LeishMANIAdb
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4F5_protein_family_putative/Pfam:PF04419

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
4F5_protein_family_putative/Pfam:PF04419
Gene product:
4F5 protein family, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H4U3_LEIDO
TriTrypDb:
LdCL_010008000 , LDHU3_01.0330
Length:
59

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4U3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4U3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 35 37 PF00675 0.264
CLV_NRD_NRD_1 52 54 PF00675 0.360
CLV_PCSK_KEX2_1 35 37 PF00082 0.319
CLV_PCSK_SKI1_1 13 17 PF00082 0.280
DOC_USP7_UBL2_3 13 17 PF12436 0.463
LIG_BIR_II_1 1 5 PF00653 0.438
TRG_Pf-PMV_PEXEL_1 7 12 PF00026 0.302

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IZ21 Bodo saltans 69% 100%
A4H354 Leishmania braziliensis 80% 100%
A4HRF1 Leishmania infantum 100% 100%
A5JSS4 Capra hircus 60% 100%
B1MTI8 Plecturocebus moloch 60% 100%
C9ZXE6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9AC19 Leishmania major 95% 100%
E9AJB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
O88892 Mus musculus 54% 95%
P84101 Homo sapiens 60% 100%
P84102 Mus musculus 60% 100%
Q32P76 Bos taurus 59% 95%
Q3E7B7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 55% 87%
Q5R7C4 Pongo abelii 60% 100%
Q9BKU8 Caenorhabditis elegans 57% 72%
Q9VEW2 Drosophila melanogaster 56% 98%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS