cwf21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4T7_LEIDO

TriTrypDb:

LdBPK_010190.1 , LdCL_010006900 , LDHU3_01.0210

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S5H4T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.528
CLV_NRD_NRD_1	113	115	PF00675	0.496
CLV_NRD_NRD_1	172	174	PF00675	0.532
CLV_NRD_NRD_1	187	189	PF00675	0.608
CLV_NRD_NRD_1	53	55	PF00675	0.656
CLV_PCSK_FUR_1	185	189	PF00082	0.559
CLV_PCSK_KEX2_1	112	114	PF00082	0.511
CLV_PCSK_KEX2_1	171	173	PF00082	0.529
CLV_PCSK_KEX2_1	184	186	PF00082	0.543
CLV_PCSK_KEX2_1	187	189	PF00082	0.529
CLV_PCSK_KEX2_1	53	55	PF00082	0.656
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.449
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.499
CLV_PCSK_SKI1_1	113	117	PF00082	0.447
CLV_PCSK_SKI1_1	78	82	PF00082	0.370
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SPOP_SBC_1	141	145	PF00917	0.675
DOC_MAPK_DCC_7	86	96	PF00069	0.414
DOC_MAPK_gen_1	70	79	PF00069	0.431
DOC_MAPK_MEF2A_6	70	79	PF00069	0.390
DOC_USP7_UBL2_3	112	116	PF12436	0.545
DOC_USP7_UBL2_3	125	129	PF12436	0.564
LIG_Actin_WH2_2	59	75	PF00022	0.446
LIG_APCC_ABBA_1	79	84	PF00400	0.402
LIG_APCC_ABBAyCdc20_2	78	84	PF00400	0.375
LIG_FHA_1	137	143	PF00498	0.545
LIG_FHA_1	27	33	PF00498	0.618
LIG_FHA_2	165	171	PF00498	0.598
LIG_LIR_Gen_1	102	111	PF02991	0.457
LIG_LIR_Nem_3	102	107	PF02991	0.460
LIG_PDZ_Class_1	202	207	PF00595	0.482
LIG_Pex14_2	130	134	PF04695	0.428
LIG_SH2_CRK	104	108	PF00017	0.483
LIG_SH2_STAP1	104	108	PF00017	0.425
LIG_SH2_STAT5	18	21	PF00017	0.439
LIG_TRAF2_1	158	161	PF00917	0.626
LIG_TRAF2_1	167	170	PF00917	0.525
LIG_TRAF2_1	33	36	PF00917	0.624
MOD_CK2_1	155	161	PF00069	0.589
MOD_CK2_1	164	170	PF00069	0.506
MOD_GlcNHglycan	144	147	PF01048	0.655
MOD_GlcNHglycan	15	18	PF01048	0.441
MOD_GlcNHglycan	150	153	PF01048	0.678
MOD_GSK3_1	136	143	PF00069	0.637
MOD_NEK2_1	103	108	PF00069	0.369
MOD_NEK2_1	155	160	PF00069	0.648
MOD_Plk_1	155	161	PF00069	0.546
MOD_Plk_2-3	92	98	PF00069	0.473
MOD_Plk_4	103	109	PF00069	0.381
TRG_ENDOCYTIC_2	104	107	PF00928	0.454
TRG_ENDOCYTIC_2	2	5	PF00928	0.464
TRG_ER_diArg_1	113	115	PF00400	0.506
TRG_ER_diArg_1	171	173	PF00400	0.583
TRG_ER_diArg_1	185	188	PF00400	0.579
TRG_ER_diArg_1	21	24	PF00400	0.547
TRG_ER_diArg_1	75	78	PF00400	0.477
TRG_NLS_Bipartite_1	171	188	PF00514	0.526
TRG_NLS_MonoExtC_3	111	116	PF00514	0.435
TRG_NLS_MonoExtC_3	183	188	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C9	Leptomonas seymouri	65%	100%
A0A0S4IKH1	Bodo saltans	37%	100%
A0A1X0P2X2	Trypanosomatidae	43%	100%
A0A3R7MZG4	Trypanosoma rangeli	44%	100%
A4H343	Leishmania braziliensis	79%	99%
A4HRE0	Leishmania infantum	100%	100%
C9ZXF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AC08	Leishmania major	96%	100%
E9AJA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q38FI2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	42%	100%