Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4U8_LEIDO

TriTrypDb:

LdBPK_010380.1 , LdCL_010008800 , LDHU3_01.0410

Length:

189

Annotations

LeishMANIAdb annotations

This protein appears to have an Ala-rich signal peptide and a single TM segment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H4U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.357
CLV_C14_Caspase3-7	75	79	PF00656	0.638
CLV_NRD_NRD_1	176	178	PF00675	0.771
CLV_NRD_NRD_1	186	188	PF00675	0.660
CLV_PCSK_FUR_1	74	78	PF00082	0.487
CLV_PCSK_KEX2_1	175	177	PF00082	0.776
CLV_PCSK_KEX2_1	18	20	PF00082	0.461
CLV_PCSK_KEX2_1	186	188	PF00082	0.649
CLV_PCSK_KEX2_1	76	78	PF00082	0.485
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.493
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.459
CLV_PCSK_SKI1_1	7	11	PF00082	0.482
DEG_COP1_1	16	23	PF00400	0.675
DOC_MAPK_gen_1	118	127	PF00069	0.529
DOC_MAPK_MEF2A_6	121	129	PF00069	0.354
DOC_PP2B_LxvP_1	23	26	PF13499	0.707
DOC_PP4_MxPP_1	1	4	PF00568	0.688
DOC_USP7_MATH_1	140	144	PF00917	0.410
DOC_USP7_MATH_1	167	171	PF00917	0.439
DOC_USP7_UBL2_3	72	76	PF12436	0.638
DOC_WW_Pin1_4	54	59	PF00397	0.696
LIG_14-3-3_CanoR_1	41	49	PF00244	0.721
LIG_14-3-3_CanoR_1	7	14	PF00244	0.669
LIG_Actin_WH2_2	28	43	PF00022	0.694
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_BIR_III_1	1	5	PF00653	0.680
LIG_BIR_III_3	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	119	123	PF00533	0.478
LIG_BRCT_BRCA1_1	65	69	PF00533	0.596
LIG_EH_1	138	142	PF12763	0.412
LIG_FHA_1	31	37	PF00498	0.618
LIG_FHA_1	8	14	PF00498	0.691
LIG_FHA_2	66	72	PF00498	0.595
LIG_FXI_DFP_1	89	93	PF00024	0.496
LIG_LIR_Apic_2	143	149	PF02991	0.435
LIG_LIR_Gen_1	120	131	PF02991	0.478
LIG_LIR_Gen_1	68	75	PF02991	0.592
LIG_LIR_Gen_1	86	96	PF02991	0.710
LIG_LIR_Nem_3	120	126	PF02991	0.478
LIG_LIR_Nem_3	68	73	PF02991	0.587
LIG_LIR_Nem_3	86	92	PF02991	0.715
LIG_SH2_CRK	70	74	PF00017	0.606
LIG_SH2_NCK_1	146	150	PF00017	0.361
LIG_SH3_2	93	98	PF14604	0.690
LIG_SH3_3	134	140	PF00018	0.388
LIG_SH3_3	46	52	PF00018	0.716
LIG_SH3_3	90	96	PF00018	0.691
LIG_SUMO_SIM_par_1	51	57	PF11976	0.594
LIG_TYR_ITSM	66	73	PF00017	0.587
MOD_CK1_1	170	176	PF00069	0.475
MOD_CK1_1	39	45	PF00069	0.689
MOD_CK1_1	57	63	PF00069	0.675
MOD_CK1_1	65	71	PF00069	0.538
MOD_CK2_1	77	83	PF00069	0.701
MOD_Cter_Amidation	173	176	PF01082	0.665
MOD_GlcNHglycan	170	173	PF01048	0.650
MOD_GlcNHglycan	59	62	PF01048	0.512
MOD_GSK3_1	36	43	PF00069	0.646
MOD_NEK2_1	105	110	PF00069	0.602
MOD_NEK2_1	31	36	PF00069	0.744
MOD_NEK2_1	40	45	PF00069	0.602
MOD_NEK2_1	62	67	PF00069	0.611
MOD_PKA_2	14	20	PF00069	0.725
MOD_PKA_2	168	174	PF00069	0.435
MOD_PKA_2	40	46	PF00069	0.693
MOD_Plk_4	133	139	PF00069	0.364
MOD_Plk_4	31	37	PF00069	0.661
MOD_ProDKin_1	54	60	PF00069	0.694
TRG_ENDOCYTIC_2	70	73	PF00928	0.603
TRG_ER_diArg_1	175	177	PF00400	0.572
TRG_ER_diArg_1	185	187	PF00400	0.460
TRG_ER_diArg_1	98	101	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ0	Leptomonas seymouri	47%	100%
A4H362	Leishmania braziliensis	65%	100%
A4HRF9	Leishmania infantum	99%	100%
E9AC27	Leishmania major	91%	100%
E9AJC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%