Transmembrane protein 208

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF788), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4U9_LEIDO

TriTrypDb:

LdBPK_010390.1 , LdCL_010008900 , LDHU3_01.0420

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005773	vacuole	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H4U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4U9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006624	vacuolar protein processing	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.225
CLV_NRD_NRD_1	169	171	PF00675	0.249
CLV_NRD_NRD_1	176	178	PF00675	0.251
CLV_NRD_NRD_1	181	183	PF00675	0.420
CLV_PCSK_KEX2_1	169	171	PF00082	0.248
CLV_PCSK_KEX2_1	181	183	PF00082	0.417
CLV_PCSK_KEX2_1	7	9	PF00082	0.303
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.226
CLV_PCSK_PC7_1	177	183	PF00082	0.415
CLV_PCSK_SKI1_1	184	188	PF00082	0.429
CLV_PCSK_SKI1_1	8	12	PF00082	0.286
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.261
DOC_MAPK_gen_1	11	19	PF00069	0.455
DOC_PP2B_LxvP_1	122	125	PF13499	0.251
DOC_PP4_FxxP_1	120	123	PF00568	0.324
DOC_USP7_UBL2_3	171	175	PF12436	0.471
DOC_USP7_UBL2_3	3	7	PF12436	0.424
DOC_WW_Pin1_4	71	76	PF00397	0.306
LIG_14-3-3_CanoR_1	18	23	PF00244	0.467
LIG_BIR_II_1	1	5	PF00653	0.424
LIG_deltaCOP1_diTrp_1	99	105	PF00928	0.211
LIG_FHA_1	22	28	PF00498	0.249
LIG_FHA_2	150	156	PF00498	0.418
LIG_LIR_Gen_1	44	53	PF02991	0.270
LIG_LIR_Nem_3	44	48	PF02991	0.234
LIG_LIR_Nem_3	58	62	PF02991	0.195
LIG_LIR_Nem_3	90	96	PF02991	0.267
LIG_SH2_CRK	62	66	PF00017	0.271
LIG_SH2_NCK_1	94	98	PF00017	0.267
LIG_SH2_PTP2	31	34	PF00017	0.190
LIG_SH2_SRC	121	124	PF00017	0.245
LIG_SH2_STAT5	121	124	PF00017	0.263
LIG_SH2_STAT5	144	147	PF00017	0.520
LIG_SH2_STAT5	31	34	PF00017	0.310
LIG_SH2_STAT5	59	62	PF00017	0.276
LIG_SH2_STAT5	94	97	PF00017	0.294
LIG_SH3_3	133	139	PF00018	0.475
LIG_SH3_3	65	71	PF00018	0.358
LIG_TRAF2_1	55	58	PF00917	0.224
LIG_TYR_ITIM	119	124	PF00017	0.245
LIG_TYR_ITIM	29	34	PF00017	0.190
LIG_TYR_ITIM	60	65	PF00017	0.306
LIG_TYR_ITIM	91	96	PF00017	0.267
LIG_WRC_WIRS_1	42	47	PF05994	0.253
LIG_WW_3	161	165	PF00397	0.457
MOD_CK1_1	21	27	PF00069	0.345
MOD_CK1_1	41	47	PF00069	0.313
MOD_CK1_1	63	69	PF00069	0.367
MOD_CMANNOS	102	105	PF00535	0.245
MOD_GlcNHglycan	147	150	PF01048	0.297
MOD_GlcNHglycan	184	187	PF01048	0.398
MOD_GSK3_1	145	152	PF00069	0.476
MOD_N-GLC_1	38	43	PF02516	0.457
MOD_NEK2_1	145	150	PF00069	0.510
MOD_NEK2_1	60	65	PF00069	0.285
MOD_PKB_1	16	24	PF00069	0.506
MOD_Plk_4	124	130	PF00069	0.506
MOD_Plk_4	132	138	PF00069	0.506
MOD_Plk_4	60	66	PF00069	0.283
MOD_ProDKin_1	71	77	PF00069	0.306
TRG_ENDOCYTIC_2	121	124	PF00928	0.293
TRG_ENDOCYTIC_2	31	34	PF00928	0.304
TRG_ENDOCYTIC_2	62	65	PF00928	0.218
TRG_ENDOCYTIC_2	93	96	PF00928	0.267
TRG_ER_diArg_1	15	18	PF00400	0.518
TRG_ER_diArg_1	163	166	PF00400	0.455
TRG_ER_diArg_1	180	182	PF00400	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P720	Leptomonas seymouri	67%	100%
A0A0S4ILZ6	Bodo saltans	42%	100%
A0A1X0P3E2	Trypanosomatidae	55%	100%
A0A422NY40	Trypanosoma rangeli	56%	100%
A4H363	Leishmania braziliensis	82%	100%
A4HRG0	Leishmania infantum	100%	100%
C9ZXI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AC28	Leishmania major	96%	100%
E9AJC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q6NYP0	Danio rerio	25%	100%
Q9BTX3	Homo sapiens	28%	100%
Q9CR96	Mus musculus	28%	100%