_Nem_3	361	366	PF02991	0.387
LIG_LIR_Nem_3	376	381	PF02991	0.250
LIG_LIR_Nem_3	442	448	PF02991	0.289
LIG_LIR_Nem_3	773	777	PF02991	0.563
LIG_LIR_Nem_3	782	787	PF02991	0.492
LIG_LYPXL_yS_3	443	446	PF13949	0.308
LIG_MLH1_MIPbox_1	9	13	PF16413	0.539
LIG_NRBOX	170	176	PF00104	0.539
LIG_NRBOX	209	215	PF00104	0.510
LIG_NRBOX	365	371	PF00104	0.364
LIG_NRBOX	395	401	PF00104	0.257
LIG_PCNA_yPIPBox_3	501	514	PF02747	0.248
LIG_Pex14_2	241	245	PF04695	0.546
LIG_Pex14_2	441	445	PF04695	0.248
LIG_Pex14_2	783	787	PF04695	0.497
LIG_SH2_CRK	645	649	PF00017	0.396
LIG_SH2_NCK_1	645	649	PF00017	0.457
LIG_SH2_PTP2	371	374	PF00017	0.334
LIG_SH2_STAP1	481	485	PF00017	0.539
LIG_SH2_STAP1	622	626	PF00017	0.439
LIG_SH2_STAT3	531	534	PF00017	0.462
LIG_SH2_STAT3	595	598	PF00017	0.491
LIG_SH2_STAT5	12	15	PF00017	0.448
LIG_SH2_STAT5	264	267	PF00017	0.539
LIG_SH2_STAT5	337	340	PF00017	0.456
LIG_SH2_STAT5	371	374	PF00017	0.289
LIG_SH2_STAT5	531	534	PF00017	0.484
LIG_SH2_STAT5	595	598	PF00017	0.491
LIG_SH2_STAT5	626	629	PF00017	0.543
LIG_SH3_3	152	158	PF00018	0.462
LIG_SH3_3	249	255	PF00018	0.457
LIG_SH3_3	291	297	PF00018	0.491
LIG_SH3_3	47	53	PF00018	0.523
LIG_SH3_3	510	516	PF00018	0.289
LIG_SH3_3	80	86	PF00018	0.491
LIG_SH3_3	809	815	PF00018	0.690
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.472
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.457
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.581
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.240
LIG_SUMO_SIM_anti_2	450	458	PF11976	0.290
LIG_SUMO_SIM_anti_2	678	684	PF11976	0.463
LIG_SUMO_SIM_anti_2	767	773	PF11976	0.678
LIG_SUMO_SIM_par_1	264	273	PF11976	0.527
LIG_SUMO_SIM_par_1	398	403	PF11976	0.318
LIG_SUMO_SIM_par_1	450	458	PF11976	0.310
LIG_SUMO_SIM_par_1	491	496	PF11976	0.370
LIG_TRAF2_1	675	678	PF00917	0.507
LIG_TRAF2_1	773	776	PF00917	0.646
LIG_TYR_ITIM	369	374	PF00017	0.289
LIG_TYR_ITIM	620	625	PF00017	0.448
LIG_UBA3_1	103	112	PF00899	0.578
LIG_UBA3_1	318	327	PF00899	0.448
LIG_UBA3_1	399	405	PF00899	0.240
LIG_UBA3_1	652	661	PF00899	0.527
MOD_CK1_1	270	276	PF00069	0.560
MOD_CK1_1	345	351	PF00069	0.469
MOD_CK1_1	696	702	PF00069	0.466
MOD_CK1_1	744	750	PF00069	0.741
MOD_CK2_1	163	169	PF00069	0.537
MOD_CK2_1	303	309	PF00069	0.462
MOD_CK2_1	359	365	PF00069	0.381
MOD_CK2_1	562	568	PF00069	0.467
MOD_CK2_1	577	583	PF00069	0.554
MOD_CK2_1	672	678	PF00069	0.510
MOD_CK2_1	770	776	PF00069	0.619
MOD_GlcNHglycan	114	117	PF01048	0.322
MOD_GlcNHglycan	160	163	PF01048	0.320
MOD_GlcNHglycan	179	182	PF01048	0.155
MOD_GlcNHglycan	252	255	PF01048	0.196
MOD_GlcNHglycan	258	261	PF01048	0.189
MOD_GlcNHglycan	275	278	PF01048	0.332
MOD_GlcNHglycan	279	282	PF01048	0.326
MOD_GlcNHglycan	285	288	PF01048	0.317
MOD_GlcNHglycan	353	356	PF01048	0.334
MOD_GlcNHglycan	482	486	PF01048	0.291
MOD_GlcNHglycan	550	553	PF01048	0.284
MOD_GlcNHglycan	580	583	PF01048	0.301
MOD_GlcNHglycan	701	704	PF01048	0.347
MOD_GlcNHglycan	708	712	PF01048	0.383
MOD_GlcNHglycan	746	749	PF01048	0.512
MOD_GlcNHglycan	793	796	PF01048	0.412
MOD_GSK3_1	108	115	PF00069	0.499
MOD_GSK3_1	149	156	PF00069	0.460
MOD_GSK3_1	173	180	PF00069	0.482
MOD_GSK3_1	246	253	PF00069	0.519
MOD_GSK3_1	269	276	PF00069	0.523
MOD_GSK3_1	338	345	PF00069	0.517
MOD_GSK3_1	403	410	PF00069	0.263
MOD_GSK3_1	548	555	PF00069	0.483
MOD_GSK3_1	573	580	PF00069	0.564
MOD_GSK3_1	693	700	PF00069	0.507
MOD_GSK3_1	7	14	PF00069	0.512
MOD_GSK3_1	737	744	PF00069	0.548
MOD_N-GLC_1	403	408	PF02516	0.535
MOD_N-GLC_2	303	305	PF02516	0.257
MOD_N-GLC_2	726	728	PF02516	0.196
MOD_NEK2_1	108	113	PF00069	0.520
MOD_NEK2_1	149	154	PF00069	0.474
MOD_NEK2_1	173	178	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.481
MOD_NEK2_1	213	218	PF00069	0.430
MOD_NEK2_1	248	253	PF00069	0.490
MOD_NEK2_1	301	306	PF00069	0.539
MOD_NEK2_1	380	385	PF00069	0.250
MOD_NEK2_1	391	396	PF00069	0.226
MOD_NEK2_1	400	405	PF00069	0.145
MOD_NEK2_1	413	418	PF00069	0.234
MOD_NEK2_1	448	453	PF00069	0.313
MOD_NEK2_1	539	544	PF00069	0.490
MOD_PIKK_1	455	461	PF00454	0.284
MOD_PIKK_1	693	699	PF00454	0.559
MOD_PKA_2	108	114	PF00069	0.529
MOD_PKA_2	407	413	PF00069	0.356
MOD_PKA_2	548	554	PF00069	0.497
MOD_PKA_2	805	811	PF00069	0.621
MOD_Plk_1	189	195	PF00069	0.524
MOD_Plk_1	364	370	PF00069	0.339
MOD_Plk_1	735	741	PF00069	0.457
MOD_Plk_1	751	757	PF00069	0.546
MOD_Plk_2-3	764	770	PF00069	0.702
MOD_Plk_4	213	219	PF00069	0.509
MOD_Plk_4	237	243	PF00069	0.534
MOD_Plk_4	345	351	PF00069	0.524
MOD_Plk_4	364	370	PF00069	0.253
MOD_Plk_4	380	386	PF00069	0.214
MOD_Plk_4	449	455	PF00069	0.341
MOD_Plk_4	741	747	PF00069	0.491
MOD_Plk_4	788	794	PF00069	0.498
MOD_ProDKin_1	200	206	PF00069	0.539
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	342	348	PF00069	0.480
MOD_ProDKin_1	467	473	PF00069	0.539
MOD_ProDKin_1	672	678	PF00069	0.504
MOD_ProDKin_1	90	96	PF00069	0.539
TRG_DiLeu_BaEn_1	169	174	PF01217	0.432
TRG_DiLeu_BaEn_1	365	370	PF01217	0.381
TRG_DiLeu_BaEn_1	387	392	PF01217	0.348
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.553
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.491
TRG_DiLeu_LyEn_5	169	174	PF01217	0.527
TRG_ENDOCYTIC_2	371	374	PF00928	0.274
TRG_ENDOCYTIC_2	378	381	PF00928	0.237
TRG_ENDOCYTIC_2	443	446	PF00928	0.308
TRG_ENDOCYTIC_2	622	625	PF00928	0.439
TRG_ENDOCYTIC_2	774	777	PF00928	0.576
TRG_ER_diArg_1	683	685	PF00400	0.478
TRG_ER_diArg_1	79	81	PF00400	0.492
TRG_ER_FFAT_2	8	18	PF00635	0.491
TRG_NES_CRM1_1	365	376	PF08389	0.388
TRG_NES_CRM1_1	590	604	PF08389	0.491
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M9	Leptomonas seymouri	55%	97%
A0A0S4JPV7	Bodo saltans	26%	100%
A0A1X0P2R5	Trypanosomatidae	32%	100%
A0A422NY99	Trypanosoma rangeli	33%	100%
A4H364	Leishmania braziliensis	74%	98%
A4HRG1	Leishmania infantum	100%	100%
C9ZXI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AC29	Leishmania major	91%	100%
E9AJC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AX12	Trypanosoma cruzi	33%	100%