Thioredoxin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Thioredoxin

Gene product:

thioredoxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4U0_LEIDO

TriTrypDb:

LdBPK_010270.1 , LdCL_010007700 , LDHU3_01.0300

Length:

107

Annotations

Annotations by Jardim et al.

Redox homeostasis, Thioredoxin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S5H4U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4U0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0015035	protein-disulfide reductase activity	3	8
GO:0015036	disulfide oxidoreductase activity	4	8
GO:0016491	oxidoreductase activity	2	8
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	52	56	PF00082	0.429
DOC_USP7_UBL2_3	35	39	PF12436	0.490
LIG_14-3-3_CanoR_1	43	47	PF00244	0.511
LIG_FHA_1	18	24	PF00498	0.488
LIG_FHA_1	60	66	PF00498	0.452
LIG_FHA_1	73	79	PF00498	0.346
LIG_LIR_Apic_2	27	33	PF02991	0.410
LIG_LIR_Gen_1	45	56	PF02991	0.446
LIG_LIR_Gen_1	75	84	PF02991	0.410
LIG_LIR_Nem_3	10	15	PF02991	0.410

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL85	Leptomonas seymouri	33%	69%
A0A0N1PD08	Leptomonas seymouri	84%	100%
A0A0S4IQ93	Bodo saltans	24%	77%
A0A0S4ISI9	Bodo saltans	39%	70%
A0A0S4IZF8	Bodo saltans	68%	100%
A0A1X0P2Q9	Trypanosomatidae	68%	100%
A0A3Q8IGH5	Leishmania donovani	36%	69%
A0A3R7NZW1	Trypanosoma rangeli	65%	100%
A4H351	Leishmania braziliensis	94%	100%
A4HRE8	Leishmania infantum	100%	100%

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