Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4U7_LEIDO

TriTrypDb:

LdBPK_010360.1 , LdCL_010008600 , LDHU3_01.0390

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H4U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.381
CLV_NRD_NRD_1	208	210	PF00675	0.456
CLV_NRD_NRD_1	39	41	PF00675	0.441
CLV_PCSK_FUR_1	10	14	PF00082	0.391
CLV_PCSK_KEX2_1	12	14	PF00082	0.392
CLV_PCSK_KEX2_1	207	209	PF00082	0.427
CLV_PCSK_SKI1_1	149	153	PF00082	0.349
DOC_CDC14_PxL_1	221	229	PF14671	0.444
DOC_CKS1_1	184	189	PF01111	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	231	240	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.656
DOC_MAPK_gen_1	207	216	PF00069	0.568
DOC_MAPK_MEF2A_6	130	139	PF00069	0.655
DOC_MAPK_MEF2A_6	208	217	PF00069	0.569
DOC_PP2B_LxvP_1	210	213	PF13499	0.660
DOC_USP7_MATH_1	118	122	PF00917	0.700
DOC_USP7_MATH_1	223	227	PF00917	0.444
DOC_USP7_MATH_1	73	77	PF00917	0.753
DOC_USP7_MATH_1	83	87	PF00917	0.771
DOC_USP7_UBL2_3	41	45	PF12436	0.636
DOC_WW_Pin1_4	183	188	PF00397	0.352
DOC_WW_Pin1_4	81	86	PF00397	0.743
DOC_WW_Pin1_4	89	94	PF00397	0.735
LIG_14-3-3_CanoR_1	207	213	PF00244	0.608
LIG_APCC_ABBA_1	140	145	PF00400	0.649
LIG_BIR_II_1	1	5	PF00653	0.724
LIG_BIR_III_2	222	226	PF00653	0.444
LIG_FHA_1	100	106	PF00498	0.721
LIG_FHA_1	3	9	PF00498	0.679
LIG_FHA_2	171	177	PF00498	0.413
LIG_FHA_2	66	72	PF00498	0.749
LIG_GBD_Chelix_1	232	240	PF00786	0.549
LIG_LIR_Gen_1	43	53	PF02991	0.658
LIG_LIR_LC3C_4	230	233	PF02991	0.447
LIG_LIR_Nem_3	43	49	PF02991	0.596
LIG_PDZ_Class_2	248	253	PF00595	0.461
LIG_Pex14_2	139	143	PF04695	0.670
LIG_REV1ctd_RIR_1	136	145	PF16727	0.676
LIG_SH2_CRK	15	19	PF00017	0.599
LIG_SH2_PTP2	218	221	PF00017	0.408
LIG_SH2_STAT5	203	206	PF00017	0.604
LIG_SH2_STAT5	218	221	PF00017	0.270
LIG_SH3_3	171	177	PF00018	0.386
LIG_SH3_3	59	65	PF00018	0.736
LIG_SH3_3	69	75	PF00018	0.797
LIG_SH3_3	90	96	PF00018	0.768
LIG_SUMO_SIM_anti_2	237	242	PF11976	0.432
LIG_SUMO_SIM_par_1	159	164	PF11976	0.361
LIG_TRAF2_1	68	71	PF00917	0.782
LIG_TRFH_1	244	248	PF08558	0.319
LIG_TYR_ITIM	216	221	PF00017	0.369
MOD_CK1_1	183	189	PF00069	0.424
MOD_CK1_1	2	8	PF00069	0.670
MOD_CK1_1	201	207	PF00069	0.594
MOD_CK1_1	24	30	PF00069	0.705
MOD_CK1_1	66	72	PF00069	0.759
MOD_CK1_1	84	90	PF00069	0.794
MOD_CK2_1	1	7	PF00069	0.744
MOD_CK2_1	65	71	PF00069	0.779
MOD_GlcNHglycan	210	213	PF01048	0.428
MOD_GlcNHglycan	27	30	PF01048	0.503
MOD_GlcNHglycan	59	62	PF01048	0.542
MOD_GlcNHglycan	65	68	PF01048	0.601
MOD_GlcNHglycan	81	84	PF01048	0.360
MOD_GSK3_1	143	150	PF00069	0.617
MOD_GSK3_1	176	183	PF00069	0.455
MOD_GSK3_1	194	201	PF00069	0.188
MOD_GSK3_1	21	28	PF00069	0.701
MOD_GSK3_1	75	82	PF00069	0.713
MOD_LATS_1	206	212	PF00433	0.530
MOD_N-GLC_1	143	148	PF02516	0.417
MOD_N-GLC_1	234	239	PF02516	0.605
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	143	148	PF00069	0.662
MOD_NEK2_1	170	175	PF00069	0.445
MOD_NEK2_1	236	241	PF00069	0.376
MOD_NEK2_1	25	30	PF00069	0.725
MOD_PIKK_1	201	207	PF00454	0.599
MOD_PKA_1	208	214	PF00069	0.606
MOD_PKA_2	208	214	PF00069	0.523
MOD_PKA_2	21	27	PF00069	0.690
MOD_Plk_1	234	240	PF00069	0.407
MOD_Plk_4	147	153	PF00069	0.528
MOD_Plk_4	161	167	PF00069	0.305
MOD_Plk_4	170	176	PF00069	0.381
MOD_Plk_4	180	186	PF00069	0.301
MOD_Plk_4	198	204	PF00069	0.243
MOD_Plk_4	236	242	PF00069	0.404
MOD_Plk_4	247	253	PF00069	0.482
MOD_ProDKin_1	183	189	PF00069	0.352
MOD_ProDKin_1	81	87	PF00069	0.746
MOD_ProDKin_1	89	95	PF00069	0.733
MOD_SUMO_rev_2	37	47	PF00179	0.634
TRG_DiLeu_BaEn_4	37	43	PF01217	0.625
TRG_ENDOCYTIC_2	15	18	PF00928	0.580
TRG_ENDOCYTIC_2	218	221	PF00928	0.344
TRG_ENDOCYTIC_2	46	49	PF00928	0.595
TRG_ER_diArg_1	10	13	PF00400	0.591
TRG_ER_diArg_1	207	209	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C0	Leptomonas seymouri	40%	95%
A0A1X0P2R1	Trypanosomatidae	29%	100%
A0A3R7NR92	Trypanosoma rangeli	28%	93%
A4H360	Leishmania braziliensis	65%	100%
A4HRF7	Leishmania infantum	98%	100%
E9AC25	Leishmania major	90%	100%
E9AJC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5AQ19	Trypanosoma cruzi	28%	86%